Choriocarcinoma in situ: a case at an early gestational stage.


:A case of choriocarcinoma in situ arising in an 11 week gestational placenta is reported. Histologically, a localized nodule, measuring 5 mm, of neoplastic trophoblastic proliferation appeared to arise directly from normal stem villi and projected into the intervillous space. The tumour was composed of biphasic cytotrophoblast and syncytiotrophoblast. No fetal elements were observed. The patient had a normal full-term spontaneous vaginal delivery 22 months after curettage and was free of disease without therapy at 32 months. This tumour provides evidence for an origin of choriocarcinoma from villous trophoblast. Our report illustrates the need to perform thorough microscopic examination of the products of conception, especially in the absence of a fetus or fetal parts.






Fukunaga M,Ushigome S,Ishikawa E




Has Abstract


1995-11-01 00:00:00












  • Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR.

    abstract:AIMS:To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas. METHODS AND RESULTS:A total of 57 carcinomas and respective gastric tissues were inc...


    pub_type: 杂志文章


    authors: Lacueva J,Perez-Ramos M,Soto JL,Oliver I,Andrada E,Medrano J,Perez-Vazquez T,Arroyo A,Carrato A,Ferragut JA,Calpena R

    更新日期:2005-04-01 00:00:00

  • Intramuscular angioma: a clinicopathological analysis of 74 cases.

    abstract::We have studied 74 benign intramuscular angiomas in order to try and correlate clinical behaviour with histological appearances. The purpose was to find means of predicting those which would recur. Mean age at presentation was 17.6 years and 85% of the cases presented before age 30. The male: female ratio was 1.4:1. A...


    pub_type: 杂志文章


    authors: Beham A,Fletcher CD

    更新日期:1991-01-01 00:00:00

  • Working at the microscope: analysis of the activities involved in diagnostic pathology.

    abstract:AIMS:To study the current work practice of histopathologists to inform the design of digital microscopy systems. METHODS AND RESULTS:Four gastrointestinal histopathologists were video-recorded as they undertook their routine work. Analysis of the video data shows a range of activities beyond viewing slides involved in...


    pub_type: 杂志文章


    authors: Randell R,Ruddle RA,Quirke P,Thomas RG,Treanor D

    更新日期:2012-02-01 00:00:00

  • Glandular lesions of the uterine cervix: the present state of our knowledge.

    abstract::The assessment of squamous lesions of the uterine cervix is a major preoccupation of diagnostic histopathologists and this can overshadow the recognition of significant abnormalities affecting the adjacent endocervical glands. This review gives an account of recent advances in our knowledge of the histology and histoc...


    pub_type: 杂志文章


    authors: Wells M,Brown LJ

    更新日期:1986-08-01 00:00:00

  • Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.

    abstract:AIMS:Colorectal carcinoma (CRC) with micropapillary (MP) features has only been described recently and is still being characterized. METHODS AND RESULTS:We reviewed the clinicopathological and molecular features of 42 CRC with MP features. Twenty-nine cases were also evaluated for immunohistochemical evidence of epith...


    pub_type: 杂志文章


    authors: Gonzalez RS,Huh WJ,Cates JM,Washington K,Beauchamp RD,Coffey RJ,Shi C

    更新日期:2017-01-01 00:00:00

  • A histological comparison of cutaneous malignant melanoma between the Oxford Region and Western Australia.

    abstract::Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predomi...


    pub_type: 杂志文章


    authors: Heenan PJ,Holman CD

    更新日期:1982-11-01 00:00:00

  • Aortic intimal sarcoma: an unusual case with pulmonary vasculature involvement.

    abstract::A disseminated intravascular tumour, presenting initially with splenic and small bowel infarction, caused both clinical and histological diagnostic difficulty. At subsequent autopsy the main tumour mass was identified within the aorta. Dissemination of this tumour was confirmed histologically and lectin and immunohist...


    pub_type: 杂志文章


    authors: Fitzmaurice RJ,McClure J

    更新日期:1990-11-01 00:00:00

  • Dysplasia in Barrett's oesophagus: p53 immunostaining is more reproducible than haematoxylin and eosin diagnosis and improves overall reliability, while grading is poorly reproducible.

    abstract:AIMS:p53 immunostaining in Barrett's oesophagus (BO) has been shown to be predictive of progression, but data regarding its generalizability to routine practice are lacking. This study compared the reliability of p53 and dysplasia interpretation and grading. METHODS AND RESULTS:Seventy-two cases encompassing the full ...


    pub_type: 杂志文章


    authors: Kaye PV,Ilyas M,Soomro I,Haider SA,Atwal G,Menon S,Gill S,Richards C,Harrison R,West K,Ragunath K

    更新日期:2016-09-01 00:00:00

  • Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis.

    abstract:AIMS:Because of its efficacy, oxaliplatin (OX) is increasingly used as a chemotherapeutic agent in the treatment of colorectal liver metastases (CRLM). Oxaliplatin-associated liver toxicity has been reported and can affect clinical practice, but studies on its prevalence and a full pathological description are lacking....


