The role of CD5 expression in thymic carcinoma: possible mechanism for interaction with CD5+ lymphoid stroma (microenvironment).

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：AIMS:  Ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) exhibit frequent RUNX3 inactivation by promoter hypermethylation and protein mislocalization. The aim of this study was to analyse columnar cell lesions (CCLs) to further characterize RUNX3 involvement in breast carcinogenesis. METHODS AND RESU...

journal_title：Histopathology

authors： Subramaniam MM,Chan JY,Omar MF,Ito K,Ito Y,Yeoh KG,Salto-Tellez M,Putti TC

更新日期：2010-10-01 00:00:00

abstract：AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

journal_title：Histopathology

authors： Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

更新日期：2015-01-01 00:00:00

abstract：AIMS:Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non-tumour tissue. METHODS AND RESULTS:I...

journal_title：Histopathology

authors： Chau GY,Lee AF,Tsay SH,Ke YR,Kao HL,Wong FH,Tsou AP,Chau YP

更新日期：2007-08-01 00:00:00

abstract：:The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, ...

journal_title：Histopathology

authors： Shanks JH,Srigley JR,Brimo F,Comperat E,Delahunt B,Koch M,Lopez-Beltran A,Reuter VE,Samaratunga H,Tsuzuki T,van der Kwast T,Varma M,Grignon D

更新日期：2019-10-01 00:00:00

abstract：AIMS:To study three atypical glioneuronal tumours (GNTs), in order to shed light on the clinical and pathological features of this diverse tumour group. METHODS AND RESULTS:Clinical and neuropathological data for each case were retrospectively reviewed. Case 1 involved a 17-year-old boy with left leg movement difficul...

journal_title：Histopathology

authors： Chen SY,Wang W,Wang LM,Lin QT,Zhao GG,Xu G,Lu DH,Piao YS

更新日期：2016-02-01 00:00:00

abstract：AIM:Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in ...

journal_title：Histopathology

authors： Lin CK,Tsai WC,Lin YC,Hueng DY

更新日期：2012-01-01 00:00:00

abstract：AIM:To assess a new HER2 fluorescence in situ hybridization (FISH) test and report on multicentre intrasite and intersite variation. METHODS AND RESULTS:HER2 results were scored from 45 breast cancers in eight laboratories using the Kreatech Poseidon HER2 FISH probe (Kreatech Diagnostics, Amsterdam, the Netherlands). ...

journal_title：Histopathology

authors： Bartlett JM,Campbell FM,Ibrahim M,Thomas J,Wencyk P,Ellis I,Kay E,Connolly Y,O'Grady A,Barnett S,Starczynski J,Cunningham P,Miller K

更新日期：2010-02-01 00:00:00

abstract：:We reviewed 45 pulmonary B-cell non-Hodgkin's lymphomas to determine whether their morphology and immunohistochemical features were those of lymphomas arising from mucosa-associated lymphoid tissue (MALT), as described in other sites. The polymerase chain reaction was used to provide further information on clonality. ...

journal_title：Histopathology

authors： Nicholson AG,Wotherspoon AC,Diss TC,Butcher DN,Sheppard MN,Isaacson PG,Corrin B

更新日期：1995-05-01 00:00:00

abstract：:Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method...

journal_title：Histopathology

authors： Tomita T,Millard DM

更新日期：1992-11-01 00:00:00

abstract：AIMS:To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas. METHODS AND RESULTS:A total of 57 carcinomas and respective gastric tissues were inc...

journal_title：Histopathology

authors： Lacueva J,Perez-Ramos M,Soto JL,Oliver I,Andrada E,Medrano J,Perez-Vazquez T,Arroyo A,Carrato A,Ferragut JA,Calpena R

更新日期：2005-04-01 00:00:00

abstract：:Occasional biopsies of genital lesions due to chancroid, secondary syphilis (the condyloma latum) and granuloma inguinale are encountered in routine histopathological practice. These lesions have specific microscopical appearances enabling a confident, or at least a presumptive, diagnosis to be made in most cases, yet...

