Impact of the reactive microenvironment on the bone marrow involvement of follicular lymphoma.

Abstract:

AIMS:  Follicular lymphoma (FL) is associated with bone marrow (BM) involvement in approximately 40-70% of cases. Previous studies have suggested that the immune-microenvironment of FL plays an important role in the clinical behaviour of the disease. To investigate the role of the microenvironment in BM involvement of FL, we performed immunophenotypical analysis of the reactive cell populations in lymph nodes (LN) and corresponding BM of 35 patients with FL. Microenvironment patterns of BM infiltrates were compared to the corresponding features of the LN in cases with BM manifestation, and the LN microenvironment was compared in FL cases with and without BM involvement. METHODS AND RESULTS:  Automated image-segmentation-based quantitation was performed in whole digital slides of tissue microarrays of formalin-fixed paraffin-embedded tissue biopsies. We found significantly more CD8(+) T lymphocytes, forkhead box protein 3 (FoxP3)(+) T lymphocytes and CD68(+) macrophages and fewer PD1(+) T lymphocytes in the BM than in the matching LN samples. Furthermore, we observed significantly fewer CD8(+) T cells and CD68(+) macrophages in cases involving the BM compared to those localized only to the LNs. CONCLUSIONS:  Our study showed that different tumour cell growth in the LN and BM may generate different microenvironments, and suggested that the reduced number of cytotoxic T lymphocytes and macrophages in LNs favours BM infiltration of neoplastic cells in FL.

journal_name

Histopathology

journal_title

Histopathology

authors

Rajnai H,Bödör C,Balogh Z,Gagyi E,Csomor J,Krenács T,Tóth E,Matolcsy A

doi

10.1111/j.1365-2559.2012.04187.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

E66-75

issue

6B

eissn

0309-0167

issn

1365-2559

journal_volume

60

pub_type

杂志文章
  • Pigmented spindle cell carcinoid tumour of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms.

    abstract:AIMS:A variety of histological variants of thymic carcinoid tumour have been described. A rare case of pigmented spindle cell carcinoid tumour of the thymus is documented and compared with the reported cases of thymic pigmented carcinoid tumour in the literature, with a discussion of the differential diagnosis of spind...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2002.01339.x

    authors: Kuo TT

    更新日期:2002-02-01 00:00:00

  • Finding of conjunctival melanocytic pigmented lesions within pterygium.

    abstract:AIMS:Conjunctival pigmented lesions have characteristic clinical and histopathological appearances. Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva. Our aim was to evaluate the possibility of...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02346.x

    authors: Perra MT,Colombari R,Maxia C,Zucca I,Piras F,Corbu A,Bravo S,Scarpa A,Sirigu P

    更新日期:2006-03-01 00:00:00

  • The normal parathyroid and the borderline with early hyperplasia: a light microscopic study.

    abstract::The light microscopical appearance of the normal parathyroid gland based on an autopsy study of 138 glands from 38 adults without evidence of hyperparathyroidism, is described. It differs from earlier descriptions in that we found less adipose tissue in the glands of many normal adults than had been reported. This obs...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1984.tb02353.x

    authors: Saffos RO,Rhatigan RM,Urgulu S

    更新日期:1984-05-01 00:00:00

  • Chromosomal numerical aberrations are frequent in oesophageal and gastric adenocarcinomas: a study using in-situ hybridization.

    abstract:AIMS:(i) To investigate and compare the numerical aberrations of chromosomes 7, 8, 11, 17 and Y in a series of 60 adenocarcinomas of the oesophagus, gastric cardia and gastric antrum; and (ii) to specify the sequence of chromosomal aberrations occurring during the neoplastic progression of Barrett's oesophagus. METHOD...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2000.00887.x

    authors: Beuzen F,Dubois S,Fléjou JF

    更新日期:2000-09-01 00:00:00

  • Secondary vascular changes in pulmonary sequestrations.

