Abstract:
:Pancreatic acinar metaplasia of the gastric mucosa is a newly recognized entity. Its physiological relevance and association with other pathological conditions in the stomach remain to be elucidated. We studied by immunohistochemistry the expression of growth markers in the gastric mucosa in biopsies from 15 patients with recognized pancreatic metaplasia. Pancreatic metaplasia (both acinar and dispersed forms) was found in routine paraffin sections and confirmed by strong lipase immunoreactivity. In parallel paraffin sections we performed immunostaining for epidermal growth factor (EGF), transforming growth factor-alpha (TGF alpha) and epidermal growth factor receptor (EGFr) using a biotin streptavidin method. Strong expression of TGF alpha but only weak expression of EGF was noted within metaplastic mucosa. EGFr was strongly expressed, not only in areas of pancreatic metaplasia but also in the surrounding gastric mucosa.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Stachura J,Konturek J,Urbańczyk K,Bogdal J,Domschke Wdoi
10.1111/j.1365-2559.1995.tb00321.xsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
509-15issue
6eissn
0309-0167issn
1365-2559journal_volume
27pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:Biphenotypic sinonasal sarcoma (SNS) is a locally aggressive tumour that occurs in the sinonasal region. PAX3-MAML3 has recently been identified as a recurrent fusion gene event in this entity; however, a subset of tumours harbour alternative PAX3 rearrangement without the involvement of MAML3. In this study we so...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13045
更新日期:2016-12-01 00:00:00
abstract:AIMS:Fibroadenomas (FAs) and phyllodes tumours (PTs) are fibroepithelial tumours. Mutations in MED12 exon 2 have been reported in FAs. This study investigated the MED12 mutations in a spectrum of fibroepithelial tumours. METHODS AND RESULTS:Using direct sequencing, we analysed MED12 exon 2 mutations on 121 samples, in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12764
更新日期:2016-02-01 00:00:00
abstract::Nine cases of Mullerian adenosarcoma of the uterine body, first defined in 1974 by Clement & Scully, are described. The tumour usually occurs in elderly women and appears macroscopically as a polypoid mass filling the uterine cavity. Histologically these neoplasms are characterized by having a benign epithelial compon...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1979.tb02994.x
更新日期:1979-05-01 00:00:00
abstract:AIMS:The diagnosis of polymorphous low-grade adenocarcinoma (PLGA) remains difficult for general pathologists, particularly in cases of small biopsy samples. We aimed to characterize the histopathological spectrum and immunohistochemical aspects by using an accessible immunohistochemical panel of cytoskeletal proteins ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12880
更新日期:2016-06-01 00:00:00
abstract:AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12314
更新日期:2014-04-01 00:00:00
abstract::Thirty kidney tumours of various histological type were histochemically investigated under the light microscope by means of the ABC-method. We used four biotinylated lectins which are known to bind also to normal renal tubular epithelial cells of different nephron segments. The nuclear grade, the histological growth p...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1985.tb02783.x
更新日期:1985-10-01 00:00:00
abstract:AIMS:Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationsh...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12132
更新日期:2013-06-01 00:00:00
abstract:AIMS:There is increasing evidence of Gleason score (GS) drift in prostatic core biopsies during the last two decades. The ProtecT study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate-specific antigen (PSA) level, perineural invasion, tumour length and age on GS. ...
