The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.

abstract：AIMS:To address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin. METHODS AND RESULTS:Fifty-four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF-1, CK7, CK20 and CDX2 ...

journal_title：Histopathology

authors： Kim MY,Go H,Koh J,Lee K,Min HS,Kim MA,Jeon YK,Lee HS,Moon KC,Park SY,Kim WH,Chung DH

更新日期：2014-08-01 00:00:00

abstract：:Advances in modern chemotherapy and targeted treatments have resulted in lengthened survival in a variety of tumour types in the last decade. Increasingly in the 21st century, postchemotherapy resections are considered as a possible mode of treatment. Due to their exquisite chemosensitivity, resection of postchemother...

journal_title：Histopathology

authors： Berney DM,Lu YJ,Shamash J,Idrees M

更新日期：2017-01-01 00:00:00

abstract：AIMS:In skull base chordoma, c-MET expression has been reported to correlate with younger patient age and favourable prognosis; however, it also contributes to tumour invasiveness, especially in recurrent lesions, suggesting variable roles for c-MET according to clinical status. The aim of this study was to investigate...

journal_title：Histopathology

authors： Naka T,Boltze C,Samii A,Samii M,Herold C,Ostertag H,Iwamoto Y,Oda Y,Tsuneyoshi M,Kuester D,Roessner A

更新日期：2009-04-01 00:00:00

abstract：:Epidermolysis bullosa, a rare genodermatosis, is characterized by increased skin fragility manifest as blistering and sometimes accompanied by scarring. The latter is particularly severe in the recessive dystrophic variant and may be complicated by the development of squamous carcinoma in up to 30% of patients. We hav...

journal_title：Histopathology

authors： Slater SD,McGrath JA,Hobbs C,Eady RA,McKee PH

更新日期：1992-03-01 00:00:00

abstract：:A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...

journal_title：Histopathology

authors： Chan WY,Hui PK,Leung KM,Thomas TM

更新日期：1992-12-01 00:00:00

abstract：AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...

journal_title：Histopathology

authors： Shinozaki-Ushiku A,Ushiku T,Morita S,Anraku M,Nakajima J,Fukayama M

更新日期：2017-04-01 00:00:00

abstract：AIMS:Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to frequent cytokeratin expression, variable ALK expression and worrisome morphological features suggestive of malignancy. Conversely, sarcomatoid urothelial carcin...

journal_title：Histopathology

authors： Bertz S,Stöhr R,Gaisa NT,Wullich B,Hartmann A,Agaimy A

更新日期：2020-12-01 00:00:00

abstract：AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...

journal_title：Histopathology

authors： Akita M,Hong SM,Sung YN,Kim MJ,Ajiki T,Fukumoto T,Itoh T,Zen Y

更新日期：2020-06-01 00:00:00

abstract：:The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...

journal_title：Histopathology

authors： Delsol G,Chittal S,Brousset P,Caveriviere P,Roda D,Mazerolles C,Barillet-Alard C,al Saati T,Gorguet B,Voigt JJ

更新日期：1989-11-01 00:00:00

abstract：AIMS:To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells. METHODS AND RESULTS:KIT and SCF expression were studied in 248 human tumours consisting of 15 different histological types using immunohistochemistry and in situ hybridization for KIT ...

journal_title：Histopathology

authors： Sihto H,Tynninen O,Halonen M,Puputti M,Karjalainen-Lindsberg ML,Kukko H,Joensuu H

更新日期：2009-11-01 00:00:00

abstract：:Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, in...

journal_title：Histopathology

authors： Wood KM,Cadogan MD,Ramshaw AL,Parums DV

更新日期：1993-05-01 00:00:00

abstract：:Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...

journal_title：Histopathology

authors： Tan SY,Pepys MB

更新日期：1994-11-01 00:00:00

abstract：AIMS:We investigated a group of oral mucosal lesions with characteristic hyperorthokeratotic foci, which we termed orthokeratotic dysplasia (OKD), to determine if it could be identified as a distinct histopathological entity. METHODS AND RESULTS:We screened 282 surgical specimens from 200 patients with oral leucoplaki...

journal_title：Histopathology

authors： Kobayashi T,Maruyama S,Abé T,Cheng J,Takagi R,Saito C,Saku T

更新日期：2012-11-01 00:00:00

abstract：:We report three cases of an unusual primary carcinoma of the liver composed of small cells. The patients were adult males (56 to 89 years) who presented with jaundice, weight loss and abdominal discomfort. Surgery was attempted in one case. Clinical evolution was rapid, with death ensuing between 1 and 5 months after ...

journal_title：Histopathology

authors： Zanconati F,Falconieri G,Lamovec J,Zidar A

更新日期：1996-11-01 00:00:00

abstract：:Hodgkin lymphoma (HL) is an unusual malignancy in that the tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, are a minor component of the tumour mass, the bulk of which is a mixed cellular infiltrate. There is compelling evidence that HRS cells are clonal B cells that have lost their B cell phenotype. Mature B...

journal_title：Histopathology

authors： Farrell K,Jarrett RF

更新日期：2011-01-01 00:00:00

abstract：AIMS:Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncer...

journal_title：Histopathology

authors： Miligy I,Mohan P,Gaber A,Aleskandarany MA,Nolan CC,Diez-Rodriguez M,Mukherjee A,Chapman C,Ellis IO,Green AR,Rakha EA

