SMAD4 alteration associates with invasive-front pathological markers and poor prognosis in colorectal cancer.

abstract：:The p24 protein is the major core protein of LAV/HTLV III which is the putative agent of the lymphadenopathy syndrome. By the use of an anti-p24 monoclonal antibody we have studied the presence of LAV/HTLV III infected cells in 20 lymph nodes obtained from lymphadenopathy syndrome patients: 14 lymph nodes were charact...

journal_title：Histopathology

authors： Baroni CD,Pezzella F,Mirolo M,Ruco LP,Rossi GB

更新日期：1986-01-01 00:00:00

abstract：AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...

journal_title：Histopathology

authors： Mitra A,Jameson C,Barbachano Y,Sanchez L,Kote-Jarai Z,Peock S,Sodha N,Bancroft E,Fletcher A,Cooper C,Easton D,IMPACT Steering Committee and IMPACT and EMBRACE Collaborators.,Eeles R,Foster CS

更新日期：2009-12-01 00:00:00

abstract：AIMS:NTRK gene rearranged sarcomas are emerging as a distinct class of sarcomas of particular importance in the era of targeted therapy. In this study we used Array Comparative Genomic Hybridisation (aCGH) to explore the cytogenetic profile of 6 adult soft tissue sarcomas harbouring NTRK gene fusions. METHODS AND RESU...

journal_title：Histopathology

authors： Vargas AC,Mesbah Ardakani N,Wong DD,Maclean FM,Kattampallil J,Boyle R,Santos L,Gill AJ

更新日期：2020-10-31 00:00:00

abstract：AIMS:Thymic carcinoma is rare and usually has a fatal outcome. Gene mutations in the epidermal growth factor receptor (EGFR) signalling pathway and TP53 have not been well analysed in thymic carcinoma. METHODS AND RESULTS:We examined a large cohort of thymic carcinoma and thymoma type A/B3 and looked for gene mutation...

journal_title：Histopathology

authors： Sakane T,Murase T,Okuda K,Saida K,Masaki A,Yamada T,Saito Y,Nakanishi R,Inagaki H

更新日期：2019-11-01 00:00:00

abstract：AIMS:Using intraoperative frozen sections to diagnose pulmonary sclerosing pneumocytoma is always challenging. However, an accurate diagnosis is needed to guide surgical management and prevent unnecessary treatment. The aim of this study was to investigate the most frequently misdiagnosed histological patterns and eval...

journal_title：Histopathology

authors： Yang CH,Lee LY

更新日期：2018-02-01 00:00:00

abstract：AIMS:The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). METHODS AND RESULTS:We examined the relationship between clinicopathological factors and ...

journal_title：Histopathology

authors： Jung CW,Kong JS,Seol H,Park S,Koh JS,Lee SS,Kim MJ,Choi IJ,Myung JK

更新日期：2017-01-01 00:00:00

abstract：:The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, ...

journal_title：Histopathology

authors： Shanks JH,Srigley JR,Brimo F,Comperat E,Delahunt B,Koch M,Lopez-Beltran A,Reuter VE,Samaratunga H,Tsuzuki T,van der Kwast T,Varma M,Grignon D

更新日期：2019-10-01 00:00:00

abstract：AIMS:Development of effective immune-based therapies for patients with non-small-cell lung carcinoma (NSCLC) depends on an accurate characterization of complex interactions that occur between immune cells and the tumour environment. METHODS AND RESULTS:Innate and adaptive immune responses were evaluated in relation to...

journal_title：Histopathology

authors： da Costa Souza P,Parra ER,Atanazio MJ,da Silva OB,Noleto GS,Ab'Saber AM,de Morais Fernezlian S,Takagaki T,Capelozzi VL

更新日期：2012-10-01 00:00:00

abstract：:The differential diagnosis of melanocytic lesions is fraught with difficulty and a common source of litigation either if a lesion misreported as 'benign' recurs locally or re-presents with nodal metastases or if an atypical naevus is called 'malignant' leading to a cosmetically unsatisfactory wider resection, unwarran...

