Abstract:
:We report a case of oesophageal carcinosarcoma with prominent rhabdomyoblastic differentiation. Immunohistochemically, the rhabdomyblasts were mainly reactive to vimentin, cytokeratin, desmin, muscle-specific actin, myosin, and myoglobin, and were surrounded by laminin and type IV collagen-positive basement membranes. The tumour had dual differentiation, carcinomatous and sarcomatous, but also showed evident features of transition between the two components; suggesting a common origin. An epithelial-mesenchymal conversion could be the pathogenetic mechanism involved in the histogenesis of this lesion. The word carcinosarcoma, from a descriptive point of view, seems the most suitable to describe a tumour composed of both carcinomatous and true sarcomatous elements.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Guarino M,Reale D,Micoli G,Forloni Bdoi
10.1111/j.1365-2559.1993.tb00164.xsubject
Has Abstractpub_date
1993-05-01 00:00:00pages
493-8issue
5eissn
0309-0167issn
1365-2559journal_volume
22pub_type
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