The emerging role of GSK-3β in the pathobiology of classical Hodgkin lymphoma.

abstract：:Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging...

journal_title：Histopathology

authors： Magers MJ,Lopez-Beltran A,Montironi R,Williamson SR,Kaimakliotis HZ,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:Clinicopathological and immunohistological features of three cases of large cell lymphoma of bone are reported. On histological grounds, all the cases were diagnosed as histiocytic lymphomas (Rappaport) or primary centroblastic lymphomas, polymorphic subtype (Kiel). On immunophenotyping, malignant cells strongly react...

journal_title：Histopathology

authors： Falini B,Binazzi R,Pileri S,Mori A,Bertoni F,Canino S,Fagioli M,Minelli O,Ciani C,Pellicioli P

更新日期：1988-02-01 00:00:00

abstract：:A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

journal_title：Histopathology

authors： Islam A,Henderson ES

更新日期：1988-06-01 00:00:00

abstract：AIMS:To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' biopsy (MT), the accuracy of these diagnoses, and whether it is justified not to undertake surgical excision of non-malignant papillary lesions so diagnosed. METHODS AND RESULTS:...

journal_title：Histopathology

authors： Yamaguchi R,Tanaka M,Tse GM,Yamaguchi M,Terasaki H,Hirai Y,Nonaka Y,Morita M,Yokoyama T,Kanomata N,Naito Y,Akiba J,Yano H

更新日期：2015-03-01 00:00:00

abstract：AIMS:AP2alpha (TFAP2A) and AP2gamma (TFAP2G) transcription factors have been implicated in the control of proliferation, differentiation and apoptosis of normal breast epithelium and in breast cancer. The aim of this study was to provide a comprehensive analysis of the expression patterns of TFAP2A and TFAP2G in the de...

journal_title：Histopathology

authors： Friedrichs N,Steiner S,Buettner R,Knoepfle G

更新日期：2007-12-01 00:00:00

abstract：AIMS:We tried to improve the evaluation of E-cadherin immunostaining in paraffin sections, to distinguish the less aggressive variants of ductal infiltrating breast cancer from other variants. METHODS AND RESULTS:The method graded the membrane staining and estimated the fraction of area of cancer tissue stained at the...

journal_title：Histopathology

authors： Elzagheid A,Kuopio T,Ilmen M,Collan Y

更新日期：2002-08-01 00:00:00

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：:Alongside histomorphology and immunohistochemistry, molecular pathology is now established as one of the cornerstones in the tissue diagnosis of bone tumours. We describe the principal molecular pathological techniques employed, and each of the bone tumour entities where their identified characteristic molecular patho...

journal_title：Histopathology

authors： Puls F,Niblett AJ,Mangham DC

更新日期：2014-03-01 00:00:00

abstract：:This review intends to update current knowledge regarding molecular cytogenetics in melanocytic tumours with a focus on cutaneous melanocytic lesions. Advantages and limitations of diverse, already established methods, such as (fluorescence) in situ hybridization and mutation analysis, to detect these cytogenetic alte...

journal_title：Histopathology

authors： Blokx WA,van Dijk MC,Ruiter DJ

更新日期：2010-01-01 00:00:00

abstract：AIMS:SOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated in cancer progression, its role in breast carcinoma is poorly understood. MATERIALS AND METHODS:Fifty-seven ductal carcinomas in situ (DCIS), 552 invasive breast carcinomas and 107 corresponding metastatic lymph nodes were eval...

journal_title：Histopathology

authors： Huang YH,Luo MH,Ni YB,Tsang JY,Chan SK,Lui PC,Yu AM,Tan PH,Tse GM

更新日期：2014-03-01 00:00:00

abstract：AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architec...

journal_title：Histopathology

authors： Ko YH,Kim SH,Ree HJ

更新日期：1998-12-01 00:00:00

abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...

