Standardization and the histopathology of tumours.

abstract：AIMS:The diagnosis of polymorphous low-grade adenocarcinoma (PLGA) remains difficult for general pathologists, particularly in cases of small biopsy samples. We aimed to characterize the histopathological spectrum and immunohistochemical aspects by using an accessible immunohistochemical panel of cytoskeletal proteins ...

journal_title：Histopathology

authors： Sedassari BT,Dos Santos HT,Pigatti FM,Martins Mussi MC,Tobouti PL,Altemani A,Sousa S

更新日期：2016-06-01 00:00:00

abstract：AIMS:To characterise the mutational profiles of poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) and to identify markers with potential diagnostic, prognostic and therapeutic significance. METHODS AND RESULTS:Targeted next-generation sequencing with a panel of 18 thyroid carcinoma-...

journal_title：Histopathology

authors： Duan H,Li Y,Hu P,Gao J,Ying J,Xu W,Zhao D,Wang Z,Ye J,Lizaso A,He Y,Wu H,Liang Z

更新日期：2019-12-01 00:00:00

abstract：AIM:To assess the potential prognostic significance of a range of molecular and morphological parameters in glioblastomas that can be applied in the setting of a routine diagnostic neuropathology laboratory. METHODS AND RESULTS:A consecutive series of 107 adult glioblastomas were studied. Retinoblastoma and deleted-in...

journal_title：Histopathology

authors： Hilton DA,Penney M,Pobereskin L,Sanders H,Love S

更新日期：2004-06-01 00:00:00

abstract：AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

journal_title：Histopathology

authors： Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

更新日期：2012-09-01 00:00:00

abstract：AIMS:To investigate the immunohistochemical expression of KDR/flk-1 in a series of 114 urothelial bladder carcinomas in relation to clinicopathological parameters, Ki67, p53 and Bcl-2 protein expression and patient survival. KDR/flk-1 is a high-affinity tyrosine kinase receptor for vascular endothelial growth factor (V...

journal_title：Histopathology

authors： Gakiopoulou-Givalou H,Nakopoulou L,Panayotopoulou EG,Zervas A,Mavrommatis J,Giannopoulos A

更新日期：2003-09-01 00:00:00

abstract：AIMS:Collagenous spherulosis (CS) is a rare lesion which is an incidental finding in breast and salivary glands. It is characterized by fibrillar spherules exhibiting an intrinsic radiating or concentric pattern which are surrounded by myoepithelial cells. This entity can be misdiagnosed as adenoid cystic carcinoma and...

journal_title：Histopathology

authors： Treilleux I,Godeneche J,Duvillard P,Clement-Chassagne C,Suignard Y,Bailly C

更新日期：1999-09-01 00:00:00

abstract：AIMS:To investigate platelet-derived growth factor receptor (PDGFR)alpha and PDGFRbeta expression and a mutational analysis of PDGFRalpha (exons 11, 12, 17 and 18) and PDGFRbeta (exon 12) genes in endometrial stromal sarcomas (ESS). Gastrointestinal stromal tumours (GISTs), which have somatic mutations of the transmemb...

journal_title：Histopathology

authors： Liegl B,Gülly C,Reich O,Nogales FF,Beham A,Regauer S

更新日期：2007-03-01 00:00:00

abstract：AIMS:  To review the histopathological features of cervical LNs, and to clarify the changes in extracervical LNs, in acute Kawasaki disease (KD). METHODS AND RESULTS:  The samples were obtained from 33 patients with acute-phase KD. We divided the LNs into those in the neck (n = 23) and those located elsewhere (n = 26)...

journal_title：Histopathology

authors： Yokouchi Y,Oharaseki T,Harada M,Ihara F,Naoe S,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：:The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type...

journal_title：Histopathology

authors： Quincey C,Raitt N,Bell J,Ellis IO

更新日期：1991-07-01 00:00:00

abstract：:The aim of this study was to examine the immunohistochemical expression of p53 and bcl-2 in Kaposi's sarcoma and relate this with proliferation index (as measured by MIB-1 staining) and clinicopathological subtypes. Twenty formalin-fixed, paraffin-embedded cases of Kaposi's sarcoma were stained with commercially avail...

