Abstract:
:A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) and density of Helicobacter-like organism (Helicobacter-grade: 0 to 6, in ascending order of bacterial density). Three modes of colonization were identified: free-in-mucus, surface-adhesion and intercellular colonization. Because light microscopy cannot definitely prove the presence of intracellular colonization, bacteria located between cells and below the apical cell border were counted together as intercellular colonization. Bacteria free-in-mucus were seen in all biopsies. Surface adhesion was seen in 50-87.9% of biopsies, without obvious correlation with the epithelial-damage- and Helicobacter-grades. The incidences of intercellular and intracellular colonization were directly proportional to the epithelial-damage- and Helicobacter-grades. Free-in-mucus as the predominant mode of colonization was mainly seen in biopsies with lower (1-3) epithelial-damage- and Helicobacter-grades. Conversely, biopsies with intercellular colonization as the predominant mode of colonization were mainly cases with higher (4-6) epithelial-damage- and Helicobacter-grades. In cases showing predominantly bacteria between cells, 69.2% had a gastric ulcer whereas only 38.8% of cases showing predominantly bacteria free-in-mucus showed ulceration (P < 0.01). These results indicate that Helicobacter-like organisms can invade and penetrate between epithelial cells. When free-in-mucus, Helicobacter-like organisms are less likely to induce epithelial damage. However, the more invasive modes of colonization (intercellular) were associated with severe epithelial damage and high Helicobacter density.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Histopathologyjournal_title
Histopathologyauthors
Chan WY,Hui PK,Leung KM,Thomas TMdoi
10.1111/j.1365-2559.1992.tb00439.xkeywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
521-8issue
6eissn
0309-0167issn
1365-2559journal_volume
21pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract::Surgical biopsy specimens from five children with cerebellar medulloblastoma were examined for ultrastructural evidence of differentiating activity. At light microscope level, all the tumour samples appeared primitive and featureless, and could not be classified as showing either neuroblastic or spongioblastic differe...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02306.x
更新日期:1983-11-01 00:00:00
abstract::Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01570.x
更新日期:1994-08-01 00:00:00
abstract:AIMS:Segmental atrophy (SA) of the liver is a recently described pseudotumour that can show a broad spectrum of histological changes. The previously described histological differential diagnosis of SA has included cystic disease of the liver, amyloid, cancer-associated elastosis, and epithelioid haemangioendothelioma. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13961
更新日期:2019-12-01 00:00:00
abstract::This report describes a female of 54 years with a past history of repeated breast biopsies all showing benign epithelial hyperplasia. The patient subsequently had a simple mastectomy and axillary lymph node biopsy. No evidence of malignancy was found in the specimen but there were numerous foci of epithelial hyperplas...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1980.tb02958.x
更新日期:1980-11-01 00:00:00
abstract:AIMS:To evaluate the independent prognostic value of apoptotic versus proliferative fractions in a series of 92 patients with non-Hodgkin's lymphomas (NHL). METHODS AND RESULTS:Apoptotic fractions were quantified by use of the TdT (terminal deoxynucleotidyl-transferase)-mediated in-situ end-labelling technique (TUNEL)...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00489.x
更新日期:1998-09-01 00:00:00
abstract::In view of the critical role of dendritic cells in immune mediated skin diseases, we have investigated the membrane antigen patterns and ultrastructure of cutaneous dendritic cells in eight patients with chronic discoid lupus erythematosus and five with subacute cutaneous lupus erythematosus. In the lesional epidermis...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00531.x
更新日期:1994-04-01 00:00:00
abstract:AIMS:We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus. METHODS AND RESULTS:The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies. Grossly, all tumours were present in the uterine body, an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2003.01602.x
更新日期:2003-04-01 00:00:00
abstract:AIMS:Breast cancer 1 (BRCA1) expression is down-regulated in a significant proportion of non-hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen (ER)-negative tumours. Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12801
更新日期:2016-04-01 00:00:00
abstract::The histopathological classification of ovarian surface epithelial carcinomas (referred to hereafter as 'ovarian carcinoma') has shifted over the past 10 years to reflect more clearly our understanding of molecular events during carcinogenesis. Ovarian carcinoma is no longer viewed as a single entity but as multiple d...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12033
更新日期:2013-01-01 00:00:00
abstract:AIMS:An increased risk of adenocarcinoma of the oesophagus has been demonstrated in patients with long segments of Barrett's mucosa. The risk of cancer associated with short segments of metaplasia of the oesophagogastric junction is not known. METHODS AND RESULTS:We report a case of early adenocarcinoma of the oesopha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.5910816.x
更新日期:1997-07-01 00:00:00
abstract::Fifteen cases of non-Hodgkin's lymphoma of the anterior mediastinum are reported. In the first group of four, fresh tissue was available and immunohistochemical studies demonstrated their B-cell origin, with monotypic immunoglobulin production in two. Only fixed tissue was available in the second group of 11 patients....