journal_title：Histopathology

authors： Okun MR,Edelstein LM,Kasznica J,Kirkham N,Slater DN

更新日期：2000-11-01 00:00:00

abstract：AIMS:To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge-shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. METHODS AND RESULTS:The hi...

journal_title：Histopathology

authors： Araya J,Kawabata Y,Tomichi N,Kaneko K,Hayashi K,Iwabuchi K,Terasaki Y,Kawashima T,Watanabe M

更新日期：2007-10-01 00:00:00

abstract：:The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...

journal_title：Histopathology

authors： Delsol G,Chittal S,Brousset P,Caveriviere P,Roda D,Mazerolles C,Barillet-Alard C,al Saati T,Gorguet B,Voigt JJ

更新日期：1989-11-01 00:00:00

abstract：:The clinical, light microscopic and immunohistochemical features of six cutaneous heterotopic meningeal nodules (primary, or type I, cutaneous meningiomas) are described. These are rare lesions of the scalp and back which generally present at birth or in childhood. They appear as small subcutaneous fibrous nodules, wi...

journal_title：Histopathology

authors： Theaker JM,Fletcher CD,Tudway AJ

更新日期：1990-05-01 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1 (HIF-1) activity is regulated by prolyl hydroxylase (PHD1, PHD2, PHD3) and factor inhibiting HIF-1 (FIH) that target the α subunit of HIF-1 (HIF-1α) for proteosomal degradation. We hypothesised that the elevated HIF-1α level is due in some tumours to epigenetic silencing by DNA hypermeth...

journal_title：Histopathology

authors： Huang KT,Mikeska T,Dobrovic A,Fox SB

更新日期：2010-09-01 00:00:00

abstract：:The ultrastructure of stromal mononuclear cells and giant cells were studied in two cases of central giant cell granuloma of the jaws. The majority of stromal cells superficially resembled fibroblasts, but also contained intracytoplasmic myofilaments with electron dense bodies similar to smooth muscle cells. These cel...

journal_title：Histopathology

authors： El-Labban NG,Lee KW

更新日期：1983-11-01 00:00:00

abstract：:This study demonstrates the presence of three antigens in glandular metaplasia occurring in patients with cholecystitis and cholelithiasis: specifically carcinoembryonic antigen (CEA), large intestinal mucin antigen (LIMA) and small intestinal mucin antigen (SIMA). These antigens could not be detected in normal gall b...

journal_title：Histopathology

authors： De Boer WG,Ma J,Rees JW,Nayman J

更新日期：1981-05-01 00:00:00

abstract：AIM:To assess the potential prognostic significance of a range of molecular and morphological parameters in glioblastomas that can be applied in the setting of a routine diagnostic neuropathology laboratory. METHODS AND RESULTS:A consecutive series of 107 adult glioblastomas were studied. Retinoblastoma and deleted-in...

journal_title：Histopathology

authors： Hilton DA,Penney M,Pobereskin L,Sanders H,Love S

更新日期：2004-06-01 00:00:00

abstract：AIMS:To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS:We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our instituti...

journal_title：Histopathology

authors： Vingiani A,Maisonneuve P,Dell'orto P,Farante G,Rotmensz N,Lissidini G,Del Castillo A,Renne G,Luini A,Colleoni M,Viale G,Pruneri G

更新日期：2013-08-01 00:00:00

abstract：AIMS:  To review the histopathological features of cervical LNs, and to clarify the changes in extracervical LNs, in acute Kawasaki disease (KD). METHODS AND RESULTS:  The samples were obtained from 33 patients with acute-phase KD. We divided the LNs into those in the neck (n = 23) and those located elsewhere (n = 26)...

journal_title：Histopathology

authors： Yokouchi Y,Oharaseki T,Harada M,Ihara F,Naoe S,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：AIMS:To investigate whether localization of beta-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. Extra-ovarian cancers which metastasize to the ovaries, especially from colorectal adenocarcinoma, frequently mimic primary ovarian carcinomas,...

