Abstract:
AIMS:To examine the usefulness of Hep Par 1 together with selected antibodies in the separation of hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC), combined tumours (HCC-CC) and metastatic carcinoma. METHODS AND RESULTS:Antibodies to Hep Par 1, CK19, CK20 and factor XIIIa were applied to 32 HCCs, 27 CCs, five HCC-CCs and 19 metastatic carcinomas from a variety of sites. Hep Par 1 produced distinctive granular staining of all benign hepatocytes and stained 30 HCCs in a heterogeneous manner, irrespective of the degree of differentiation. While labelling all cases of combined HCC-CC, the antibody also stained the mucus-secreting cells of four cases of pure CC. Anti-CK19 produced distinctive staining of bile ducts and CC but also decorated four HCCs and 10 metastatic tumours. Factor XIIIa was not found in normal, reactive or neoplastic hepatocytes. CK20 was found in some cases of HCC and CC and in all cases of metastatic carcinomas from the colon. CONCLUSIONS:Hep Par 1 was a sensitive marker of hepatocytes but its variable staining in HCC may produce false negative results in small biopsies and it was occasionally found in CC. The highest diagnostic yield was obtained when anti-Hep Par 1, CK19 and CK20 were used in a panel. Factor XIIIa staining has no role in the diagnosis of liver cancers.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Leong AS,Sormunen RT,Tsui WM,Liew CTdoi
10.1046/j.1365-2559.1998.00522.xsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
318-24issue
4eissn
0309-0167issn
1365-2559journal_volume
33pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity. METHODS AND RESULTS:We report a case of clear cell carcinoma in a 53-year-old man involving the head of the pancreas and which ha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00411.x
更新日期:1998-05-01 00:00:00
abstract:AIMS:Secretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low-grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, i...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14251
更新日期:2020-09-15 00:00:00
abstract:AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architec...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00571.x
更新日期:1998-12-01 00:00:00
abstract::The distribution of epithelial L1 antigen was evaluated in 139 bronchogenic carcinomas which had been classified by a panel of pathologists according to the WHO recommendation of 1981. L1 was not found in three large cell and 13 small cell carcinomas, but it was expressed by tumour cells in 67 of 69 squamous cell carc...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb02185.x
更新日期:1989-05-01 00:00:00
abstract::A review of 76 endomyocardial biopsies and 54 autopsies of patients with dilated cardiomyopathy (DCM) revealed features of hypertrophy and degenerative changes associated with long-standing hypertrophy. Long-term survivors had significantly heavier heart weights. Short-term survivors had heavier than normal right vent...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1985.tb02821.x
更新日期:1985-04-01 00:00:00
abstract:AIMS:Pulmonary fibrosis in acute and chronic lung disease has been much investigated, but little attention has been directed at the elastic tissue in these situations. Our aim was to verify whether elastic deposition accompanies collagen deposition in the repairing process of acute and chronic lung injury. METHODS AND...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00992.x
更新日期:2000-11-01 00:00:00
abstract:AIMS:Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, in which turnaround tim...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13804
更新日期:2019-05-01 00:00:00
abstract:AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13123
更新日期:2017-04-01 00:00:00
abstract::Some antigenic determinants can be preserved in tissues after plastic embedding. In the present study liver tissue was fixed with glutaraldehyde or paraformaldehyde, dehydrated with ethanol and toluene and embedded in araldite which was then polymerized at 37 degrees C. Immunofluorescence was performed on semi-thin se...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1977.tb01674.x
更新日期:1977-09-01 00:00:00
abstract::The mononuclear phagocytic system is composed of cells which display a marked immunohistological heterogeneity. In the present study we have investigated the immunohistochemical and enzymatic features of macrophages and accessory cells present in human lymph nodes and spleen and, as control tissues, in thymus, liver, ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1987.tb01843.x
更新日期:1987-10-01 00:00:00
abstract::Six cases of polymorphous low-grade adenocarcinoma (terminal duct adenocarcinoma) of the minor salivary glands are presented. In all but one there was a history of a painless intra-oral mass of fairly long duration. The histopathological appearances were characterized by cytological uniformity in a variety of morpholo...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00002.x
更新日期:1991-08-01 00:00:00
abstract:AIMS:The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). METHODS AND RESULTS:We examined the relationship between clinicopathological factors and ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13065
更新日期:2017-01-01 00:00:00
abstract::There are many significant differences, but also considerable overlap between the quantitative histopathological features of mild and marked atypical endometrial hyperplasias and well and moderately differentiated carcinomas, thus preventing its application to individual patient care. To try to overcome this problem, ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1981.tb01835.x
更新日期:1981-11-01 00:00:00
abstract::Twenty-eight patients with a diagnosis of either atypical or malignant meningioma, according to the World Health Organisation (WHO) classification, were followed up to relate histopathological features with times to recurrence and death. Five year disease-free survival was 41% with a median disease free survival of 27...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01218.x
