Different morphology, stage and treatment affect immune cell infiltration and long-term outcome in patients with non-small-cell lung carcinoma.

abstract：:A disseminated intravascular tumour, presenting initially with splenic and small bowel infarction, caused both clinical and histological diagnostic difficulty. At subsequent autopsy the main tumour mass was identified within the aorta. Dissemination of this tumour was confirmed histologically and lectin and immunohist...

journal_title：Histopathology

authors： Fitzmaurice RJ,McClure J

更新日期：1990-11-01 00:00:00

abstract：:In a prospective autopsy study of male subjects with solic malignant neoplasms, six were shown to have metastatic deposits within the testis (2.5%). These were metastases from carcinoma of the prostate (two cases), melanoma (two cases), bronchial carcinoma (one case) and pleural mesothelioma (one case). In addition, f...

journal_title：Histopathology

authors： Tiltman AJ

更新日期：1979-01-01 00:00:00

abstract：AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

journal_title：Histopathology

authors： Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

更新日期：2002-11-01 00:00:00

abstract：:A case of undifferentiated carcinoma of the salivary gland occurring in the parotid gland of a southern Chinese was reported. Tumour cells showed immunofluorescence for Epstein-Barr virus (EBV)-associated nuclear antigen, and DNA hybridization demonstrated the presence of EBV-DNA in tumour tissue. The findings in this...

journal_title：Histopathology

authors： Huang DP,Ng HK,Ho YH,Chan KM

更新日期：1988-11-01 00:00:00

abstract：:Three cases of gastric parietal cell carcinoma are described. Tumour cells are round to polygonal, with abundant eosinophilic, granular cytoplasm reactive with phosphotungstic acid haematoxylin and Luxol Fast Blue. Ultrastructurally the tumour cells are characterized by abundant mitochondria, tubulovesicles, intracell...

journal_title：Histopathology

authors： Capella C,Frigerio B,Cornaggia M,Solcia E,Pinzon-Trujillo Y,Chejfec G

更新日期：1984-09-01 00:00:00

abstract：AIMS:To examine how accurately immunohistochemical markers discriminate between pancreatobiliary and intestinal-type adenocarcinomas in the pancreatic head and to explore the prognostic importance of these markers among each of these histological types. METHODS AND RESULTS:Histopathological features of 114 consecutive...

journal_title：Histopathology

authors： Westgaard A,Schjølberg AR,Cvancarova M,Eide TJ,Clausen OP,Gladhaug IP

更新日期：2009-02-01 00:00:00

abstract：AIMS:To establish the prevalence of CD44 protein expression in a large surgical series of Barrett's adenocarcinoma and associated preneoplastic lesions and to correlate this expression with clinicopathological data and prognosis. METHODS AND RESULTS:CD44H and variants (V4/V5, V6) expression was detected by immunohisto...

journal_title：Histopathology

authors： Lagorce-Pages C,Paraf F,Dubois S,Belghiti J,Fléjou JF

更新日期：1998-01-01 00:00:00

abstract：AIMS:To estimate the likelihood of the upgrade for atypical ductal hyperplasia (ADH) diagnosed on a core needle biopsy of a mammographically detected lesion. METHODS AND RESULTS:A total of 203 consecutive ADH cases diagnosed on core biopsy in mammographically detected lesions and having subsequent surgical excision we...

journal_title：Histopathology

authors： Khoury T,Chen X,Wang D,Kumar P,Qin M,Liu S,Turner B

更新日期：2015-07-01 00:00:00

abstract：AIMS:Maspin, a protein belonging to the serpin superfamily, is the product of a tumour suppressor gene. Tissue distribution studies have shown maspin expression in normal mammary epithelial cells, in the placenta, prostate, thymus, testis, oral cavity, small intestine, skin, and cornea. Maspin is expressed but down-reg...

journal_title：Histopathology

authors： Marioni G,Blandamura S,Giacomelli L,Calgaro N,Segato P,Leo G,Fischetto D,Staffieri A,de Filippis C

更新日期：2005-05-01 00:00:00

abstract：AIMS:To investigate redox-regulating enzymes that may have a special role in melanoma pathogenesis due to continuous exposure to microenvironment-produced and ultraviolet radiation-induced oxidative stress. METHODS AND RESULTS:We assessed immunohistochemically the expression of antioxidant enzymes peroxiredoxins (Prxs...

