Prevalence of follicular lymphoma in situ in consecutively analysed reactive lymph nodes.

Abstract:

AIMS:Follicular lymphoma (FL) in situ is defined as strongly bcl-2-positive B cells in germinal centres of morphologically inconspicuous lymph nodes. The prevalence and biological and clinical significance of this lesion are still not clear. Therefore we aimed at the detection of the prevalence of this phenomenon in an unselected series of lymph nodes, as a surrogate for the normal population. METHODS AND RESULTS:All 1294 reactive lymph nodes from unselected consecutive surgical specimens of 132 patients in a 3-month period were stained for bcl-2 protein. The t(14;18) translocation was investigated by fluorescence in-situ hybridization (FISH) analysis. FL in situ was identified in 22 lymph nodes in 3/132 patients (2.3%) without evidence or history of malignant lymphoma, and confirmed by detection of the t(14;18) translocation by FISH. Interestingly, in one patient, a lymph node excised 2 years before also contained FL in situ. CONCLUSIONS:We found a prevalence of 2.3% for FL in situ lesions in an unselected series of lymph nodes, as a surrogate for the normal population. Taking into account the incidence of manifest FL, the risk of progression of this lesion is probably limited. It can be speculated that some FL in situ lesions do indeed represent an early step in lymphomagenesis, whereas others persist without further progression to overt FL. The underlying mechanisms, however, remain to be elucidated.

journal_name

Histopathology

journal_title

Histopathology

authors

Henopp T,Quintanilla-Martínez L,Fend F,Adam P

doi

10.1111/j.1365-2559.2011.03897.x

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

139-42

issue

1

eissn

0309-0167

issn

1365-2559

journal_volume

59

pub_type

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