Inappropriate mucin production in gall bladder metaplasia and neoplasia--an immunohistological study.

abstract：AIMS:To study the current work practice of histopathologists to inform the design of digital microscopy systems. METHODS AND RESULTS:Four gastrointestinal histopathologists were video-recorded as they undertook their routine work. Analysis of the video data shows a range of activities beyond viewing slides involved in...

journal_title：Histopathology

authors： Randell R,Ruddle RA,Quirke P,Thomas RG,Treanor D

更新日期：2012-02-01 00:00:00

abstract：AIMS:Diffuse parenchymal lung diseases (DPLD) in children comprise a wide spectrum of rare disorders. In 2007 the Children's Interstitial Lung Disease (chILD) Research Cooperative proposed a classification system for DPLD in children <2 years of age. The aims of our study were to determine the utility and reproducibili...

journal_title：Histopathology

authors： Rice A,Tran-Dang MA,Bush A,Nicholson AG

更新日期：2013-12-01 00:00:00

abstract：AIM:To determine the inter-observer variation in the histological diagnosis of colorectal polyps. METHODS AND RESULTS:Four hundred and forty polyps were randomly selected from a colorectal cancer screening programme. Polyps were first evaluated by a general (324 polyps) or expert (116 polyps) pathologist, and subseque...

journal_title：Histopathology

authors： van Putten PG,Hol L,van Dekken H,Han van Krieken J,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2011-05-01 00:00:00

abstract：:Eight cases of myelosarcoma without acute leukaemia at time of diagnosis were reviewed and biopsies were immunostained using antibodies reacting with myeloid/monocytic markers. Initial tumour location included lymph nodes, paranasal sinuses, nasopharyngeal and/or orbital regions and other extranodal locations. Three c...

journal_title：Histopathology

authors： Furebring-Fredén M,Martinsson U,Sundström C

更新日期：1990-03-01 00:00:00

abstract：AIMS:CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC), but neither its sensitivity nor its specificity is absolute. The aim of this study was to compare CDX1 and A33 with CDX2 as immunomarkers for CRC. METHODS AND RESULTS:As a pilot study, whole sections of 51 cases of liver ...

journal_title：Histopathology

authors： Wong NACS,Adamczyk LA,Evans S,Cullen J,Oniscu A,Oien KA

更新日期：2017-07-01 00:00:00

abstract：AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

journal_title：Histopathology

authors： Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

更新日期：2004-08-01 00:00:00

abstract：AIMS:To analyse expression and distribution of vascular endothelial growth factor (VEGF-C1), podocalyxin and synaptopodin within renal tissue in nephrotic syndrome glomerulopathies in children. METHODS AND RESULTS:Renal biopsies performed at the time and in the manner recommended by the World Health Organization. The ...

journal_title：Histopathology

authors： Ostalska-Nowicka D,Zachwieja J,Nowicki M,Kaczmarek E,Siwinska A,Witt M

更新日期：2005-02-01 00:00:00

abstract：AIMS:Lectins, and especially galectins, appear to be important in malignancy-associated processes. The aim was to analyse comprehensively the presence of galectins in urothelial tumours. METHODS AND RESULTS:Non-cross-reactive antibodies against seven family members from the three subgroups (prototype: galectin-1, -2 a...

journal_title：Histopathology

authors： Langbein S,Brade J,Badawi JK,Hatzinger M,Kaltner H,Lensch M,Specht K,André S,Brinck U,Alken P,Gabius HJ

更新日期：2007-11-01 00:00:00

abstract：AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...

journal_title：Histopathology

authors： Stanoszek LM,Chan MP,Palanisamy N,Carskadon S,Siddiqui J,Patel RM,Harms KL,Lowe L,Fullen DR,Harms PW

更新日期：2019-02-01 00:00:00

abstract：AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...

journal_title：Histopathology

authors： Shinto E,Mochizuki H,Ueno H,Matsubara O,Jass JR

更新日期：2005-07-01 00:00:00

abstract：AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...

