Biomarker assessment and molecular testing for prognostication in breast cancer.

abstract：AIMS:We present the histopathological findings of a series of six cases of a benign uterine smooth muscle tumour with an unusual growth pattern. METHODS AND RESULTS:All cases have the appearances of the recently described dissecting (cotyledonoid) leiomyoma. In addition, three of these lesions demonstrate the features...

journal_title：Histopathology

authors： Jordan LB,Al-Nafussi A,Beattie G

更新日期：2002-03-01 00:00:00

abstract：AIMS:There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to g...

journal_title：Histopathology

authors： Kaye P,Lindsay D,Madhusudan S,Vohra R,Catton J,Platt C,Ragunath K

更新日期：2019-05-01 00:00:00

abstract：:Surgical biopsy specimens from five children with cerebellar medulloblastoma were examined for ultrastructural evidence of differentiating activity. At light microscope level, all the tumour samples appeared primitive and featureless, and could not be classified as showing either neuroblastic or spongioblastic differe...

journal_title：Histopathology

authors： Moss TH

更新日期：1983-11-01 00:00:00

abstract：:Four cases of endocrine neoplasia within fibroadenomas of the breast are described. The tumours are identifiable by light microscopic, silver impregnation and ultrastructural studies. Argyrophilia and the presence of dense-core granules establish the identity of this tumour type. The differential diagnosis from, and p...

journal_title：Histopathology

authors： Eusebi V,Azzopardi JG

更新日期：1980-07-01 00:00:00

abstract：AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...

journal_title：Histopathology

authors： Shinozaki-Ushiku A,Ushiku T,Morita S,Anraku M,Nakajima J,Fukayama M

更新日期：2017-04-01 00:00:00

abstract：AIMS:Breast cancer is one of the most common cancer diseases in women, with >1.67 million cases being diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumour spreads, and it is usually located in the ipsilateral axilla. In patients with no c...

journal_title：Histopathology

authors： Holten-Rossing H,Talman MM,Jylling AMB,Laenkholm AV,Kristensson M,Vainer B

更新日期：2017-12-01 00:00:00

abstract：:Lobular carcinoma in situ and atypical lobular hyperplasia were first described over 50 years ago. Despite this long incubation period, the biological nature of the lesions remains controversial. They are generally regarded as 'risk indicators' of invasive cancer rather than true precursor lesions. When first describe...

journal_title：Histopathology

authors： Lishman SC,Lakhani SR

更新日期：1999-09-01 00:00:00

abstract：AIMS:Comedo carcinoma is generally regarded as the subtype of ductal carcinoma in situ (DCIS) most likely to progress to invasive carcinoma. Increased angiogenesis could be associated with an enhanced risk of progression and might therefore be a marker of poor prognosis, as can be demonstrated for invasive breast tumou...

journal_title：Histopathology

authors： Vogl G,Dietze O,Hauser-Kronberger C

更新日期：2005-12-01 00:00:00

abstract：AIMS:Patients with aggressive CD8+ cutaneous T-cell lymphomas (CTCLs) progress rapidly and respond poorly to therapy. Confounding treatment planning, there is clinicopathological overlap between aggressive CD8+ CTCLs and other lymphoproliferative disorders (LPDs). Hence, improved diagnostic methods and therapeutic opti...

journal_title：Histopathology

authors： Geller S,Hollmann TJ,Horwitz SM,Myskowski PL,Pulitzer M

更新日期：2020-01-01 00:00:00

abstract：:Anaplastic choroid plexus carcinoma is a tumour with a predilection for the posterior fossa of infants and can be difficult to distinguish histologically from medulloblastoma without the aid of immunocytochemistry using a panel of antibodies. Of a series of 17 choroid plexus carcinomas (five of which were classed as m...

journal_title：Histopathology

authors： Newbould MJ,Kelsey AM,Arango JC,Ironside JW,Birch J

更新日期：1995-02-01 00:00:00

abstract：AIMS:A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS:Nineteen relevant papers published during the period 1979-2005 were identified. Individu...

