Digital pathology for the primary diagnosis of breast histopathological specimens: an innovative validation and concordance study on digital pathology validation and training.

abstract：AIMS:To investigate the prognostic significance of chromosomal alterations in colorectal cancer patients. Histopathological tumour classification is still considered to be the gold standard for the characterization of solid tumours. However, it is well known that such established parameters do not satisfactorily predic...

journal_title：Histopathology

authors： Knösel T,Schlüns K,Stein U,Schwabe H,Schlag PM,Dietel M,Petersen I

更新日期：2003-10-01 00:00:00

abstract：AIMS:In this study, we aimed to investigate the clinicopathological features of CD4+ and/or CD56+ immature haematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN). METHODS AND RESULTS:We analysed the clinicopathological features of 46 patients diagnosed consecutively with CD4+...

journal_title：Histopathology

authors： Suzuki Y,Kato S,Kohno K,Satou A,Eladl AE,Asano N,Kono M,Kato Y,Taniwaki M,Akiyama M,Nakamura S

更新日期：2017-12-01 00:00:00

abstract：:Three cases of angiolymphoid hyperplasia with eosinophilia are reported at the site of tetanus toxoid vaccination. All presented as nodules on the upper arm, a known adverse effect of the vaccine following superficial inoculation. Histologically the nodules showed numerous small and medium sized vessels, some lined by...

journal_title：Histopathology

authors： Akosa AB,Ali MH,Khoo CT,Evans DM

更新日期：1990-06-01 00:00:00

abstract：AIMS:Because of its efficacy, oxaliplatin (OX) is increasingly used as a chemotherapeutic agent in the treatment of colorectal liver metastases (CRLM). Oxaliplatin-associated liver toxicity has been reported and can affect clinical practice, but studies on its prevalence and a full pathological description are lacking....

journal_title：Histopathology

authors： Rubbia-Brandt L,Lauwers GY,Wang H,Majno PE,Tanabe K,Zhu AX,Brezault C,Soubrane O,Abdalla EK,Vauthey JN,Mentha G,Terris B

更新日期：2010-03-01 00:00:00

abstract：AIMS:Neoadjuvant radiochemotherapy (RCT) followed by surgical resection is the treatment for locally advanced mid-rectal or low rectal cancer. The aim of this study was to evaluate postoperative histological prognostic factors in a series of surgical specimens after neoadjuvant RCT. METHODS AND RESULTS:One hundred and...

journal_title：Histopathology

authors： Sannier A,Lefèvre JH,Panis Y,Cazals-Hatem D,Bedossa P,Guedj N

更新日期：2014-11-01 00:00:00

abstract：AIMS:To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase-3 (apoptotic markers) and Ki67 (proliferation marker). METHODS AND RESULTS:Immunohi...

journal_title：Histopathology

authors： Sington J,Giatromanolaki A,Campo L,Turley H,Pezzella F,Gatter KC

更新日期：2007-04-01 00:00:00

abstract：AIMS:To study the current work practice of histopathologists to inform the design of digital microscopy systems. METHODS AND RESULTS:Four gastrointestinal histopathologists were video-recorded as they undertook their routine work. Analysis of the video data shows a range of activities beyond viewing slides involved in...

journal_title：Histopathology

authors： Randell R,Ruddle RA,Quirke P,Thomas RG,Treanor D

更新日期：2012-02-01 00:00:00

abstract：AIMS:To examine the natural history of columnar-lined oesophagus with routinely diagnosed low-grade dysplasia and ascertain the risk of oesophageal adenocarcinoma development. METHODS AND RESULTS:A multicentre retrospective cohort study of 283 patients with low-grade dysplasia. Follow-up data were obtained from examin...

journal_title：Histopathology

authors： Gatenby P,Ramus J,Caygill C,Shepherd N,Winslet M,Watson A

更新日期：2009-06-01 00:00:00

abstract：AIMS:The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). METHODS AND RESULTS:We examined the relationship between clinicopathological factors and ...

