Chromosomal translocation detected by bcl-1 and bcl-2 rearrangement in low-grade B-cell lymphomas in a European population.

Abstract:

:Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-centrocytic lymphomas. bcl-1 rearrangements were found in two cases of chronic lymphocytic leukaemia. As the chromosomal translocation t(14;18) is reported to occur in up to 85% of follicular lymphomas, our results provide additional evidence that the differentiation of low-grade B-cell lymphomas according to the Kiel classification defines biologically distinct entities.

journal_name

Histopathology

journal_title

Histopathology

authors

Ott MM,Müller-Hermelink HK,Schmitt B,Feller AC

doi

10.1111/j.1365-2559.1991.tb00007.x

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

163-7

issue

2

eissn

0309-0167

issn

1365-2559

journal_volume

19

pub_type

杂志文章
  • Focal nodular hyperplasia-like areas in cirrhosis.

    abstract:AIMS:Focal nodular hyperplasia-like lesions have rarely been described in cirrhotic livers. We describe five cases of such lesions. METHODS AND RESULTS:Between 1998 and 2001, 146 liver transplants were performed at the Royal Free Hospital for cirrhosis of the liver. Nodular lesions identified in the livers removed at ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01550.x

    authors: Quaglia A,Tibballs J,Grasso A,Prasad N,Nozza P,Davies SE,Burroughs AK,Watkinson A,Dhillon AP

    更新日期:2003-01-01 00:00:00

  • Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.

    abstract:AIMS:Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in gallbladder tissues. I...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13797

    authors: Espinoza JA,Riquelme I,Sagredo EA,Rosa L,García P,Bizama C,Apud-Bell M,Leal P,Weber H,Benavente F,Vargas S,Romero D,Kalergis AM,Roa JC

    更新日期:2019-03-01 00:00:00

  • Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation.

    abstract:AIMS:Pulmonary sequelae, reported as chronic graft-versus-host disease (cGVHD), of haematopoietic stem cell transplantation (HSCT) include constrictive bronchiolitis obliterans (CBO), lymphocytic bronchiolitis (LB), and veno-occlusive disease (VOD); recently, pleuroparenchymal fibroelastosis (PPFE) has also been descri...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12553

    authors: Takeuchi Y,Miyagawa-Hayashino A,Chen F,Kubo T,Handa T,Date H,Haga H

    更新日期:2015-03-01 00:00:00

  • Diagnosis of acute myeloid leukaemia with the use of monoclonal anti-neutrophil elastase (NP57) reactive with routinely processed biopsy samples.

    abstract::The reactivity of a monoclonal anti-neutrophil elastase antibody (NP57) with routinely processed biopsy samples from various acute leukaemias has been examined and compared with that of chloroacetate esterase and CD15 (hapten X), two other myeloid cell-associated markers detectable in paraffin sections. No staining wa...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1989.tb02205.x

    authors: Ralfkiaer E,Pulford KA,Lauritzen AF,Avnstrøm S,Guldhammer B,Mason DY

    更新日期:1989-06-01 00:00:00

  • Papillary carcinoma of the thyroid gland with lipomatous stroma: report of a peculiar histological type of thyroid tumour.

    abstract::The author reports a case of a 53-year-old woman with a slowly growing thyroid papillary carcinoma. Microscopically the presence of adult adipose tissue was detected in numerous papillae. The recognition of this histological type as a new variety of papillary carcinoma is proposed. ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1986.tb02464.x

    authors: Vestfrid MA

    更新日期:1986-01-01 00:00:00

  • Current diagnostic strategies for undifferentiated tumours of the nasal cavities and paranasal sinuses.

    abstract::Several malignant tumours occurring in the sinonasal tract may present with an undifferentiated morphology. Overall, these lesions pose significant diagnostic difficulties for the surgical pathologist, especially in limited biopsy material, but their correct classification is becoming increasingly important for an app...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2011.03813.x

    authors: Franchi A,Palomba A,Cardesa A

    更新日期:2011-12-01 00:00:00

  • Quality aspects of the tissue microarray technique in a population-based cohort with ductal carcinoma in situ of the breast.

    abstract:AIMS:Tissue microarray (TMA) is an efficient technique for analysis of molecular markers. Prospectively collected samples have been reported to give excellent concordance between TMA data and corresponding whole-sections. The aim was to evaluate the usefulness of TMA in a population-based cohort of 213 women with ducta...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03156.x

    authors: Wärnberg F,Amini RM,Goldman M,Jirström K

    更新日期:2008-12-01 00:00:00

  • Adult granulosa cell tumour-like areas occurring in ovarian epithelial neoplasms: report of a case series with investigation of FOXL2 mutation status.

