A cytokeratin immunohistochemical study of cholestatic liver disease: evidence that hepatocytes can express 'bile duct-type' cytokeratins.

abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...

journal_title：Histopathology

authors： Capella C,Frigerio B,Cornaggia M,Solcia E,Pinzon-Trujillo Y,Chejfec G

更新日期：1984-09-01 00:00:00

abstract：:Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-c...

journal_title：Histopathology

authors： Ott MM,Müller-Hermelink HK,Schmitt B,Feller AC

更新日期：1991-08-01 00:00:00

abstract：AIMS:We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS:Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according...

journal_title：Histopathology

authors： Chan AC,Ho JW,Chiang AK,Srivastava G

更新日期：1999-01-01 00:00:00

abstract：AIMS:Five cases of a characteristic low-grade thymic epithelial tumour are described that we suggest calling metaplastic carcinoma of the thymus. METHODS AND RESULTS:The patients' ages ranged from 44 to 71 (mean 56.2) years. Four of the patients were male. Three of five tumours showed invasion into mediastinal fat or ...

journal_title：Histopathology

authors： Yoneda S,Marx A,Heimann S,Shirakusa T,Kikuchi M,Müller-Hermelink HK

更新日期：1999-07-01 00:00:00

abstract：:A study was made of the cells forming the crescents in human crescentic glomerulonephritis. The investigation was performed using a panel of antibodies with immunoperoxidase techniques in formalin fixed, paraffin embedded renal biopsy material. Some of the cells of glomerular crescents were found to contain cytokerati...

journal_title：Histopathology

authors： Harrison DJ,MacDonald MK

更新日期：1986-09-01 00:00:00

abstract：AIMS:The handling and examination of sentinel lymph nodes (SLNs) to detect metastasis is critical in the assessment of early breast cancer patients. This survey investigates the variation in practise followed by pathology units across the United Kingdom in the staging evaluation of axillary lymph nodes (ALNs). METHODS...

journal_title：Histopathology

authors： Verma R,Sundara Rajan S,Verghese ET,Horgan K,Hanby AM,Lane S

更新日期：2014-11-01 00:00:00

abstract：AIMS:There is increasing evidence of Gleason score (GS) drift in prostatic core biopsies during the last two decades. The ProtecT study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate-specific antigen (PSA) level, perineural invasion, tumour length and age on GS. ...

journal_title：Histopathology

authors： Oxley J,Simpkin A,Goepel J,Varma M,Griffiths D,Grigor K,Mayer N,Warren A,Deshmukh N,Bhattarai S,Dormer J,Hounsome L,Adamczyk LA,Metcalfe C,Lane JA,Davis M,Donovan JL,Neal DE,Hamdy FC,Robinson MC,ProtecT Study Grou

更新日期：2015-02-01 00:00:00

abstract：AIMS:The purpose of this study was to examine the occurrence of CD44 isoforms in breast carcinomas and their role in predicting clinical outcome. METHODS AND RESULTS:Shock-frozen tumour tissues from 110 patients with breast carcinoma were examined by immunohistochemistry using antibodies directed against CD44s, v5, v6...

journal_title：Histopathology

authors： Berner HS,Suo Z,Risberg B,Villman K,Karlsson MG,Nesland JM

更新日期：2003-06-01 00:00:00

abstract：AIMS:Several studies have demonstrated that Na(+) /H(+) exchanger regulatory factor 1 (NHERF1) protein, which is overexpressed and heterogeneously distributed in different stages of breast cancer, could be used as a tumour marker for prognosis in molecular detection strategies. We observed that tumour-infiltrated lymph...

journal_title：Histopathology

authors： Bellizzi A,Mangia A,Malfettone A,Cardone RA,Simone G,Reshkin SJ,Paradiso A

更新日期：2011-06-01 00:00:00

abstract：AIMS:To analyse expression and distribution of vascular endothelial growth factor (VEGF-C1), podocalyxin and synaptopodin within renal tissue in nephrotic syndrome glomerulopathies in children. METHODS AND RESULTS:Renal biopsies performed at the time and in the manner recommended by the World Health Organization. The ...