journal_title：Histopathology

authors： Jung CW,Kong JS,Seol H,Park S,Koh JS,Lee SS,Kim MJ,Choi IJ,Myung JK

更新日期：2017-01-01 00:00:00

abstract：:In a prospective autopsy study of male subjects with solic malignant neoplasms, six were shown to have metastatic deposits within the testis (2.5%). These were metastases from carcinoma of the prostate (two cases), melanoma (two cases), bronchial carcinoma (one case) and pleural mesothelioma (one case). In addition, f...

journal_title：Histopathology

authors： Tiltman AJ

更新日期：1979-01-01 00:00:00

abstract：AIMS:Calretinin, a calcium-binding protein, is expressed primarily in certain subtypes of neurons. It has also been reported to be present in mesotheliomas and other tumours. The aim was to determine the expression of calretinin in selected odontogenic neoplasms. METHODS AND RESULTS:Immunohistochemistry for calretinin...

journal_title：Histopathology

authors： Alaeddini M,Etemad-Moghadam S,Baghaii F

更新日期：2008-02-01 00:00:00

abstract：AIMS:To examine the usefulness of Hep Par 1 together with selected antibodies in the separation of hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC), combined tumours (HCC-CC) and metastatic carcinoma. METHODS AND RESULTS:Antibodies to Hep Par 1, CK19, CK20 and factor XIIIa were applied to 32 HCCs, 27 CCs, f...

journal_title：Histopathology

authors： Leong AS,Sormunen RT,Tsui WM,Liew CT

更新日期：1998-10-01 00:00:00

abstract：AIM:Achalasia is a disease of the oesophagus characterized by increased lower oesophageal sphincter (LOS) tone, absence of LOS relaxation with swallowing and aperistalsis of the body of the oesophagus. The aetiology and pathogenesis of idiopathic achalasia is still controversial. METHODS AND RESULTS:We examined 16 oes...

journal_title：Histopathology

authors： Raymond L,Lach B,Shamji FM

更新日期：1999-11-01 00:00:00

abstract：:Anaplastic choroid plexus carcinoma is a tumour with a predilection for the posterior fossa of infants and can be difficult to distinguish histologically from medulloblastoma without the aid of immunocytochemistry using a panel of antibodies. Of a series of 17 choroid plexus carcinomas (five of which were classed as m...

journal_title：Histopathology

authors： Newbould MJ,Kelsey AM,Arango JC,Ironside JW,Birch J

更新日期：1995-02-01 00:00:00

abstract：:A recently described unifying proposal for mantle cell lymphoma has led to the formulation of strict diagnostic criteria based on morphology, immunology and molecular data to define this specific entity. Previous studies were often based on broader definitions such as centrocytic lymphoma, intermediately differentiate...

journal_title：Histopathology

authors： Pittaluga S,Wlodarska I,Stul MS,Thomas J,Verhoef G,Cassiman JJ,Van den Berghe H,de Wolf-Peeters C

更新日期：1995-01-01 00:00:00

abstract：AIMS:The purpose of this study was to examine the occurrence of CD44 isoforms in breast carcinomas and their role in predicting clinical outcome. METHODS AND RESULTS:Shock-frozen tumour tissues from 110 patients with breast carcinoma were examined by immunohistochemistry using antibodies directed against CD44s, v5, v6...

journal_title：Histopathology

authors： Berner HS,Suo Z,Risberg B,Villman K,Karlsson MG,Nesland JM

更新日期：2003-06-01 00:00:00

abstract：AIMS:To investigate the relation of fatty acid synthase (FAS) expression to the clinicopathological characteristics of gastric cancers and gastric tumorigenesis. METHODS AND RESULTS:FAS expression was examined immunohistochemically in 626 gastric cancers, 51 gastric adenomas, and non-neoplastic epithelium contiguous w...

journal_title：Histopathology

authors： Kusakabe T,Nashimoto A,Honma K,Suzuki T

更新日期：2002-01-01 00:00:00

abstract：:Signet ring cell differentiation in adenocarcinoma of the prostate is uncommon. In a review of 200 cases of prostatic carcinoma, we identified five cases with this change, all in moderately to poorly differentiated prostatic carcinomas. The signet ring cells in prostatic carcinoma contain an intracytoplasmic lumen, sh...

