Histological grading based on poorly differentiated clusters is predictive of tumour response and clinical outcome in rectal carcinoma treated with neoadjuvant chemoradiotherapy.

abstract：:Prolongation of ovarian epithelial cancer survival depends on early detection or improved responses to chemotherapy. Gains in either have been modest at best. Understanding the diverse pathogenesis of this disease is critical to early intervention or prevention. This review addresses six important variables, including...

journal_title：Histopathology

authors： Jarboe EA,Folkins AK,Drapkin R,Ince TA,Agoston ES,Crum CP

更新日期：2008-08-01 00:00:00

abstract：:Wilms' tumour (nephroblastoma) has been associated with chromosomal abnormalities at the 11p13, 11p15 and 16q regions. A study into the possibility of mutations occurring within p53, the ubiquitous adult tumour suppressor gene, in Wilms' tumour was carried out. Thirty-eight cases were studied. Of these 36 were categor...

journal_title：Histopathology

authors： Cheah PL,Looi LM,Chan LL

更新日期：1996-01-01 00:00:00

abstract：AIM:Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, functioning as a global genome organizer. This study aims to investigate the expression pattern and the prognostic value of SATB1 in colorectal cancer. METHODS AND RESULTS:Prospectively collected da...

journal_title：Histopathology

authors： Al-Sohaily S,Henderson C,Selinger C,Pangon L,Segelov E,Kohonen-Corish MR,Warusavitarne J

更新日期：2014-08-01 00:00:00

abstract：:The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type...

journal_title：Histopathology

authors： Quincey C,Raitt N,Bell J,Ellis IO

更新日期：1991-07-01 00:00:00

abstract：:Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, in...

journal_title：Histopathology

authors： Wood KM,Cadogan MD,Ramshaw AL,Parums DV

更新日期：1993-05-01 00:00:00

abstract：AIMS:Segmental atrophy (SA) of the liver is a recently described pseudotumour that can show a broad spectrum of histological changes. The previously described histological differential diagnosis of SA has included cystic disease of the liver, amyloid, cancer-associated elastosis, and epithelioid haemangioendothelioma. ...

journal_title：Histopathology

authors： Findeis-Hosey JJ,Zhou Z,Gonzalez RS

更新日期：2019-12-01 00:00:00

abstract：AIMS:Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic int...

journal_title：Histopathology

authors： Nuñez C,Cansino JR,Bethencourt F,Pérez-Utrilla M,Fraile B,Martínez-Onsurbe P,Olmedilla G,Paniagua R,Royuela M

更新日期：2008-08-01 00:00:00

abstract：:The introduction of fast and robust whole slide scanners has facilitated the implementation of 'digital pathology' with various uses, the final challenge being full digital diagnostics. In this article, we describe the implementation process of a fully digital workflow for primary diagnostics in 2015 at the University...

journal_title：Histopathology

authors： Stathonikos N,Nguyen TQ,Spoto CP,Verdaasdonk MAM,van Diest PJ

更新日期：2019-11-01 00:00:00

abstract：AIMS:To investigate platelet-derived growth factor receptor (PDGFR)alpha and PDGFRbeta expression and a mutational analysis of PDGFRalpha (exons 11, 12, 17 and 18) and PDGFRbeta (exon 12) genes in endometrial stromal sarcomas (ESS). Gastrointestinal stromal tumours (GISTs), which have somatic mutations of the transmemb...

journal_title：Histopathology

authors： Liegl B,Gülly C,Reich O,Nogales FF,Beham A,Regauer S

更新日期：2007-03-01 00:00:00

abstract：AIMS:The clinical significance of common histological parameters in acute interstitial nephritis (AIN) is uncertain. We aimed to evaluate the utility of histology in predicting clinical outcomes in patients with AIN. METHODS AND RESULTS:Adult renal biopsies yielding a diagnosis of AIN between 2000 and 2015 were re-exa...

journal_title：Histopathology

authors： Rankin AJ,Cannon E,Gillis K,Crosby J,Mark PB,Geddes CC,Fox JG,Mackinnon B,McQuarrie EP,Kipgen D