journal_title：Histopathology

authors： Hintsala HR,Soini Y,Haapasaari KM,Karihtala P

更新日期：2015-09-01 00:00:00

abstract：AIMS:Primary sclerosing cholangitis (PSC) is characterized histologically by portal inflammation, bile duct injury and regeneration and concentric periductal fibrosis. Although seen commonly in our experience, the significance of histological thickening of the bile duct basement membrane on periodic acid Schiff (PAS)-p...

journal_title：Histopathology

authors： Colling R,Verrill C,Fryer E,Kartsonaki C,Wang LM,Chapman R,Rajabally N,Fleming K

更新日期：2016-05-01 00:00:00

abstract：AIMS:Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, are morphologically similar to pulmonary hamartomas, which are much more common. There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB imm...

journal_title：Histopathology

authors： Chatzopoulos K,Fritchie KJ,Aubry MC,Carney JA,Folpe AL,Boland JM

更新日期：2019-12-01 00:00:00

abstract：:Two cases of pedunculated hepatocellular carcinoma are reported. One of these was known to have been present for 5 years. Both patients are alive 1 and 2 years after surgery though the former has developed a solitary bone metastasis. The literature on 30 previously published cases is reviewed and it is concluded that,...

journal_title：Histopathology

authors： Anthony PP,James K

更新日期：1987-04-01 00:00:00

abstract：AIMS:p53 immunostaining in Barrett's oesophagus (BO) has been shown to be predictive of progression, but data regarding its generalizability to routine practice are lacking. This study compared the reliability of p53 and dysplasia interpretation and grading. METHODS AND RESULTS:Seventy-two cases encompassing the full ...

journal_title：Histopathology

authors： Kaye PV,Ilyas M,Soomro I,Haider SA,Atwal G,Menon S,Gill S,Richards C,Harrison R,West K,Ragunath K

更新日期：2016-09-01 00:00:00

abstract：AIMS:Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a downstream effector of Ras signalling, and is overexpressed in several types of human malignancy. However, its role in gastric cancer remains unclear. The aim of this study was to investigate the prognostic significance of G3BP1 in gastric can...

journal_title：Histopathology

authors： Min L,Ruan Y,Shen Z,Jia D,Wang X,Zhao J,Sun Y,Gu J

更新日期：2015-11-01 00:00:00

abstract：AIMS:To characterize the histomorphological features of endometrial carcinomas (ECs) harbouring polymerase ε (POLE) mutations. METHODS AND RESULTS:Forty-three ECs with POLE mutations were compared with a cohort of 202 ECs. Most POLE-mutated ECs were endometrioid [34/43 (79%)]; the remaining tumours were mixed [6/43 (1...

journal_title：Histopathology

authors： Bakhsh S,Kinloch M,Hoang LN,Soslow RA,Köbel M,Lee CH,McAlpine JN,McConechy MK,Gilks CB

更新日期：2016-05-01 00:00:00

abstract：AIMS:To investigate whether Glia maturation factor-beta (GMFB) is expressed in thymomas and is associated with T-cell development. METHODS AND RESULTS:We investigated the expression of GMFB by immunohistochemistry in 86 cases of thymoma classified into five type A, 35 type AB, 11 type B1, 26 type B2, and nine type B3 ...

journal_title：Histopathology

authors： Yamazaki H,Tateyama H,Asai K,Fukai I,Fujii Y,Tada T,Eimoto T

更新日期：2005-09-01 00:00:00

abstract：AIMS:Whilst parenchymal changes in pulmonary sequestrations are well described, there are comparatively little data on associated vascular changes and their extent. The aim of this study was to retrospectively review morphological changes within sequestrations, concentrating on vascular changes and associations with cl...

journal_title：Histopathology

authors： Desai S,Dusmet M,Ladas G,Pomplun S,Padley SP,Griffin N,Badreddine J,Goldstraw P,Nicholson AG

更新日期：2010-07-01 00:00:00

abstract：AIMS:Mucinous tubular and spindle cell carcinoma (MTSC) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported MTSC with high-grade features and have brought into question w...

journal_title：Histopathology

authors： Sadimin ET,Chen YB,Wang L,Argani P,Epstein JI

更新日期：2017-11-01 00:00:00

abstract：:Four cases of primary leiomyosarcoma of bone are presented. The histology of this rare tumour has been studied with a panel of monoclonal antibodies to the intermediate filaments desmin and vimentin, and to other markers including smooth muscle actin, myosin, alpha 1-antitrypsin, alpha 1-antichymotrypsin, lysozyme, S-...