    pub_type: 杂志文章


    authors: Rubbia-Brandt L,Lauwers GY,Wang H,Majno PE,Tanabe K,Zhu AX,Brezault C,Soubrane O,Abdalla EK,Vauthey JN,Mentha G,Terris B

    更新日期:2010-03-01 00:00:00

  • Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis.

    abstract:AIMS:To evaluate primary and recurrent embryonal sarcoma of the liver and to improve recognition of its morphological variants and immunohistochemical features. METHODS AND RESULTS:Fourteen primary and two recurrent cases of hepatic embryonal sarcoma were evaluated histologically and investigated immunohistochemically...


    pub_type: 杂志文章


    authors: Zheng JM,Tao X,Xu AM,Chen XF,Wu MC,Zhang SH

    更新日期:2007-08-01 00:00:00

  • Application of automated image analysis reduces the workload of manual screening of sentinel lymph node biopsies in breast cancer.

    abstract:AIMS:Breast cancer is one of the most common cancer diseases in women, with >1.67 million cases being diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumour spreads, and it is usually located in the ipsilateral axilla. In patients with no c...


    pub_type: 杂志文章


    authors: Holten-Rossing H,Talman MM,Jylling AMB,Laenkholm AV,Kristensson M,Vainer B

    更新日期:2017-12-01 00:00:00

  • Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour.

    abstract:AIMS:Several studies have demonstrated that Na(+) /H(+) exchanger regulatory factor 1 (NHERF1) protein, which is overexpressed and heterogeneously distributed in different stages of breast cancer, could be used as a tumour marker for prognosis in molecular detection strategies. We observed that tumour-infiltrated lymph...


    pub_type: 杂志文章


    authors: Bellizzi A,Mangia A,Malfettone A,Cardone RA,Simone G,Reshkin SJ,Paradiso A

    更新日期:2011-06-01 00:00:00

  • Tumour regression grade (TRG) analyses in patients with resectable gastro-oesophageal adenocarcinomas treated with platinum-based neoadjuvant chemotherapy.

    abstract:AIMS:Neoadjuvant chemotherapy followed by surgery is the standard of care for patients with gastro-oesophageal adenocarcinoma. The aims were to validate the utility of the tumour regression grade (TRG) in patients who have received chemotherapy and to investigate if (i) TRG correlates with tumour downstaging and (ii) T...


    pub_type: 杂志文章


    authors: Fareed KR,Ilyas M,Kaye PV,Soomro IN,Lobo DN,Parsons SL,Madhusudan S

    更新日期:2009-10-01 00:00:00

  • Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.

    abstract:AIMS:To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs). METHODS AND RESULTS:Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7,...


    pub_type: 杂志文章


    authors: Handra-Luca A,Fléjou JF,Rufat P,Corcos O,Belghiti J,Ruszniewski P,Degott C,Bedossa P,Couvelard A

    更新日期:2006-06-01 00:00:00

  • Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.

    abstract:AIMS:To investigate the relation of fatty acid synthase (FAS) expression to the clinicopathological characteristics of gastric cancers and gastric tumorigenesis. METHODS AND RESULTS:FAS expression was examined immunohistochemically in 626 gastric cancers, 51 gastric adenomas, and non-neoplastic epithelium contiguous w...


    pub_type: 杂志文章


    authors: Kusakabe T,Nashimoto A,Honma K,Suzuki T

    更新日期:2002-01-01 00:00:00

  • TNF/IL-1/NIK/NF-kappa B transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma).

    abstract:AIMS:Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic int...


    pub_type: 杂志文章


    authors: Nuñez C,Cansino JR,Bethencourt F,Pérez-Utrilla M,Fraile B,Martínez-Onsurbe P,Olmedilla G,Paniagua R,Royuela M

    更新日期:2008-08-01 00:00:00

  • Intestinal metaplasia subtyping: evaluation of Gomori's aldehyde fuchsin for routine diagnostic use.

    abstract:AIMS:Intestinal metaplasia (IM) has been implicated in the pathogenesis of gastro-oesophageal carcinoma, but because of its common occurrence, its specificity for use in cancer surveillance is low. IM subtypes characterized by mucin phenotype have been studied to try and improve specificity. METHODS AND RESULTS:On bal...


    pub_type: 临床试验,杂志文章


    authors: Shah KA,Deacon AJ,Dunscombe P,Price AB

    更新日期:1997-09-01 00:00:00

  • Quality aspects of the tissue microarray technique in a population-based cohort with ductal carcinoma in situ of the breast.

    abstract:AIMS:Tissue microarray (TMA) is an efficient technique for analysis of molecular markers. Prospectively collected samples have been reported to give excellent concordance between TMA data and corresponding whole-sections. The aim was to evaluate the usefulness of TMA in a population-based cohort of 213 women with ducta...


    pub_type: 杂志文章


    authors: Wärnberg F,Amini RM,Goldman M,Jirström K

    更新日期:2008-12-01 00:00:00

  • Variable fidelity of tissue-marking dyes in surgical pathology.

    abstract:AIMS:Pathology specimens often contain important margins that must be identified from gross examination of specimens through to microscopic examination. Commonly, unique colours of tissue-marking dye (TMD) are applied to each margin, which facilitates both macroscopic and microscopic identification. Various techniques ...