    abstract:AIMS:Whilst parenchymal changes in pulmonary sequestrations are well described, there are comparatively little data on associated vascular changes and their extent. The aim of this study was to retrospectively review morphological changes within sequestrations, concentrating on vascular changes and associations with cl...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2010.03586.x

    authors: Desai S,Dusmet M,Ladas G,Pomplun S,Padley SP,Griffin N,Badreddine J,Goldstraw P,Nicholson AG

    更新日期:2010-07-01 00:00:00

  • Value of long-core biopsy in the detection of discrete bone marrow lesions.

    abstract::A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1988.tb01988.x

    authors: Islam A,Henderson ES

    更新日期:1988-06-01 00:00:00

  • Clonal reticulohistiocytosis of the skin and bone marrow associated with systemic mastocytosis and acute myeloid leukaemia.

    abstract:AIMS:The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent a precursor of more aggressive forms of disease. METHODS AND RESULTS:A 59-year-old man with diffuse cutaneous reticulohistiocytosis experienced bone marrow locali...

    journal_title:Histopathology

    pub_type:

    doi:10.1111/his.13166

    authors: Fusco N,Bonometti A,Augello C,Fabris S,Boiocchi L,Fiori S,Morotti D,Fracchiolla N,Berti E,Gianelli U

    更新日期:2017-05-01 00:00:00

  • Assessment of a new system for primary site assignment in high-grade serous carcinoma of the fallopian tube, ovary, and peritoneum.

    abstract:AIMS:The available evidence indicates that most non-uterine high-grade serous carcinomas (HGSCs) arise from the fallopian tube (FT), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment. METHODS...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12651

    authors: Singh N,Gilks CB,Wilkinson N,McCluggage WG

    更新日期:2015-09-01 00:00:00

  • Female adnexal tumour of probable Wolffian origin: a clinicopathological and immunohistochemical study of three cases.

    abstract::The clinical and pathological features of three adnexal tumours of probable Wolffian origin are reported. One case was an incidental finding in a patient who died from ovarian carcinoma; in the other two cases the patients presented with lower abdominal pain. The three tumours were well-circumscribed, solid masses ari...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1995.tb00623.x

    authors: Rahilly MA,Williams AR,Krausz T,al Nafussi A

    更新日期:1995-01-01 00:00:00

  • Digital pathology is a practical alternative to on-site intraoperative frozen section diagnosis in thoracic surgery.

    abstract:AIMS:Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, in which turnaround tim...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13804

    authors: French JMR,Betney DT,Abah U,Bhatt N,Internullo E,Casali G,Batchelor TJP,West DG

    更新日期:2019-05-01 00:00:00

  • Morphological and molecular changes following neoadjuvant endocrine therapy of ER positive breast cancer: implications for clinical practice.

    abstract:BACKGROUND:Neoadjuvant endocrine therapy (NAET) is used in the management of estrogen receptor positive (ER+) breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular profile remain unclear. MATERIAL AND METHODS:A single large instit...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14331

    authors: Badr NM,Spooner D,Steven J,Stevens A,Shaaban AM

    更新日期:2021-01-10 00:00:00

  • Rhabdomyomatosis of the newborn lung unassociated with other malformations.

    abstract:AIMS:To describe a case of rhabdomyomatosis of the lung unassociated with other external or visceral malformations in a newborn infant. METHODS AND RESULTS:A 26 weeks gestation newborn male with no relevant medical or family history presented a well-circumscribed solid area in the posterior mediastinum occupying the u...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1997.2830880.x

    authors: Hardisson D,García-Jiménez JA,Jiménez-Heffernan JA,Nistal M

    更新日期:1997-11-01 00:00:00

  • Current problems in the pathology of intra-epithelial lesions of the uterine cervix.

