Abstract:
AIMS:Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immunohistochemistry the specialized nail mesenchyme. METHODS AND RESULTS:Thirty supernumerary digits were obtained during operations to correct polydactyly. Longitudinal and transverse sections were obtained from formalin-fixed paraffin-embedded blocks. In sections stained with haematoxylin and eosin, a mesenchymal area that showed much more cellularity and less eosinophilic, loose connective tissue was identified beneath the nail matrix and nail bed. Using Alcian blue staining, mucin was detected in this mesenchymal area below the nail matrix and nail bed. Immnunohistochemically, CD10 and versican were expressed strongly in the mesenchyme containing onychofibroblasts under the nail matrix and nail bed. CONCLUSIONS:These results demonstrate the presence and localization of a specialized nail mesenchyme containing onychofibroblasts in a well-defined area beneath the nail matrix and nail bed. Thus, we propose the term onychodermis for this specialized nail mesenchyme that is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Lee DY,Park JH,Shin HT,Yang JM,Jang KT,Kwon GY,Lee KH,Shim JSdoi
10.1111/j.1365-2559.2012.04210.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
123-30issue
1eissn
0309-0167issn
1365-2559journal_volume
61pub_type
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