journal_title：Histopathology

authors： Dada MA,Chetty R,Biddolph SC,Schneider JW,Gatter KC

更新日期：1996-08-01 00:00:00

abstract：AIMS:The clinicopathological distinctiveness of nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL) remains to be clarified. We investigated 26 patients with this lymphoma compared to nodal CM(+) EBV(-) PTCL (n = 39) and extranasal natural killer/T cell lymphoma ...

journal_title：Histopathology

authors： Kato S,Takahashi E,Asano N,Tanaka T,Megahed N,Kinoshita T,Nakamura S

更新日期：2012-08-01 00:00:00

abstract：:The author reports a case of a 53-year-old woman with a slowly growing thyroid papillary carcinoma. Microscopically the presence of adult adipose tissue was detected in numerous papillae. The recognition of this histological type as a new variety of papillary carcinoma is proposed. ...

journal_title：Histopathology

authors： Vestfrid MA

更新日期：1986-01-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to det...

journal_title：Histopathology

authors： Yamauchi A,Ikeda J,Nakamichi I,Kohara M,Fukuhara S,Hino M,Kanakura Y,Ogawa H,Sugiyama H,Kanamaru A,Aozasa K,Osaka Lymphoma Study Group.

更新日期：2008-05-01 00:00:00

abstract：AIMS:To study three atypical glioneuronal tumours (GNTs), in order to shed light on the clinical and pathological features of this diverse tumour group. METHODS AND RESULTS:Clinical and neuropathological data for each case were retrospectively reviewed. Case 1 involved a 17-year-old boy with left leg movement difficul...

journal_title：Histopathology

authors： Chen SY,Wang W,Wang LM,Lin QT,Zhao GG,Xu G,Lu DH,Piao YS

更新日期：2016-02-01 00:00:00

abstract：AIMS:Biphenotypic sinonasal sarcoma (SNS) is a locally aggressive tumour that occurs in the sinonasal region. PAX3-MAML3 has recently been identified as a recurrent fusion gene event in this entity; however, a subset of tumours harbour alternative PAX3 rearrangement without the involvement of MAML3. In this study we so...

journal_title：Histopathology

authors： Fritchie KJ,Jin L,Wang X,Graham RP,Torbenson MS,Lewis JE,Rivera M,Garcia JJ,Schembri-Wismayer DJ,Westendorf JJ,Chou MM,Dong J,Oliveira AM

更新日期：2016-12-01 00:00:00

abstract：AIMS:Prognostic factors affecting survival in cases of leiomyosarcoma of soft parts were investigated in this study. METHODS AND RESULTS:A retrospective study of 267 patients was carried out. This group comprised 142 females (53%) and 125 males (47%), whose ages ranged from 7 to 95 years (median 58 years). One hundred...

journal_title：Histopathology

authors： Miyajima K,Oda Y,Oshiro Y,Tamiya S,Kinukawa N,Masuda K,Tsuneyoshi M

更新日期：2002-04-01 00:00:00

abstract：:Five antibodies, MT1 (CD43), UCHL1 (CD45RO), OPD4, poly-CD3 and beta F1, were assessed for their reactivity with 50 archival cases of T-cell lymphoma in formalin-fixed paraffin-embedded tissue. All cases had been previously characterized as T-cell lymphomas, and the histological types included 14 cases of small cerebr...

journal_title：Histopathology

authors： Cabeçadas JM,Isaacson PG

更新日期：1991-11-01 00:00:00

abstract：:Many classification schemes have been proposed for ductal carcinoma in situ. Architectural heterogeneity is widely recognized. Cytonuclear grade appears to have greater prognostic significance than architectural pattern. This study assesses heterogeneity using a classification based on cytological grade and compares t...

journal_title：Histopathology

authors： Harrison M,Coyne JD,Gorey T,Dervan PA

更新日期：1996-05-01 00:00:00

abstract：AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...

