Ulceration and prognosis in cutaneous malignant melanoma.

abstract：AIMS:SOX11 is known as an essential transcription factor for regulating neurogenesis. Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL). However, SOX11 expression in other tumour types has not yet been extensively studied. METH...

journal_title：Histopathology

authors： Xu S,Dong Y,Huo Z,Yu L,Xue J,Wang G,Duan Y

更新日期：2019-02-01 00:00:00

abstract：AIMS:Different methods to substage extraprostatic extension (EPE) were correlated with biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS AND RESULTS:  A total of 157 consecutive RP specimens with EPE were completely embedded. Twenty-three patients with adjuvant therapy or detectable postoperative ...

journal_title：Histopathology

authors： van Veggel BA,van Oort IM,Witjes JA,Kiemeney LA,Hulsbergen-van de Kaa CA

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma c...

journal_title：Histopathology

authors： Morris HB,Mason DY,Stein H,Lennert K

更新日期：1983-11-01 00:00:00

abstract：AIMS:Primary sclerosing cholangitis (PSC) is characterized histologically by portal inflammation, bile duct injury and regeneration and concentric periductal fibrosis. Although seen commonly in our experience, the significance of histological thickening of the bile duct basement membrane on periodic acid Schiff (PAS)-p...

journal_title：Histopathology

authors： Colling R,Verrill C,Fryer E,Kartsonaki C,Wang LM,Chapman R,Rajabally N,Fleming K

更新日期：2016-05-01 00:00:00

abstract：:Elastosis, a previously unreported feature, was found to be common in granular cell tumours. Twenty-four of 28 consecutive granular cell tumours were shown to display elastosis. The elastosis was found in three main sites: adventitial, interstitial and septal. Elastosis is statistically associated with the fibrosis pr...

journal_title：Histopathology

authors： McMahon JN,Rigby HS,Davies JD

更新日期：1990-01-01 00:00:00

abstract：:We have reviewed 60 liver specimens from 47 patients with the diagnosis of incomplete septal cirrhosis observed between 1968 and 1987. In reaching this diagnosis evaluation of the following histological features appeared to be helpful: parenchymal nodularity, thin incomplete septa, hypoplastic portal tracts, increased...

journal_title：Histopathology

authors： Sciot R,Staessen D,Van Damme B,Van Steenbergen W,Fevery J,De Groote J,Desmet VJ

更新日期：1988-12-01 00:00:00

abstract：AIMS:The aim of this study was to examine clinicopathological features of patients with core biopsy diagnoses of ductal carcinoma in situ (DCIS) that may predict invasion on subsequent excision, as upstaging has significant implications regarding the need for axillary staging via sentinel lymph node biopsy (SLNB). MET...

journal_title：Histopathology

authors： Walters LL,Pang JC,Zhao L,Jorns JM

更新日期：2015-03-01 00:00:00

abstract：AIMS:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive haematological malignancy derived from plasmacytoid dendritic cell precursors. Almost all patients show cutaneous manifestations, and >60% show bone marrow (BM) involvement at initial presentation. In cases where there is BM involvement ...

journal_title：Histopathology

authors： Hwang K,Park CJ,Jang S,Chi HS,Huh JR,Lee JH,Suh C,Lee KH

更新日期：2013-04-01 00:00:00

abstract：:We report three cases of an unusual primary carcinoma of the liver composed of small cells. The patients were adult males (56 to 89 years) who presented with jaundice, weight loss and abdominal discomfort. Surgery was attempted in one case. Clinical evolution was rapid, with death ensuing between 1 and 5 months after ...

journal_title：Histopathology

authors： Zanconati F,Falconieri G,Lamovec J,Zidar A

更新日期：1996-11-01 00:00:00

abstract：AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...

journal_title：Histopathology

authors： Noske A,Ammann JU,Wagner DC,Denkert C,Lebeau A,Sinn P,Kreipe HH,Sommer U,Baretton G,Steiger K,Kiechle M,Hieke-Schulz S,Flores M,Roth W,Weichert W