    abstract:AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12314

    authors: Singh N,Gilks CB,Huntsman DG,Smith JH,Coutts M,Ganesan R,McCluggage WG

    更新日期:2014-04-01 00:00:00

  • Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in intrahepatic cholangiocarcinoma.

    abstract::Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1994.tb01570.x

    authors: Terada T,Nakanuma Y

    更新日期:1994-08-01 00:00:00

  • Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours.

    abstract:AIMS:To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells. METHODS AND RESULTS:KIT and SCF expression were studied in 248 human tumours consisting of 15 different histological types using immunohistochemistry and in situ hybridization for KIT ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2009.03418.x

    authors: Sihto H,Tynninen O,Halonen M,Puputti M,Karjalainen-Lindsberg ML,Kukko H,Joensuu H

    更新日期:2009-11-01 00:00:00

  • Glia maturation factor-beta is produced by thymoma and may promote intratumoral T-cell differentiation.

    abstract:AIMS:To investigate whether Glia maturation factor-beta (GMFB) is expressed in thymomas and is associated with T-cell development. METHODS AND RESULTS:We investigated the expression of GMFB by immunohistochemistry in 86 cases of thymoma classified into five type A, 35 type AB, 11 type B1, 26 type B2, and nine type B3 ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2005.02224.x

    authors: Yamazaki H,Tateyama H,Asai K,Fukai I,Fujii Y,Tada T,Eimoto T

    更新日期:2005-09-01 00:00:00

  • A study of Gleason score interpretation in different groups of UK pathologists; techniques for improving reproducibility.

    abstract:AIMS:To test the effectiveness of a teaching resource (a decision tree with diagnostic criteria based on published literature) in improving the proficiency of Gleason grading of prostatic cancer by general pathologists. METHODS:A decision tree with diagnostic criteria was developed by a panel of urological pathologist...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02394.x

    authors: Griffiths DF,Melia J,McWilliam LJ,Ball RY,Grigor K,Harnden P,Jarmulowicz M,Montironi R,Moseley R,Waller M,Moss S,Parkinson MC

    更新日期:2006-05-01 00:00:00

  • Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases of a tumour frequently misdiagnosed as a vascular neoplasm.

    abstract::Forty cases of the distinctive but poorly recognized aneurysmal variant of cutaneous fibrous histiocytoma are described. These tumours presented most commonly in middle-age adults, with a slight predilection for females. Anatomical distribution was wide with most cases occurring in the lower limb/limb girdle (50%), up...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1995.tb00193.x

    authors: Calonje E,Fletcher CD

    更新日期:1995-04-01 00:00:00

  • A histological comparison of cutaneous malignant melanoma between the Oxford Region and Western Australia.

    abstract::Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predomi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1982.tb02765.x

    authors: Heenan PJ,Holman CD

    更新日期:1982-11-01 00:00:00

  • High expression of MDR-1 gene and P-glycoprotein in initial and re-biopsy specimens of relapsed B-cell lymphoma.

    abstract:AIMS:Multidrug resistance (MDR) is a major obstacle in the treatment of lymphoma. The expression of MDR-1 mRNA and P-glycoprotein (MDR-1/P-gp) has been linked to MDR. We aimed to investigate the expression of MDR-1/P-gp in B-cell lymphoma. METHODS AND RESULTS:Samples at diagnosis and relapse from 10 patients with B-ce...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2001.01076.x

    authors: Liu Q,Ohshima K,Kikuchi M

    更新日期:2001-03-01 00:00:00

  • Mucin profiles in the mucosa adjacent to large bowel non-adenocarcinoma neoplasias.

    abstract::Morphological features and mucin secretion patterns were investigated in the colonic mucosa adjacent to or overlying mesenchymal or primary epithelial neoplasias, other than adenomas and adenocarcinomas. The material included 15 cases of non-adenocarcinoma tumours examined during 1978-1981. Increased sialomucins and m...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1984.tb02396.x

    authors: Lapertosa G,Fulcheri E,Acquarone M,Filipe MI

    更新日期:1984-09-01 00:00:00

  • Counting invasive breast cancer cells in the HER2 silver in-situ hybridization test: how many cells are enough?

    abstract:AIM:To evaluate the intraobserver and interobserver reproducibility of the HER2 in-situ hybridization (ISH) test in breast cancer by measuring the impact of counting different numbers of invasive cancer cells. METHODS AND RESULTS:A cohort of 101 primary invasive breast cancer cases were evaluated for HER2 gene amplifi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13208

    authors: Polónia A,Eloy C,Pinto J,Braga AC,Oliveira G,Schmitt F

    更新日期:2017-08-01 00:00:00

  • Genome-wide analysis of long non-coding RNA in primary nasopharyngeal carcinoma by microarray.

    abstract:AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12616

    authors: Yang QQ,Deng YF

    更新日期:2015-06-01 00:00:00

  • Hepatic sclerosing cavernous haemangioma can mimic the nodular elastosis stage of segmental atrophy.