journal_title：Histopathology

authors： Young MP,Freemont AJ

更新日期：1991-09-01 00:00:00

abstract：AIMS:To verify the applicability, reproducibility and predictive value of a proposed unified classification (amended Ljubljana classification) for laryngeal squamous intraepithelial lesions (SILs). METHODS AND RESULTS:Six internationally recognized experts and three pathologists from Ljubljana contributed to this stud...

journal_title：Histopathology

authors： Gale N,Blagus R,El-Mofty SK,Helliwell T,Prasad ML,Sandison A,Volavšek M,Wenig BM,Zidar N,Cardesa A

更新日期：2014-10-01 00:00:00

abstract：AIMS:Glutamate receptor antagonists have failed clinical stroke trials and it has been proposed that the action of N-methyl D-aspartate receptors is necessary for neuronal survival. Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial e...

journal_title：Histopathology

authors： Beschorner R,Simon P,Schauer N,Mittelbronn M,Schluesener HJ,Trautmann K,Dietz K,Meyermann R

更新日期：2007-06-01 00:00:00

abstract：AIMS:Small cell (neuroendocrine) carcinoma of the urinary bladder is clinically more aggressive than urothelial (transitional cell) carcinoma. We have investigated the immunohistochemical markers most useful in diagnosing small cell carcinoma in bladder. METHODS AND RESULTS:We evaluated the expression of chromogranin ...

journal_title：Histopathology

authors： Iczkowski KA,Shanks JH,Allsbrook WC,Lopez-Beltran A,Pantazis CG,Collins TR,Wetherington RW,Bostwick DG

更新日期：1999-08-01 00:00:00

abstract：AIMS:Clear cell chondrosarcomas are known to occasionally contain areas of low-grade conventional chondrosarcoma; however, the opposite phenomenon has not yet been described. We identified five cases of conventional chondrosarcoma alongside clear cell chondrosarcoma. Here, we report on their clinicopathological and mol...

journal_title：Histopathology

authors： Lam SW,van Langevelde K,Suurmeijer AJH,Cleven AHG,Bovée JVMG

更新日期：2019-12-01 00:00:00

abstract：AIMS:To study the expression of the epithelial adhesion molecule E-cadherin and its associated proteins alpha and beta catenin in paraffin sections of normal ovaries, benign cystadenomas and ovarian carcinomas, and in immortalized normal ovarian surface epithelial cells and ovarian carcinoma cells in culture. METHODS ...

journal_title：Histopathology

authors： Davies BR,Worsley SD,Ponder BA

更新日期：1998-01-01 00:00:00

abstract：AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved...

journal_title：Histopathology

authors： Yang QQ,Deng YF

更新日期：2015-06-01 00:00:00

abstract：:The author reports a case of a 53-year-old woman with a slowly growing thyroid papillary carcinoma. Microscopically the presence of adult adipose tissue was detected in numerous papillae. The recognition of this histological type as a new variety of papillary carcinoma is proposed. ...

journal_title：Histopathology

authors： Vestfrid MA

更新日期：1986-01-01 00:00:00

abstract：AIMS:Hepatocellular adenoma is an uncommon liver neoplasm and the studies of HCA subtypes have been primarily limited to France, United States and Japan. We aimed to describe the clinicopathologic features of hepatocellular adenoma subtypes in Turkey. METHODS AND RESULTS:The resection specimens of 59 cases diagnosed a...

journal_title：Histopathology

authors： Deniz K,Umetsu SE,Ferrell L,Yılmaz F,Güllüoğlu M,Sağol Ö,Bülbül Doğusoy G,Kırımlıoğlu H,Turhan N,Doran F,Kepil N,Çelikel ÇA,Nart D,Özgüven BY,Ceyran B,Karadağ N,Kır G,Erden E,Yılmaz G,Akyol G

更新日期：2021-01-06 00:00:00

abstract：:Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical...

journal_title：Histopathology

authors： Acquaviva G,Visani M,Repaci A,Rhoden KJ,de Biase D,Pession A,Giovanni T

更新日期：2018-01-01 00:00:00

abstract：AIMS:Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of BAP1 and EZH2 in malignant mes...

journal_title：Histopathology

authors： Shinozaki-Ushiku A,Ushiku T,Morita S,Anraku M,Nakajima J,Fukayama M

更新日期：2017-04-01 00:00:00