journal_title：Histopathology

authors： Ostalska-Nowicka D,Zachwieja J,Nowicki M,Kaczmarek E,Siwinska A,Witt M

更新日期：2005-02-01 00:00:00

abstract：:Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method...

journal_title：Histopathology

authors： Tomita T,Millard DM

更新日期：1992-11-01 00:00:00

abstract：:We have investigated the immunohistochemical expression of p53 protein in 96 cases of non-Hodgkin's lymphoma using a panel of five antibodies. Positive neoplastic cells were found in 30 (31.2%) cases, which could be divided into two groups according to their patterns of reactivity with the different antibodies; i.e. t...

journal_title：Histopathology

authors： Pezzella F,Morrison H,Jones M,Gatter KC,Lane D,Harris AL,Mason DY

更新日期：1993-01-01 00:00:00

abstract：:The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...

journal_title：Histopathology

authors： Renshaw AA

更新日期：2002-10-01 00:00:00

abstract：AIMS:To compare the expression and prognostic value of the cell cycle markers Aurora kinase A (AURKA) and Ki67 in neuroblastoma, because AURKA expression levels have greater prognostic significance than those of Ki67 in some cancers. METHODS AND RESULTS:Eighty-eight neuroblastomas were immunostained with anti-AURKA an...

journal_title：Histopathology

authors： Ramani P,Nash R,Rogers CA

更新日期：2015-02-01 00:00:00

abstract：AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

journal_title：Histopathology

authors： Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

更新日期：2015-01-01 00:00:00

abstract：:There are many significant differences, but also considerable overlap between the quantitative histopathological features of mild and marked atypical endometrial hyperplasias and well and moderately differentiated carcinomas, thus preventing its application to individual patient care. To try to overcome this problem, ...

journal_title：Histopathology

authors： Baak JP,Kurver PH,Overdiep SH,Delemarre JF,Boon ME,Lindeman J,Diegenbach PC

更新日期：1981-11-01 00:00:00

abstract：AIMS:To investigate the expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors and decoy receptors, including osteoprotegerin (OPG) in infantile haemangioma (IH). METHODS AND RESULTS:Immunostaining, Western blotting and quantitative reverse transcription-polymerase chain react...

journal_title：Histopathology

authors： Vishvanath A,Itinteang T,Tan ST,Day DJ

更新日期：2011-09-01 00:00:00

abstract：:The detailed documentation of ocular pathology has become an important component in the autopsy investigation of suspected cases of non-accidental injury in infants and young children. Careful histological examination of retinal haemorrhages is of critical importance, but there remains debate about the significance of...

journal_title：Histopathology

authors： Gilliland MG,Luthert P

更新日期：2003-12-01 00:00:00

abstract：AIMS:This study aimed to assess the feasibility of using virtual slides to create 3D histopathological reconstructions to aid in the study of the biology of DCIS. METHODS:Four μm thick serial sections of formalin fixed paraffin embedded tissue from three cases were cut and mounted onto glass slides, stained with haema...

journal_title：Histopathology

authors： Booth ME,Treanor D,Roberts N,Magee DR,Speirs V,Hanby AM

更新日期：2015-06-01 00:00:00

abstract：:Two cases of tubulovillous adenoma and adjacent colonic mucosa were studied in which intestinal spirochaetosis had heavily colonized the non-neoplastic but not the neoplastic epithelium. Ultrastructural and histochemical studies were performed and we postulate that the reason for this disparity is the normal microvill...

journal_title：Histopathology

authors： Coyne JD,Curry A,Purnell P,Haboubi NY

更新日期：1995-10-01 00:00:00

abstract：:A review of 76 endomyocardial biopsies and 54 autopsies of patients with dilated cardiomyopathy (DCM) revealed features of hypertrophy and degenerative changes associated with long-standing hypertrophy. Long-term survivors had significantly heavier heart weights. Short-term survivors had heavier than normal right vent...

