Abstract:
:Recently, there has been intense interest in the study of gastrointestinal stromal tumour (GIST); one might call it a virtual GIST revolution. This is due largely to the realization that most GISTs express KIT and harbour activating c-KIT (KIT) or platelet-derived growth factor receptor-alpha (PDGFRA) receptor tyrosine kinase mutations that can be targeted by small molecule pharmacological inhibitors. Pathologists have benefited greatly from this revolution, mainly in the form of an improved ability to classify GISTs and, even more recently, in understanding the molecular underpinnings that underlie many fascinating clinical and pathological correlations. It is the purpose of this review to summarize recent developments in GIST classification and the molecular pathogenesis of GIST.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Rubin BPdoi
10.1111/j.1365-2559.2005.02291.xkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
83-96issue
1eissn
0309-0167issn
1365-2559pii
HIS2291journal_volume
48pub_type
杂志文章,评审相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:We evaluated polymerase chain reaction (PCR) amplification of specific immunoglobulin heavy chain (IgH) gene rearrangements as a means of demonstrating monoclonality during follow-up of conservatively treated gastric MALT lymphoma, and compared the reproducibility of PCR on sequential frozen and paraffin-embedded ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00628.x
更新日期:1999-04-01 00:00:00
abstract:AIMS:Calretinin, a calcium-binding protein, is expressed primarily in certain subtypes of neurons. It has also been reported to be present in mesotheliomas and other tumours. The aim was to determine the expression of calretinin in selected odontogenic neoplasms. METHODS AND RESULTS:Immunohistochemistry for calretinin...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02948.x
更新日期:2008-02-01 00:00:00
abstract::An immunocytochemical and cytophotometrical analysis of 30 renal cell carcinomas was carried out in order to investigate the expression of cytokeratin and vimentin in relation to the ploidy and mitotic index. Thirty renal cell carcinomas were studied using monoclonal antibodies CAM 5.2 and anti-vimentin in a biotin-st...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00852.x
更新日期:1991-04-01 00:00:00
abstract:AIMS:The B7 family check-point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status in human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the expression profiles of the B7 family check-point proteins PD-L1, PD-L2, B7-H3, B7-H4, VISTA and B7-...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13882
更新日期:2019-09-01 00:00:00
abstract::A case of choriocarcinoma in situ arising in an 11 week gestational placenta is reported. Histologically, a localized nodule, measuring 5 mm, of neoplastic trophoblastic proliferation appeared to arise directly from normal stem villi and projected into the intervillous space. The tumour was composed of biphasic cytotr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00313.x
更新日期:1995-11-01 00:00:00
abstract:AIMS:Lectins, and especially galectins, appear to be important in malignancy-associated processes. The aim was to analyse comprehensively the presence of galectins in urothelial tumours. METHODS AND RESULTS:Non-cross-reactive antibodies against seven family members from the three subgroups (prototype: galectin-1, -2 a...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02852.x
更新日期:2007-11-01 00:00:00
abstract::The histopathological classification of ovarian surface epithelial carcinomas (referred to hereafter as 'ovarian carcinoma') has shifted over the past 10 years to reflect more clearly our understanding of molecular events during carcinogenesis. Ovarian carcinoma is no longer viewed as a single entity but as multiple d...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12033
更新日期:2013-01-01 00:00:00
abstract:AIMS:Mucinous tubular and spindle cell carcinoma (MTSC) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported MTSC with high-grade features and have brought into question w...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13298
更新日期:2017-11-01 00:00:00
abstract:AIMS:To determine the expression of matrix metalloproteinases (MMPs)-2, -7 and -9 and beta-catenin in uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) and to investigate any difference in expression between EEC and USC which might explain the mechanism of invasion and aggressive behaviour of ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02612.x
更新日期:2007-02-01 00:00:00
abstract:AIMS:Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosar...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2001.01277.x
更新日期:2001-11-01 00:00:00
abstract:AIM:We describe the unusual association of fallopian tubal prolapse and herpetic infection, an occurrence not previously reported to our knowledge. METHODS AND RESULTS:A 37-year-old woman presented with a small polypoid mass of the vaginal vault, 3 months after abdominal hysterectomy and abdominoplasty. The vaginal ma...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1999.00644.x
更新日期:1999-06-01 00:00:00
abstract::A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00439.x
更新日期:1992-12-01 00:00:00
abstract:AIMS:To investigate whether an antibody against an intracellular epitope can detect CD19 in routine biopsy specimens and thus to document in detail its expression in human lymphomas. METHOD AND RESULTS:A polyclonal antibody to the C terminus of CD19 was used to immunostain paraffin-embedded samples of normal and neopl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02317.x
更新日期:2006-02-01 00:00:00
abstract::Recently, great interest has been shown in the histological identification of small cell tumours of childhood--nephroblastoma (Wilms' tumour), neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma--using immunohistochemical methods. However, several antigens operationally specific for leucocyte typing in blood and marro...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb02163.x
