Genome-wide analysis of long non-coding RNA in primary nasopharyngeal carcinoma by microarray.

Abstract:

AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved in NPC on a genome-wide scale and predict their potential functions. METHODS AND RESULTS:Using high-throughput microarray with 30,586 lncRNA and 26,109 mRNA probes, 856 lncRNAs and 767 mRNAs were expressed differentially between NPC and chronic nasopharyngitis tissues. Bioinformatic analysis (clustering analysis, gene ontology analysis and pathway analysis) was used for further research. Differentially expressed lncRNAs were subgrouped into three types and differentially expressed mRNAs were clustered into 28 pathways. The first coexpression network analysis revealed that 46 lncRNAs interacting with three mRNAs involved the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling pathway. Quantitative real-time polymerase chain reaction (PCR) verified 11 up- and down-regulated lncRNAs and eight mRNAs in NPC. The second coexpression network analysis showed that 23 significantly aberrantly expressed mRNAs interacted with three validated lncRNAs. CONCLUSIONS:This study could provide new insight into the molecular mechanisms of lncRNAs and their potential role in NPC for further study. These differentially expressed lncRNAs may act as novel biomarkers and therapeutic targets for NPC.

journal_name

Histopathology

journal_title

Histopathology

authors

Yang QQ,Deng YF

doi

10.1111/his.12616

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

1022-30

issue

7

eissn

0309-0167

issn

1365-2559

journal_volume

66

pub_type

杂志文章
  • Extracellular matrix in hepatoblastoma: an immunohistochemical investigation.

    abstract::Eleven hepatoblastomas of various subtypes and normal liver tissue were investigated with antibodies against collagen types I-VI, laminin, fibronectin and endothelial and macrophage-associated antigens. Epithelial hepatoblastoma cells, unlike non-neoplastic hepatocytes, exhibited intracellular immunoreactivity for var...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb00359.x

    authors: Ruck P,Kaiserling E

    更新日期:1992-08-01 00:00:00

  • The classification of amyloid deposits in clinicopathological practice.

    abstract::A series of 104 biopsy cases with histopathological proof of amyloid, submitted to our department of pathology over the last 19 years, were re-examined. The survey investigated the medical indication for surgery, the origin and quality of the biopsy and the clinical information as documented on the request form for hi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1996.tb01416.x

    authors: Röcken C,Schwotzer EB,Linke RP,Saeger W

    更新日期:1996-10-01 00:00:00

  • Histochemistry and electron microscopy in the diagnosis of small mucous cells in carcinoma of the stomach.

    abstract::One hundred and two cases of poorly differentiated adenocarcinoma were obtained from 71 surgical and 31 biopsy specimens of the stomach. These tumours produced both intracellular and extracellular mucins, which were demonstrated to be neutral mucins, N-acetyl sialomucins, sulphomucins and O-acetyl sialomucins. The maj...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1988.tb01970.x

    authors: Huang CB,Li WC,Xu J,Zhang YC

    更新日期:1988-05-01 00:00:00

  • Variable fidelity of tissue-marking dyes in surgical pathology.

    abstract:AIMS:Pathology specimens often contain important margins that must be identified from gross examination of specimens through to microscopic examination. Commonly, unique colours of tissue-marking dye (TMD) are applied to each margin, which facilitates both macroscopic and microscopic identification. Various techniques ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12328

    authors: Williams AS,Dakin Haché K

    更新日期:2014-05-01 00:00:00

  • Inter-observer variation in the histological diagnosis of polyps in colorectal cancer screening.

    abstract:AIM:To determine the inter-observer variation in the histological diagnosis of colorectal polyps. METHODS AND RESULTS:Four hundred and forty polyps were randomly selected from a colorectal cancer screening programme. Polyps were first evaluated by a general (324 polyps) or expert (116 polyps) pathologist, and subseque...

    journal_title:Histopathology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2559.2011.03822.x

    authors: van Putten PG,Hol L,van Dekken H,Han van Krieken J,van Ballegooijen M,Kuipers EJ,van Leerdam ME

    更新日期:2011-05-01 00:00:00

  • Diffuse lung disease in infancy and childhood: expanding the chILD classification.

    abstract:AIMS:Diffuse parenchymal lung diseases (DPLD) in children comprise a wide spectrum of rare disorders. In 2007 the Children's Interstitial Lung Disease (chILD) Research Cooperative proposed a classification system for DPLD in children <2 years of age. The aims of our study were to determine the utility and reproducibili...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12185

    authors: Rice A,Tran-Dang MA,Bush A,Nicholson AG

    更新日期:2013-12-01 00:00:00

  • Expression of platelet-derived growth factor receptor in low-grade endometrial stromal sarcomas in the absence of activating mutations.