更新日期：2020-04-01 00:00:00

abstract：AIMS:A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS:Nineteen relevant papers published during the period 1979-2005 were identified. Individu...

journal_title：Histopathology

authors： King J,Thatcher N,Pickering C,Hasleton P

更新日期：2006-12-01 00:00:00

abstract：:We report a case of oesophageal carcinosarcoma with prominent rhabdomyoblastic differentiation. Immunohistochemically, the rhabdomyblasts were mainly reactive to vimentin, cytokeratin, desmin, muscle-specific actin, myosin, and myoglobin, and were surrounded by laminin and type IV collagen-positive basement membranes....

journal_title：Histopathology

authors： Guarino M,Reale D,Micoli G,Forloni B

更新日期：1993-05-01 00:00:00

abstract：:A case of visceral botryomycosis of the liver in a 50-year-old man is reported. The clinical diagnosis was hepatocellular carcinoma. Pathological examination of the surgically resected specimen demonstrated microabscesses containing gram- positive microorganisms with surrounding fibrosis replacing liver parenchyma. An...

journal_title：Histopathology

authors： Omar T,Cooper K

更新日期：1995-07-01 00:00:00

abstract：:Chromosomal rearrangements resulting in the fusion of coding parts from two genes or in the exchange of regulatory sequences are present in approximately 20% of all human neoplasms. More than 1000 such gene fusions have now been described, with close to 100 of them in soft tissue tumours. Although little is still know...

journal_title：Histopathology

authors： Mertens F,Tayebwa J

更新日期：2014-01-01 00:00:00

abstract：AIMS:Macrophage colony-stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and stimulates proliferation and differentiation of monocytes, macrophages and their bone marrow progenitors. M-CSF, CSF-1R, the macrophage marker CD68, and the pan T-lymphocyte marker CD3 are increased in many huma...

journal_title：Histopathology

authors： Richardsen E,Uglehus RD,Due J,Busch C,Busund LT

更新日期：2008-07-01 00:00:00

abstract：AIMS:It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC). METHODS AND RESUL...

journal_title：Histopathology

authors： Sun C,Jin XL,Xiao JC

更新日期：2006-04-01 00:00:00

abstract：:Tumour budding in colorectal cancer, defined as single tumour cells or small clusters containing four or fewer tumour cells, is a robust and independent biomarker of aggressive tumour biology. On the basis of published data in the literature, the evidence is certainly in favour of reporting tumour budding in routine p...

journal_title：Histopathology

authors： Studer L,Blank A,Bokhorst JM,Nagtegaal ID,Zlobec I,Lugli A,Fischer A,Dawson H

更新日期：2020-10-01 00:00:00

abstract：AIM:To determine the extent of clonal outgrowth in the lymphocytic tissue infiltrate of lichen sclerosus (LS). The presence of T cells with a monoclonally rearranged T-cell receptor gamma-gene (TCRgamma) has been described in up to 50% of biopsies of vulvar and penile LS. MATERIAL AND RESULTS:We analysed 33 foreskin s...

journal_title：Histopathology

authors： Regauer S,Beham-Schmid C

更新日期：2006-05-01 00:00:00

abstract：AIMS:Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterized by malignant transformation of a pre-existing benign trichoblastoma and subdivided histologically into low- and high-grade tumours. While morphologically low-grade trichoblastic carcinomas show an indolent b...

journal_title：Histopathology

authors： Mehta A,Davey J,Wiedemeyer K,Brenn T

更新日期：2021-01-03 00:00:00

abstract：AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

journal_title：Histopathology

authors： Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

更新日期：2015-01-01 00:00:00

abstract：AIMS:Maspin, a protein belonging to the serpin superfamily, is the product of a tumour suppressor gene. Tissue distribution studies have shown maspin expression in normal mammary epithelial cells, in the placenta, prostate, thymus, testis, oral cavity, small intestine, skin, and cornea. Maspin is expressed but down-reg...

journal_title：Histopathology

authors： Marioni G,Blandamura S,Giacomelli L,Calgaro N,Segato P,Leo G,Fischetto D,Staffieri A,de Filippis C

