Stereological estimates of nuclear volume in carcinoma of the ampulla of Vater.

Abstract:

:The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases--five papillary and 16 intestinal--all treated by the same surgical procedure. The volume-weighted mean nuclear volume (nuclear nu v) and the mean nuclear area were calculated. The mean volumes of nuclear nu v were significantly different (P less than 0.01) between the papillary and intestinal carcinomas, but no differences were found between normal mucosa and papillary carcinoma. The variance was significantly larger in the intestinal group than the papillary and normal groups. The nuclear nu v showed a significant association with survival, larger nuclear nu v (greater than 150 microns 3) being associated with a lower survival rate.

journal_name

Histopathology

journal_title

Histopathology

authors

Artacho-Perula E,Roldan-Villalobos R,Lopez-Rubio F,Vaamonde-Lemos R

doi

10.1111/j.1365-2559.1992.tb00382.x

keywords:

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

241-8

issue

3

eissn

0309-0167

issn

1365-2559

journal_volume

21

pub_type

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