    abstract:AIMS:To investigate platelet-derived growth factor receptor (PDGFR)alpha and PDGFRbeta expression and a mutational analysis of PDGFRalpha (exons 11, 12, 17 and 18) and PDGFRbeta (exon 12) genes in endometrial stromal sarcomas (ESS). Gastrointestinal stromal tumours (GISTs), which have somatic mutations of the transmemb...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02634.x

    authors: Liegl B,Gülly C,Reich O,Nogales FF,Beham A,Regauer S

    更新日期:2007-03-01 00:00:00

  • Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel.

    abstract:AIMS:Owing to their close embryological relationship, soft tissue perineurioma and meningioma may closely mimic each other, not only histologically but also by immunohistochemistry. We aimed to compare the frequency of perineurial marker expression in these two entities, and to determine whether somatostatin receptor 2...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12366

    authors: Agaimy A,Buslei R,Coras R,Rubin BP,Mentzel T

    更新日期:2014-07-01 00:00:00

  • Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland.

    abstract:AIMS:The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns, and the tubular variant is the one that presents the str...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12339

    authors: Montalli VA,Martinez E,Tincani A,Martins A,Abreu Mdo C,Neves C,Costa AF,Araújo VC,Altemani A

    更新日期:2014-05-01 00:00:00

  • Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases.

    abstract:AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2002.01459.x

    authors: Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

    更新日期:2002-11-01 00:00:00

  • Choriocarcinoma in situ: a case at an early gestational stage.

    abstract::A case of choriocarcinoma in situ arising in an 11 week gestational placenta is reported. Histologically, a localized nodule, measuring 5 mm, of neoplastic trophoblastic proliferation appeared to arise directly from normal stem villi and projected into the intervillous space. The tumour was composed of biphasic cytotr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1995.tb00313.x

    authors: Fukunaga M,Ushigome S,Ishikawa E

    更新日期:1995-11-01 00:00:00

  • Prognostic indicators in breast cancer--morphometric methods.

    abstract::Morphometric methods were applied to predict the clinical course of individual patients with breast cancer. Measurement of tumour diameter, assessment of mitotic and cellular indices, and quantitative microscopy of nuclear features were assessed together with nuclear features and histological grades. Of the tumours fr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1982.tb02727.x

    authors: Baak JP,Kurver PH,De Snoo-Niewlaat AJ,De Graef S,Makkink B,Boon ME

    更新日期:1982-05-01 00:00:00

  • A monoclonal antibody against SV40 large T antigen (PAb416) does not label Merkel cell carcinoma.

    abstract:AIMS:Merkel cell carcinoma represents poorly differentiated neuroendocrine carcinoma of cutaneous origin. In most studies, the vast majority of Merkel cell carcinomas are Merkel cell polyomavirus (MCPyV)-associated. SV40 polyomavirus immunohistochemistry is typically used in the diagnosis of other polyomavirus-associat...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13483

    authors: Pelletier DJ,Czeczok TW,Bellizzi AM

    更新日期:2018-07-01 00:00:00

  • Nodular intra-abdominal panniculitis: an accompaniment of colorectal carcinoma and diverticular disease.

    abstract::Intra-abdominal panniculitis is a tumour-like inflammatory condition of adipose tissue. The aetiology and pathogenesis of the disease is unknown, but a number of associated diseases have been recorded. It has been customary to deal with only primary cases in the literature. This study was undertaken in order to descri...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1996.d01-486.x

    authors: Bak M

    更新日期:1996-07-01 00:00:00

  • Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics?

    abstract::The recognition of recurrent genetic alterations in specific tumour types has provided the basis for the reclassification of certain soft tissue neoplasms, and molecular analysis of patient material has the potential to provide both diagnostic and prognostic information. In this review, we evaluate the role of molecul...

    journal_title:Histopathology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1046/j.1365-2559.2000.01107.x

    authors: Pfeifer JD,Hill DA,O'Sullivan MJ,Dehner LP

    更新日期:2000-12-01 00:00:00

  • Mucin profiles in the mucosa adjacent to large bowel non-adenocarcinoma neoplasias.

    abstract::Morphological features and mucin secretion patterns were investigated in the colonic mucosa adjacent to or overlying mesenchymal or primary epithelial neoplasias, other than adenomas and adenocarcinomas. The material included 15 cases of non-adenocarcinoma tumours examined during 1978-1981. Increased sialomucins and m...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1984.tb02396.x

    authors: Lapertosa G,Fulcheri E,Acquarone M,Filipe MI

    更新日期:1984-09-01 00:00:00

  • Staging of prostate cancer.

    abstract::Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging sy...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2011.04025.x

    authors: Cheng L,Montironi R,Bostwick DG,Lopez-Beltran A,Berney DM

    更新日期:2012-01-01 00:00:00

  • Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp.

    abstract:AIMS:Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harbouring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS:We performed next-generation sequenc...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13688

    authors: Cho H,Hashimoto T,Yoshida H,Taniguchi H,Ogawa R,Mori T,Hiraoka N,Saito Y,Sekine S

    更新日期:2018-10-01 00:00:00

  • Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study.

    abstract:AIMS:It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC). METHODS AND RESUL...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02372.x

    authors: Sun C,Jin XL,Xiao JC

    更新日期:2006-04-01 00:00:00

  • The weight of the prostate gland is an excellent surrogate for gland volume.