    abstract::Problems in the interpretation and diagnosis of intraepithelial lesions of the uterine cervix include interobserver differences in respect of grading, uncertainty as to the significance of human papillomavirus infection and debate about the current terminology. The role of human papillomaviruses in cervical intra-epit...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.1990.tb00657.x

    authors: Fox H,Buckley CH

    更新日期:1990-07-01 00:00:00

  • Focal nodular hyperplasia-like areas in cirrhosis.

    abstract:AIMS:Focal nodular hyperplasia-like lesions have rarely been described in cirrhotic livers. We describe five cases of such lesions. METHODS AND RESULTS:Between 1998 and 2001, 146 liver transplants were performed at the Royal Free Hospital for cirrhosis of the liver. Nodular lesions identified in the livers removed at ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01550.x

    authors: Quaglia A,Tibballs J,Grasso A,Prasad N,Nozza P,Davies SE,Burroughs AK,Watkinson A,Dhillon AP

    更新日期:2003-01-01 00:00:00

  • Partial regression in primary carcinoma of the lung: does it occur?

    abstract:AIMS:To study immunohistochemically a group of 28 primary lung cancers which demonstrated histological features reminiscent of those characteristic of regression in malignant melanoma, to determine the phenotype of their immune cell infiltrates. METHODS AND RESULTS:Using a standard s-ABC immunoperoxidase method then q...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:

    authors: Kerr KM,Johnson SK,King G,Kennedy MM,Weir J,Jeffrey R

    更新日期:1998-07-01 00:00:00

  • Renal interstitial foam cells are macrophages.

    abstract::Immunohistochemical studies on renal biopsies from eight patients with various types of glomerulonephritis showed that the interstitial foam cells belonged to the monocyte-macrophage lineage. There was a strong association between hypercholesterolaemia and the presence of renal interstitial foam cells. ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb00949.x

    authors: Franco M,Schmitt F,Rejaili WA,Viero RM,Bacchi CE

    更新日期:1992-02-01 00:00:00

  • Infantile haemangioma expresses tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, osteoprotegerin and receptor activator for nuclear factor кB ligand (RANKL).

    abstract:AIMS:To investigate the expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors and decoy receptors, including osteoprotegerin (OPG) in infantile haemangioma (IH). METHODS AND RESULTS:Immunostaining, Western blotting and quantitative reverse transcription-polymerase chain react...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2011.03970.x

    authors: Vishvanath A,Itinteang T,Tan ST,Day DJ

    更新日期:2011-09-01 00:00:00

  • Low-grade metaplastic carcinoma of the thymus.

    abstract:AIMS:Five cases of a characteristic low-grade thymic epithelial tumour are described that we suggest calling metaplastic carcinoma of the thymus. METHODS AND RESULTS:The patients' ages ranged from 44 to 71 (mean 56.2) years. Four of the patients were male. Three of five tumours showed invasion into mediastinal fat or ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1999.00691.x

    authors: Yoneda S,Marx A,Heimann S,Shirakusa T,Kikuchi M,Müller-Hermelink HK

    更新日期:1999-07-01 00:00:00

  • Familial mediterranean fever and acute myocardial infarction secondary to coronary vasculitis.

    abstract:AIMS:We report a case study to elucidate the pathogenesis of polyarteritis nodosa (PAN) type vasculitis, a rare complication of familial mediterranean fever (FMF). METHODS AND RESULTS:A woman with amyloidosis complicating FMF underwent a cadaveric renal transplantation and 5 years later suffered an acute myocardial in...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1998.00462.x

    authors: Serrano R,Martínez MA,Andrés A,Morales JM,Samartin R

    更新日期:1998-08-01 00:00:00

  • Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in intrahepatic cholangiocarcinoma.

    abstract::Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1994.tb01570.x

    authors: Terada T,Nakanuma Y

    更新日期:1994-08-01 00:00:00

  • Prevalence of somatic and germline mutations of Fumarate hydratase in uterine leiomyomas from young patients.

