Abstract:
AIMS:Tyrosine kinase receptors Her2/neu and c-Met play an important role in breast cancer development and progression. Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by two different immunocytochemical techniques, classical immunohistochemistry and immunofluorescence, and to correlate their expression levels with histopathological and clinical characteristics. METHODS AND RESULTS:Both methods revealed similar c-Met staining patterns in both the in situ component and the adjacent normal tissue (P < 0.001). However, an imbalance in c-Met expression between tumour and surrounding normal tissue was correlated with high-grade DCIS (Van Nuys Grade 3). No correlation existed between Her2/neu and c-Met expression. High HGF/SF immunoreactivity was observed in 43.6% of the cases, yet the adjacent cellular stroma revealed only low levels of HGF/SF. No correlation existed between c-Met, Her2/neu or HGF/SF expression and clinicopathological factors. CONCLUSION:An imbalance in c-Met expression between tumour and surrounding normal tissue is associated with an aggressive DCIS phenotype. Moreover, c-Met and HGF/SF may contribute to tumour development by different means than those controlled by Her2/neu.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Lindemann K,Resau J,Nährig J,Kort E,Leeser B,Annecke K,Welk A,Schäfer J,Vande Woude GF,Lengyel E,Harbeck Ndoi
10.1111/j.1365-2559.2007.02732.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
54-62issue
1eissn
0309-0167issn
1365-2559pii
HIS2732journal_volume
51pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates in a subset of patients suggest that a sensitive companion diagnostic test is required. The predictive value of programmed death ligand 1 (PD-L1) staining in melanoma has been questioned due to inconsist...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13528
更新日期:2018-09-01 00:00:00
abstract::Intra-abdominal panniculitis is a tumour-like inflammatory condition of adipose tissue. The aetiology and pathogenesis of the disease is unknown, but a number of associated diseases have been recorded. It has been customary to deal with only primary cases in the literature. This study was undertaken in order to descri...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-486.x
更新日期:1996-07-01 00:00:00
abstract:AIM:To determine the extent of clonal outgrowth in the lymphocytic tissue infiltrate of lichen sclerosus (LS). The presence of T cells with a monoclonally rearranged T-cell receptor gamma-gene (TCRgamma) has been described in up to 50% of biopsies of vulvar and penile LS. MATERIAL AND RESULTS:We analysed 33 foreskin s...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02406.x
更新日期:2006-05-01 00:00:00
abstract:AIMS:To examine how accurately immunohistochemical markers discriminate between pancreatobiliary and intestinal-type adenocarcinomas in the pancreatic head and to explore the prognostic importance of these markers among each of these histological types. METHODS AND RESULTS:Histopathological features of 114 consecutive...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03227.x
更新日期:2009-02-01 00:00:00
abstract:AIMS:Although delayed hypopituitarism is a common complication of conventional radiotherapy of sellar tumours, histological changes that may account for it have been rarely reported. To elucidate the changes, hypofunctional pituitary glands following irradiation were studied. METHODS AND RESULTS:Two pituitary glands o...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2001.01132.x
更新日期:2001-06-01 00:00:00
abstract:AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12314
更新日期:2014-04-01 00:00:00
abstract:AIMS:Orientation and digital analysis of the biliary remnants in the resected porta hepatis in infants with biliary atresia. METHODS AND RESULTS:Samples were orientated intra-operatively then stained with haematoxylin and eosin and immunostained for cytokeratin 7 (CK7). Sections were then digitized and analysed. Most ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13028
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS-CoV-2 infection. METHODS:Cytologic findings in cases under investigation of SARS-CoV-2 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSC...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14257
更新日期:2020-09-24 00:00:00
abstract::We report an unusual and possibly unique example of cerebral ganglioglioma with an anaplastic oligodendroglial component. The latter was documented on both morphological and immunohistochemical grounds. Immunohistochemically, the anaplastic cells were strongly positive with the monoclonal antibody anti-Leu-7, while th...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb00765.x
更新日期:1990-11-01 00:00:00
abstract::A large variety of lymphoma types may develop as primary intestinal neoplasms in the small intestines or, less often, in the colorectum. Among these are a few entities such as enteropathy-associated T-cell lymphoma or immunoproliferative small intestinal disease that, essentially, do not arise elsewhere than in the ga...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12596
更新日期:2015-01-01 00:00:00
abstract:AIMS:Central neurocytoma is a rare central nervous system tumour typically found in the lateral ventricles and at the septum pellucidum. Histologically, it resembles oligodendrogliomas and yet ultrastructurally, it shows neuronal differentiation. Its molecular oncogenesis is not known. The aim of this study was to exam...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00977.x
更新日期:2000-08-01 00:00:00
abstract::The published literature is awash with examples of new tissue biomarkers promising to predict responses to therapy in breast cancer patients. However, few, if any, of these progress from the laboratory to the clinic. In this review we discuss some of the reasons for this, illustrating our discussion with a selection o...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2007.02896.x
更新日期:2008-01-01 00:00:00
abstract:AIMS:Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationsh...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12132
