Abstract:
:Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-centrocytic lymphomas. bcl-1 rearrangements were found in two cases of chronic lymphocytic leukaemia. As the chromosomal translocation t(14;18) is reported to occur in up to 85% of follicular lymphomas, our results provide additional evidence that the differentiation of low-grade B-cell lymphomas according to the Kiel classification defines biologically distinct entities.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Ott MM,Müller-Hermelink HK,Schmitt B,Feller ACdoi
10.1111/j.1365-2559.1991.tb00007.xsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
163-7issue
2eissn
0309-0167issn
1365-2559journal_volume
19pub_type
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