    abstract:AIMS:Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is caused by germline mutations in the Fumarate hydratase (FH) gene. In young women, the syndrome often presents with symptomatic uterine leiomyomas, leading to myomectomy or hysterectomy. In this study, we aimed to investigate the incidence and muta...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14007

    authors: Liu C,Dillon J,Beavis AL,Liu Y,Lombardo K,Fader AN,Hung CF,Wu TC,Vang R,Garcia JE,Xing D

    更新日期:2020-02-01 00:00:00

  • Urinary bladder carcinoma with a neoplastic squamous component: a mapping study of 31 cases.

    abstract::A mapping study of cystectomy specimens in three cases of pure squamous cell carcinoma and 28 cases with transitional cell carcinoma with squamous differentiation is described, with an emphasis on the histogenesis of pure squamous cell carcinoma. Two of the three cases of pure squamous cell carcinoma had extensive ben...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb00361.x

    authors: Sakamoto N,Tsuneyoshi M,Enjoji M

    更新日期:1992-08-01 00:00:00

  • Immunohistochemical demonstration of p24 HTLV III major core protein in different cell types within lymph nodes from patients with lymphadenopathy syndrome (LAS).

    abstract::The p24 protein is the major core protein of LAV/HTLV III which is the putative agent of the lymphadenopathy syndrome. By the use of an anti-p24 monoclonal antibody we have studied the presence of LAV/HTLV III infected cells in 20 lymph nodes obtained from lymphadenopathy syndrome patients: 14 lymph nodes were charact...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1986.tb02456.x

    authors: Baroni CD,Pezzella F,Mirolo M,Ruco LP,Rossi GB

    更新日期:1986-01-01 00:00:00

  • A monoclonal antibody against SV40 large T antigen (PAb416) does not label Merkel cell carcinoma.

    abstract:AIMS:Merkel cell carcinoma represents poorly differentiated neuroendocrine carcinoma of cutaneous origin. In most studies, the vast majority of Merkel cell carcinomas are Merkel cell polyomavirus (MCPyV)-associated. SV40 polyomavirus immunohistochemistry is typically used in the diagnosis of other polyomavirus-associat...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13483

    authors: Pelletier DJ,Czeczok TW,Bellizzi AM

    更新日期:2018-07-01 00:00:00

  • Immunohistochemical characterization of prototypical endometrial clear cell carcinoma--diagnostic utility of HNF-1β and oestrogen receptor.

    abstract:AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12286

    authors: Hoang LN,Han G,McConechy M,Lau S,Chow C,Gilks CB,Huntsman DG,Köbel M,Lee CH

    更新日期:2014-03-01 00:00:00

  • Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection.

    abstract:AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12499

    authors: Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

    更新日期:2015-01-01 00:00:00

  • A histological comparison of cutaneous malignant melanoma between the Oxford Region and Western Australia.

    abstract::Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predomi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1982.tb02765.x

    authors: Heenan PJ,Holman CD

    更新日期:1982-11-01 00:00:00

  • Sweat-gland carcinomas: prognosis related to histological type.

    abstract::A series of 10 sweat-gland carcinomas is reported. The ages of the patients at presentation ranged from 12 to 79 years. Three of the tumours had shown long latent periods with a mass present for up to 20 years. Prognosis proved to be related to the histological subtype. Thus, two papillary syringocystadeno-carcinomas,...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1980.tb02939.x

    authors: Dissanayake RV,Salm R

    更新日期:1980-07-01 00:00:00

  • The histopathology of congenital haemangioma and its clinical correlations: a long-term follow-up study of 55 cases.

    abstract:AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14114

    authors: El Zein S,Boccara O,Soupre V,Vieira AF,Bodemer C,Coulomb A,Wassef M,Fraitag S

    更新日期:2020-08-01 00:00:00

  • Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland.

    abstract:AIMS:The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns, and the tubular variant is the one that presents the str...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12339

    authors: Montalli VA,Martinez E,Tincani A,Martins A,Abreu Mdo C,Neves C,Costa AF,Araújo VC,Altemani A

    更新日期:2014-05-01 00:00:00