更新日期:1993-10-01 00:00:00
abstract::We report an unusual and possibly unique example of cerebral ganglioglioma with an anaplastic oligodendroglial component. The latter was documented on both morphological and immunohistochemical grounds. Immunohistochemically, the anaplastic cells were strongly positive with the monoclonal antibody anti-Leu-7, while th...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb00765.x
更新日期:1990-11-01 00:00:00
abstract::An increased incidence of non-Hodgkin's lymphoma is seen in patients with immunodeficiency from any cause. The majority of these are high grade B-cell lymphoma and most are associated with the Epstein-Barr virus (EBV). In post-transplant lymphoma/lymphoproliferative disorders the tumour may regress following reduction...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.292338.x
更新日期:1996-02-01 00:00:00
abstract:AIMS:CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. For reliable implementation in daily practice and meaningful selection of patients for clinical trials, information on techni...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13647
更新日期:2018-09-01 00:00:00
abstract:AIMS:SOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated in cancer progression, its role in breast carcinoma is poorly understood. MATERIALS AND METHODS:Fifty-seven ductal carcinomas in situ (DCIS), 552 invasive breast carcinomas and 107 corresponding metastatic lymph nodes were eval...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12257
更新日期:2014-03-01 00:00:00
abstract:AIMS:Atypical polypoid adenomyoma (APAM) is an uncommon uterine lesion composed of complex endometrioid glands with frequent squamous morular metaplasia and fibromuscular stroma. On endometrial curettage, biopsy, or polypectomy specimens, the admixture of endometrioid glands and smooth muscle raises the differential di...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14338
更新日期:2021-01-18 00:00:00
abstract:AIMS:Residual cancer morphology in radical prostatectomies (RPs) after neoadjuvant hormone therapy includes inconspicuous cytology, and treated tumour cells can be difficult to identify in lymph nodes. The aim of this study was to evaluate the role of immunohistochemistry (IHC) in identifying occult lymph node metastas...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12739
更新日期:2016-01-01 00:00:00
abstract::This study demonstrates the presence of three antigens in glandular metaplasia occurring in patients with cholecystitis and cholelithiasis: specifically carcinoembryonic antigen (CEA), large intestinal mucin antigen (LIMA) and small intestinal mucin antigen (SIMA). These antigens could not be detected in normal gall b...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1981.tb01788.x
更新日期:1981-05-01 00:00:00
abstract:AIMS:To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV). METHODS AND RESULTS:We investigated retrospectively 26 cases with a median age of 76.5. O...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13449
更新日期:2018-05-01 00:00:00
abstract::We reviewed 45 pulmonary B-cell non-Hodgkin's lymphomas to determine whether their morphology and immunohistochemical features were those of lymphomas arising from mucosa-associated lymphoid tissue (MALT), as described in other sites. The polymerase chain reaction was used to provide further information on clonality. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00246.x
更新日期:1995-05-01 00:00:00
abstract:AIMS:Neoadjuvant chemotherapy followed by surgery is the standard of care for patients with gastro-oesophageal adenocarcinoma. The aims were to validate the utility of the tumour regression grade (TRG) in patients who have received chemotherapy and to investigate if (i) TRG correlates with tumour downstaging and (ii) T...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03404.x
更新日期:2009-10-01 00:00:00
abstract::The ultrastructure of stromal mononuclear cells and giant cells were studied in two cases of central giant cell granuloma of the jaws. The majority of stromal cells superficially resembled fibroblasts, but also contained intracytoplasmic myofilaments with electron dense bodies similar to smooth muscle cells. These cel...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02305.x
更新日期:1983-11-01 00:00:00
abstract:AIMS:Expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) has been found to be decreased in several types of cancer by promoter gene hypermethylation. However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in endometrial carcinomas and its pr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12047
更新日期:2013-03-01 00:00:00
abstract:AIMS:Breast cancer 1 (BRCA1) expression is down-regulated in a significant proportion of non-hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen (ER)-negative tumours. Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12801
更新日期:2016-04-01 00:00:00
abstract:AIMS:Intestinal metaplasia is considered to be a precursor lesion in both Barrett's and intestinal-type gastric cancer. The aim was to clarify the differences in molecular pathology between specialized intestinal metaplasia (SIM) in Barrett's oesophagus (BO), cardiac (CIM) and gastric intestinal metaplasia (GIM). METH...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03370.x
更新日期:2009-09-01 00:00:00
abstract::The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb01606.x
更新日期:1989-11-01 00:00:00
abstract::An ovarian and rectal carcinoid within the same person is described. The ovarian carcinoid is non-argentaffinic with typical regular granules. The rectal tumour consists of two types of APUD cells, some argentaffinic and diazo-positive, whilst others are non-argyrophilic. These features are mirrored ultrastructurally,...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1979.tb02978.x
更新日期:1979-01-01 00:00:00