更新日期:1989-04-01 00:00:00
abstract:AIMS:BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR-associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR-associated non-uterine sarcomas in adult patients. METHODS AND RESULTS:The patients were four men an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14023
更新日期:2020-03-01 00:00:00
abstract::A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1988.tb01988.x
更新日期:1988-06-01 00:00:00
abstract::S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reaction...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb01457.x
更新日期:1991-02-01 00:00:00
abstract::The relationship between proliferating cell nuclear antigen (PCNA) expression and various clinicopathological indices (age, sex, tumour location, histological type and grade and treatment) and post-operative survival were studied in patients with central nervous system gliomas using univariate and multivariate analysi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01353.x
更新日期:1994-10-01 00:00:00
abstract::The so-called sclerosing haemangioma of the lung is an uncommon tumour with predilection for Chinese women. Twenty-five cases showed a predominantly solid/cellular pattern in three, a haemorrhagic/angiomatoid pattern in three, a papillary pattern in one, a sclerotic pattern in one, and in seventeen, a mixed pattern wa...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00020.x
更新日期:1995-08-01 00:00:00
abstract:AIMS:In T cells, protein kinase C (PKC) theta plays a major role in T-cell receptor (TCR)-mediated activation of a novel nuclear factor (NF)-kappaB pathway that involves phosphorylation of p65 at serine 536 (Pp65(Ser536)). Bcl-10 acts along the same pathway downstream of PKC theta to activate NF-kappaB. The aim was to ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03250.x
更新日期:2009-03-01 00:00:00
abstract:AIMS:To address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin. METHODS AND RESULTS:Fifty-four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF-1, CK7, CK20 and CDX2 ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12383
更新日期:2014-08-01 00:00:00
abstract:AIMS:To describe a case of rhabdomyomatosis of the lung unassociated with other external or visceral malformations in a newborn infant. METHODS AND RESULTS:A 26 weeks gestation newborn male with no relevant medical or family history presented a well-circumscribed solid area in the posterior mediastinum occupying the u...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2830880.x
更新日期:1997-11-01 00:00:00
abstract::We reviewed 45 pulmonary B-cell non-Hodgkin's lymphomas to determine whether their morphology and immunohistochemical features were those of lymphomas arising from mucosa-associated lymphoid tissue (MALT), as described in other sites. The polymerase chain reaction was used to provide further information on clonality. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00246.x
更新日期:1995-05-01 00:00:00
abstract:AIMS:Adenoviral inclusions are commonly seen in appendices from infants with intussusception. They are associated with focal epithelial budding and less frequently with epithelial shedding. These morphological changes could depend on the opposing effects of adenoviral gene products on CD95-mediated apoptosis. METHODS ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2840875.x
更新日期:1997-10-01 00:00:00
abstract:AIMS:Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. RESULTS:The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immuno...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12733
更新日期:2015-12-01 00:00:00
abstract::A series of 104 biopsy cases with histopathological proof of amyloid, submitted to our department of pathology over the last 19 years, were re-examined. The survey investigated the medical indication for surgery, the origin and quality of the biopsy and the clinical information as documented on the request form for hi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1996.tb01416.x
更新日期:1996-10-01 00:00:00
abstract:AIMS:We present the histopathological findings of a series of six cases of a benign uterine smooth muscle tumour with an unusual growth pattern. METHODS AND RESULTS:All cases have the appearances of the recently described dissecting (cotyledonoid) leiomyoma. In addition, three of these lesions demonstrate the features...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2002.01359.x
更新日期:2002-03-01 00:00:00
abstract::Expression of the epidermal growth factor receptor (EGFR) was studied in cryosections from human thyroid tissues. Normal tissue (4 cases), nodular goitre (12), toxic goitre (9), adenoma (9), follicular carcinoma (1), papillary carcinoma (7) and poorly differentiated carcinoma (1) were used for immunohistochemistry. No...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-427.x
更新日期:1996-03-01 00:00:00
abstract::A series of 20 cases of radiation bowel disease (RBD) was studied qualitatively and the arterial changes were studied quantitatively. A control series of 45 cases was studied. In the control cases there were positive correlations between the medial thickness of all vessels studied and the diastolic blood pressure as w...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1985.tb02833.x
更新日期:1985-05-01 00:00:00
abstract::We report three cases of an unusual primary carcinoma of the liver composed of small cells. The patients were adult males (56 to 89 years) who presented with jaundice, weight loss and abdominal discomfort. Surgery was attempted in one case. Clinical evolution was rapid, with death ensuing between 1 and 5 months after ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-514.x
更新日期:1996-11-01 00:00:00