Pathological evaluation of the staging axillary lymph nodes for breast cancer: a national survey in the United Kingdom.

abstract：AIMS:Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate...

journal_title：Histopathology

authors： Lee HJ,Shin DH,Kim SY,Hwang CS,Lee JH,Park WY,Choi KU,Kim JY,Lee CH,Sol MY,Rha SH,Park SW

更新日期：2018-11-01 00:00:00

abstract：AIMS:Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL), and is associated with a poor outcome. The histological manifestations of RT are variable, and include an increase in the proportion of prolymphocytes, immunoblasts, and other pleomorphi...

journal_title：Histopathology

authors： Salem A,Loghavi S,Khoury JD,Agbay RL,Jorgensen JL,Medeiros LJ

更新日期：2017-04-01 00:00:00

abstract：:We investigated the expression of androgen receptor (AR) protein in transitional cell carcinoma of human urinary bladder in paraffin-embedded sections of tumours obtained from nine patients with urinary bladder cancer treated by radical cystectomy. In addition, immunoblotting of AR was also performed on selected sampl...

journal_title：Histopathology

authors： Zhuang YH,Bläuer M,Tammela T,Tuohimaa P

更新日期：1997-06-01 00:00:00

abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...

journal_title：Histopathology

authors： Capella C,Frigerio B,Cornaggia M,Solcia E,Pinzon-Trujillo Y,Chejfec G

更新日期：1984-09-01 00:00:00

abstract：:This morphological study of small ducts with in situ breast carcinoma demonstrates the changes that occur in the adjacent stroma when it stains metachromatically with toluidine blue. They are indistinguishable from those reported in areas with infiltrative tumour growth, and are accompanied by progressive damage to th...

journal_title：Histopathology

authors： Sandstad E,Hartveit F

更新日期：1987-01-01 00:00:00

abstract：AIMS:To determine the expression of matrix metalloproteinases (MMPs)-2, -7 and -9 and beta-catenin in uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) and to investigate any difference in expression between EEC and USC which might explain the mechanism of invasion and aggressive behaviour of ...

journal_title：Histopathology

authors： Monaghan H,MacWhinnie N,Williams AR

更新日期：2007-02-01 00:00:00

abstract：AIM:Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC) is a rare biphasic liver cancer. Recent studies have demonstrated that cHCC-CC originates from hepatic progenitor cells (HPCs). Spalt-like transcription factor 4 (SALL4) is a marker for a progenitor subclass of HCC with an aggressive phen...

journal_title：Histopathology

authors： Tanaka Y,Aishima S,Kohashi K,Okumura Y,Wang H,Hida T,Kotoh K,Shirabe K,Maehara Y,Takayanagi R,Oda Y

更新日期：2016-04-01 00:00:00

abstract：AIM:To assess the potential prognostic significance of a range of molecular and morphological parameters in glioblastomas that can be applied in the setting of a routine diagnostic neuropathology laboratory. METHODS AND RESULTS:A consecutive series of 107 adult glioblastomas were studied. Retinoblastoma and deleted-in...

journal_title：Histopathology

authors： Hilton DA,Penney M,Pobereskin L,Sanders H,Love S

更新日期：2004-06-01 00:00:00

abstract：AIMS:To evaluate concordance, upgrades and downgrades from biopsy to prostatectomy, and associated clincopathological parameters, using the recently proposed Gleason grade groups/International Society of Urologic Pathology (ISUP) grades. METHODS AND RESULTS:We evaluated 2529 patients who underwent biopsy and prostatec...

journal_title：Histopathology

authors： Athanazio D,Gotto G,Shea-Budgell M,Yilmaz A,Trpkov K

更新日期：2017-06-01 00:00:00

abstract：AIMS:The clinical significance of common histological parameters in acute interstitial nephritis (AIN) is uncertain. We aimed to evaluate the utility of histology in predicting clinical outcomes in patients with AIN. METHODS AND RESULTS:Adult renal biopsies yielding a diagnosis of AIN between 2000 and 2015 were re-exa...

