Abstract:
AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architecture of the lymph node was diffusely effaced by small to medium sized monomorphic blastoid lymphoid cells which frequently formed Homer-Wright type pseudorosettes. Immunophenotyping of the tumour using immunohistochemistry and flow cytometry revealed LCA+, CD4+, CD56+, CD43+, TdT+, CD2-, cCD3-, CD8-, CD7-, CD34- and TIA-1-. DNA analysis revealed no gene rearrangement of TCR beta and gamma genes. In situ hybridization for EBER 1 & 2 was negative. No azurophilic granules were found in the Wright stain. Complete remission was achieved with six cycles of chemotherapy with the CHOP regimen. The disease recurred in the paranasal sinuses and bone marrow 2 years later. CONCLUSIONS:Immunophenotypic and genotypic similarities of the present case to those of TdT-negative blastic NK-cell lymphoma suggest that these diseases might be categorized as one entity irrespective of expression of TdT.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Ko YH,Kim SH,Ree HJdoi
10.1046/j.1365-2559.1998.00571.xsubject
Has Abstractpub_date
1998-12-01 00:00:00pages
547-53issue
6eissn
0309-0167issn
1365-2559journal_volume
33pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract::A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00439.x
更新日期:1992-12-01 00:00:00
abstract::A male infant was diagnosed as having diabetes mellitus 1 d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin-secreting cells. There was no evidence of insulitis. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1988.tb01974.x
更新日期:1988-05-01 00:00:00
abstract:AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04307.x
更新日期:2012-12-01 00:00:00
abstract::An ovarian and rectal carcinoid within the same person is described. The ovarian carcinoid is non-argentaffinic with typical regular granules. The rectal tumour consists of two types of APUD cells, some argentaffinic and diazo-positive, whilst others are non-argyrophilic. These features are mirrored ultrastructurally,...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1979.tb02978.x
更新日期:1979-01-01 00:00:00
abstract::We present a 27-year-old woman with non-systemic diffuse lymphangiomatosis of spleen and liver. The tumour consisted of capillary and cavernous lymphatic vessels located in abundant fibrous tissue. The vascular endothelium showed immunoreactivity for factor VIII-related antigen. A basal lamina could be demonstrated im...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00884.x
更新日期:1991-05-01 00:00:00
abstract:AIMS:Previous studies have shown that increased vascularity is associated with tumour progression in human neuroblastoma (NB). The involvement of erythropoietin (Epo) in tumour angiogenesis has also been reported. The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in end...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02653.x
更新日期:2007-04-01 00:00:00
abstract:AIMS:To establish the prevalence of CD44 protein expression in a large surgical series of Barrett's adenocarcinoma and associated preneoplastic lesions and to correlate this expression with clinicopathological data and prognosis. METHODS AND RESULTS:CD44H and variants (V4/V5, V6) expression was detected by immunohisto...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00316.x
更新日期:1998-01-01 00:00:00
abstract:AIMS:In T cells, protein kinase C (PKC) theta plays a major role in T-cell receptor (TCR)-mediated activation of a novel nuclear factor (NF)-kappaB pathway that involves phosphorylation of p65 at serine 536 (Pp65(Ser536)). Bcl-10 acts along the same pathway downstream of PKC theta to activate NF-kappaB. The aim was to ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03250.x
更新日期:2009-03-01 00:00:00
abstract::Gonadoblastoma is defined as a neoplasm containing nests of germ cells and cells resembling Sertoli cells or granulosa cells. Gonadoblastomas arise almost exclusively in dysgenetic gonads. They are associated with an increased risk of developing germ cell tumours. Testicular germ cell tumours in adults are preceded by...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.d01-580.x
更新日期:1997-02-01 00:00:00
abstract::Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a d...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1987.tb02668.x
更新日期:1987-06-01 00:00:00
abstract::Thirty-two young women who desired sexual reassignment were treated with large doses of androgen for a period of 1 year or more, followed by total hysterectomy. Histological examination revealed marked atrophy of cervical epithelium which could mimic dysplasia, and variable degrees of endometrial atrophy. The ovaries ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1986.tb02520.x
更新日期:1986-07-01 00:00:00
abstract:AIMS:Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare malignancy, and its clinicopathological characteristics have not yet been fully elucidated. This study aimed to elucidate the clinicopathological features of CAED through immunostaining of enteroblastic lineage markers alpha-fetoprotein ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13973
更新日期:2020-01-01 00:00:00
abstract:AIMS:To examine 13 cases of mesothelioma with metastases and compare these with 29 biopsy samples of patients without metastases. Metastatic disease was defined as tumour in which tumour appeared in a different cavity/tissue of the body and which showed no direct spread. Consequently, mediastinal nodal and parenchymal ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2004.01844.x
更新日期:2004-04-01 00:00:00
abstract:AIMS:Breast cancer 1 (BRCA1) expression is down-regulated in a significant proportion of non-hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen (ER)-negative tumours. Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12801
更新日期:2016-04-01 00:00:00
abstract::While the histological grade of a renal cell carcinoma is of prognostic significance there is poor concordance amongst pathologists in the use of these grading systems. Many grading systems have been described, but none has achieved widespread acceptance. The objective of this study was to assess the degree of interob...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00557.x
更新日期:1994-05-01 00:00:00
abstract::Morphometric methods were applied to predict the clinical course of individual patients with breast cancer. Measurement of tumour diameter, assessment of mitotic and cellular indices, and quantitative microscopy of nuclear features were assessed together with nuclear features and histological grades. Of the tumours fr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1982.tb02727.x
更新日期:1982-05-01 00:00:00
abstract:AIMS:To study immunohistochemically a group of 28 primary lung cancers which demonstrated histological features reminiscent of those characteristic of regression in malignant melanoma, to determine the phenotype of their immune cell infiltrates. METHODS AND RESULTS:Using a standard s-ABC immunoperoxidase method then q...
