Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.

abstract：AIMS:Ectomesenchymal chondromyxoid tumour (ECT) is a rare, benign intraoral neoplasm showing a predilection for the anterior dorsum of the tongue. The World Health Organization includes ECT in the pathological spectrum of soft tissue myoepithelioma. EWS RNA-binding protein 1 gene (EWSR1) rearrangement is found in 45% o...

journal_title：Histopathology

authors： Argyris PP,Bilodeau EA,Yancoskie AE,Trochesset D,Pambuccian SE,Wetzel SL,Shah SS,Edelman M,Freedman P,Dolan M,Koutlas IG

更新日期：2016-10-01 00:00:00

abstract：:Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging sy...

journal_title：Histopathology

authors： Cheng L,Montironi R,Bostwick DG,Lopez-Beltran A,Berney DM

更新日期：2012-01-01 00:00:00

abstract：:Many classification schemes have been proposed for ductal carcinoma in situ. Architectural heterogeneity is widely recognized. Cytonuclear grade appears to have greater prognostic significance than architectural pattern. This study assesses heterogeneity using a classification based on cytological grade and compares t...

journal_title：Histopathology

authors： Harrison M,Coyne JD,Gorey T,Dervan PA

更新日期：1996-05-01 00:00:00

abstract：:Identical adolescent Negro twins presented with multiple bilateral breast adenomata. There were three pure tubular adenomata, one mixed tubular and fibroadenoma, four glandular fibroadenomata and one typical intracanalicular fibroadenoma. Tubular adenomata are exceedingly rare and this report adds a further three to t...

journal_title：Histopathology

authors： Morris JA,Kelly JF

更新日期：1982-09-01 00:00:00

abstract：AIMS:Using intraoperative frozen sections to diagnose pulmonary sclerosing pneumocytoma is always challenging. However, an accurate diagnosis is needed to guide surgical management and prevent unnecessary treatment. The aim of this study was to investigate the most frequently misdiagnosed histological patterns and eval...

journal_title：Histopathology

authors： Yang CH,Lee LY

更新日期：2018-02-01 00:00:00

abstract：AIMS:To analyse the expression of alphavbeta6, an epithelial integrin involved in wound healing and tumorigenesis, in various human carcinoma types. METHODS AND RESULTS:A new monoclonal antibody to the human beta6 subunit, 5C4, was used to locate alphavbeta6 in 157 cancers of gastroenteropancreatic and 21 of lung orig...

journal_title：Histopathology

authors： Sipos B,Hahn D,Carceller A,Piulats J,Hedderich J,Kalthoff H,Goodman SL,Kosmahl M,Klöppel G

更新日期：2004-09-01 00:00:00

abstract：AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...

journal_title：Histopathology

authors： Mitra A,Jameson C,Barbachano Y,Sanchez L,Kote-Jarai Z,Peock S,Sodha N,Bancroft E,Fletcher A,Cooper C,Easton D,IMPACT Steering Committee and IMPACT and EMBRACE Collaborators.,Eeles R,Foster CS

更新日期：2009-12-01 00:00:00

abstract：:Tylosis is an autosomal dominant inherited defect of keratinization, associated in two Liverpool families with a high risk of developing oesophageal squamous carcinoma. In 29 individuals, followed by regular endoscopy and biopsy, we have noted several morphological abnormalities of the epithelium in this pre-cancerous...

journal_title：Histopathology

authors： Ashworth MT,Nash JR,Ellis A,Day DW

更新日期：1991-10-01 00:00:00

abstract：AIM:To determine the inter-observer variation in the histological diagnosis of colorectal polyps. METHODS AND RESULTS:Four hundred and forty polyps were randomly selected from a colorectal cancer screening programme. Polyps were first evaluated by a general (324 polyps) or expert (116 polyps) pathologist, and subseque...

journal_title：Histopathology

authors： van Putten PG,Hol L,van Dekken H,Han van Krieken J,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2011-05-01 00:00:00

abstract：AIMS:Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate...

journal_title：Histopathology

authors： Lee HJ,Shin DH,Kim SY,Hwang CS,Lee JH,Park WY,Choi KU,Kim JY,Lee CH,Sol MY,Rha SH,Park SW

更新日期：2018-11-01 00:00:00

abstract：AIMS:To evaluate whether a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in bone marrow trephine biopsies (BMBs) of primary myelofibrosis (PMF) patients may have prognostic implications. METHODS AND RESULTS:Reticulin fibrosis, collagen deposition and osteosclerosis...

journal_title：Histopathology

authors： Gianelli U,Fiori S,Cattaneo D,Bossi A,Cortinovis I,Bonometti A,Ercoli G,Bucelli C,Orofino N,Bulfamante G,Iurlo A

更新日期：2017-12-01 00:00:00

abstract：AIMS:Pathological staging in penectomies may be difficult due to the anatomical complexity of penile anatomy, and may be additionally challenging due to the low volume at most institutions. Our study aimed to assess the feasibility of whole-mount processing for penectomy specimens. METHODS AND RESULTS:A 7-year retrosp...

journal_title：Histopathology

authors： Ebel JJ,Shabsigh A,Sharp DS,Zynger DL

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma c...

journal_title：Histopathology

authors： Morris HB,Mason DY,Stein H,Lennert K

更新日期：1983-11-01 00:00:00

abstract：AIMS:To evaluate the relationship between phenotypic expression and tumour progression as represented by macroscopic features, submucosal invasion and lymph node metastasis in early differentiated gastric adenocarcinoma. METHODS:One hundred and fifty-five cases of early gastric differentiated adenocarcinoma without an...