journal_title：Histopathology

authors： Rankin AJ,Cannon E,Gillis K,Crosby J,Mark PB,Geddes CC,Fox JG,Mackinnon B,McQuarrie EP,Kipgen D

更新日期：2020-04-01 00:00:00

abstract：AIMS:Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationsh...

journal_title：Histopathology

authors： Zhu JL,Song YX,Wang ZN,Gao P,Wang MX,Dong YL,Xing CZ,Xu HM

更新日期：2013-06-01 00:00:00

abstract：AIMS:The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent a precursor of more aggressive forms of disease. METHODS AND RESULTS:A 59-year-old man with diffuse cutaneous reticulohistiocytosis experienced bone marrow locali...

journal_title：Histopathology

authors： Fusco N,Bonometti A,Augello C,Fabris S,Boiocchi L,Fiori S,Morotti D,Fracchiolla N,Berti E,Gianelli U

更新日期：2017-05-01 00:00:00

abstract：AIMS:Metastatic melanoma involving the epidermis and/or upper dermis may show significant histological overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathological classification is crucial to appropriate staging and management, but is often challenging. The aim of this study was to...

journal_title：Histopathology

authors： Skala SL,Arps DP,Zhao L,Cha KB,Wang M,Harms PW,Andea AA,Fullen DR,Chan MP

更新日期：2018-02-01 00:00:00

abstract：AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

journal_title：Histopathology

authors： Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

更新日期：2004-08-01 00:00:00

abstract：AIMS:Class III beta-tubulin (TUBB3) reduces microtubule stability and confers resistance to microtubule-stabilizing taxanes, including paclitaxel and docetaxel. Pancreatic ductal adenocarcinomas show limited responsiveness to taxanes, but little is known of the underlying mechanisms. The aim of this study was to examin...

journal_title：Histopathology

authors： Lee KM,Cao D,Itami A,Pour PM,Hruban RH,Maitra A,Ouellette MM

更新日期：2007-10-01 00:00:00

abstract：AIMS:Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic int...

journal_title：Histopathology

authors： Nuñez C,Cansino JR,Bethencourt F,Pérez-Utrilla M,Fraile B,Martínez-Onsurbe P,Olmedilla G,Paniagua R,Royuela M

更新日期：2008-08-01 00:00:00

abstract：:12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue. The diagnostic utility of 12E7 as a marker of Ewing's sarcoma and peripheral neuroectodermal tumour was assessed. Immunocytochemical studies were performed on 120 small round-cell tumours from childre...

journal_title：Histopathology

authors： Ramani P,Rampling D,Link M

更新日期：1993-12-01 00:00:00

abstract：AIMS:To study the relevance of periostin, known to be involved in epithelial-mesenchymal transition (EMT), in hepatocellular and bile duct cancer. METHODS AND RESULTS:Immunohistochemical periostin expression was semiquantitatively analysed in normal liver tissue (n = 20), hepatocellular carcinoma (HCC; n = 91), liver-...

journal_title：Histopathology

authors： Riener MO,Fritzsche FR,Soll C,Pestalozzi BC,Probst-Hensch N,Clavien PA,Jochum W,Soltermann A,Moch H,Kristiansen G

更新日期：2010-04-01 00:00:00

abstract：:A review of 76 endomyocardial biopsies and 54 autopsies of patients with dilated cardiomyopathy (DCM) revealed features of hypertrophy and degenerative changes associated with long-standing hypertrophy. Long-term survivors had significantly heavier heart weights. Short-term survivors had heavier than normal right vent...

journal_title：Histopathology

authors： Rose AG,Beck W

更新日期：1985-04-01 00:00:00

abstract：:A case is reported of squamous carcinoma of the peri-anal region arising in a giant condyloma. In situ DNA hybridization showed human papillomavirus (HPV) types 6 and 11. These HPV types are commonly demonstrated in ano-genital condylomas but have not previously been reported in association with malignant change at th...