    abstract:AIMS:Segmental atrophy (SA) of the liver is a recently described pseudotumour that can show a broad spectrum of histological changes. The previously described histological differential diagnosis of SA has included cystic disease of the liver, amyloid, cancer-associated elastosis, and epithelioid haemangioendothelioma. ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13961

    authors: Findeis-Hosey JJ,Zhou Z,Gonzalez RS

    更新日期:2019-12-01 00:00:00

  • Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy.

    abstract:AIMS:To investigate the protein expressions of breast cancer 1 (BRCA1) and 2 (BRCA2) in prostatectomy specimens of localized prostate cancer (PC) patients, along with their associations with cancer characteristics and prognosis. METHODS AND RESULTS:Immunohistochemistry for BRCA1 and BRCA2 was performed on tissue micro...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12809

    authors: Kim SH,Park WS,Yun SI,Joo J,Joung JY,Seo HK,Chung J,Lee GK,Lee KH

    更新日期:2016-04-01 00:00:00

  • Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomas.

    abstract:AIMS:Central neurocytoma is a rare central nervous system tumour typically found in the lateral ventricles and at the septum pellucidum. Histologically, it resembles oligodendrogliomas and yet ultrastructurally, it shows neuronal differentiation. Its molecular oncogenesis is not known. The aim of this study was to exam...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2000.00977.x

    authors: Tong CY,Ng HK,Pang JC,Hu J,Hui AB,Poon WS

    更新日期:2000-08-01 00:00:00

  • Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp.

    abstract:AIMS:Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harbouring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS:We performed next-generation sequenc...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13688

    authors: Cho H,Hashimoto T,Yoshida H,Taniguchi H,Ogawa R,Mori T,Hiraoka N,Saito Y,Sekine S

    更新日期:2018-10-01 00:00:00

  • Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR.

    abstract:AIMS:To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas. METHODS AND RESULTS:A total of 57 carcinomas and respective gastric tissues were inc...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2005.02100.x

    authors: Lacueva J,Perez-Ramos M,Soto JL,Oliver I,Andrada E,Medrano J,Perez-Vazquez T,Arroyo A,Carrato A,Ferragut JA,Calpena R

    更新日期:2005-04-01 00:00:00

  • 'Atypical adenomatous hyperplasia' in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion?

    abstract::Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes simila...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb00660.x

    authors: Nakanuma Y,Terada T,Terasaki S,Ueda K,Nonomura A,Kawahara E,Matsui O

    更新日期:1990-07-01 00:00:00

  • TFE3 translocation and protein expression in renal cell carcinoma are correlated with poor prognosis.

    abstract:AIMS:Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13700

    authors: Lee HJ,Shin DH,Kim SY,Hwang CS,Lee JH,Park WY,Choi KU,Kim JY,Lee CH,Sol MY,Rha SH,Park SW

    更新日期:2018-11-01 00:00:00

  • Biliary intraductal tubule-forming neoplasm: a whole exome sequencing study of MUC5AC-positive and -negative cases.

    abstract:AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14103

    authors: Akita M,Hong SM,Sung YN,Kim MJ,Ajiki T,Fukumoto T,Itoh T,Zen Y

    更新日期:2020-06-01 00:00:00

  • Amyloidosis.

    abstract::Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.1994.tb00001.x

    authors: Tan SY,Pepys MB

    更新日期:1994-11-01 00:00:00

  • T-cell receptor-δ expression and γδ+ T-cell infiltrates in primary cutaneous γδ T-cell lymphoma and other cutaneous T-cell lymphoproliferative disorders.

    abstract:AIMS:The diagnosis of cutaneous γδ T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Our aim in this study was, by using a new monoclonal antibody (mAb) against TCRδ, to evaluate TCRδ expression in formalin-fixed paraffin-embedded (FFPE) skin tissue from TCRγ+ cutaneous T-ce...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13671

    authors: Pulitzer M,Geller S,Kumar E,Frosina D,Moskowitz A,Horwitz S,Myskowski P,Kheterpal M,Chan A,Dogan A,Jungbluth A

    更新日期:2018-10-01 00:00:00

  • Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective.

    abstract::Prolongation of ovarian epithelial cancer survival depends on early detection or improved responses to chemotherapy. Gains in either have been modest at best. Understanding the diverse pathogenesis of this disease is critical to early intervention or prevention. This review addresses six important variables, including...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2007.02938.x

    authors: Jarboe EA,Folkins AK,Drapkin R,Ince TA,Agoston ES,Crum CP

    更新日期:2008-08-01 00:00:00

  • Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study.

    abstract:AIMS:It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC). METHODS AND RESUL...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02372.x

    authors: Sun C,Jin XL,Xiao JC

    更新日期:2006-04-01 00:00:00