更新日期:2013-06-01 00:00:00
abstract:AIMS:We report a series of five unusual subcutaneous lipomas characterized by prominent stromal sclerosis in a storiform arrangement. METHODS AND RESULTS:All lesions occurred in young male adults (23.0 +/- 9.5 years), three lesions were on the scalp and two on the hands. Clinically, lipoma, chondroma or some form of c...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2310836.x
更新日期:1997-08-01 00:00:00
abstract:AIM:Clear cell chondrosarcoma (CCC) is a rare malignant cartilaginous neoplasm of bone. CCC is characterized by clear cells (CCC cells), osteoclasts and osteoblasts. Many important questions concerning the varied histological features of CCC, and the interactions between CCC cells and coexisting osteoclasts and osteobl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00656.x
更新日期:1999-05-01 00:00:00
abstract:AIMS:The diagnosis of epithelioid haemangioendothelioma (EHE) is usually straightforward, based on characteristic histological features. However, it is sometimes difficult to differentiate EHE from a variety of other tumours with epithelioid morphology. The WW domain-containing transcription regulator 1-calmodulin-bind...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12713
更新日期:2015-12-01 00:00:00
abstract:AIMS:To investigate the expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors and decoy receptors, including osteoprotegerin (OPG) in infantile haemangioma (IH). METHODS AND RESULTS:Immunostaining, Western blotting and quantitative reverse transcription-polymerase chain react...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.03970.x
更新日期:2011-09-01 00:00:00
abstract:AIMS:Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia-associated transcription factor family on chromosome Xp11.2. Dual-colour break-apart fluorescence in-situ hybridisation (FISH) is recommended to confir...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13866
更新日期:2019-08-01 00:00:00
abstract:AIMS:Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to ass...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2003.01644.x
更新日期:2003-07-01 00:00:00
abstract:AIMS:MYC is a proto-oncogene that is frequently dysregulated in various malignancies, through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification, and immunohistochemical expression has been shown to be a reliable surrogate marker for amplification, but less is known abo...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14168
更新日期:2020-10-01 00:00:00
abstract::In view of the critical role of dendritic cells in immune mediated skin diseases, we have investigated the membrane antigen patterns and ultrastructure of cutaneous dendritic cells in eight patients with chronic discoid lupus erythematosus and five with subacute cutaneous lupus erythematosus. In the lesional epidermis...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00531.x
更新日期:1994-04-01 00:00:00
abstract:AIMS:Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histological appearances. Not uncommonly, there is discrepancy between the clinicoradiological diagnosis and histology. Therefore, we sought to characterise the histological features of tissue submitted as 'synovial cysts'...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13465
更新日期:2018-05-01 00:00:00
abstract::Neuroendocrine neoplasms (NENs) of the gastrointestinal tract (GIT) comprise neuroendocrine tumours (NETs) and neuroendocrine carcinomas (NECs). During the last decade the classification and grading of GIT NENs has undergone significant changes, culminating in the World Health Organisation (WHO) 2019 classification. T...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14172
更新日期:2021-01-01 00:00:00
abstract:AIMS:To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme. METHODS AND RESULTS:Twelve benign polyps representative of BCS cases were identified from pathology files and reported by 28 BCS histopathologists ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12110
更新日期:2013-05-01 00:00:00
abstract:AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14103
更新日期:2020-06-01 00:00:00
abstract:AIMS:The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). METHODS AND RESULTS:We examined the relationship between clinicopathological factors and ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13065
更新日期:2017-01-01 00:00:00
abstract::Waldeyer ring lymphomas belong to a category of tumours which has not yet been fully defined. Their relation to mucosa-associated lymphoid tissue (MALT) and other extranodal lymphomas remains largely unknown. We performed a clinicopathological retrospective study of 79 patients, and compared them with a series of MALT...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01266.x
更新日期:1994-01-01 00:00:00
abstract::A villous adenoma of the duodenum was studied histologically and histochemically by semi-thin sections using glycol-methacrylate as embedding medium. All the four epithelial cell types which are present in normal duodenal mucosa (absorptive columnar, goblet, Paneth, endocrine) were found in the tumour, as well as undi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1982.tb02718.x
更新日期:1982-03-01 00:00:00
abstract::Thirty-two cases of mucoepidermoid carcinoma of the salivary glands were studied in order to characterize the expression of simple mucin-type carbohydrate antigens T, Tn and sialosyl-Tn and to evaluate its implication for tumour histogenesis. Monoclonal antibodies of known specificity were used on formalin-fixed, para...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01372.x
更新日期:1994-12-01 00:00:00
abstract:AIMS:To discern the differences in expression profiling of two histological subtypes of colorectal carcinoma (CRC) arising from the serrated route (serrated adenocarcinoma (SAC) and CRC showing histological and molecular features of a high level of microsatellite instability (hmMSI-H) both sharing common features (fema...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13889
更新日期:2019-10-01 00:00:00