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...

journal_title：Histopathology

authors： Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

更新日期：2021-01-10 00:00:00

abstract：AIMS:To determine the expression of matrix metalloproteinases (MMPs)-2, -7 and -9 and beta-catenin in uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) and to investigate any difference in expression between EEC and USC which might explain the mechanism of invasion and aggressive behaviour of ...

journal_title：Histopathology

authors： Monaghan H,MacWhinnie N,Williams AR

更新日期：2007-02-01 00:00:00

abstract：:Six cases of polymorphous low-grade adenocarcinoma (terminal duct adenocarcinoma) of the minor salivary glands are presented. In all but one there was a history of a painless intra-oral mass of fairly long duration. The histopathological appearances were characterized by cytological uniformity in a variety of morpholo...

journal_title：Histopathology

authors： Simpson RH,Clarke TJ,Sarsfield PT,Gluckman PG,Babajews AV

更新日期：1991-08-01 00:00:00

abstract：AIMS:To investigate the prognostic significance of chromosomal alterations in colorectal cancer patients. Histopathological tumour classification is still considered to be the gold standard for the characterization of solid tumours. However, it is well known that such established parameters do not satisfactorily predic...

journal_title：Histopathology

authors： Knösel T,Schlüns K,Stein U,Schwabe H,Schlag PM,Dietel M,Petersen I

更新日期：2003-10-01 00:00:00

abstract：AIM:To assess a new HER2 fluorescence in situ hybridization (FISH) test and report on multicentre intrasite and intersite variation. METHODS AND RESULTS:HER2 results were scored from 45 breast cancers in eight laboratories using the Kreatech Poseidon HER2 FISH probe (Kreatech Diagnostics, Amsterdam, the Netherlands). ...

journal_title：Histopathology

authors： Bartlett JM,Campbell FM,Ibrahim M,Thomas J,Wencyk P,Ellis I,Kay E,Connolly Y,O'Grady A,Barnett S,Starczynski J,Cunningham P,Miller K

更新日期：2010-02-01 00:00:00

abstract：AIMS:Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. This study assessed the accuracy of punch biopsy 'scori...

journal_title：Histopathology

authors： Grogan J,Cooper CL,Dodds TJ,Guitera P,Menzies SW,Scolyer RA

更新日期：2018-01-01 00:00:00

abstract：:Problems in the interpretation and diagnosis of intraepithelial lesions of the uterine cervix include interobserver differences in respect of grading, uncertainty as to the significance of human papillomavirus infection and debate about the current terminology. The role of human papillomaviruses in cervical intra-epit...

journal_title：Histopathology

authors： Fox H,Buckley CH

更新日期：1990-07-01 00:00:00

abstract：AIMS:Telomerase is reactivated in most cancers and there is accumulating evidence that this is a driver event in malignant melanoma (MM). Thus, our aim was to evaluate if in-situ hybridization (ISH)-based quantification of telomerase RNA (hTR) could be used to distinguish MM from naevi, and if there was a correlation w...

journal_title：Histopathology

authors： Vagner J,Steiniche T,Stougaard M

更新日期：2015-04-01 00:00:00

abstract：AIM:Clear cell chondrosarcoma (CCC) is a rare malignant cartilaginous neoplasm of bone. CCC is characterized by clear cells (CCC cells), osteoclasts and osteoblasts. Many important questions concerning the varied histological features of CCC, and the interactions between CCC cells and coexisting osteoclasts and osteobl...

journal_title：Histopathology

authors： Masui F,Ushigome S,Fujii K

更新日期：1999-05-01 00:00:00

abstract：AIMS:Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate efflux in glycolytic tumours. However, their role in solid tumours is still poorly understood. Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in...

journal_title：Histopathology

authors： Pinheiro C,Albergaria A,Paredes J,Sousa B,Dufloth R,Vieira D,Schmitt F,Baltazar F