journal_title:Histopathology
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2000.00894.x
更新日期:2000-05-01 00:00:00
abstract:AIMS:To study three atypical glioneuronal tumours (GNTs), in order to shed light on the clinical and pathological features of this diverse tumour group. METHODS AND RESULTS:Clinical and neuropathological data for each case were retrospectively reviewed. Case 1 involved a 17-year-old boy with left leg movement difficul...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12750
更新日期:2016-02-01 00:00:00
abstract::Surgical biopsy specimens from five children with cerebellar medulloblastoma were examined for ultrastructural evidence of differentiating activity. At light microscope level, all the tumour samples appeared primitive and featureless, and could not be classified as showing either neuroblastic or spongioblastic differe...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02306.x
更新日期:1983-11-01 00:00:00
abstract:AIMS:The B7 family check-point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status in human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the expression profiles of the B7 family check-point proteins PD-L1, PD-L2, B7-H3, B7-H4, VISTA and B7-...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13882
更新日期:2019-09-01 00:00:00
abstract::The clinical, light microscopic and immunohistochemical features of six cutaneous heterotopic meningeal nodules (primary, or type I, cutaneous meningiomas) are described. These are rare lesions of the scalp and back which generally present at birth or in childhood. They appear as small subcutaneous fibrous nodules, wi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb01547.x
更新日期:1990-05-01 00:00:00
abstract::The author reports a case of a 53-year-old woman with a slowly growing thyroid papillary carcinoma. Microscopically the presence of adult adipose tissue was detected in numerous papillae. The recognition of this histological type as a new variety of papillary carcinoma is proposed. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1986.tb02464.x
更新日期:1986-01-01 00:00:00
abstract::The new World Health Organization (WHO) classification of soft tissue tumours was published in early 2013, almost 11 years after the previous edition. While the number of newly recognized entities included for the first time is fewer than that in 2002, there have instead been substantial steps forward in molecular gen...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12267
更新日期:2014-01-01 00:00:00
abstract::Vulvar squamous cell carcinoma (VSCC) accounts for >90% of the malignant tumours of the vulva. Most VSCCs originate in intraepithelial lesions, named vulvar intraepithelial neoplasia (VIN), that precede the development of VSCC by a variable period of time. Strong evidence has accumulated showing that there are two dif...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12034
更新日期:2013-01-01 00:00:00
abstract:AIMS:Lectins, and especially galectins, appear to be important in malignancy-associated processes. The aim was to analyse comprehensively the presence of galectins in urothelial tumours. METHODS AND RESULTS:Non-cross-reactive antibodies against seven family members from the three subgroups (prototype: galectin-1, -2 a...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02852.x
更新日期:2007-11-01 00:00:00
abstract:AIMS:Atypical polypoid adenomyoma (APAM) is an uncommon uterine lesion composed of complex endometrioid glands with frequent squamous morular metaplasia and fibromuscular stroma. On endometrial curettage, biopsy, or polypectomy specimens, the admixture of endometrioid glands and smooth muscle raises the differential di...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14338
更新日期:2021-01-18 00:00:00
abstract::An example of a cutaneous ciliated cyst in the buttock of a 42 year old woman is reported. The histological and immunohistochemical features of the cyst are presented: comparisons with fallopian tube are made and this rare lesion is discussed. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb01165.x
更新日期:1990-06-01 00:00:00
abstract:AIMS:The cadherin-catenin complex is known to play a critical role in maintenance of cell adhesion. Additionally beta-catenin (beta-ct) can also take part in signal transduction and nuclear beta-ct expression could be correlated with poor prognosis in several malignancies. Since, in gastric cancer, this role of beta-ct...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2001.01177.x
更新日期:2001-08-01 00:00:00
abstract:AIMS:Colorectal cancers deficient in DNA mismatch repair (MMR) are often characterized by the presence of numerous intraepithelial lymphocytes (IELs). These CD8+ T cells selectively express CD103, which is upregulated locally by transforming growth factor (TGF)-beta, and adhere to E-cadherin expressed by mucosal epithe...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02520.x
更新日期:2006-10-01 00:00:00