journal_title：Histopathology

authors： Capella C,Frigerio B,Cornaggia M,Solcia E,Pinzon-Trujillo Y,Chejfec G

更新日期：1984-09-01 00:00:00

abstract：AIMS:We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus. METHODS AND RESULTS:The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies. Grossly, all tumours were present in the uterine body, an...

journal_title：Histopathology

authors： Watanabe K,Ogura G,Suzuki T

更新日期：2003-04-01 00:00:00

abstract：:Carcinosarcomas of the bladder are rare. We describe three such tumours, including an apparently unique case in which the components comprised liposarcoma and poorly-differentiated transitional cell elements. A second example included chondrosarcomatous elements. These two tumours showed architectural and immunocytoch...

journal_title：Histopathology

authors： Bloxham CA,Bennett MK,Robinson MC

更新日期：1990-01-01 00:00:00

abstract：AIMS:Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic ...

journal_title：Histopathology

authors： Gremel G,Bergman J,Djureinovic D,Edqvist PH,Maindad V,Bharambe BM,Khan WA,Navani S,Elebro J,Jirström K,Hellberg D,Uhlén M,Micke P,Pontén F

更新日期：2014-01-01 00:00:00

abstract：AIMS:The immunoregulatory enzyme indoleamine dioxygenase 2,3 (IDO) has been implicated in cervical and vulvar squamous carcinomas (SCC) and may represent a mechanism of resistance to anti-PD-1/anti-PD-L1 therapy. However, the relationship between IDO and PD-L1 has not been well-investigated. METHODS AND RESULTS:Sixty-...

journal_title：Histopathology

authors： Chinn Z,Stoler MH,Mills AM

更新日期：2019-01-01 00:00:00

abstract：AIMS:To investigate the immunohistochemical expression of KDR/flk-1 in a series of 114 urothelial bladder carcinomas in relation to clinicopathological parameters, Ki67, p53 and Bcl-2 protein expression and patient survival. KDR/flk-1 is a high-affinity tyrosine kinase receptor for vascular endothelial growth factor (V...

journal_title：Histopathology

authors： Gakiopoulou-Givalou H,Nakopoulou L,Panayotopoulou EG,Zervas A,Mavrommatis J,Giannopoulos A

更新日期：2003-09-01 00:00:00

abstract：AIMS:This study has compared the tissue expression of the p53 tumour suppressor protein and DNA repair proteins APE1, hMSH2 and ERCC1 in normal, dysplastic and malignant lip epithelium. METHODS AND RESULTS:Morphological analysis and immunohistochemistry were performed on archived specimens of normal lip mucosa (n=15),...

journal_title：Histopathology

authors： Souza LR,Fonseca-Silva T,Pereira CS,Santos EP,Lima LC,Carvalho HA,Gomez RS,Guimarães AL,De Paula AM

更新日期：2011-02-01 00:00:00

abstract：AIMS:The third edition of the World Health Organization (WHO) classification of lung tumours has been published and is expected to become the standard nomenclature. The aim of this study was to assess the usability and prognostic significance of the WHO classification in comparison with other recent classifications. M...

journal_title：Histopathology

authors： Aida S,Shimazaki H,Sato K,Sato M,Deguchi H,Ozeki Y,Tamai S

更新日期：2004-11-01 00:00:00

abstract：AIM:Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC) is a rare biphasic liver cancer. Recent studies have demonstrated that cHCC-CC originates from hepatic progenitor cells (HPCs). Spalt-like transcription factor 4 (SALL4) is a marker for a progenitor subclass of HCC with an aggressive phen...

journal_title：Histopathology

authors： Tanaka Y,Aishima S,Kohashi K,Okumura Y,Wang H,Hida T,Kotoh K,Shirabe K,Maehara Y,Takayanagi R,Oda Y

更新日期：2016-04-01 00:00:00

abstract：:Occasional biopsies of genital lesions due to chancroid, secondary syphilis (the condyloma latum) and granuloma inguinale are encountered in routine histopathological practice. These lesions have specific microscopical appearances enabling a confident, or at least a presumptive, diagnosis to be made in most cases, yet...