journal_title：Histopathology

authors： King J,Thatcher N,Pickering C,Hasleton P

更新日期：2006-12-01 00:00:00

abstract：:This article considers the issues of image manipulation within the context of electronic/digital images. The possibility for such alterations has occurred with the increasing availability of simple and cheap computer software, permitting modification of digitized images as a whole, or in part. The concepts of acceptab...

journal_title：Histopathology

authors： Suvarna SK,Ansary MA

更新日期：2001-11-01 00:00:00

abstract：AIMS:Helicobacter pylori has been claimed to be an important aetiological factor which raises the risk of mucosa-associated tissue lymphoid (MALT) lymphoma. However, some studies on gastric MALT lymphoma revealed a low rate of H. pylori infection suggesting that not all gastric lymphomas are related to H. pylori infect...

journal_title：Histopathology

authors： Bouzourene H,Haefliger T,Delacretaz F,Saraga E

更新日期：1999-02-01 00:00:00

abstract：AIMS:To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs). METHODS AND RESULTS:Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7,...

journal_title：Histopathology

authors： Handra-Luca A,Fléjou JF,Rufat P,Corcos O,Belghiti J,Ruszniewski P,Degott C,Bedossa P,Couvelard A

更新日期：2006-06-01 00:00:00

abstract：:The syndrome of postmastectomy lymphangiosarcoma (LAS) has been universally accepted since it was first outlined by Stewart & Treves (1948), except for a small number of authors who concluded that the neoplasms arising in the chronic lymphoedematous arms were in fact due to retrograde spread from the original breast c...

journal_title：Histopathology

authors： Schafler K,McKenzie CG,Salm R

更新日期：1979-03-01 00:00:00

abstract：AIMS:Y-box binding protein-1 (YB-1) is known to modulate gene transcription and protein translation, as well as cellular response to drug treatment. The aim of this study is to correlate YB-1 protein expression levels with clinicopathological parameters in intestinal-type gastric cancer tissue samples (as categorized b...

journal_title：Histopathology

authors： Guo T,Yu Y,Yip GW,Baeg GH,Thike AA,Lim TK,Tan PH,Matsumoto K,Bay BH

更新日期：2015-03-01 00:00:00

abstract：AIMS:Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non-tumour tissue. METHODS AND RESULTS:I...

journal_title：Histopathology

authors： Chau GY,Lee AF,Tsay SH,Ke YR,Kao HL,Wong FH,Tsou AP,Chau YP

更新日期：2007-08-01 00:00:00

abstract：AIMS:Tissue microarray (TMA) is an efficient technique for analysis of molecular markers. Prospectively collected samples have been reported to give excellent concordance between TMA data and corresponding whole-sections. The aim was to evaluate the usefulness of TMA in a population-based cohort of 213 women with ducta...

journal_title：Histopathology

authors： Wärnberg F,Amini RM,Goldman M,Jirström K

更新日期：2008-12-01 00:00:00

abstract：AIMS:Pulmonary adenosquamous carcinoma (ASC) is more aggressive than adenocarcinoma (AC) and squamous cell carcinoma (SCC). The genetic features and biomarkers of ASC are not well known. Here, we attempted to identify potential therapeutic markers for ASC. METHODS AND RESULTS:Surgically resected ASC samples from 65 pa...

journal_title：Histopathology

authors： Watanabe Y,Shiraishi K,Takahashi F,Yoshida A,Suzuki K,Asamura H,Takeuchi M,Furuta K,Tsuta K

更新日期：2015-06-01 00:00:00

abstract：AIMS:Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity. METHODS AND RESULTS:We report a case of clear cell carcinoma in a 53-year-old man involving the head of the pancreas and which ha...

journal_title：Histopathology

authors： Lüttges J,Vogel I,Menke M,Henne-Bruns D,Kremer B,Klöppel G

更新日期：1998-05-01 00:00:00

abstract：AIMS:To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confu...