    pub_type: 杂志文章


    authors: Williams AS,Dakin Haché K

    更新日期:2014-05-01 00:00:00

  • Genome-wide analysis of long non-coding RNA in primary nasopharyngeal carcinoma by microarray.

    abstract:AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved...


    pub_type: 杂志文章


    authors: Yang QQ,Deng YF

    更新日期:2015-06-01 00:00:00

  • Villous adenoma of the duodenum: cellular composition and histochemical findings.

    abstract::A villous adenoma of the duodenum was studied histologically and histochemically by semi-thin sections using glycol-methacrylate as embedding medium. All the four epithelial cell types which are present in normal duodenal mucosa (absorptive columnar, goblet, Paneth, endocrine) were found in the tumour, as well as undi...


    pub_type: 杂志文章


    authors: Mingazzini PL,Malchiodi Albedi F,Blandamura V

    更新日期:1982-03-01 00:00:00

  • VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours.

    abstract:AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...


    pub_type: 杂志文章


    authors: Ramani P,Nash R,Radevsky L,Patel A,Luckett M,Rogers C

    更新日期:2012-12-01 00:00:00

  • Low grade gastric B-cell lymphoma of mucosa associated lymphoid tissue in immunocompromised patients.

    abstract::An increased incidence of non-Hodgkin's lymphoma is seen in patients with immunodeficiency from any cause. The majority of these are high grade B-cell lymphoma and most are associated with the Epstein-Barr virus (EBV). In post-transplant lymphoma/lymphoproliferative disorders the tumour may regress following reduction...


    pub_type: 杂志文章


    authors: Wotherspoon AC,Diss TC,Pan L,Singh N,Whelan J,Isaacson PG

    更新日期:1996-02-01 00:00:00

  • Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies.

    abstract:AIMS:Littoral cell angioma (LCA) is a rare primary splenic tumour that is frequently associated with internal malignancies. Immunohistochemistry can demonstrate a distinct hybrid endothelial-histiocytic phenotype of littoral cells, and is a helpful adjunct for making the correct diagnosis. The aims of this study were t...


    pub_type: 杂志文章


    authors: Peckova K,Michal M,Hadravsky L,Suster S,Damjanov I,Miesbauerova M,Kazakov DV,Vernerova Z,Michal M

    更新日期:2016-11-01 00:00:00

  • Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma.

    abstract:AIMS:The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). METHODS AND RESULTS:We examined the relationship between clinicopathological factors and ...


    pub_type: 杂志文章


    authors: Jung CW,Kong JS,Seol H,Park S,Koh JS,Lee SS,Kim MJ,Choi IJ,Myung JK

    更新日期:2017-01-01 00:00:00

  • Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease.

    abstract:AIMS:Pulmonary Langerhans cell histiocytosis (PLCH) is an idiopathic cigarette smoking-related disorder of the lung. Molecular changes in cellular or fibrotic stages of PLCH have not been investigated. We studied the prevalence of extracellular signal-regulated kinase (ERK) pathway mutations in different PLCH stages an...


    pub_type: 杂志文章


    authors: Kamionek M,Ahmadi Moghaddam P,Sakhdari A,Kovach AE,Welch M,Meng X,Dresser K,Tomaszewicz K,Cosar EF,Mark EJ,Fraire AE,Hutchinson L

    更新日期:2016-09-01 00:00:00

  • Pedunculated hepatocellular carcinoma. Is it an entity?

    abstract::Two cases of pedunculated hepatocellular carcinoma are reported. One of these was known to have been present for 5 years. Both patients are alive 1 and 2 years after surgery though the former has developed a solitary bone metastasis. The literature on 30 previously published cases is reviewed and it is concluded that,...


    pub_type: 杂志文章


    authors: Anthony PP,James K

    更新日期:1987-04-01 00:00:00

  • Rosai-Dorfman disease of the genito-urinary tract: analysis of six cases from the testis and kidney.

    abstract:AIMS:Rosai-Dorfman disease (RDD) commonly occurs in lymph nodes, but it can also affect the genitourinary (GU) system. In a search of GU RDD, we identified three cases involving the testis and three the kidney. METHODS AND RESULTS:The mean age was 52.4 (35-76) years. Tumour sizes were 3.6 cm on average (1.5-4.3) for t...


    pub_type: 杂志文章


    authors: Wang CC,Al-Hussain TO,Serrano-Olmo J,Epstein JI

    更新日期:2014-12-01 00:00:00

  • Biliary intraductal tubule-forming neoplasm: a whole exome sequencing study of MUC5AC-positive and -negative cases.

    abstract:AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...


    pub_type: 杂志文章


    authors: Akita M,Hong SM,Sung YN,Kim MJ,Ajiki T,Fukumoto T,Itoh T,Zen Y

    更新日期:2020-06-01 00:00:00

  • Morphological and molecular changes following neoadjuvant endocrine therapy of ER positive breast cancer: implications for clinical practice.

    abstract:BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...


    pub_type: 杂志文章


    authors: Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

    更新日期:2021-01-10 00:00:00