journal_title：Histopathology

authors： Singh N,Gilks CB,Huntsman DG,Smith JH,Coutts M,Ganesan R,McCluggage WG

更新日期：2014-04-01 00:00:00

abstract：AIMS:To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS:We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our instituti...

journal_title：Histopathology

authors： Vingiani A,Maisonneuve P,Dell'orto P,Farante G,Rotmensz N,Lissidini G,Del Castillo A,Renne G,Luini A,Colleoni M,Viale G,Pruneri G

更新日期：2013-08-01 00:00:00

abstract：:A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...

journal_title：Histopathology

authors： Chan WY,Hui PK,Leung KM,Thomas TM

更新日期：1992-12-01 00:00:00

abstract：:An example of a cutaneous ciliated cyst in the buttock of a 42 year old woman is reported. The histological and immunohistochemical features of the cyst are presented: comparisons with fallopian tube are made and this rare lesion is discussed. ...

journal_title：Histopathology

authors： al-Nafussi AI,Carder P

更新日期：1990-06-01 00:00:00

abstract：:We have studied 74 benign intramuscular angiomas in order to try and correlate clinical behaviour with histological appearances. The purpose was to find means of predicting those which would recur. Mean age at presentation was 17.6 years and 85% of the cases presented before age 30. The male: female ratio was 1.4:1. A...

journal_title：Histopathology

authors： Beham A,Fletcher CD

更新日期：1991-01-01 00:00:00

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：AIMS:Y-box binding protein-1 (YB-1) is known to modulate gene transcription and protein translation, as well as cellular response to drug treatment. The aim of this study is to correlate YB-1 protein expression levels with clinicopathological parameters in intestinal-type gastric cancer tissue samples (as categorized b...

journal_title：Histopathology

authors： Guo T,Yu Y,Yip GW,Baeg GH,Thike AA,Lim TK,Tan PH,Matsumoto K,Bay BH

更新日期：2015-03-01 00:00:00

abstract：:Wilms' tumour (nephroblastoma) has been associated with chromosomal abnormalities at the 11p13, 11p15 and 16q regions. A study into the possibility of mutations occurring within p53, the ubiquitous adult tumour suppressor gene, in Wilms' tumour was carried out. Thirty-eight cases were studied. Of these 36 were categor...

journal_title：Histopathology

authors： Cheah PL,Looi LM,Chan LL

更新日期：1996-01-01 00:00:00

abstract：AIMS:Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity. METHODS AND RESULTS:We report a case of clear cell carcinoma in a 53-year-old man involving the head of the pancreas and which ha...

journal_title：Histopathology

authors： Lüttges J,Vogel I,Menke M,Henne-Bruns D,Kremer B,Klöppel G

更新日期：1998-05-01 00:00:00

abstract：AIM:To determine the extent of clonal outgrowth in the lymphocytic tissue infiltrate of lichen sclerosus (LS). The presence of T cells with a monoclonally rearranged T-cell receptor gamma-gene (TCRgamma) has been described in up to 50% of biopsies of vulvar and penile LS. MATERIAL AND RESULTS:We analysed 33 foreskin s...

journal_title：Histopathology

authors： Regauer S,Beham-Schmid C

更新日期：2006-05-01 00:00:00

abstract：AIMS:We tried to improve the evaluation of E-cadherin immunostaining in paraffin sections, to distinguish the less aggressive variants of ductal infiltrating breast cancer from other variants. METHODS AND RESULTS:The method graded the membrane staining and estimated the fraction of area of cancer tissue stained at the...

journal_title：Histopathology

authors： Elzagheid A,Kuopio T,Ilmen M,Collan Y

更新日期：2002-08-01 00:00:00

abstract：AIMS:Regional differences in proliferative activity are commonly seen within breast cancers, but little is known on the extent of intratumoral heterogeneity of Ki67 expression. Our aim was to study the intratumoral heterogeneity of Ki67 expression in early breast cancers and its association with clinicopathological fea...

journal_title：Histopathology

authors： Focke CM,Decker T,van Diest PJ

更新日期：2016-11-01 00:00:00