    abstract:AIMS:Prostate gland volume is generally assessed by transrectal ultrasound examination or magnetic resonance imaging at the time of prostatic biopsy or pre-brachytherapy planning. The volume is most commonly measured using the formula, prostate volume = height x width x length x pi/6, which is derived considering the g...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2010.03591.x

    authors: Varma M,Morgan JM

    更新日期:2010-07-01 00:00:00

  • The renin-secreting cell in polyarteritis--an immunocytochemical study.

    abstract::We studied kidney sections from 15 cases of polyarteritis using an immunocytochemical technique to demonstrate cells containing immunoreactive renin. Ten cases of classical polyarteritis nodosa showed hyperplasia of renin-containing cells in areas of renal cortex with histological evidence of ischaemia--appearances in...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1990.tb01137.x

    authors: Graham PC,Lindop GB

    更新日期:1990-04-01 00:00:00

  • Microglandular adenosis of the breast--a lesion simulating tubular carcinoma.

    abstract::The clinical and pathological features of six cases of a hitherto undescribed lesion of the breast are reported for which the term 'microglandular adenosis' has been proposed. This is characterized by a proliferation of small uniform glands lined by epithelial cells without apparent myoepithelial cells and with usuall...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1983.tb02233.x

    authors: Clement PB,Azzopardi JG

    更新日期:1983-03-01 00:00:00

  • Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms.

    abstract::In recent years, there have been several important refinements in the classification of cutaneous mesenchymal neoplasms, including the description of new tumour types, along with the identification of novel and recurrent molecular genetic findings. In addition to providing new insights into tumour biology, many of the...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/his.12930

    authors: Costigan DC,Doyle LA

    更新日期:2016-05-01 00:00:00

  • No evidence for c-erbB-2 overexpression in gastric carcinogenesis.

    abstract:AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1998.00376.x

    authors: Blok P,Craanen ME,Dekker W,Offerhaus GJ,Tytgat GN

    更新日期:1998-04-01 00:00:00

  • Paediatric chondrosarcomas: a retrospective review of 17 cases.

    abstract:AIMS:Chondrosarcoma is primarily a tumour of adulthood and old age. Some studies indicate that survival is worse in paediatric than in adult chondrosarcomas. In view of the rarity of paediatric chondrosarcoma, few large studies are currently available. METHODS AND RESULTS:We evaluated the clinical, radiological and pa...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12881

    authors: Gambarotti M,Righi A,Picci P,Bertoni F,Manfrini M,Donati DM,Dei Tos AP,Vanel D

    更新日期:2016-06-01 00:00:00

  • Smoking-related changes in the background lung of specimens resected for lung cancer: a semiquantitative study with correlation to postoperative course.

    abstract:AIMS:To assess the pathological findings in lobectomy specimens, to correlate them with smoking history and postoperative course and to compare the findings with those in smoking-related interstitial lung disease. METHODS AND RESULTS:Patients who had undergone lobectomy for lung cancer were reviewed. Subjects included...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03183.x

    authors: Kawabata Y,Hoshi E,Murai K,Ikeya T,Takahashi N,Saitou Y,Kurashima K,Ubukata M,Takayanagi N,Sugita H,Kanauchi S,Colby TV

    更新日期:2008-12-01 00:00:00

  • Neuropilin-2 expression in cancer.

    abstract:AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2012.04224.x

    authors: Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

    更新日期:2012-09-01 00:00:00

  • Eosinophilic oesophagitis: relevance of mast cell infiltration.

    abstract:AIMS:Eosinophilic oesophagitis (EoE) is a chronic inflammatory disease characterised clinically by symptoms of oesophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having a histologically predominant position, their role in the immunopathogenesis of the disease i...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13653

    authors: Strasser DS,Seger S,Bussmann C,Pierlot GM,Groenen PMA,Stalder AK,Straumann A

    更新日期:2018-09-01 00:00:00

  • Stereological estimates of nuclear volume in carcinoma of the ampulla of Vater.

    abstract::The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases--five papillary and 16 intestinal--all treated by the same surgical pro...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb00382.x

    authors: Artacho-Perula E,Roldan-Villalobos R,Lopez-Rubio F,Vaamonde-Lemos R

    更新日期:1992-09-01 00:00:00

  • Immunohistochemical demonstration of p24 HTLV III major core protein in different cell types within lymph nodes from patients with lymphadenopathy syndrome (LAS).

    abstract::The p24 protein is the major core protein of LAV/HTLV III which is the putative agent of the lymphadenopathy syndrome. By the use of an anti-p24 monoclonal antibody we have studied the presence of LAV/HTLV III infected cells in 20 lymph nodes obtained from lymphadenopathy syndrome patients: 14 lymph nodes were charact...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1986.tb02456.x

    authors: Baroni CD,Pezzella F,Mirolo M,Ruco LP,Rossi GB

    更新日期:1986-01-01 00:00:00