更新日期：2017-08-01 00:00:00

abstract：:The new World Health Organization (WHO) classification of soft tissue tumours was published in early 2013, almost 11 years after the previous edition. While the number of newly recognized entities included for the first time is fewer than that in 2002, there have instead been substantial steps forward in molecular gen...

journal_title：Histopathology

authors： Fletcher CD

更新日期：2014-01-01 00:00:00

abstract：AIMS:To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma. METHODS AND RESULTS:Over a 10-year (1990-2000) study period 53 carcinomas mimicking diffuse pleural mesothelioma ('pseudomesotheliomatous' carc...

journal_title：Histopathology

authors： Attanoos RL,Gibbs AR

更新日期：2003-11-01 00:00:00

abstract：AIMS:To discern the differences in expression profiling of two histological subtypes of colorectal carcinoma (CRC) arising from the serrated route (serrated adenocarcinoma (SAC) and CRC showing histological and molecular features of a high level of microsatellite instability (hmMSI-H) both sharing common features (fema...

journal_title：Histopathology

authors： García-Solano J,Turpin-Sevilla MDC,García-García F,Carbonell-Muñoz R,Torres-Moreno D,Conesa A,Conesa-Zamora P

更新日期：2019-10-01 00:00:00

abstract：AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...

journal_title：Histopathology

authors： Noske A,Ammann JU,Wagner DC,Denkert C,Lebeau A,Sinn P,Kreipe HH,Sommer U,Baretton G,Steiger K,Kiechle M,Hieke-Schulz S,Flores M,Roth W,Weichert W

更新日期：2020-09-16 00:00:00

abstract：:The treatment of cancer has changed dramatically over the last decade, driven by increased understanding of the cancer genome, immune landscape, molecular alterations and aberrant pathways that drive cancer progression. Advances in molecular biology have led to the development of targeted agents, including monoclonal ...

journal_title：Histopathology

authors： Crusz SM,Miller RE

更新日期：2020-01-01 00:00:00

abstract：AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common intra-oral salivary gland malignancy. The vast majority of PLGAs harbour a PRKD1 E710D hot-spot somatic mutation or somatic rearrangements of PRKD1, PRKD2 or PRKD3. Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to def...

journal_title：Histopathology

authors： Piscuoglio S,Fusco N,Ng CK,Martelotto LG,da Cruz Paula A,Katabi N,Rubin BP,Skálová A,Weinreb I,Weigelt B,Reis-Filho JS

更新日期：2016-06-01 00:00:00

abstract：AIMS:Although delayed hypopituitarism is a common complication of conventional radiotherapy of sellar tumours, histological changes that may account for it have been rarely reported. To elucidate the changes, hypofunctional pituitary glands following irradiation were studied. METHODS AND RESULTS:Two pituitary glands o...

journal_title：Histopathology

authors： Nishioka H,Ito H,Haraoka J,Hirano A

更新日期：2001-06-01 00:00:00

abstract：AIMS:We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS:Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according...

journal_title：Histopathology

authors： Chan AC,Ho JW,Chiang AK,Srivastava G

更新日期：1999-01-01 00:00:00

abstract：AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

journal_title：Histopathology

authors： Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

更新日期：2002-11-01 00:00:00

abstract：AIMS:Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic int...

journal_title：Histopathology

authors： Nuñez C,Cansino JR,Bethencourt F,Pérez-Utrilla M,Fraile B,Martínez-Onsurbe P,Olmedilla G,Paniagua R,Royuela M

更新日期：2008-08-01 00:00:00

abstract：AIMS:We report a series of five unusual subcutaneous lipomas characterized by prominent stromal sclerosis in a storiform arrangement. METHODS AND RESULTS:All lesions occurred in young male adults (23.0 +/- 9.5 years), three lesions were on the scalp and two on the hands. Clinically, lipoma, chondroma or some form of c...

journal_title：Histopathology

authors： Zelger BG,Zelger B,Steiner H,Rütten A

更新日期：1997-08-01 00:00:00

abstract：:Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...

journal_title：Histopathology

authors： Olenick SJ,Fan CC,Ryoo JW

更新日期：1994-08-01 00:00:00

abstract：:An immunohistochemical study of non-small cell lung carcinoma using PC10, a monoclonal antibody against PCNA, was performed on tissues routinely processed with formalin fixation and paraffin embedding. The PCNA labelling index and mitotic index were determined from sections of these tissues. Tumours showed a high mean...

journal_title：Histopathology

authors： Theunissen PH,Leers MP,Bollen EC

更新日期：1992-03-01 00:00:00

abstract：AIMS:In T cells, protein kinase C (PKC) theta plays a major role in T-cell receptor (TCR)-mediated activation of a novel nuclear factor (NF)-kappaB pathway that involves phosphorylation of p65 at serine 536 (Pp65(Ser536)). Bcl-10 acts along the same pathway downstream of PKC theta to activate NF-kappaB. The aim was to ...

journal_title：Histopathology

authors： Briones J,Moga E,Espinosa I,Vergara C,Alvarez E,Villa J,Bordes R,Delgado J,Prat J,Sierra J

更新日期：2009-03-01 00:00:00