journal_title：Histopathology

authors： Rose AG,Beck W

更新日期：1985-04-01 00:00:00

abstract：AIMS:To clarify the lineage-specific carcinogenesis of gland-forming gastric neoplasms, by characterizing mucin phenotypes and proliferation patterns immunohistochemically using monoclonal antibodies against MUC2, MUC5AC, MUC6, CD10 and Ki67. METHODS AND RESULTS:We analysed 49 gland-forming intramucosal neoplasms, inc...

journal_title：Histopathology

authors： Nishimura R,Mukaisho K,Yamamoto H,Sonoda A,Andoh A,Fujiyama Y,Hattori T,Sugihara H

更新日期：2013-11-01 00:00:00

abstract：AIMS:To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells. METHODS AND RESULTS:KIT and SCF expression were studied in 248 human tumours consisting of 15 different histological types using immunohistochemistry and in situ hybridization for KIT ...

journal_title：Histopathology

authors： Sihto H,Tynninen O,Halonen M,Puputti M,Karjalainen-Lindsberg ML,Kukko H,Joensuu H

更新日期：2009-11-01 00:00:00

abstract：AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...

journal_title：Histopathology

authors： Noske A,Ammann JU,Wagner DC,Denkert C,Lebeau A,Sinn P,Kreipe HH,Sommer U,Baretton G,Steiger K,Kiechle M,Hieke-Schulz S,Flores M,Roth W,Weichert W

更新日期：2020-09-16 00:00:00

abstract：:Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1), a causative virus of adult T-cell leukaemia/lymphoma (ATLL), is known to be transmitted by breast-feeding. Using a monoclonal antibody HML-1 which labels human intestinal intra-epithelial T lymphocytes, we have immunohistochemically examined ATLL tissues in order ...

journal_title：Histopathology

authors： Kitajima S,Tokunaga M,Goto M,Sato E,Utsunomiya A,Ohtsuka M,Hanada S,Arima T

更新日期：1994-09-01 00:00:00

abstract：AIMS:It is known that thyroid transcription factor-1 (TTF-1) is expressed in a small percentage of primary gynaecological adenocarcinomas. Following the observation of TTF-1 positivity in a number of endometrioid adenocarcinomas of the uterine corpus which behaved aggressively, we undertook immunohistochemical staining...

journal_title：Histopathology

authors： Ervine A,Leung S,Gilks CB,McCluggage WG

更新日期：2014-05-01 00:00:00

abstract：AIMS:To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase-3 (apoptotic markers) and Ki67 (proliferation marker). METHODS AND RESULTS:Immunohi...

journal_title：Histopathology

authors： Sington J,Giatromanolaki A,Campo L,Turley H,Pezzella F,Gatter KC

更新日期：2007-04-01 00:00:00

abstract：AIMS:To evaluate the relationship between phenotypic expression and tumour progression as represented by macroscopic features, submucosal invasion and lymph node metastasis in early differentiated gastric adenocarcinoma. METHODS:One hundred and fifty-five cases of early gastric differentiated adenocarcinoma without an...

journal_title：Histopathology

authors： Nakamura T,Yao T,Kabashima A,Nishiyama K,Maehara Y,Tsuneyoshi M

更新日期：2005-10-01 00:00:00

abstract：:Morphological features and mucin secretion patterns were investigated in the colonic mucosa adjacent to or overlying mesenchymal or primary epithelial neoplasias, other than adenomas and adenocarcinomas. The material included 15 cases of non-adenocarcinoma tumours examined during 1978-1981. Increased sialomucins and m...

journal_title：Histopathology

authors： Lapertosa G,Fulcheri E,Acquarone M,Filipe MI

更新日期：1984-09-01 00:00:00

abstract：AIM:Dual-colour chromogenic in-situ hybridization (dc-CISH) is an emerging methodology for characterizing genomic alterations. This study was aimed at evaluating the performance of a dc-CISH kit (ZytoVision) in determining human epidermal growth factor receptor 2 (HER2) status in breast cancer. METHODS AND RESULTS:Two...

journal_title：Histopathology

authors： Hwang CC,Pintye M,Chang LC,Chen HY,Yeh KY,Chein HP,Lee N,Chen JR

更新日期：2011-11-01 00:00:00