Primary extrarenal Wilms' tumour: identification of a putative precursor lesion.

abstract：AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...

journal_title：Histopathology

authors： Blok P,Craanen ME,Dekker W,Offerhaus GJ,Tytgat GN

更新日期：1998-04-01 00:00:00

abstract：AIMS:Colorectal carcinoma (CRC) with micropapillary (MP) features has only been described recently and is still being characterized. METHODS AND RESULTS:We reviewed the clinicopathological and molecular features of 42 CRC with MP features. Twenty-nine cases were also evaluated for immunohistochemical evidence of epith...

journal_title：Histopathology

authors： Gonzalez RS,Huh WJ,Cates JM,Washington K,Beauchamp RD,Coffey RJ,Shi C

更新日期：2017-01-01 00:00:00

abstract：:A case of squamous cell carcinoma of the lung showing extensive spindle transformation is presented. On light microscopy, the tumour showed sheets and fascicles of elongated fusiform cells resulting in a growth pattern which closely resembled a sarcoma. Immunocytochemistry using tissue-specific antibodies against inte...

journal_title：Histopathology

authors： Suster S,Huszar M,Herczeg E

更新日期：1987-08-01 00:00:00

abstract：AIMS:To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma. METHODS AND RESULTS:Over a 10-year (1990-2000) study period 53 carcinomas mimicking diffuse pleural mesothelioma ('pseudomesotheliomatous' carc...

journal_title：Histopathology

authors： Attanoos RL,Gibbs AR

更新日期：2003-11-01 00:00:00

abstract：AIMS:We have previously shown that hypertrophic scar tissue from burn patients contains abnormally high amounts of the proteoglycans versican and biglycan and reduced amounts of decorin, in comparison with normal dermis or mature scar. The lack of decorin may account for the poor organization of collagen fibrils in the...

journal_title：Histopathology

authors： Sayani K,Dodd CM,Nedelec B,Shen YJ,Ghahary A,Tredget EE,Scott PG

更新日期：2000-03-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) of the gastrointestinal tract (GIT) comprise neuroendocrine tumours (NETs) and neuroendocrine carcinomas (NECs). During the last decade the classification and grading of GIT NENs has undergone significant changes, culminating in the World Health Organisation (WHO) 2019 classification. T...

journal_title：Histopathology

authors： Gill AJ

更新日期：2021-01-01 00:00:00

abstract：AIMS:We report the clinicopathological and immunohistochemical characteristics of 12 cases of a recently recognized entity, oncocytic papillary thyroid carcinoma (PC) with lymphoid stroma (Warthin-like tumour). METHODS AND RESULTS:The cases were retrieved from the surgical pathology files of our departments. There wer...

journal_title：Histopathology

authors： Ludvíková M,Ryska A,Korabecná M,Rydlová M,Michal M

更新日期：2001-07-01 00:00:00

abstract：AIMS:HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy ...

journal_title：Histopathology

authors： Holzschuh MA,Czyz Z,Hauke S,Inwald EC,Polzer B,Brockhoff G

更新日期：2017-10-01 00:00:00

abstract：:Carcinosarcomas of the bladder are rare. We describe three such tumours, including an apparently unique case in which the components comprised liposarcoma and poorly-differentiated transitional cell elements. A second example included chondrosarcomatous elements. These two tumours showed architectural and immunocytoch...

journal_title：Histopathology

authors： Bloxham CA,Bennett MK,Robinson MC

更新日期：1990-01-01 00:00:00

abstract：AIMS:Several studies have demonstrated that Na(+) /H(+) exchanger regulatory factor 1 (NHERF1) protein, which is overexpressed and heterogeneously distributed in different stages of breast cancer, could be used as a tumour marker for prognosis in molecular detection strategies. We observed that tumour-infiltrated lymph...

journal_title：Histopathology

authors： Bellizzi A,Mangia A,Malfettone A,Cardone RA,Simone G,Reshkin SJ,Paradiso A

更新日期：2011-06-01 00:00:00

abstract：:The generic term aggressive B-cell lymphoma includes a variety of entities, each with particular diagnostic and therapeutic issues. To define these entities better and to help confront such issues, a workshop was organized by the European Association of Haematopathology (EAHP) and the Society of Haematology during the...

