Abstract:
AIMS:The aim of this study was to examine clinicopathological features of patients with core biopsy diagnoses of ductal carcinoma in situ (DCIS) that may predict invasion on subsequent excision, as upstaging has significant implications regarding the need for axillary staging via sentinel lymph node biopsy (SLNB). METHODS AND RESULTS:We identified 186 patients with a diagnosis of DCIS as the highest-stage lesion on core biopsy. Pathological and clinical features were assessed via slide and chart review, respectively. Distorting sclerosis was defined as irregular angulation of glands involved by DCIS but lacking definite invasion according to histology and/or immunohistochemical staining for myoepithelial markers. Thirty-two of 186 (17.2%) cases had upstaging to either microinvasive (nine) or invasive (23) ductal carcinoma. SLNB was performed in 29 of 32 (90.6%) cases with upstaging and in 55 of 154 (35.7%) cases without (P < 0.0001). Upstaging was significantly associated with the presurgical variables of radiological mass (P = 0.009) and distorting sclerosis (P = 0.0005) and the postsurgical feature of multifocality (P < 0.0001). CONCLUSIONS:Sentinel lymph node biopsy is frequently performed for patients with upstaging from DCIS on core biopsy to microinvasive or invasive carcinoma on excision. DCIS with distorting sclerosis without definite invasion on core biopsy may be predictive of upstaging. This feature may be useful in selecting patients to undergo SLNB at the time of excision to avoid reoperation.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Walters LL,Pang JC,Zhao L,Jorns JMdoi
10.1111/his.12550subject
Has Abstractpub_date
2015-03-01 00:00:00pages
577-86issue
4eissn
0309-0167issn
1365-2559journal_volume
66pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract::12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue. The diagnostic utility of 12E7 as a marker of Ewing's sarcoma and peripheral neuroectodermal tumour was assessed. Immunocytochemical studies were performed on 120 small round-cell tumours from childre...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01243.x
更新日期:1993-12-01 00:00:00
abstract:AIMS:To verify the applicability, reproducibility and predictive value of a proposed unified classification (amended Ljubljana classification) for laryngeal squamous intraepithelial lesions (SILs). METHODS AND RESULTS:Six internationally recognized experts and three pathologists from Ljubljana contributed to this stud...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12427
更新日期:2014-10-01 00:00:00
abstract::The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2002.01420.x
更新日期:2002-10-01 00:00:00
abstract:AIMS:Follicular lymphoma (FL) in situ is defined as strongly bcl-2-positive B cells in germinal centres of morphologically inconspicuous lymph nodes. The prevalence and biological and clinical significance of this lesion are still not clear. Therefore we aimed at the detection of the prevalence of this phenomenon in an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.03897.x
更新日期:2011-07-01 00:00:00
abstract:AIMS:The blastic variant of mantle cell lymphoma (MCL-BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL-BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00745.x
更新日期:1999-10-01 00:00:00
abstract:AIMS:To describe a case of rhabdomyomatosis of the lung unassociated with other external or visceral malformations in a newborn infant. METHODS AND RESULTS:A 26 weeks gestation newborn male with no relevant medical or family history presented a well-circumscribed solid area in the posterior mediastinum occupying the u...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2830880.x
更新日期:1997-11-01 00:00:00
abstract:AIMS:Small cell (neuroendocrine) carcinoma of the urinary bladder is clinically more aggressive than urothelial (transitional cell) carcinoma. We have investigated the immunohistochemical markers most useful in diagnosing small cell carcinoma in bladder. METHODS AND RESULTS:We evaluated the expression of chromogranin ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00715.x
更新日期:1999-08-01 00:00:00
abstract::Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predomi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1982.tb02765.x
更新日期:1982-11-01 00:00:00
abstract::This report describes a female of 54 years with a past history of repeated breast biopsies all showing benign epithelial hyperplasia. The patient subsequently had a simple mastectomy and axillary lymph node biopsy. No evidence of malignancy was found in the specimen but there were numerous foci of epithelial hyperplas...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1980.tb02958.x
更新日期:1980-11-01 00:00:00
abstract:AIMS: Ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) exhibit frequent RUNX3 inactivation by promoter hypermethylation and protein mislocalization. The aim of this study was to analyse columnar cell lesions (CCLs) to further characterize RUNX3 involvement in breast carcinogenesis. METHODS AND RESU...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2010.03675.x
更新日期:2010-10-01 00:00:00
abstract::HLA-DR expression was examined in 50 consecutive primary cutaneous malignant melanomas with a Breslow depth greater than 2 mm using two well-characterized monoclonal antibodies which detect fixation-resistant epitopes. In 31 of these cases (62%) a subpopulation of tumour cells was reactive, although there was consider...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb01011.x
更新日期:1992-05-01 00:00:00
abstract::Signet ring cell differentiation in adenocarcinoma of the prostate is uncommon. In a review of 200 cases of prostatic carcinoma, we identified five cases with this change, all in moderately to poorly differentiated prostatic carcinomas. The signet ring cells in prostatic carcinoma contain an intracytoplasmic lumen, sh...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00137.x
更新日期:1993-04-01 00:00:00