journal_title：Histopathology

authors： De Cecco L,Gariboldi M,Reid JF,Lagonigro MS,Tamborini E,Albertini V,Staurengo S,Pilotti S,Pierotti MA

更新日期：2005-03-01 00:00:00

abstract：:Problems in the interpretation and diagnosis of intraepithelial lesions of the uterine cervix include interobserver differences in respect of grading, uncertainty as to the significance of human papillomavirus infection and debate about the current terminology. The role of human papillomaviruses in cervical intra-epit...

journal_title：Histopathology

authors： Fox H,Buckley CH

更新日期：1990-07-01 00:00:00

abstract：:The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type...

journal_title：Histopathology

authors： Quincey C,Raitt N,Bell J,Ellis IO

更新日期：1991-07-01 00:00:00

abstract：AIMS:Calcific aortic stenosis is a progressive disease characterized by massive fibrosis andmineralization of the valve leaflets. The aim of this study was to determine whether the onset of native calcific aortic stenosis is associated primarily with matrix remodelling events, and particularly with elastin degradation....

journal_title：Histopathology

authors： Perrotta I,Russo E,Camastra C,Filice G,Di Mizio G,Colosimo F,Ricci P,Tripepi S,Amorosi A,Triumbari F,Donato G

更新日期：2011-09-01 00:00:00

abstract：AIMS:Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immun...

journal_title：Histopathology

authors： Lee DY,Park JH,Shin HT,Yang JM,Jang KT,Kwon GY,Lee KH,Shim JS

更新日期：2012-07-01 00:00:00

abstract：AIMS:Maspin, a protein belonging to the serpin superfamily, is the product of a tumour suppressor gene. Tissue distribution studies have shown maspin expression in normal mammary epithelial cells, in the placenta, prostate, thymus, testis, oral cavity, small intestine, skin, and cornea. Maspin is expressed but down-reg...

journal_title：Histopathology

authors： Marioni G,Blandamura S,Giacomelli L,Calgaro N,Segato P,Leo G,Fischetto D,Staffieri A,de Filippis C

更新日期：2005-05-01 00:00:00

abstract：AIM:Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC) is a rare biphasic liver cancer. Recent studies have demonstrated that cHCC-CC originates from hepatic progenitor cells (HPCs). Spalt-like transcription factor 4 (SALL4) is a marker for a progenitor subclass of HCC with an aggressive phen...

journal_title：Histopathology

authors： Tanaka Y,Aishima S,Kohashi K,Okumura Y,Wang H,Hida T,Kotoh K,Shirabe K,Maehara Y,Takayanagi R,Oda Y

更新日期：2016-04-01 00:00:00

abstract：AIMS:Littoral cell angioma (LCA) is a rare primary splenic tumour that is frequently associated with internal malignancies. Immunohistochemistry can demonstrate a distinct hybrid endothelial-histiocytic phenotype of littoral cells, and is a helpful adjunct for making the correct diagnosis. The aims of this study were t...

journal_title：Histopathology

authors： Peckova K,Michal M,Hadravsky L,Suster S,Damjanov I,Miesbauerova M,Kazakov DV,Vernerova Z,Michal M

更新日期：2016-11-01 00:00:00

abstract：AIMS:Pulmonary Langerhans cell histiocytosis (PLCH) is characterized by the presence of lesions containing numerous activated Langerhans cells (LCs). An uncontrolled immune response sustained by activated LCs seems to be involved in the pathogenesis of the disease. The aim of this study was to establish whether disrupt...

journal_title：Histopathology

authors： Marchal J,Kambouchner M,Tazi A,Valeyre D,Soler P

更新日期：2004-07-01 00:00:00

abstract：AIMS:Telomerase is reactivated in most cancers and there is accumulating evidence that this is a driver event in malignant melanoma (MM). Thus, our aim was to evaluate if in-situ hybridization (ISH)-based quantification of telomerase RNA (hTR) could be used to distinguish MM from naevi, and if there was a correlation w...

journal_title：Histopathology

authors： Vagner J,Steiniche T,Stougaard M

更新日期：2015-04-01 00:00:00