Cutaneous perineurioma: a poorly recognized tumour often misdiagnosed as epithelioid histiocytoma.

abstract：AIMS:We tried to improve the evaluation of E-cadherin immunostaining in paraffin sections, to distinguish the less aggressive variants of ductal infiltrating breast cancer from other variants. METHODS AND RESULTS:The method graded the membrane staining and estimated the fraction of area of cancer tissue stained at the...

journal_title：Histopathology

authors： Elzagheid A,Kuopio T,Ilmen M,Collan Y

更新日期：2002-08-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a d...

journal_title：Histopathology

authors： Johnson A,Akerman M,Cavallin-Ståhl E

更新日期：1987-06-01 00:00:00

abstract：AIMS:To estimate the likelihood of the upgrade for atypical ductal hyperplasia (ADH) diagnosed on a core needle biopsy of a mammographically detected lesion. METHODS AND RESULTS:A total of 203 consecutive ADH cases diagnosed on core biopsy in mammographically detected lesions and having subsequent surgical excision we...

journal_title：Histopathology

authors： Khoury T,Chen X,Wang D,Kumar P,Qin M,Liu S,Turner B

更新日期：2015-07-01 00:00:00

abstract：AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...

journal_title：Histopathology

authors： Segawa Y,Oda Y,Yamamoto H,Uryu H,Shiratsuchi H,Hirakawa N,Tomita K,Yamamoto T,Oda S,Yamada T,Komune S,Tsuneyoshi M

更新日期：2008-01-01 00:00:00

abstract：:Current treatment of breast cancer incorporates clinical, pathological and molecular data. Oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) define prognosis and identify tumours for targeted therapy, and remain the sole established single-molecule biomarkers defin...

journal_title：Histopathology

authors： Kos Z,Dabbs DJ

更新日期：2016-01-01 00:00:00

abstract：AIMS:(i) To investigate and compare the numerical aberrations of chromosomes 7, 8, 11, 17 and Y in a series of 60 adenocarcinomas of the oesophagus, gastric cardia and gastric antrum; and (ii) to specify the sequence of chromosomal aberrations occurring during the neoplastic progression of Barrett's oesophagus. METHOD...

journal_title：Histopathology

authors： Beuzen F,Dubois S,Fléjou JF

更新日期：2000-09-01 00:00:00

abstract：:Hairy leukoplakia is a recently described oral mucosal condition seen in immunosuppressed individuals, usually in association with HIV infection, when it is thought to be a sign of decreasing immunocompetence. It probably results from reactivation of infection by Epstein-Barr virus (EBV) and usually presents as bilate...

journal_title：Histopathology

authors： Southam JC,Felix DH,Wray D,Cubie HA

更新日期：1991-07-01 00:00:00

abstract：AIMS:Colonic and rectal biopsies, often taken from an endoscopically normal large bowel, form a significant proportion of the histopathology workload. The aim of this study was to determine diagnostic yield from mucosal biopsies in patients with normal colonoscopy or sigmoidoscopy, and whether or not diarrhoea is predi...

journal_title：Histopathology

authors： O'Mahony OH,Burgoyne M,Going JJ

更新日期：2012-12-01 00:00:00

abstract：AIMS:There is controversy regarding the use of adjuvant therapy in patients with Dukes' B colorectal cancer (CRC). New markers, identifying high-risk Dukes' B patients, are needed. Here, we examine the utility of Raf kinase inhibitor protein (RKIP) as such a marker and promoter methylation as a mechanism of RKIP down-r...

journal_title：Histopathology

authors： Doyle B,Hagan S,Al-Mulla F,Scott L,Harden S,Paul J,Mulcahy H,Murray GI,Sheahan K,O'Sullivan J,Kolch W

更新日期：2013-02-01 00:00:00

abstract：:The treatment of cancer has changed dramatically over the last decade, driven by increased understanding of the cancer genome, immune landscape, molecular alterations and aberrant pathways that drive cancer progression. Advances in molecular biology have led to the development of targeted agents, including monoclonal ...

journal_title：Histopathology

authors： Crusz SM,Miller RE

更新日期：2020-01-01 00:00:00

abstract：AIMS:To compare the morphological and immunohistochemical characteristics of oestrogen receptor (ER)-negative and ER-positive ductal carcinoma in situ (DCIS) of the breast, in an attempt to establish more objective criteria for the classification of DCIS. METHODS AND RESULTS:Sections of 64 cases of in-situ carcinoma o...

journal_title：Histopathology

authors： Baqai T,Shousha S

更新日期：2003-05-01 00:00:00

abstract：AIMS:The immunoregulatory enzyme indoleamine dioxygenase 2,3 (IDO) has been implicated in cervical and vulvar squamous carcinomas (SCC) and may represent a mechanism of resistance to anti-PD-1/anti-PD-L1 therapy. However, the relationship between IDO and PD-L1 has not been well-investigated. METHODS AND RESULTS:Sixty-...

journal_title：Histopathology

authors： Chinn Z,Stoler MH,Mills AM

更新日期：2019-01-01 00:00:00

abstract：:The new World Health Organization (WHO) classification of soft tissue tumours was published in early 2013, almost 11 years after the previous edition. While the number of newly recognized entities included for the first time is fewer than that in 2002, there have instead been substantial steps forward in molecular gen...

journal_title：Histopathology

authors： Fletcher CD

更新日期：2014-01-01 00:00:00

abstract：AIMS:Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationsh...

journal_title：Histopathology

authors： Zhu JL,Song YX,Wang ZN,Gao P,Wang MX,Dong YL,Xing CZ,Xu HM

更新日期：2013-06-01 00:00:00

abstract：:A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

journal_title：Histopathology

authors： Islam A,Henderson ES

更新日期：1988-06-01 00:00:00

abstract：:Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...

