Keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA-1) positive cells in evolving allergic contact dermatitis reactions.

Abstract:

:Adhesion molecules are considered to have an important role in inflammatory reactions. We investigated the kinetics of ICAM-1 expression on keratinocytes and correlated this with the numbers of lymphocytes expressing LFA-1 in the dermis and epidermis of evolving allergic contact dermatitis reactions. In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules.

journal_name

Histopathology

journal_title

Histopathology

authors

Garioch JJ,Mackie RM,Campbell I,Forsyth A

doi

10.1111/j.1365-2559.1991.tb00050.x

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

351-4

issue

4

eissn

0309-0167

issn

1365-2559

journal_volume

19

pub_type

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