更新日期：2010-06-01 00:00:00

abstract：AIMS:Orientation and digital analysis of the biliary remnants in the resected porta hepatis in infants with biliary atresia. METHODS AND RESULTS:Samples were orientated intra-operatively then stained with haematoxylin and eosin and immunostained for cytokeratin 7 (CK7). Sections were then digitized and analysed. Most ...

journal_title：Histopathology

authors： Shalaby A,Hajhosseiny R,Zen Y,Davenport M,Quaglia A

更新日期：2016-12-01 00:00:00

abstract：AIMS:The available evidence indicates that most non-uterine high-grade serous carcinomas (HGSCs) arise from the fallopian tube (FT), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment. METHODS...

journal_title：Histopathology

authors： Singh N,Gilks CB,Wilkinson N,McCluggage WG

更新日期：2015-09-01 00:00:00

abstract：:Two cases of tubulovillous adenoma and adjacent colonic mucosa were studied in which intestinal spirochaetosis had heavily colonized the non-neoplastic but not the neoplastic epithelium. Ultrastructural and histochemical studies were performed and we postulate that the reason for this disparity is the normal microvill...

journal_title：Histopathology

authors： Coyne JD,Curry A,Purnell P,Haboubi NY

更新日期：1995-10-01 00:00:00

abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...

journal_title：Histopathology

authors： Capella C,Frigerio B,Cornaggia M,Solcia E,Pinzon-Trujillo Y,Chejfec G

更新日期：1984-09-01 00:00:00

abstract：AIMS:In this study, we aimed to investigate the clinicopathological features of CD4+ and/or CD56+ immature haematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN). METHODS AND RESULTS:We analysed the clinicopathological features of 46 patients diagnosed consecutively with CD4+...

journal_title：Histopathology

authors： Suzuki Y,Kato S,Kohno K,Satou A,Eladl AE,Asano N,Kono M,Kato Y,Taniwaki M,Akiyama M,Nakamura S

更新日期：2017-12-01 00:00:00

abstract：AIMS:Secretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low-grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, i...

journal_title：Histopathology

authors： Taverna C,Baněčková M,Lorenzon M,Palomba A,Franchi A,Skalova A,Agaimy A

更新日期：2020-09-15 00:00:00

abstract：:The light microscopical appearance of the normal parathyroid gland based on an autopsy study of 138 glands from 38 adults without evidence of hyperparathyroidism, is described. It differs from earlier descriptions in that we found less adipose tissue in the glands of many normal adults than had been reported. This obs...

journal_title：Histopathology

authors： Saffos RO,Rhatigan RM,Urgulu S

更新日期：1984-05-01 00:00:00

abstract：:A rapidly fatal bladder tumour which had the features of a rhabdoid tumour was studied by sequential biopsies and at autopsy. This is the first rhabdoid tumour recorded at this site and the first in which there was co-existent transitional cell carcinoma. The possibility that rhabdoid tumour is histogenetically hetero...

journal_title：Histopathology

authors： Harris M,Eyden BP,Joglekar VM

更新日期：1987-10-01 00:00:00

abstract：AIMS:Progressive changes have been reported in lymph nodes in HIV infection, but few accounts describe altered splenic histology at different stages of the disease. Investigation of splenic changes accompanying the progressive CD4+ T-cell depletion that occurs in HIV infection could shed light on normal immunological i...

journal_title：Histopathology

authors： Wilkins BS,Davis Z,Lucas SB,Delsol G,Jones DB

更新日期：2003-02-01 00:00:00

abstract：AIMS:Regional differences in proliferative activity are commonly seen within breast cancers, but little is known on the extent of intratumoral heterogeneity of Ki67 expression. Our aim was to study the intratumoral heterogeneity of Ki67 expression in early breast cancers and its association with clinicopathological fea...

journal_title：Histopathology

authors： Focke CM,Decker T,van Diest PJ

更新日期：2016-11-01 00:00:00