Abstract:
:Adhesion molecules are considered to have an important role in inflammatory reactions. We investigated the kinetics of ICAM-1 expression on keratinocytes and correlated this with the numbers of lymphocytes expressing LFA-1 in the dermis and epidermis of evolving allergic contact dermatitis reactions. In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Garioch JJ,Mackie RM,Campbell I,Forsyth Adoi
10.1111/j.1365-2559.1991.tb00050.xsubject
Has Abstractpub_date
1991-10-01 00:00:00pages
351-4issue
4eissn
0309-0167issn
1365-2559journal_volume
19pub_type
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