journal_title：Histopathology

authors： Leoncini L,Delsol G,Gascoyne RD,Harris NL,Pileri SA,Piris MA,Stein H

更新日期：2005-03-01 00:00:00

abstract：:Problems in the interpretation and diagnosis of intraepithelial lesions of the uterine cervix include interobserver differences in respect of grading, uncertainty as to the significance of human papillomavirus infection and debate about the current terminology. The role of human papillomaviruses in cervical intra-epit...

journal_title：Histopathology

authors： Fox H,Buckley CH

更新日期：1990-07-01 00:00:00

abstract：AIMS:Regional differences in proliferative activity are commonly seen within breast cancers, but little is known on the extent of intratumoral heterogeneity of Ki67 expression. Our aim was to study the intratumoral heterogeneity of Ki67 expression in early breast cancers and its association with clinicopathological fea...

journal_title：Histopathology

authors： Focke CM,Decker T,van Diest PJ

更新日期：2016-11-01 00:00:00

abstract：AIMS:The 2009 International Society of Urological Pathology consensus conference recommended reporting the extent of extraprostatic extension (EPE) for the prediction of outcome in prostate cancer. Our aim was to stratify EPE into prognostic groups. METHODS AND RESULTS:We reviewed 1051 radical prostatectomy (RP) speci...

journal_title：Histopathology

authors： Danneman D,Wiklund F,Wiklund NP,Egevad L

更新日期：2013-10-01 00:00:00

abstract：AIMS:There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to g...

journal_title：Histopathology

authors： Kaye P,Lindsay D,Madhusudan S,Vohra R,Catton J,Platt C,Ragunath K

更新日期：2019-05-01 00:00:00

abstract：AIMS:Pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) are two metabolic and oncogenic markers of cancer. In this study, we sought to investigate their expression patterns and prognostic value in tongue squamous cell carcinoma (TSCC). METHODS AND RESULTS:The expression and subcellular localization of PKM2 a...

journal_title：Histopathology

authors： Yuan C,Li Z,Wang Y,Qi B,Zhang W,Ye J,Wu H,Jiang H,Song LN,Yang J,Cheng J

更新日期：2014-11-01 00:00:00

abstract：:We report a case of an adrenal lipoma, a very rare lesion first described in 1899 and of which a total of six cases have previously been reported (Lange 1966, Page, De Lellis & Hough 1986). Five of these cases were found incidentally at post mortem. In one case an acute hypertensive episode intra-operatively simulated...

journal_title：Histopathology

authors： Avinoach I,Robinson CR,Avinoah E,Peiser J

更新日期：1989-08-01 00:00:00

abstract：AIMS:The majority of patients with Down syndrome (DS), trisomy 21, have morphologically abnormal thymuses and present with intrinsic immunological abnormalities affecting mainly the cellular immune response. The aim of this study was to examine whether the expression of functionally important molecules is altered in th...

journal_title：Histopathology

authors： Tomaru U,Tsuji T,Kiuchi S,Ishizu A,Suzuki A,Otsuka N,Ito T,Ikeda H,Fukasawa Y,Kasahara M

更新日期：2015-08-01 00:00:00

abstract：:Gonadoblastoma is defined as a neoplasm containing nests of germ cells and cells resembling Sertoli cells or granulosa cells. Gonadoblastomas arise almost exclusively in dysgenetic gonads. They are associated with an increased risk of developing germ cell tumours. Testicular germ cell tumours in adults are preceded by...

journal_title：Histopathology

authors： Jørgensen N,Müller J,Jaubert F,Clausen OP,Skakkebaek NE

更新日期：1997-02-01 00:00:00

abstract：AIMS:To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell angiofibromas. METHODS AND RESULTS:Sections of formalin-fixed paraffin-embedded specimens were studied by haematoxylin and eosin, reticulin and immunohistochemical stains. Electr...

journal_title：Histopathology

authors： Thomas R,Banerjee SS,Eyden BP,Shanks JH,Bisset DL,Hunt R,Byers RJ,Oogarah P,Harris M

更新日期：2001-10-01 00:00:00

abstract：AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...

journal_title：Histopathology

authors： El Zein S,Boccara O,Soupre V,Vieira AF,Bodemer C,Coulomb A,Wassef M,Fraitag S