journal_title：Histopathology

authors： Guerin D,Hasan N,Keen CE

更新日期：1993-04-01 00:00:00

abstract：:Two cases of pedunculated hepatocellular carcinoma are reported. One of these was known to have been present for 5 years. Both patients are alive 1 and 2 years after surgery though the former has developed a solitary bone metastasis. The literature on 30 previously published cases is reviewed and it is concluded that,...

journal_title：Histopathology

authors： Anthony PP,James K

更新日期：1987-04-01 00:00:00

abstract：AIMS:Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic ...

journal_title：Histopathology

authors： Gremel G,Bergman J,Djureinovic D,Edqvist PH,Maindad V,Bharambe BM,Khan WA,Navani S,Elebro J,Jirström K,Hellberg D,Uhlén M,Micke P,Pontén F

更新日期：2014-01-01 00:00:00

abstract：AIM:Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in ...

journal_title：Histopathology

authors： Lin CK,Tsai WC,Lin YC,Hueng DY

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...

journal_title：Histopathology

authors： Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

更新日期：2021-01-10 00:00:00

abstract：:Standardization of tumor classifications is a prerequisite in facilitating international communication in cancer research. Standardized classifications are not meant to replace, or compete with, conceptual classifications. The World Health Organization's efforts in this field give consideration to definitions of tumou...

journal_title：Histopathology

authors： Sobin LH

更新日期：1977-03-01 00:00:00

abstract：AIMS:To characterise the mutational profiles of poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) and to identify markers with potential diagnostic, prognostic and therapeutic significance. METHODS AND RESULTS:Targeted next-generation sequencing with a panel of 18 thyroid carcinoma-...

journal_title：Histopathology

authors： Duan H,Li Y,Hu P,Gao J,Ying J,Xu W,Zhao D,Wang Z,Ye J,Lizaso A,He Y,Wu H,Liang Z

更新日期：2019-12-01 00:00:00

abstract：:Low grade fibromyxoid sarcoma is a recently recognized, uncommon soft tissue neoplasm with a tendency to develop in deep soft tissue of young adults. Diagnostic criteria have not been well defined and this tumour has not been widely accepted as a distinct entity. Eleven new cases are reported here for which reproducib...

journal_title：Histopathology

authors： Goodlad JR,Mentzel T,Fletcher CD

更新日期：1995-03-01 00:00:00

abstract：AIMS:Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia-associated transcription factor family on chromosome Xp11.2. Dual-colour break-apart fluorescence in-situ hybridisation (FISH) is recommended to confir...

journal_title：Histopathology

authors： Kato I,Furuya M,Baba M,Kameda Y,Yasuda M,Nishimoto K,Oyama M,Yamasaki T,Ogawa O,Niino H,Nakaigawa N,Yano Y,Sakamoto K,Urata Y,Mikami K,Yamasaki S,Tanaka R,Takagi T,Kondo T,Nagashima Y

更新日期：2019-08-01 00:00:00

abstract：:Occasional biopsies of genital lesions due to chancroid, secondary syphilis (the condyloma latum) and granuloma inguinale are encountered in routine histopathological practice. These lesions have specific microscopical appearances enabling a confident, or at least a presumptive, diagnosis to be made in most cases, yet...

journal_title：Histopathology

authors： Freinkel AL

更新日期：1987-08-01 00:00:00

abstract：:A case of squamous cell carcinoma of the lung showing extensive spindle transformation is presented. On light microscopy, the tumour showed sheets and fascicles of elongated fusiform cells resulting in a growth pattern which closely resembled a sarcoma. Immunocytochemistry using tissue-specific antibodies against inte...

journal_title：Histopathology

authors： Suster S,Huszar M,Herczeg E

更新日期：1987-08-01 00:00:00

abstract：AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

journal_title：Histopathology

authors： Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

更新日期：2004-08-01 00:00:00

abstract：:This report describes a female of 54 years with a past history of repeated breast biopsies all showing benign epithelial hyperplasia. The patient subsequently had a simple mastectomy and axillary lymph node biopsy. No evidence of malignancy was found in the specimen but there were numerous foci of epithelial hyperplas...

journal_title：Histopathology

authors： Turner DR,Millis RR

更新日期：1980-11-01 00:00:00