journal_title：Histopathology

authors： Freinkel AL

更新日期：1987-08-01 00:00:00

abstract：AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...

journal_title：Histopathology

authors： Ramani P,Nash R,Radevsky L,Patel A,Luckett M,Rogers C

更新日期：2012-12-01 00:00:00

abstract：:Nine cases of Mullerian adenosarcoma of the uterine body, first defined in 1974 by Clement & Scully, are described. The tumour usually occurs in elderly women and appears macroscopically as a polypoid mass filling the uterine cavity. Histologically these neoplasms are characterized by having a benign epithelial compon...

journal_title：Histopathology

authors： Fox H,Harilal KR,Youell A

更新日期：1979-05-01 00:00:00

abstract：AIMS:Hepatocellular adenoma is an uncommon liver neoplasm and the studies of HCA subtypes have been primarily limited to France, United States and Japan. We aimed to describe the clinicopathologic features of hepatocellular adenoma subtypes in Turkey. METHODS AND RESULTS:The resection specimens of 59 cases diagnosed a...

journal_title：Histopathology

authors： Deniz K,Umetsu SE,Ferrell L,Yılmaz F,Güllüoğlu M,Sağol Ö,Bülbül Doğusoy G,Kırımlıoğlu H,Turhan N,Doran F,Kepil N,Çelikel ÇA,Nart D,Özgüven BY,Ceyran B,Karadağ N,Kır G,Erden E,Yılmaz G,Akyol G

更新日期：2021-01-06 00:00:00

abstract：:The recognition of recurrent genetic alterations in specific tumour types has provided the basis for the reclassification of certain soft tissue neoplasms, and molecular analysis of patient material has the potential to provide both diagnostic and prognostic information. In this review, we evaluate the role of molecul...

journal_title：Histopathology

authors： Pfeifer JD,Hill DA,O'Sullivan MJ,Dehner LP

更新日期：2000-12-01 00:00:00

abstract：AIM:To assess whether the distribution of the recently described proapoptotic ligand, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), and the apoptosis effector, caspase-3 alters with the degree of inflammation and fibrosis present in liver biopsy specimens from patients with chronic hepatitis C virus...

journal_title：Histopathology

authors： Piekarska A,Kubiak R,Omulecka A,Szymczak W,Piekarski J

更新日期：2007-11-01 00:00:00

abstract：AIMS:We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B cell lymphoma (DLBCLsn ) in a series of 240 cases of DLBCL not otherwise specified [DLBCLall (NOS) ], including DLBCLsn training set (n = 11) and validation set (n = 18), and DLBCLnon-sn (n = 211). METHODS AND RESUL...

journal_title：Histopathology

authors： Carreras J,Kikuti YY,Beà S,Miyaoka M,Hiraiwa S,Ikoma H,Nagao R,Tomita S,Martin-Garcia D,Salaverria I,Sato A,Ichiki A,Roncador G,Garcia JF,Ando K,Campo E,Nakamura N

更新日期：2017-03-01 00:00:00

abstract：:Review of the histological sections of the tumours of 889 patients from the files of the SIOP Nephroblastoma trials and studies has revealed 23 cases with a distinctive growth pattern. Due to the similarity of the histological structures with the architecture of adenofibroma (fibroadenoma) of the ovary we have called ...

journal_title：Histopathology

authors： Delemarre JF,Sandstedt B,Tournade MF

更新日期：1984-01-01 00:00:00

abstract：:A cytokeratin immunohistochemical study was performed on 38 liver biopsies from cases of primary biliary cirrhosis, primary sclerosing cholangitis, extrahepatic biliary obstruction or drug-induced liver disease in order to analyse the cytoskeletal changes in detail. On paraffin sections of 27 cases, a variable number ...

journal_title：Histopathology

authors： Van Eyken P,Sciot R,Desmet VJ

更新日期：1989-08-01 00:00:00

abstract：:The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...

journal_title：Histopathology

authors： Renshaw AA

更新日期：2002-10-01 00:00:00