Abstract:
:Advances in modern chemotherapy and targeted treatments have resulted in lengthened survival in a variety of tumour types in the last decade. Increasingly in the 21st century, postchemotherapy resections are considered as a possible mode of treatment. Due to their exquisite chemosensitivity, resection of postchemotherapy masses has long been part of the armamentarium of treatment in testicular germ cell neoplasia, which has resulted in a variety of new morphological variants being described after treatment. Here we discuss the possible reasons for germ cell tumour chemosensitivity and hypotheses on the biological pathways leading to resistance to treatment, as well as an outline of the diverse morphology of those tumours which prove recalcitrant to standard treatment methods. The large range of morphologies and their diagnostic challenges may throw light upon the future problems to be encountered in non-germ cell solid tumour pathology, as the resection of postchemotherapy masses becomes increasingly important in patient management.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Berney DM,Lu YJ,Shamash J,Idrees Mdoi
10.1111/his.13078subject
Has Abstractpub_date
2017-01-01 00:00:00pages
26-39issue
1eissn
0309-0167issn
1365-2559journal_volume
70pub_type
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