journal_title:Histopathology
pub_type: 杂志文章,随机对照试验
doi:10.1111/his.12549
更新日期:2015-02-01 00:00:00
abstract:AIMS:A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS:Nineteen relevant papers published during the period 1979-2005 were identified. Individu...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2006.02442.x
更新日期:2006-12-01 00:00:00
abstract::Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a d...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1987.tb02668.x
更新日期:1987-06-01 00:00:00
abstract:AIMS:Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biolo...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2003.01587.x
更新日期:2003-03-01 00:00:00
abstract:AIMS:To analyse the possible activation of distinct molecular pathways in mucosa-associated lymphoid tissue (MALT) lymphoma, we determined the prevalence of trisomies 3, 12, 18 in MALT lymphomas from different organs, as well as the prevalence of translocations of the MALT1 gene in a subset of primary breast MALT lymph...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02580.x
更新日期:2007-01-01 00:00:00
abstract:AIMS:Genome-wide next-generation sequencing has revealed several driver mutations and has allowed the establishment of a molecular taxonomy of gastric cancer. However, there are few detailed studies on the mutational spectrum of poorly cohesive gastric carcinoma. Thus, this study aim to investigate its mutation profile...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13383
更新日期:2018-03-01 00:00:00
abstract::A male infant was diagnosed as having diabetes mellitus 1 d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin-secreting cells. There was no evidence of insulitis. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1988.tb01974.x
更新日期:1988-05-01 00:00:00
abstract::Acquired Hirschsprung's disease is a rare and controversial form of colonic aganglionosis. Little is known about its aetiology and pathogenesis. We report five cases encountered amongst 173 long-term follow-up patients treated for classical Hirschsprung's disease between 1957 and 1990 at the Red Cross Children's Hospi...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.1993.tb00096.x
更新日期:1993-02-01 00:00:00
abstract:AIM:To train and individually validate a group of breast pathologists in specialty-specific digital primary diagnosis by using a novel protocol endorsed by the Royal College of Pathologists' new guideline for digital pathology. The protocol allows early exposure to live digital reporting, in a risk-mitigated environmen...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13403
更新日期:2018-03-01 00:00:00
abstract::High levels of bcl-2 protein have been found in a wide variety of human cancers. Since p53 gene inactivation occurs in over half of human cancers, it is possible that loss of p53-mediated repression of bcl-2 gene expression accounts, at least in part, for the frequent abnormalities in bcl-2 protein production seen in ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-431.x
更新日期:1996-04-01 00:00:00
abstract::The generic term aggressive B-cell lymphoma includes a variety of entities, each with particular diagnostic and therapeutic issues. To define these entities better and to help confront such issues, a workshop was organized by the European Association of Haematopathology (EAHP) and the Society of Haematology during the...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2005.02068.x
更新日期:2005-03-01 00:00:00
abstract::Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon n...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13735
更新日期:2019-01-01 00:00:00
abstract:AIMS:Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is caused by germline mutations in the Fumarate hydratase (FH) gene. In young women, the syndrome often presents with symptomatic uterine leiomyomas, leading to myomectomy or hysterectomy. In this study, we aimed to investigate the incidence and muta...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14007
更新日期:2020-02-01 00:00:00
abstract:AIMS:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remark...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14105
更新日期:2020-07-01 00:00:00
abstract::Elastosis, a previously unreported feature, was found to be common in granular cell tumours. Twenty-four of 28 consecutive granular cell tumours were shown to display elastosis. The elastosis was found in three main sites: adventitial, interstitial and septal. Elastosis is statistically associated with the fibrosis pr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb01057.x
更新日期:1990-01-01 00:00:00
abstract::Three cases are reported in which an initial diagnosis of the plasma cell variant of Castleman's disease was made, but in which a second lymph node biopsy within a year showed evidence of Hodgkin's disease. Review of the initial biopsy indicated that atypical CD15 and CD30 positive cells were present in the initial bi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00833.x
更新日期:1991-03-01 00:00:00
abstract:AIMS:Chondrosarcoma is primarily a tumour of adulthood and old age. Some studies indicate that survival is worse in paediatric than in adult chondrosarcomas. In view of the rarity of paediatric chondrosarcoma, few large studies are currently available. METHODS AND RESULTS:We evaluated the clinical, radiological and pa...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12881
更新日期:2016-06-01 00:00:00
abstract:AIMS:Serum amyloid A is an acute phase reactant that is produced by hepatocytes in response to either inflammatory or neoplastic conditions. Because inflammatory adenomas produce this protein, serum amyloid A immunohistochemistry has been used in the evaluation of hepatocellular neoplasms. However, studies evaluating t...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13016
更新日期:2016-12-01 00:00:00
abstract:AIMS:AP2alpha (TFAP2A) and AP2gamma (TFAP2G) transcription factors have been implicated in the control of proliferation, differentiation and apoptosis of normal breast epithelium and in breast cancer. The aim of this study was to provide a comprehensive analysis of the expression patterns of TFAP2A and TFAP2G in the de...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02887.x
更新日期:2007-12-01 00:00:00
abstract:AIMS:BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR-associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR-associated non-uterine sarcomas in adult patients. METHODS AND RESULTS:The patients were four men an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14023
更新日期:2020-03-01 00:00:00
abstract::Wilms' tumour (nephroblastoma) has been associated with chromosomal abnormalities at the 11p13, 11p15 and 16q regions. A study into the possibility of mutations occurring within p53, the ubiquitous adult tumour suppressor gene, in Wilms' tumour was carried out. Thirty-eight cases were studied. Of these 36 were categor...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-384.x
更新日期:1996-01-01 00:00:00
abstract::The paper reports a re-evaluation--based on the Kiel classification for non-Hodgkin lymphomas--of a group of cases initially diagnosed as undifferentiated small cell carcinomas or primary lymphomas of the thyroid. Twelve such cases were found among the 155 cases of primary malignant tumours of the thyroid recorded at ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1978.tb01710.x
更新日期:1978-05-01 00:00:00
abstract::The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma c...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02298.x
更新日期:1983-11-01 00:00:00