Abstract:
:The post-transplant lymphoproliferative disorders represent a spectrum of life-threatening, generally Epstein-Barr virus-associated lymphoid proliferations which occur in the setting of exogenous immunosuppression following organ transplantation. Histopathological, phenotypic, genotypic and Epstein-Barr virus studies have revealed a broad range of abnormalities. At one end of the spectrum, they are polymorphic polyclonal proliferations with many features of a florid viral infection and, at the other end, they are monomorphic and monoclonal which would fulfill the criteria for a conventional non-Hodgkin's lymphoma, usually of B-cell type. Some patients have both polyclonal and monoclonal lesions and some have two or more monoclonal populations. Finally, because of the varied appearances, different classification schemes have been developed with reported prognostic implications.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Swerdlow SHdoi
10.1111/j.1365-2559.1992.tb01007.xkeywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
373-85issue
5eissn
0309-0167issn
1365-2559journal_volume
20pub_type
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