journal_title：Histopathology

authors： Tan SY,Pepys MB

更新日期：1994-11-01 00:00:00

abstract：:Primary intrathoracic sarcomas constitute a rare, heterogeneous group of neoplasms that occur in the lung parenchyma, pleura, and mediastinum. Although pathologically diverse, they frequently show similar clinical and radiological features, and accurate histopathological diagnosis is therefore crucial for correct mana...

journal_title：Histopathology

authors： Thway K,Jordan S,Fisher C,Nicholson AG

更新日期：2015-12-01 00:00:00

abstract：AIMS:Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, are morphologically similar to pulmonary hamartomas, which are much more common. There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB imm...

journal_title：Histopathology

authors： Chatzopoulos K,Fritchie KJ,Aubry MC,Carney JA,Folpe AL,Boland JM

更新日期：2019-12-01 00:00:00

abstract：:Elastosis, a previously unreported feature, was found to be common in granular cell tumours. Twenty-four of 28 consecutive granular cell tumours were shown to display elastosis. The elastosis was found in three main sites: adventitial, interstitial and septal. Elastosis is statistically associated with the fibrosis pr...

journal_title：Histopathology

authors： McMahon JN,Rigby HS,Davies JD

更新日期：1990-01-01 00:00:00

abstract：AIMS:We report the clinicopathological and immunohistochemical characteristics of 12 cases of a recently recognized entity, oncocytic papillary thyroid carcinoma (PC) with lymphoid stroma (Warthin-like tumour). METHODS AND RESULTS:The cases were retrieved from the surgical pathology files of our departments. There wer...

journal_title：Histopathology

authors： Ludvíková M,Ryska A,Korabecná M,Rydlová M,Michal M

更新日期：2001-07-01 00:00:00

abstract：AIMS:CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. For reliable implementation in daily practice and meaningful selection of patients for clinical trials, information on techni...

journal_title：Histopathology

authors： Koens L,van de Ven PM,Hijmering NJ,Kersten MJ,Diepstra A,Chamuleau M,de Jong D

更新日期：2018-09-01 00:00:00

abstract：AIMS:Pulmonary Langerhans cell histiocytosis (PLCH) is characterized by the presence of lesions containing numerous activated Langerhans cells (LCs). An uncontrolled immune response sustained by activated LCs seems to be involved in the pathogenesis of the disease. The aim of this study was to establish whether disrupt...

journal_title：Histopathology

authors： Marchal J,Kambouchner M,Tazi A,Valeyre D,Soler P

更新日期：2004-07-01 00:00:00

abstract：AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

journal_title：Histopathology

authors： Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

更新日期：2012-09-01 00:00:00

abstract：AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...

journal_title：Histopathology

authors： Akita M,Hong SM,Sung YN,Kim MJ,Ajiki T,Fukumoto T,Itoh T,Zen Y

更新日期：2020-06-01 00:00:00

abstract：:The mononuclear phagocytic system is composed of cells which display a marked immunohistological heterogeneity. In the present study we have investigated the immunohistochemical and enzymatic features of macrophages and accessory cells present in human lymph nodes and spleen and, as control tissues, in thymus, liver, ...

journal_title：Histopathology

authors： Baroni CD,Vitolo D,Remotti D,Biondi A,Pezzella F,Ruco LP,Uccini S

更新日期：1987-10-01 00:00:00

abstract：:Recently, there has been intense interest in the study of gastrointestinal stromal tumour (GIST); one might call it a virtual GIST revolution. This is due largely to the realization that most GISTs express KIT and harbour activating c-KIT (KIT) or platelet-derived growth factor receptor-alpha (PDGFRA) receptor tyrosin...

journal_title：Histopathology

authors： Rubin BP

更新日期：2006-01-01 00:00:00

abstract：AIMS:Members of the cadherin and catenin families are involved in chondrogenesis and catenin gene mutations have been detected in malignant tumours of bone. This study was undertaken to assess in detail expression of cadherin, beta-catenin and the associated tumour suppressor gene product APC in bone and cartilage at d...

journal_title：Histopathology

authors： Monaghan H,Bubb VJ,Sirimujalin R,Millward-Sadler SJ,Salter DM

更新日期：2001-12-01 00:00:00

abstract：:Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...

journal_title：Histopathology

authors： Olenick SJ,Fan CC,Ryoo JW

更新日期：1994-08-01 00:00:00

abstract：AIMS:Programmed death ligand 1 (PD-L1) immunohistochemistry has become a mandatory diagnostic test in the treatment of lung cancer. Several research initiatives have started to harmonise the five PD-L1 immunohistochemistry assays that have been used in clinical trials. Here, we report data on interlaboratory and intera...

journal_title：Histopathology

authors： Scheel AH,Baenfer G,Baretton G,Dietel M,Diezko R,Henkel T,Heukamp LC,Jasani B,Jöhrens K,Kirchner T,Lasitschka F,Petersen I,Reu S,Schildhaus HU,Schirmacher P,Schwamborn K,Sommer U,Stoss O,Tiemann M,Warth A,Weichert

更新日期：2018-02-01 00:00:00

abstract：:Eight cases of myelosarcoma without acute leukaemia at time of diagnosis were reviewed and biopsies were immunostained using antibodies reacting with myeloid/monocytic markers. Initial tumour location included lymph nodes, paranasal sinuses, nasopharyngeal and/or orbital regions and other extranodal locations. Three c...

journal_title：Histopathology

authors： Furebring-Fredén M,Martinsson U,Sundström C

更新日期：1990-03-01 00:00:00