journal_title：Histopathology

authors： Chou YY,Jeng YM,Kao HL,Chen T,Mao TL,Lin MC

更新日期：2003-08-01 00:00:00

abstract：AIMS:The aim of this study was to examine clinicopathological features of patients with core biopsy diagnoses of ductal carcinoma in situ (DCIS) that may predict invasion on subsequent excision, as upstaging has significant implications regarding the need for axillary staging via sentinel lymph node biopsy (SLNB). MET...

journal_title：Histopathology

authors： Walters LL,Pang JC,Zhao L,Jorns JM

更新日期：2015-03-01 00:00:00

abstract：AIMS:Pulmonary fibrosis in acute and chronic lung disease has been much investigated, but little attention has been directed at the elastic tissue in these situations. Our aim was to verify whether elastic deposition accompanies collagen deposition in the repairing process of acute and chronic lung injury. METHODS AND...

journal_title：Histopathology

authors： Negri EM,Montes GS,Saldiva PH,Capelozzi VL

更新日期：2000-11-01 00:00:00

abstract：:Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...

journal_title：Histopathology

authors： Simpson RH,Skálová A

更新日期：1997-01-01 00:00:00

abstract：:The distribution of epithelial L1 antigen was evaluated in 139 bronchogenic carcinomas which had been classified by a panel of pathologists according to the WHO recommendation of 1981. L1 was not found in three large cell and 13 small cell carcinomas, but it was expressed by tumour cells in 67 of 69 squamous cell carc...

journal_title：Histopathology

authors： Dale I,Brandtzaeg P

更新日期：1989-05-01 00:00:00

abstract：AIMS:In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. METHODS AND RESULTS:Tumours from 59 patients wi...

journal_title：Histopathology

authors： Baur AS,Meugé-Moraw C,Michel G,Delacrétaz F

更新日期：1998-06-01 00:00:00

abstract：:Occasional biopsies of genital lesions due to chancroid, secondary syphilis (the condyloma latum) and granuloma inguinale are encountered in routine histopathological practice. These lesions have specific microscopical appearances enabling a confident, or at least a presumptive, diagnosis to be made in most cases, yet...

journal_title：Histopathology

authors： Freinkel AL

更新日期：1987-08-01 00:00:00

abstract：AIMS:Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationsh...

journal_title：Histopathology

authors： Zhu JL,Song YX,Wang ZN,Gao P,Wang MX,Dong YL,Xing CZ,Xu HM

更新日期：2013-06-01 00:00:00

abstract：:An example of a cutaneous ciliated cyst in the buttock of a 42 year old woman is reported. The histological and immunohistochemical features of the cyst are presented: comparisons with fallopian tube are made and this rare lesion is discussed. ...

journal_title：Histopathology

authors： al-Nafussi AI,Carder P

更新日期：1990-06-01 00:00:00

abstract：:Identical adolescent Negro twins presented with multiple bilateral breast adenomata. There were three pure tubular adenomata, one mixed tubular and fibroadenoma, four glandular fibroadenomata and one typical intracanalicular fibroadenoma. Tubular adenomata are exceedingly rare and this report adds a further three to t...

journal_title：Histopathology

authors： Morris JA,Kelly JF

更新日期：1982-09-01 00:00:00

abstract：:We have reviewed 60 liver specimens from 47 patients with the diagnosis of incomplete septal cirrhosis observed between 1968 and 1987. In reaching this diagnosis evaluation of the following histological features appeared to be helpful: parenchymal nodularity, thin incomplete septa, hypoplastic portal tracts, increased...

journal_title：Histopathology

authors： Sciot R,Staessen D,Van Damme B,Van Steenbergen W,Fevery J,De Groote J,Desmet VJ

更新日期：1988-12-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) of the gastrointestinal tract (GIT) comprise neuroendocrine tumours (NETs) and neuroendocrine carcinomas (NECs). During the last decade the classification and grading of GIT NENs has undergone significant changes, culminating in the World Health Organisation (WHO) 2019 classification. T...

journal_title：Histopathology

authors： Gill AJ

更新日期：2021-01-01 00:00:00