journal_title：Histopathology

authors： Singh N,Gilks CB,Huntsman DG,Smith JH,Coutts M,Ganesan R,McCluggage WG

更新日期：2014-04-01 00:00:00

abstract：AIMS:To evaluate the use of the Wilms' tumour gene (WT1) marker and histomorphological parameters as indicators of prognosis in malignant peritoneal mesothelioma (MPM). METHODS AND RESULTS:Histological samples of 31 MPM were stained immunohistochemically for the WT1 protein. The results were quantified by recording th...

journal_title：Histopathology

authors： Scattone A,Serio G,Marzullo A,Nazzaro P,Corsi F,Cocca MP,Mattoni M,Punzi A,Gentile M,Buonadonna AL,Pennella A

更新日期：2012-02-01 00:00:00

abstract：AIMS:To evaluate the relationship between phenotypic expression and tumour progression as represented by macroscopic features, submucosal invasion and lymph node metastasis in early differentiated gastric adenocarcinoma. METHODS:One hundred and fifty-five cases of early gastric differentiated adenocarcinoma without an...

journal_title：Histopathology

authors： Nakamura T,Yao T,Kabashima A,Nishiyama K,Maehara Y,Tsuneyoshi M

更新日期：2005-10-01 00:00:00

abstract：:Six cases of polymorphous low-grade adenocarcinoma (terminal duct adenocarcinoma) of the minor salivary glands are presented. In all but one there was a history of a painless intra-oral mass of fairly long duration. The histopathological appearances were characterized by cytological uniformity in a variety of morpholo...

journal_title：Histopathology

authors： Simpson RH,Clarke TJ,Sarsfield PT,Gluckman PG,Babajews AV

更新日期：1991-08-01 00:00:00

abstract：AIMS:To study immunohistochemically a group of 28 primary lung cancers which demonstrated histological features reminiscent of those characteristic of regression in malignant melanoma, to determine the phenotype of their immune cell infiltrates. METHODS AND RESULTS:Using a standard s-ABC immunoperoxidase method then q...

journal_title：Histopathology

authors： Kerr KM,Johnson SK,King G,Kennedy MM,Weir J,Jeffrey R

更新日期：1998-07-01 00:00:00

abstract：AIMS:We have previously shown that hypertrophic scar tissue from burn patients contains abnormally high amounts of the proteoglycans versican and biglycan and reduced amounts of decorin, in comparison with normal dermis or mature scar. The lack of decorin may account for the poor organization of collagen fibrils in the...

journal_title：Histopathology

authors： Sayani K,Dodd CM,Nedelec B,Shen YJ,Ghahary A,Tredget EE,Scott PG

更新日期：2000-03-01 00:00:00

abstract：:We have studied the clinical, radiological and pathological features of three patients with recurrent massive lower gastrointestinal arterial haemorrhage. Case 1 was an example of Dieulafoy's vascular malformation within the proximal ascending colon in a 46-year-old woman. Cases 2 and 3 were men aged 81 and 83 years w...

journal_title：Histopathology

authors： Bateman AC,Beer TW,Bass PS,Odurny A,Gallagher PJ

更新日期：1996-09-01 00:00:00

abstract：AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...

journal_title：Histopathology

authors： Hoang LN,Han G,McConechy M,Lau S,Chow C,Gilks CB,Huntsman DG,Köbel M,Lee CH

更新日期：2014-03-01 00:00:00

abstract：AIMS:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive haematological malignancy derived from plasmacytoid dendritic cell precursors. Almost all patients show cutaneous manifestations, and >60% show bone marrow (BM) involvement at initial presentation. In cases where there is BM involvement ...

journal_title：Histopathology

authors： Hwang K,Park CJ,Jang S,Chi HS,Huh JR,Lee JH,Suh C,Lee KH

更新日期：2013-04-01 00:00:00

abstract：AIMS:  To review the histopathological features of cervical LNs, and to clarify the changes in extracervical LNs, in acute Kawasaki disease (KD). METHODS AND RESULTS:  The samples were obtained from 33 patients with acute-phase KD. We divided the LNs into those in the neck (n = 23) and those located elsewhere (n = 26)...