journal_title：Histopathology

authors： Freinkel AL

更新日期：1987-08-01 00:00:00

abstract：AIMS:Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harbouring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS:We performed next-generation sequenc...

journal_title：Histopathology

authors： Cho H,Hashimoto T,Yoshida H,Taniguchi H,Ogawa R,Mori T,Hiraoka N,Saito Y,Sekine S

更新日期：2018-10-01 00:00:00

abstract：:This study evaluates the usefulness of a combined cytological and histological approach to the diagnosis of hepatocellular carcinoma (HCC) when applied to fine needle biopsy specimens obtained under ultrasonic guidance. The material, aspirated from 51 focal liver lesions, was handled in such a way that there was suffi...

journal_title：Histopathology

authors： Zainol H,Sumithran E

更新日期：1993-06-01 00:00:00

abstract：AIMS:Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biolo...

journal_title：Histopathology

authors： Rajpert-De Meyts E,Jacobsen GK,Bartkova J,Aubry F,Samson M,Bartek J,Skakkebaek NE

更新日期：2003-03-01 00:00:00

abstract：:The published literature is awash with examples of new tissue biomarkers promising to predict responses to therapy in breast cancer patients. However, few, if any, of these progress from the laboratory to the clinic. In this review we discuss some of the reasons for this, illustrating our discussion with a selection o...

journal_title：Histopathology

authors： Faratian D,Bartlett J

更新日期：2008-01-01 00:00:00

abstract：AIMS:Clear cell chondrosarcomas are known to occasionally contain areas of low-grade conventional chondrosarcoma; however, the opposite phenomenon has not yet been described. We identified five cases of conventional chondrosarcoma alongside clear cell chondrosarcoma. Here, we report on their clinicopathological and mol...

journal_title：Histopathology

authors： Lam SW,van Langevelde K,Suurmeijer AJH,Cleven AHG,Bovée JVMG

更新日期：2019-12-01 00:00:00

abstract：:We studied kidney sections from 15 cases of polyarteritis using an immunocytochemical technique to demonstrate cells containing immunoreactive renin. Ten cases of classical polyarteritis nodosa showed hyperplasia of renin-containing cells in areas of renal cortex with histological evidence of ischaemia--appearances in...

journal_title：Histopathology

authors： Graham PC,Lindop GB

更新日期：1990-04-01 00:00:00

abstract：AIMS:To validate the use of the silver-enhanced in situ hybridization (SISH) technique in assessing HER2 status of breast carcinoma in excision biopsy specimens, and to assess its reliability in determining HER2 status in core biopsy specimens. METHODS AND RESULTS:Routinely processed paraffin sections of 65 excised br...

journal_title：Histopathology

authors： Shousha S,Peston D,Amo-Takyi B,Morgan M,Jasani B

更新日期：2009-01-01 00:00:00

abstract：AIMS:The third edition of the World Health Organization (WHO) classification of lung tumours has been published and is expected to become the standard nomenclature. The aim of this study was to assess the usability and prognostic significance of the WHO classification in comparison with other recent classifications. M...

journal_title：Histopathology

authors： Aida S,Shimazaki H,Sato K,Sato M,Deguchi H,Ozeki Y,Tamai S

更新日期：2004-11-01 00:00:00

abstract：:Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon n...

journal_title：Histopathology

authors： Delahunt B,Eble JN,Egevad L,Samaratunga H

更新日期：2019-01-01 00:00:00

abstract：AIMS:To examine the immunohistochemical expression of helicase-like transcription factor (HLTF) in relation to the prognosis of hypopharyngeal (HSCCs) and laryngeal (LSCCs) squamous cell carcinomas, and to characterize the HLTF protein variants expressed in biopsy specimens of head and neck squamous cell carcinoma (HNS...