更新日期：2005-05-01 00:00:00

abstract：AIMS:The clinicopathological distinctiveness of nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL) remains to be clarified. We investigated 26 patients with this lymphoma compared to nodal CM(+) EBV(-) PTCL (n = 39) and extranasal natural killer/T cell lymphoma ...

journal_title：Histopathology

authors： Kato S,Takahashi E,Asano N,Tanaka T,Megahed N,Kinoshita T,Nakamura S

更新日期：2012-08-01 00:00:00

abstract：AIMS:Prognostic factors affecting survival in cases of leiomyosarcoma of soft parts were investigated in this study. METHODS AND RESULTS:A retrospective study of 267 patients was carried out. This group comprised 142 females (53%) and 125 males (47%), whose ages ranged from 7 to 95 years (median 58 years). One hundred...

journal_title：Histopathology

authors： Miyajima K,Oda Y,Oshiro Y,Tamiya S,Kinukawa N,Masuda K,Tsuneyoshi M

更新日期：2002-04-01 00:00:00

abstract：:A male infant was diagnosed as having diabetes mellitus 1 d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin-secreting cells. There was no evidence of insulitis. ...

journal_title：Histopathology

authors： Wong KC,Tse K,Chan JK

更新日期：1988-05-01 00:00:00

abstract：AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common type of malignant neoplasm in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. Herein, we present three cases of de novo PLGA arising in major salivary glands. METHODS AND RESULTS:Three cases of PLGA w...

journal_title：Histopathology

authors： Nagao T,Gaffey TA,Kay PA,Minato H,Serizawa H,Lewis JE

更新日期：2004-02-01 00:00:00

abstract：AIMS:Primary sclerosing cholangitis (PSC) is characterized histologically by portal inflammation, bile duct injury and regeneration and concentric periductal fibrosis. Although seen commonly in our experience, the significance of histological thickening of the bile duct basement membrane on periodic acid Schiff (PAS)-p...

journal_title：Histopathology

authors： Colling R,Verrill C,Fryer E,Kartsonaki C,Wang LM,Chapman R,Rajabally N,Fleming K

更新日期：2016-05-01 00:00:00

abstract：AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...

journal_title：Histopathology

authors： Mitra A,Jameson C,Barbachano Y,Sanchez L,Kote-Jarai Z,Peock S,Sodha N,Bancroft E,Fletcher A,Cooper C,Easton D,IMPACT Steering Committee and IMPACT and EMBRACE Collaborators.,Eeles R,Foster CS

更新日期：2009-12-01 00:00:00

abstract：:One hundred cases of routinely fixed and processed non-Hodgkin's lymphoma from Nigeria were immunostained with a small panel of monoclonal antibodies against B-, T- and macrophage antigens. The aims of the study were to assess the suitability of stored material from a country like Nigeria for immunohistochemical exami...

journal_title：Histopathology

authors： Thomas JO,Rafindadi A,Heryet A,Jones M,Gatter KC,Mason DY

更新日期：1991-06-01 00:00:00

abstract：AIMS:Malignant transformation of Warthin's tumour (WT) is a rare event. We present two cases of mucoepidermoid carcinoma (MEC) arising in WT in the parotid gland. METHODS AND RESULTS:Two cases of MEC arising in WT, which were found in 185 cases of WT of the parotid gland, were investigated by light and electron micros...

journal_title：Histopathology

authors： Nagao T,Sugano I,Ishida Y,Tajima Y,Furuya N,Kondo Y,Nagao K

更新日期：1998-10-01 00:00:00

abstract：:Low grade fibromyxoid sarcoma is a recently recognized, uncommon soft tissue neoplasm with a tendency to develop in deep soft tissue of young adults. Diagnostic criteria have not been well defined and this tumour has not been widely accepted as a distinct entity. Eleven new cases are reported here for which reproducib...

journal_title：Histopathology

authors： Goodlad JR,Mentzel T,Fletcher CD

更新日期：1995-03-01 00:00:00