abstract::The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, ...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13877
更新日期:2019-10-01 00:00:00
abstract::The clinical and pathological features of six cases of a hitherto undescribed lesion of the breast are reported for which the term 'microglandular adenosis' has been proposed. This is characterized by a proliferation of small uniform glands lined by epithelial cells without apparent myoepithelial cells and with usuall...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1983.tb02233.x
更新日期:1983-03-01 00:00:00
abstract:AIMS:To analyse expression and distribution of vascular endothelial growth factor (VEGF-C1), podocalyxin and synaptopodin within renal tissue in nephrotic syndrome glomerulopathies in children. METHODS AND RESULTS:Renal biopsies performed at the time and in the manner recommended by the World Health Organization. The ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02076.x
更新日期:2005-02-01 00:00:00
abstract::Advances in modern chemotherapy and targeted treatments have resulted in lengthened survival in a variety of tumour types in the last decade. Increasingly in the 21st century, postchemotherapy resections are considered as a possible mode of treatment. Due to their exquisite chemosensitivity, resection of postchemother...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13078
更新日期:2017-01-01 00:00:00
abstract::Histochemical characteristics and the distribution of gastric intramucosal cysts were studied in 50 cancerous and 51 benign gastrectomy specimens. The frequency of such cysts was significantly higher in stomachs with carcinoma (70%) than in stomachs with peptic ulcer (43%) (P less than 0.01). Intramucosal cysts were c...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1987.tb02673.x
更新日期:1987-06-01 00:00:00
abstract:AIMS:Neoadjuvant radiochemotherapy (RCT) followed by surgical resection is the treatment for locally advanced mid-rectal or low rectal cancer. The aim of this study was to evaluate postoperative histological prognostic factors in a series of surgical specimens after neoadjuvant RCT. METHODS AND RESULTS:One hundred and...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12432
更新日期:2014-11-01 00:00:00
abstract:AIMS:CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC), but neither its sensitivity nor its specificity is absolute. The aim of this study was to compare CDX1 and A33 with CDX2 as immunomarkers for CRC. METHODS AND RESULTS:As a pilot study, whole sections of 51 cases of liver ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13194
更新日期:2017-07-01 00:00:00
abstract:AIMS:The staining pattern of the recently described antibody melan-A was compared with those of S100 protein and HMB-45 in a variety of melanocytic lesions to assess the specificity and sensitivity of these antibodies. METHODS AND RESULTS:Immunohistochemical staining of paraffin sections of a range of melanocytic lesi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00312.x
更新日期:1998-02-01 00:00:00
abstract::Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14124
更新日期:2020-09-01 00:00:00
abstract:AIMS:Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL), and is associated with a poor outcome. The histological manifestations of RT are variable, and include an increase in the proportion of prolymphocytes, immunoblasts, and other pleomorphi...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13137
更新日期:2017-04-01 00:00:00
abstract:AIMS: Follicular lymphoma (FL) is associated with bone marrow (BM) involvement in approximately 40-70% of cases. Previous studies have suggested that the immune-microenvironment of FL plays an important role in the clinical behaviour of the disease. To investigate the role of the microenvironment in BM involvement of ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04187.x
更新日期:2012-05-01 00:00:00
abstract::Four cases of primary leiomyosarcoma of bone are presented. The histology of this rare tumour has been studied with a panel of monoclonal antibodies to the intermediate filaments desmin and vimentin, and to other markers including smooth muscle actin, myosin, alpha 1-antitrypsin, alpha 1-antichymotrypsin, lysozyme, S-...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.1991.tb00031.x
更新日期:1991-09-01 00:00:00
abstract:AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02920.x
更新日期:2008-01-01 00:00:00
abstract:AIMS:To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' biopsy (MT), the accuracy of these diagnoses, and whether it is justified not to undertake surgical excision of non-malignant papillary lesions so diagnosed. METHODS AND RESULTS:...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12477
更新日期:2015-03-01 00:00:00
abstract:AIMS:Evaluation of angiogenesis by intratumoral vessel profiles can be performed by different methods. The aim of this study was to investigate the prognostic value of estimates obtained by the intratumoral microvessel density (MVD) method and then to compare with corresponding estimates obtained by the Chalkley method...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2004.01848.x
更新日期:2004-05-01 00:00:00
abstract:AIMS:Two-hundred and four accessible cases of malignant melanoma from the Grampian region of Scotland, collected over a period of 4 years, were studied for standard prognostic indicators for comparison with microvessel density. METHODS AND RESULTS:The range of tumour thickness varied from in-situ melanoma to 14.8 mm. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02193.x
更新日期:2005-08-01 00:00:00
abstract:AIMS:Progressive changes have been reported in lymph nodes in HIV infection, but few accounts describe altered splenic histology at different stages of the disease. Investigation of splenic changes accompanying the progressive CD4+ T-cell depletion that occurs in HIV infection could shed light on normal immunological i...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2003.01569.x
更新日期:2003-02-01 00:00:00
abstract:AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13758
更新日期:2019-02-01 00:00:00