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1986.tb02491.x
更新日期:1986-04-01 00:00:00
abstract:AIMS:Prostate gland volume is generally assessed by transrectal ultrasound examination or magnetic resonance imaging at the time of prostatic biopsy or pre-brachytherapy planning. The volume is most commonly measured using the formula, prostate volume = height x width x length x pi/6, which is derived considering the g...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2010.03591.x
更新日期:2010-07-01 00:00:00
abstract:AIMS:Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. This study assessed the accuracy of punch biopsy 'scori...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13342
更新日期:2018-01-01 00:00:00
abstract::Apoptotic bodies were investigated ultrastructurally in 10 cases of squamous cell carcinoma taken from buccal mucosa, tongue and larynx. Epithelial cells undergoing mitosis were found to show premature formation of nuclear membranes around various aggregates of chromosomal material giving the appearance of micronuclei...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1986.tb02590.x
更新日期:1986-09-01 00:00:00
abstract::The differential diagnosis of melanocytic lesions is fraught with difficulty and a common source of litigation either if a lesion misreported as 'benign' recurs locally or re-presents with nodal metastases or if an atypical naevus is called 'malignant' leading to a cosmetically unsatisfactory wider resection, unwarran...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.01002.x
更新日期:2000-11-01 00:00:00
abstract:AIMS:High levels of autofluorescence in tissue samples can entirely mask specific labellings with fluorophores and thus impair immunofluorescence histochemistry. In pancreatic tissue samples we observed autofluorescence as a common problem often mediated by the fixation and processing procedure. METHODS AND RESULTS:Us...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12935
更新日期:2016-09-01 00:00:00
abstract:AIMS:To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme. METHODS AND RESULTS:Twelve benign polyps representative of BCS cases were identified from pathology files and reported by 28 BCS histopathologists ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12110
更新日期:2013-05-01 00:00:00
abstract::This histogenesis of cystic mucinous ovarian tumours is still controversial. It has been proposed that these neoplasms may arise from metaplastic ovarian surface epithelium. Others have suggested that these tumours represent monophyletic (intestinal) types of teratoma. Against this background we have studied the prese...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02252.x
更新日期:1983-05-01 00:00:00
abstract:AIM:To determine the extent of clonal outgrowth in the lymphocytic tissue infiltrate of lichen sclerosus (LS). The presence of T cells with a monoclonally rearranged T-cell receptor gamma-gene (TCRgamma) has been described in up to 50% of biopsies of vulvar and penile LS. MATERIAL AND RESULTS:We analysed 33 foreskin s...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02406.x
更新日期:2006-05-01 00:00:00
abstract::The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma c...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02298.x
更新日期:1983-11-01 00:00:00
abstract:AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2002.01459.x
更新日期:2002-11-01 00:00:00
abstract:AIMS:The immunoregulatory enzyme indoleamine dioxygenase 2,3 (IDO) has been implicated in cervical and vulvar squamous carcinomas (SCC) and may represent a mechanism of resistance to anti-PD-1/anti-PD-L1 therapy. However, the relationship between IDO and PD-L1 has not been well-investigated. METHODS AND RESULTS:Sixty-...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13723
更新日期:2019-01-01 00:00:00
abstract::Of 44 intraoral salivary gland tumours received by the Department of Pathology, Dental Faculty, University of Oslo over the last 20 years, 21 (approx. 48%) were classified as carcinomas. Of these, the adenocarcinomas constituted the largest group, but because some of them bore a certain likeness to adenoid cystic carc...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1978.tb01690.x
更新日期:1978-01-01 00:00:00
abstract:AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14114
更新日期:2020-08-01 00:00:00
abstract:AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common intra-oral salivary gland malignancy. The vast majority of PLGAs harbour a PRKD1 E710D hot-spot somatic mutation or somatic rearrangements of PRKD1, PRKD2 or PRKD3. Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to def...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12883
更新日期:2016-06-01 00:00:00
abstract:AIM:Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, functioning as a global genome organizer. This study aims to investigate the expression pattern and the prognostic value of SATB1 in colorectal cancer. METHODS AND RESULTS:Prospectively collected da...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12295
更新日期:2014-08-01 00:00:00
abstract::To our knowledge, the in situ phase of small cell lung carcinoma (SCLC) has not been reported previously although in situ/pre-invasive lesions are commonly observed in murine models. We report a patient diagnosed with SCLC presenting mostly as carcinoma in situ after photodynamic therapy (PDT) under the diagnosis of b...
journal_title:Histopathology
pub_type: 信件
doi:10.1111/his.14308
更新日期:2020-11-30 00:00:00
abstract:AIMS:We report the clinicopathological and immunohistochemical characteristics of 12 cases of a recently recognized entity, oncocytic papillary thyroid carcinoma (PC) with lymphoid stroma (Warthin-like tumour). METHODS AND RESULTS:The cases were retrieved from the surgical pathology files of our departments. There wer...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2001.01154.x
更新日期:2001-07-01 00:00:00
abstract::The benign 'Triton' tumour is a neural tumour with benign rhabdomyomatous differentiation: it must be distinguished from the better known malignant counterpart. We describe the first case outside the peripheral soft tissues and the first to be studied ultrastructurally. It also represents the second lesion identified ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02268.x
更新日期:1983-07-01 00:00:00
abstract:AIMS:Comedo carcinoma is generally regarded as the subtype of ductal carcinoma in situ (DCIS) most likely to progress to invasive carcinoma. Increased angiogenesis could be associated with an enhanced risk of progression and might therefore be a marker of poor prognosis, as can be demonstrated for invasive breast tumou...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02299.x
更新日期:2005-12-01 00:00:00