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Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma.

Abstract：

AIMS:Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis. METHODS AND RESULTS:Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasive ductal carcinoma (IDC) samples. Staining was observed in the nucleus and cytoplasm of the carcinomas, but only nuclear staining was considered to be positive. Fibroblasts associated with IDC were also Fra-1-positive. The frequency of Fra-1 positivity in IDC (22.8%) was lower than that in DCIS (42.2%). No association was found between Fra-1 and clinico-pathological variables in DCIS. In IDC, Fra-1 expression correlated with aggressive phenotype markers, including: high grade, oestrogen receptor negativity and human epidermal growth factor receptor 2 (HER-2) positivity (P=0.001, 0.015 and 0.004, respectively), and marginally with the presence of metastasis (P=0.07). Fra-1 was more frequently positive in basal-like (34%) and in HER-2-positive (38.5%) subtypes than in luminal subtypes. Fra-1 presence did not correlate with survival. CONCLUSIONS:A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found.

journal_name

Histopathology

journal_title

Histopathology

authors

Logullo AF,Stiepcich MM,Osório CA,Nonogaki S,Pasini FS,Rocha RM,Soares FA,Brentani MM

doi

10.1111/j.1365-2559.2011.03785.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

617-25

issue

4

eissn

0309-0167

issn

1365-2559

journal_volume

58

pub_type

杂志文章

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