journal_title：Histopathology

authors： Capouillez A,Debauve G,Decaestecker C,Filleul O,Chevalier D,Mortuaire G,Coppée F,Leroy X,Belayew A,Saussez S

更新日期：2009-07-01 00:00:00

abstract：AIMS:Glutamate receptor antagonists have failed clinical stroke trials and it has been proposed that the action of N-methyl D-aspartate receptors is necessary for neuronal survival. Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial e...

journal_title：Histopathology

authors： Beschorner R,Simon P,Schauer N,Mittelbronn M,Schluesener HJ,Trautmann K,Dietz K,Meyermann R

更新日期：2007-06-01 00:00:00

abstract：:Fifteen hamartomas of the breast have been studied by dissecting microscopy of thick sections at a depth of 1.0 to 2.5 mm, and by conventional 5 microns deep sections. This combined approach has revealed six distinctive features, three in the parenchymal structure and three in the connective tissue components. Ducts (...

journal_title：Histopathology

authors： Davies JD,Kulka J,Mumford AD,Armstrong JS,Wells CA

更新日期：1994-02-01 00:00:00

abstract：:Fifteen cases of non-Hodgkin's lymphoma of the anterior mediastinum are reported. In the first group of four, fresh tissue was available and immunohistochemical studies demonstrated their B-cell origin, with monotypic immunoglobulin production in two. Only fixed tissue was available in the second group of 11 patients....

journal_title：Histopathology

authors： Addis BJ,Isaacson PG

更新日期：1986-04-01 00:00:00

abstract：:We have investigated the immunohistochemical expression of p53 protein in 96 cases of non-Hodgkin's lymphoma using a panel of five antibodies. Positive neoplastic cells were found in 30 (31.2%) cases, which could be divided into two groups according to their patterns of reactivity with the different antibodies; i.e. t...

journal_title：Histopathology

authors： Pezzella F,Morrison H,Jones M,Gatter KC,Lane D,Harris AL,Mason DY

更新日期：1993-01-01 00:00:00

abstract：AIMS:To analyse the possible activation of distinct molecular pathways in mucosa-associated lymphoid tissue (MALT) lymphoma, we determined the prevalence of trisomies 3, 12, 18 in MALT lymphomas from different organs, as well as the prevalence of translocations of the MALT1 gene in a subset of primary breast MALT lymph...

journal_title：Histopathology

authors： João C,Farinha P,da Silva MG,Martins C,Crespo M,Cabeçadas J

更新日期：2007-01-01 00:00:00

abstract：AIMS:Previous karyotyping and fluorescence in situ hybridization analysis of metanephric adenomas (MAs) has yielded controversial data. The aim of this study was to detect small genomic alterations, if any, specific to MAs by applying high-resolution oligoarrays. METHODS AND RESULTS:DNA extracted from paraffin blocks ...

journal_title：Histopathology

authors： Szponar A,Yusenko MV,Kovacs G

更新日期：2010-01-01 00:00:00

abstract：AIMS:Focal nodular hyperplasia-like lesions have rarely been described in cirrhotic livers. We describe five cases of such lesions. METHODS AND RESULTS:Between 1998 and 2001, 146 liver transplants were performed at the Royal Free Hospital for cirrhosis of the liver. Nodular lesions identified in the livers removed at ...

journal_title：Histopathology

authors： Quaglia A,Tibballs J,Grasso A,Prasad N,Nozza P,Davies SE,Burroughs AK,Watkinson A,Dhillon AP

更新日期：2003-01-01 00:00:00

abstract：:A review of 1818 patients with cutaneous malignant melanoma revealed that for both patients with localized disease (clinical stage I) and those with regional lymph node metastases at first presentation (clinical stage II), ulceration of the primary lesion was a poor prognostic sign. Although ulcerated lesions tended t...

journal_title：Histopathology

authors： McGovern VJ,Shaw HM,Milton GW,McCarthy WH

更新日期：1982-07-01 00:00:00