journal_title：Histopathology

authors： Nakamura T,Yao T,Kabashima A,Nishiyama K,Maehara Y,Tsuneyoshi M

更新日期：2005-10-01 00:00:00

abstract：:A series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for Helicobacter pylori (H. pylori) colonization in the gastric antral and/or body mucosa using Giemsa staining. Findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and...

journal_title：Histopathology

authors： Rugge M,Di Mario F,Cassaro M,Baffa R,Farinati F,Rubio J Jr,Ninfo V

更新日期：1993-01-01 00:00:00

abstract：:A series of 104 biopsy cases with histopathological proof of amyloid, submitted to our department of pathology over the last 19 years, were re-examined. The survey investigated the medical indication for surgery, the origin and quality of the biopsy and the clinical information as documented on the request form for hi...

journal_title：Histopathology

authors： Röcken C,Schwotzer EB,Linke RP,Saeger W

更新日期：1996-10-01 00:00:00

abstract：AIM:Alveolar capillary dysplasia (ACD) is a rare disorder, typically presenting with persistent pulmonary hypertension of the newborn. The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome. METHODS AND RESULTS:Three pa...

journal_title：Histopathology

authors： Melly L,Sebire NJ,Malone M,Nicholson AG

更新日期：2008-10-01 00:00:00

abstract：:A Sertoli-Leydig cell tumour of testis presented some diagnostic difficulties. The tumour cells showed strong expression of S-100 antigen. Preliminary study of non-neoplastic testis suggests that Leydig cells and, to a lesser extent, Sertoli cells express S-100 antigen; its localization may be of value in the diagnosi...

journal_title：Histopathology

authors： McLaren K,Thomson D

更新日期：1989-12-01 00:00:00

abstract：:Nephropathy remains a major cause of morbidity and mortality in diabetes mellitus and increasing numbers of patients require dialysis maintenance therapy. Diagnostic criteria of diabetic nephropathy are well established, but the relationship between the morphological changes of glomerular basement membrane thickening ...

journal_title：Histopathology

authors： Morley AR

更新日期：1988-04-01 00:00:00

abstract：AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...

journal_title：Histopathology

authors： Shinto E,Mochizuki H,Ueno H,Matsubara O,Jass JR

更新日期：2005-07-01 00:00:00

abstract：AIMS:Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL), and is associated with a poor outcome. The histological manifestations of RT are variable, and include an increase in the proportion of prolymphocytes, immunoblasts, and other pleomorphi...

journal_title：Histopathology

authors： Salem A,Loghavi S,Khoury JD,Agbay RL,Jorgensen JL,Medeiros LJ

更新日期：2017-04-01 00:00:00

abstract：:Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...

journal_title：Histopathology

authors： Terada T,Nakanuma Y

更新日期：1994-08-01 00:00:00

abstract：:A case is reported of squamous carcinoma of the peri-anal region arising in a giant condyloma. In situ DNA hybridization showed human papillomavirus (HPV) types 6 and 11. These HPV types are commonly demonstrated in ano-genital condylomas but have not previously been reported in association with malignant change at th...

journal_title：Histopathology

authors： Wells M,Robertson S,Lewis F,Dixon MF

更新日期：1988-03-01 00:00:00

abstract：AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...

journal_title：Histopathology

authors： Shinozaki-Ushiku A,Ushiku T,Morita S,Anraku M,Nakajima J,Fukayama M

更新日期：2017-04-01 00:00:00

abstract：AIMS:MUC4 is a transmembrane glycoprotein that plays a role in cell growth signalling and is expressed in various epithelial tissues. Gene expression profiling and immunohistochemical analyses revealed that MUC4 is also constantly and specifically expressed in low-grade fibromyxoid sarcomas and sclerosing epithelioid f...

journal_title：Histopathology

authors： Matsuyama A,Jotatsu M,Uchihashi K,Tsuda Y,Shiba E,Haratake J,Hisaoka M

更新日期：2019-01-01 00:00:00

abstract：:The clinical and pathological features of three adnexal tumours of probable Wolffian origin are reported. One case was an incidental finding in a patient who died from ovarian carcinoma; in the other two cases the patients presented with lower abdominal pain. The three tumours were well-circumscribed, solid masses ari...

journal_title：Histopathology

authors： Rahilly MA,Williams AR,Krausz T,al Nafussi A

更新日期：1995-01-01 00:00:00

abstract：AIMS:Residual cancer morphology in radical prostatectomies (RPs) after neoadjuvant hormone therapy includes inconspicuous cytology, and treated tumour cells can be difficult to identify in lymph nodes. The aim of this study was to evaluate the role of immunohistochemistry (IHC) in identifying occult lymph node metastas...

journal_title：Histopathology

authors： Kehr E,Masry P,Lis R,Loda M,Taplin ME,Hirsch MS

更新日期：2016-01-01 00:00:00

abstract：AIMS:We compared the immunohistochemical profiles of the rete ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. MATERIALS AND METHODS:Twenty-four women with no evide...

journal_title：Histopathology

authors： Russo L,Woolmough E,Heatley MK

更新日期：2000-07-01 00:00:00

abstract：:Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-c...

journal_title：Histopathology

authors： Ott MM,Müller-Hermelink HK,Schmitt B,Feller AC

更新日期：1991-08-01 00:00:00

abstract：:Five antibodies, MT1 (CD43), UCHL1 (CD45RO), OPD4, poly-CD3 and beta F1, were assessed for their reactivity with 50 archival cases of T-cell lymphoma in formalin-fixed paraffin-embedded tissue. All cases had been previously characterized as T-cell lymphomas, and the histological types included 14 cases of small cerebr...

journal_title：Histopathology

authors： Cabeçadas JM,Isaacson PG

更新日期：1991-11-01 00:00:00