Abstract:
AIMS:Whilst parenchymal changes in pulmonary sequestrations are well described, there are comparatively little data on associated vascular changes and their extent. The aim of this study was to retrospectively review morphological changes within sequestrations, concentrating on vascular changes and associations with clinical parameters. METHODS AND RESULTS:Twenty-seven resected cases of sequestrations (intralobar n = 20, extralobar n = 7) showed a male predominance (n = 16) and an age range of 2 months-60 years (average 13 years). Plexogenic vascular changes (medial hypertrophy and intimal fibrosis) were seen in 15 of 27 cases, as well as plexiform lesions in seven cases. Patients with plexogenic changes had a higher mean age compared with those lacking vascular changes (19 versus 6 years) and were more commonly female. Respiratory tract infections were associated solely with intralobar sequestrations. No other associations between presenting symptoms and histopathological parameters were identified. Adjacent lung showed lesser plexogenic changes in six of 22 intralobar cases. There were features of type 2 congenital cystic adenomatoid lesions in 63% of cases. Dissection of the supplying systemic artery (n = 1), intralesional aspergilloma (n = 1) and coexistent lymphangiomatosis (n = 1) were also identified. CONCLUSIONS:Hypertensive vascular changes are not uncommon in both intrapulmonary and extrapulmonary sequestrations, although their relative severity seems unrelated to presenting symptoms.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Desai S,Dusmet M,Ladas G,Pomplun S,Padley SP,Griffin N,Badreddine J,Goldstraw P,Nicholson AGdoi
10.1111/j.1365-2559.2010.03586.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
121-7issue
1eissn
0309-0167issn
1365-2559pii
HIS3586journal_volume
57pub_type
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