journal_title：Histopathology

authors： Yokouchi Y,Oharaseki T,Harada M,Ihara F,Naoe S,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：AIMS:Because of the clinical difficulty in identifying the early stages of human immunodeficiency virus (HIV) infection, the histopathologist often has to consider the diagnosis of HIV in tissue samples from patients with no previous suspicion of HIV infection. The aim was to investigate the practicality and utility of...

journal_title：Histopathology

authors： Moonim MT,Alarcon L,Freeman J,Mahadeva U,van der Walt JD,Lucas SB

更新日期：2010-03-01 00:00:00

abstract：:In the Cambridge renal transplant unit percutaneous needle biopsies of renal transplants have been extensively used to help identify the cause of impaired allograft function. During the period 1966--1973, 154 of the 269 renal allografts transplanted were biopsied at least once during the first 90 days after transplant...

journal_title：Histopathology

authors： Herbertson BM,Evans DB,Calne RY,Banerjee AK

更新日期：1977-05-01 00:00:00

abstract：AIMS:Colorectal cancers deficient in DNA mismatch repair (MMR) are often characterized by the presence of numerous intraepithelial lymphocytes (IELs). These CD8+ T cells selectively express CD103, which is upregulated locally by transforming growth factor (TGF)-beta, and adhere to E-cadherin expressed by mucosal epithe...

journal_title：Histopathology

authors： Baker K,Chong G,Foulkes WD,Jass JR

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma c...

journal_title：Histopathology

authors： Morris HB,Mason DY,Stein H,Lennert K

更新日期：1983-11-01 00:00:00

abstract：:Aneuploidy is an important prognostic factor in many cancers. Chromosome 1 abnormalities are present in most breast carcinomas. These may be part of a non-specific increase in DNA (aneuploid status) or represent a restricted chromosomal abnormality. In 16 breast carcinomas we compared chromosome 1 aneusomy with ploidy...

journal_title：Histopathology

authors： Harrison MM,Magee HM,O'Loughlin JF,Gorey TF,Coyne JD,Dervan PA

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...

journal_title：Histopathology

authors： Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

更新日期：2021-01-10 00:00:00

abstract：AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

journal_title：Histopathology

authors： Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

更新日期：2012-09-01 00:00:00

abstract：AIMS:To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell angiofibromas. METHODS AND RESULTS:Sections of formalin-fixed paraffin-embedded specimens were studied by haematoxylin and eosin, reticulin and immunohistochemical stains. Electr...

journal_title：Histopathology

authors： Thomas R,Banerjee SS,Eyden BP,Shanks JH,Bisset DL,Hunt R,Byers RJ,Oogarah P,Harris M

更新日期：2001-10-01 00:00:00

abstract：AIMS:To examine the immunohistochemical expression of helicase-like transcription factor (HLTF) in relation to the prognosis of hypopharyngeal (HSCCs) and laryngeal (LSCCs) squamous cell carcinomas, and to characterize the HLTF protein variants expressed in biopsy specimens of head and neck squamous cell carcinoma (HNS...

journal_title：Histopathology

authors： Capouillez A,Debauve G,Decaestecker C,Filleul O,Chevalier D,Mortuaire G,Coppée F,Leroy X,Belayew A,Saussez S

更新日期：2009-07-01 00:00:00

abstract：AIMS:In addition to predominant granulocytic proliferation, bone marrow morphology in Philadelphia chromosome positive (Ph1+) CML is characterized by atypical dwarf or microforms of megakaryocytes. However, following therapy with interferon-alpha 2b (IFN), these micromegakaryocytes occur less frequently. The purpose of...

journal_title：Histopathology

authors： Thiele J,Schmitz B,Gross H,Kvasnicka HM,Niederle N,Leder LD,Fischer R

更新日期：1997-09-01 00:00:00