Abstract:
:Alongside histomorphology and immunohistochemistry, molecular pathology is now established as one of the cornerstones in the tissue diagnosis of bone tumours. We describe the principal molecular pathological techniques employed, and each of the bone tumour entities where their identified characteristic molecular pathological changes can be detected to support and confirm the suspected histological diagnosis. Tumours discussed include fibrous dysplasia, classical and subtype osteosarcomas, central and surface cartilaginous tumours, Ewing's sarcoma, vascular tumours, aneurysmal bone cyst, chordoma, myoepithelioma, and angiomatoid fibrous histiocytoma. This is a rapidly evolving field with discoveries occurring every few months, and some of the newer entities (the Ewing's-like sarcomas), which are principally identified by their molecular pathology characteristics, are discussed.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Puls F,Niblett AJ,Mangham DCdoi
10.1111/his.12275subject
Has Abstractpub_date
2014-03-01 00:00:00pages
461-76issue
4eissn
0309-0167issn
1365-2559journal_volume
64pub_type
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