Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?

abstract：AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

journal_title：Histopathology

authors： Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

更新日期：2002-11-01 00:00:00

abstract：:Delta hepatitis (HDV) infection can only occur in the presence of hepatitis B (HBV) infection, as HDV requires a coat of HBV surface antigen (HBsAg) for assembly of complete virus. A number of studies have examined the variation of HBV markers in serum and liver during establishment of HDV infection, but none has syst...

journal_title：Histopathology

authors： Ryley NG,Heryet AR,Goldin R,Monjardino J,Saldanha J,Fleming KA

更新日期：1992-04-01 00:00:00

abstract：:The so-called sclerosing haemangioma of the lung is an uncommon tumour with predilection for Chinese women. Twenty-five cases showed a predominantly solid/cellular pattern in three, a haemorrhagic/angiomatoid pattern in three, a papillary pattern in one, a sclerotic pattern in one, and in seventeen, a mixed pattern wa...

journal_title：Histopathology

authors： Leong AS,Chan KW,Seneviratne HS

更新日期：1995-08-01 00:00:00

abstract：:We report a case of primary extrarenal Wilms' tumour which, on histological examination, revealed a zone of hyalinized blastema adjacent to, and within the tumour capsule. The tumour showed a predominant stromal component. The presence of the hyalinized blastema adjacent to the tumour raises the possibility that some ...

journal_title：Histopathology

authors： Sarode VR,Savitri K,Banerjee CK,Narasimharao KL,Khajuria A

更新日期：1992-07-01 00:00:00

abstract：AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...

journal_title：Histopathology

authors： Blok P,Craanen ME,Dekker W,Offerhaus GJ,Tytgat GN

更新日期：1998-04-01 00:00:00

abstract：AIMS:Five cases of a characteristic low-grade thymic epithelial tumour are described that we suggest calling metaplastic carcinoma of the thymus. METHODS AND RESULTS:The patients' ages ranged from 44 to 71 (mean 56.2) years. Four of the patients were male. Three of five tumours showed invasion into mediastinal fat or ...

journal_title：Histopathology

authors： Yoneda S,Marx A,Heimann S,Shirakusa T,Kikuchi M,Müller-Hermelink HK

更新日期：1999-07-01 00:00:00

abstract：AIMS:To investigate redox-regulating enzymes that may have a special role in melanoma pathogenesis due to continuous exposure to microenvironment-produced and ultraviolet radiation-induced oxidative stress. METHODS AND RESULTS:We assessed immunohistochemically the expression of antioxidant enzymes peroxiredoxins (Prxs...

journal_title：Histopathology

authors： Hintsala HR,Soini Y,Haapasaari KM,Karihtala P

更新日期：2015-09-01 00:00:00

abstract：AIMS:In addition to predominant granulocytic proliferation, bone marrow morphology in Philadelphia chromosome positive (Ph1+) CML is characterized by atypical dwarf or microforms of megakaryocytes. However, following therapy with interferon-alpha 2b (IFN), these micromegakaryocytes occur less frequently. The purpose of...

journal_title：Histopathology

authors： Thiele J,Schmitz B,Gross H,Kvasnicka HM,Niederle N,Leder LD,Fischer R

更新日期：1997-09-01 00:00:00

abstract：AIMS:To analyse expression and distribution of vascular endothelial growth factor (VEGF-C1), podocalyxin and synaptopodin within renal tissue in nephrotic syndrome glomerulopathies in children. METHODS AND RESULTS:Renal biopsies performed at the time and in the manner recommended by the World Health Organization. The ...

journal_title：Histopathology

authors： Ostalska-Nowicka D,Zachwieja J,Nowicki M,Kaczmarek E,Siwinska A,Witt M

更新日期：2005-02-01 00:00:00

abstract：AIMS:Pathological staging in penectomies may be difficult due to the anatomical complexity of penile anatomy, and may be additionally challenging due to the low volume at most institutions. Our study aimed to assess the feasibility of whole-mount processing for penectomy specimens. METHODS AND RESULTS:A 7-year retrosp...