更新日期：2020-08-01 00:00:00

abstract：AIMS:Endometrial stromal sarcoma (ESS) has traditionally been divided into low and high grade, but the World Health Organization (WHO, 2003) has changed the definition. Since 2003, many studies have used the old criteria, and few have focused on WHO 2003-defined ESS low grade (ESS-LG). The aim of this study was to inve...

journal_title：Histopathology

authors： Feng W,Hua K,Gudlaugsson E,Yu Y,Zhou X,Baak JP

更新日期：2013-04-01 00:00:00

abstract：AIMS:Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to ass...

journal_title：Histopathology

authors： Stewart M,Turley H,Cook N,Pezzella F,Pillai G,Ogilvie D,Cartlidge S,Paterson D,Copley C,Kendrew J,Barnes C,Harris AL,Gatter KC

更新日期：2003-07-01 00:00:00

abstract：:We report a case of oesophageal carcinosarcoma with prominent rhabdomyoblastic differentiation. Immunohistochemically, the rhabdomyblasts were mainly reactive to vimentin, cytokeratin, desmin, muscle-specific actin, myosin, and myoglobin, and were surrounded by laminin and type IV collagen-positive basement membranes....

journal_title：Histopathology

authors： Guarino M,Reale D,Micoli G,Forloni B

更新日期：1993-05-01 00:00:00

abstract：AIM:To describe a group of distinct low-grade oncocytic renal tumours that demonstrate CD117 negative/cytokeratin (CK) 7-positive immunoprofile. METHODS AND RESULTS:We identified 28 such tumours from four large renal tumour archives. We performed immunohistochemistry for: CK7, CD117, PAX8, CD10, AMACR, e-cadherin, CK2...

journal_title：Histopathology

authors： Trpkov K,Williamson SR,Gao Y,Martinek P,Cheng L,Sangoi AR,Yilmaz A,Wang C,San Miguel Fraile P,Perez Montiel DM,Bulimbasić S,Rogala J,Hes O

更新日期：2019-08-01 00:00:00

abstract：AIMS:Previous karyotyping and fluorescence in situ hybridization analysis of metanephric adenomas (MAs) has yielded controversial data. The aim of this study was to detect small genomic alterations, if any, specific to MAs by applying high-resolution oligoarrays. METHODS AND RESULTS:DNA extracted from paraffin blocks ...

journal_title：Histopathology

authors： Szponar A,Yusenko MV,Kovacs G

更新日期：2010-01-01 00:00:00

abstract：AIMS:Segmental atrophy (SA) of the liver is a recently described pseudotumour that can show a broad spectrum of histological changes. The previously described histological differential diagnosis of SA has included cystic disease of the liver, amyloid, cancer-associated elastosis, and epithelioid haemangioendothelioma. ...

journal_title：Histopathology

authors： Findeis-Hosey JJ,Zhou Z,Gonzalez RS

更新日期：2019-12-01 00:00:00

abstract：AIMS:Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase involved in glycogen metabolism, cell cycle progression, differentiation, embryogenesis, migration, metabolism, survival and cellular senescence. Its main biological function is to inhibit β-catenin by sequestration and promotion of its proteaso...

journal_title：Histopathology

authors： Agostinelli C,Carloni S,Limarzi F,Righi S,Laginestra MA,Musuraca G,Fiorentino M,Napolitano R,Cuneo A,Vergara D,Zinzani PL,Sabattini E,Pileri SA,De Matteis S

更新日期：2017-07-01 00:00:00

abstract：AIMS:Pleomorphic lobular carcinoma (PLC) is an aggressive variant of invasive lobular carcinoma. The aim of this study was to redefine PLC in terms of molecular classification. METHODS AND RESULTS:Cases of PLC were selected between 1995 and 2010. Key clinicopathological features were recorded for most of the patients....

journal_title：Histopathology

authors： Monhollen L,Morrison C,Ademuyiwa FO,Chandrasekhar R,Khoury T

更新日期：2012-09-01 00:00:00

abstract：:The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...

journal_title：Histopathology

authors： Delsol G,Chittal S,Brousset P,Caveriviere P,Roda D,Mazerolles C,Barillet-Alard C,al Saati T,Gorguet B,Voigt JJ

更新日期：1989-11-01 00:00:00