Abstract：
:HLA-DR expression was examined in 50 consecutive primary cutaneous malignant melanomas with a Breslow depth greater than 2 mm using two well-characterized monoclonal antibodies which detect fixation-resistant epitopes. In 31 of these cases (62%) a subpopulation of tumour cells was reactive, although there was considerable heterogeneity. Positive labelling did not correlate with depth but was associated with a reduced likelihood of developing early metastatic disease and a tendency for better overall survival, particularly in male patients. These findings contrast with earlier studies using cryostat sections and one study on paraffin-embedded tissue in which HLA-DR expression was shown to be a poor prognostic factor, but are consistent with the findings in other malignant tumours studied. The significance of HLA-DR expression as a marker of prognosis may depend on the type of tissue preparation, the sensitivity of the immunocytochemical techniques used and the method of assessment.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Colloby PS,West KP,Fletcher Adoi
10.1111/j.1365-2559.1992.tb01011.xkeywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
411-6issue
5eissn
0309-0167issn
1365-2559journal_volume
20pub_type
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