journal_title：Histopathology

authors： Ebel JJ,Shabsigh A,Sharp DS,Zynger DL

更新日期：2013-07-01 00:00:00

abstract：AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...

journal_title：Histopathology

authors： Mitra A,Jameson C,Barbachano Y,Sanchez L,Kote-Jarai Z,Peock S,Sodha N,Bancroft E,Fletcher A,Cooper C,Easton D,IMPACT Steering Committee and IMPACT and EMBRACE Collaborators.,Eeles R,Foster CS

更新日期：2009-12-01 00:00:00

abstract：:The assessment of squamous lesions of the uterine cervix is a major preoccupation of diagnostic histopathologists and this can overshadow the recognition of significant abnormalities affecting the adjacent endocervical glands. This review gives an account of recent advances in our knowledge of the histology and histoc...

journal_title：Histopathology

authors： Wells M,Brown LJ

更新日期：1986-08-01 00:00:00

abstract：:A villous adenoma of the duodenum was studied histologically and histochemically by semi-thin sections using glycol-methacrylate as embedding medium. All the four epithelial cell types which are present in normal duodenal mucosa (absorptive columnar, goblet, Paneth, endocrine) were found in the tumour, as well as undi...

journal_title：Histopathology

authors： Mingazzini PL,Malchiodi Albedi F,Blandamura V

更新日期：1982-03-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a d...

journal_title：Histopathology

authors： Johnson A,Akerman M,Cavallin-Ståhl E

更新日期：1987-06-01 00:00:00

abstract：AIMS:The aim of this study was to examine clinicopathological features of patients with core biopsy diagnoses of ductal carcinoma in situ (DCIS) that may predict invasion on subsequent excision, as upstaging has significant implications regarding the need for axillary staging via sentinel lymph node biopsy (SLNB). MET...

journal_title：Histopathology

authors： Walters LL,Pang JC,Zhao L,Jorns JM

更新日期：2015-03-01 00:00:00

abstract：:The syndrome of postmastectomy lymphangiosarcoma (LAS) has been universally accepted since it was first outlined by Stewart & Treves (1948), except for a small number of authors who concluded that the neoplasms arising in the chronic lymphoedematous arms were in fact due to retrograde spread from the original breast c...

journal_title：Histopathology

authors： Schafler K,McKenzie CG,Salm R

更新日期：1979-03-01 00:00:00

abstract：AIMS:To investigate platelet-derived growth factor receptor (PDGFR)alpha and PDGFRbeta expression and a mutational analysis of PDGFRalpha (exons 11, 12, 17 and 18) and PDGFRbeta (exon 12) genes in endometrial stromal sarcomas (ESS). Gastrointestinal stromal tumours (GISTs), which have somatic mutations of the transmemb...

journal_title：Histopathology

authors： Liegl B,Gülly C,Reich O,Nogales FF,Beham A,Regauer S

更新日期：2007-03-01 00:00:00

abstract：:Therapeutic use of oestrogens by males with carcinoma of the prostate leads to testicular atrophy with markedly reduced spermatogenesis after only 21 d (Oshima et al. 1974). Treatment for over a year results in paucity of germ cells, vacuolation of Sertoli cells and reduction in Leydig cells (Lu & Steinberger 1978, Sm...

journal_title：Histopathology

authors： Venizelos ID,Paradinas FJ

更新日期：1988-04-01 00:00:00

abstract：AIMS:To investigate the immunohistochemical expression of KDR/flk-1 in a series of 114 urothelial bladder carcinomas in relation to clinicopathological parameters, Ki67, p53 and Bcl-2 protein expression and patient survival. KDR/flk-1 is a high-affinity tyrosine kinase receptor for vascular endothelial growth factor (V...

journal_title：Histopathology

authors： Gakiopoulou-Givalou H,Nakopoulou L,Panayotopoulou EG,Zervas A,Mavrommatis J,Giannopoulos A

更新日期：2003-09-01 00:00:00

abstract：:The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases--five papillary and 16 intestinal--all treated by the same surgical pro...