journal_title：Histopathology

authors： Wells M,Robertson S,Lewis F,Dixon MF

更新日期：1988-03-01 00:00:00

abstract：:Signet ring cell differentiation in adenocarcinoma of the prostate is uncommon. In a review of 200 cases of prostatic carcinoma, we identified five cases with this change, all in moderately to poorly differentiated prostatic carcinomas. The signet ring cells in prostatic carcinoma contain an intracytoplasmic lumen, sh...

journal_title：Histopathology

authors： Guerin D,Hasan N,Keen CE

更新日期：1993-04-01 00:00:00

abstract：:Biopsy and autopsy material from the urinary bladder was studied using PAS and PAS-D techniques to identify glycogen and neutral mucins, the alcian blue/high iron diamine method to distinguish sialo- and sulphamucins and the PB/KOH/PAS technique to localize O-acylated sialomucins. All of 10 examples of normal urotheli...

journal_title：Histopathology

authors： Newbould M,McWilliam LJ

更新日期：1990-09-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to det...

journal_title：Histopathology

authors： Yamauchi A,Ikeda J,Nakamichi I,Kohara M,Fukuhara S,Hino M,Kanakura Y,Ogawa H,Sugiyama H,Kanamaru A,Aozasa K,Osaka Lymphoma Study Group.

更新日期：2008-05-01 00:00:00

abstract：AIMS:Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic ...

journal_title：Histopathology

authors： Gremel G,Bergman J,Djureinovic D,Edqvist PH,Maindad V,Bharambe BM,Khan WA,Navani S,Elebro J,Jirström K,Hellberg D,Uhlén M,Micke P,Pontén F

更新日期：2014-01-01 00:00:00

abstract：AIMS:Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to ass...

journal_title：Histopathology

authors： Stewart M,Turley H,Cook N,Pezzella F,Pillai G,Ogilvie D,Cartlidge S,Paterson D,Copley C,Kendrew J,Barnes C,Harris AL,Gatter KC

更新日期：2003-07-01 00:00:00

abstract：:Analgesic nephropathy is known to have a high incidence in Australia where, following the experience in Scandinavia, reports have been published for some time recording the association between analgesic nephropathy and urothelial malignancies. The morbid anatomical features of analgesic nephropathy are now sufficientl...

journal_title：Histopathology

authors： Lomax-Smith J,Seymour AE

更新日期：1980-05-01 00:00:00

abstract：AIM:Achalasia is a disease of the oesophagus characterized by increased lower oesophageal sphincter (LOS) tone, absence of LOS relaxation with swallowing and aperistalsis of the body of the oesophagus. The aetiology and pathogenesis of idiopathic achalasia is still controversial. METHODS AND RESULTS:We examined 16 oes...

journal_title：Histopathology

authors： Raymond L,Lach B,Shamji FM

更新日期：1999-11-01 00:00:00

abstract：:One hundred and eighty-seven operable lung tumours were immunostained with the monoclonal antibody Ki-67 and divided into groups of high, moderate or low proliferation. Patients have been followed clinically for up to 7 years to ascertain whether this immunocytochemical measurement reflected tumour behaviour in terms ...

journal_title：Histopathology

authors： Tungekar MF,Gatter KC,Dunnill MS,Mason DY

更新日期：1991-12-01 00:00:00

abstract：AIMS:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily. Although its overexpression in various cancers has been reported, little is known about its expression and clinical significance in oral squamous cell carcinoma (OSCC). This study aimed to elucidate the clinical significanc...

journal_title：Histopathology

authors： Shinriki S,Jono H,Ueda M,Obayashi K,Nakamura T,Ota K,Ota T,Sueyoshi T,Guo J,Hayashi M,Hiraki A,Nakayama H,Yamashita S,Shinohara M,Ando Y

更新日期：2014-02-01 00:00:00

abstract：AIMS:To investigate the pathology of colectomy specimens, from patients presenting with lower gastrointestinal haemorrhage, who had undergone preoperative mesenteric angiography. The angiography diagnoses ranged from active bleeding of unknown aetiology to angiodysplasia. METHODS AND RESULTS:The macroscopic and micros...

journal_title：Histopathology

authors： Mudhar HS,Balsitis M

更新日期：2005-01-01 00:00:00