journal_title：Histopathology

authors： Artacho-Perula E,Roldan-Villalobos R,Lopez-Rubio F,Vaamonde-Lemos R

更新日期：1992-09-01 00:00:00

abstract：:Cancer biomarkers provide an opportunity to diagnose tumours earlier and with greater accuracy. They can also identify those patients most at risk of disease recurrence and predict which tumours will respond to different therapeutic approaches. Such biomarkers will be especially useful in the diagnosis and management ...

journal_title：Histopathology

authors： Proctor I,Stoeber K,Williams GH

更新日期：2010-07-01 00:00:00

abstract：AIMS:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remark...

journal_title：Histopathology

authors： Bilecz A,Stockhammer P,Theegarten D,Kern I,Jakopovic M,Samarzija M,Klikovits T,Hoda MA,Döme B,Oberndorfer F,Muellauer L,Fillinger J,Kovács I,Pirker C,Schuler M,Plönes T,Aigner C,Klepetko W,Berger W,Brcic L,Laszlo

更新日期：2020-07-01 00:00:00

abstract：AIMS:In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. METHODS AND RESULTS:Tumours from 59 patients wi...

journal_title：Histopathology

authors： Baur AS,Meugé-Moraw C,Michel G,Delacrétaz F

更新日期：1998-06-01 00:00:00

abstract：AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...

journal_title：Histopathology

authors： Shinto E,Mochizuki H,Ueno H,Matsubara O,Jass JR

更新日期：2005-07-01 00:00:00

abstract：AIMS:Breast cancer is one of the most common cancer diseases in women, with >1.67 million cases being diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumour spreads, and it is usually located in the ipsilateral axilla. In patients with no c...

journal_title：Histopathology

authors： Holten-Rossing H,Talman MM,Jylling AMB,Laenkholm AV,Kristensson M,Vainer B

更新日期：2017-12-01 00:00:00

abstract：:Recently, there has been intense interest in the study of gastrointestinal stromal tumour (GIST); one might call it a virtual GIST revolution. This is due largely to the realization that most GISTs express KIT and harbour activating c-KIT (KIT) or platelet-derived growth factor receptor-alpha (PDGFRA) receptor tyrosin...

journal_title：Histopathology

authors： Rubin BP

更新日期：2006-01-01 00:00:00

abstract：AIMS:To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' biopsy (MT), the accuracy of these diagnoses, and whether it is justified not to undertake surgical excision of non-malignant papillary lesions so diagnosed. METHODS AND RESULTS:...

journal_title：Histopathology

authors： Yamaguchi R,Tanaka M,Tse GM,Yamaguchi M,Terasaki H,Hirai Y,Nonaka Y,Morita M,Yokoyama T,Kanomata N,Naito Y,Akiba J,Yano H

更新日期：2015-03-01 00:00:00

abstract：AIMS:To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett's oesophagus patients. METHODS AND RESULTS:Immunostaining was analysed on a total of 192 biopsy samples of 22 Barrett's patients with no dysplasia...

journal_title：Histopathology

authors： van de Winkel A,van Zoest KP,van Dekken H,Moons LM,Kuipers EJ,van der Laan LJ

更新日期：2011-01-01 00:00:00

abstract：:The treatment of cancer has changed dramatically over the last decade, driven by increased understanding of the cancer genome, immune landscape, molecular alterations and aberrant pathways that drive cancer progression. Advances in molecular biology have led to the development of targeted agents, including monoclonal ...

journal_title：Histopathology

authors： Crusz SM,Miller RE

更新日期：2020-01-01 00:00:00

abstract：AIMS:The differential diagnosis of benign hepatic lesions and well-differentiated hepatocellular carcinomas can be a challenge, especially in small biopsy specimens. Recently, novel proteins expressed by the neovasculature in hepatocellular carcinoma (HCC) have been identified. The aim of this study was to compare the ...

journal_title：Histopathology

authors： Heukamp LC,Fischer HP,Schirmacher P,Chen X,Breuhahn K,Nicolay C,Büttner R,Gütgemann I

更新日期：2006-09-01 00:00:00