Low-grade metaplastic carcinoma of the thymus.

abstract：AIMS:To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells. METHODS AND RESULTS:KIT and SCF expression were studied in 248 human tumours consisting of 15 different histological types using immunohistochemistry and in situ hybridization for KIT ...

journal_title：Histopathology

authors： Sihto H,Tynninen O,Halonen M,Puputti M,Karjalainen-Lindsberg ML,Kukko H,Joensuu H

更新日期：2009-11-01 00:00:00

abstract：AIM:To determine the extent of clonal outgrowth in the lymphocytic tissue infiltrate of lichen sclerosus (LS). The presence of T cells with a monoclonally rearranged T-cell receptor gamma-gene (TCRgamma) has been described in up to 50% of biopsies of vulvar and penile LS. MATERIAL AND RESULTS:We analysed 33 foreskin s...

journal_title：Histopathology

authors： Regauer S,Beham-Schmid C

更新日期：2006-05-01 00:00:00

abstract：AIMS:Collagenous spherulosis (CS) is a rare lesion which is an incidental finding in breast and salivary glands. It is characterized by fibrillar spherules exhibiting an intrinsic radiating or concentric pattern which are surrounded by myoepithelial cells. This entity can be misdiagnosed as adenoid cystic carcinoma and...

journal_title：Histopathology

authors： Treilleux I,Godeneche J,Duvillard P,Clement-Chassagne C,Suignard Y,Bailly C

更新日期：1999-09-01 00:00:00

abstract：AIMS:Focal nodular hyperplasia-like lesions have rarely been described in cirrhotic livers. We describe five cases of such lesions. METHODS AND RESULTS:Between 1998 and 2001, 146 liver transplants were performed at the Royal Free Hospital for cirrhosis of the liver. Nodular lesions identified in the livers removed at ...

journal_title：Histopathology

authors： Quaglia A,Tibballs J,Grasso A,Prasad N,Nozza P,Davies SE,Burroughs AK,Watkinson A,Dhillon AP

更新日期：2003-01-01 00:00:00

abstract：:HLA-DR expression was examined in 50 consecutive primary cutaneous malignant melanomas with a Breslow depth greater than 2 mm using two well-characterized monoclonal antibodies which detect fixation-resistant epitopes. In 31 of these cases (62%) a subpopulation of tumour cells was reactive, although there was consider...

journal_title：Histopathology

authors： Colloby PS,West KP,Fletcher A

更新日期：1992-05-01 00:00:00

abstract：AIM:Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in ...

journal_title：Histopathology

authors： Lin CK,Tsai WC,Lin YC,Hueng DY

更新日期：2012-01-01 00:00:00

abstract：:The published literature is awash with examples of new tissue biomarkers promising to predict responses to therapy in breast cancer patients. However, few, if any, of these progress from the laboratory to the clinic. In this review we discuss some of the reasons for this, illustrating our discussion with a selection o...

journal_title：Histopathology

authors： Faratian D,Bartlett J

更新日期：2008-01-01 00:00:00

abstract：:A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...

journal_title：Histopathology

authors： Chan WY,Hui PK,Leung KM,Thomas TM

更新日期：1992-12-01 00:00:00

abstract：:Eight cases of myelosarcoma without acute leukaemia at time of diagnosis were reviewed and biopsies were immunostained using antibodies reacting with myeloid/monocytic markers. Initial tumour location included lymph nodes, paranasal sinuses, nasopharyngeal and/or orbital regions and other extranodal locations. Three c...

journal_title：Histopathology

authors： Furebring-Fredén M,Martinsson U,Sundström C

更新日期：1990-03-01 00:00:00

abstract：AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...

journal_title：Histopathology

authors： Hoang LN,Han G,McConechy M,Lau S,Chow C,Gilks CB,Huntsman DG,Köbel M,Lee CH

更新日期：2014-03-01 00:00:00

abstract：:An immunocytochemical and cytophotometrical analysis of 30 renal cell carcinomas was carried out in order to investigate the expression of cytokeratin and vimentin in relation to the ploidy and mitotic index. Thirty renal cell carcinomas were studied using monoclonal antibodies CAM 5.2 and anti-vimentin in a biotin-st...

journal_title：Histopathology

authors： Dierick AM,Praet M,Roels H,Verbeeck P,Robyns C,Oosterlinck W

更新日期：1991-04-01 00:00:00

abstract：:Many classification schemes have been proposed for ductal carcinoma in situ. Architectural heterogeneity is widely recognized. Cytonuclear grade appears to have greater prognostic significance than architectural pattern. This study assesses heterogeneity using a classification based on cytological grade and compares t...

journal_title：Histopathology

authors： Harrison M,Coyne JD,Gorey T,Dervan PA

更新日期：1996-05-01 00:00:00

abstract：AIMS:Three cases with features of so-called 'Warthin-like tumour' of the thyroid (WaLTT) are described, in order to evaluate its relationship with papillary carcinoma (PC). METHODS AND RESULTS:We performed an histological and immunohistochemical study with emphasis on RET/PTC expression. The most striking features are...

journal_title：Histopathology

authors： D'Antonio A,De Chiara A,Santoro M,Chiappetta G,Losito NS

更新日期：2000-06-01 00:00:00

abstract：AIMS:Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, in which turnaround tim...

journal_title：Histopathology

authors： French JMR,Betney DT,Abah U,Bhatt N,Internullo E,Casali G,Batchelor TJP,West DG

更新日期：2019-05-01 00:00:00

abstract：AIMS:Littoral cell angioma (LCA) is a rare primary splenic tumour that is frequently associated with internal malignancies. Immunohistochemistry can demonstrate a distinct hybrid endothelial-histiocytic phenotype of littoral cells, and is a helpful adjunct for making the correct diagnosis. The aims of this study were t...

journal_title：Histopathology

authors： Peckova K,Michal M,Hadravsky L,Suster S,Damjanov I,Miesbauerova M,Kazakov DV,Vernerova Z,Michal M

更新日期：2016-11-01 00:00:00

abstract：AIMS:Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate...

journal_title：Histopathology

authors： Lee HJ,Shin DH,Kim SY,Hwang CS,Lee JH,Park WY,Choi KU,Kim JY,Lee CH,Sol MY,Rha SH,Park SW

更新日期：2018-11-01 00:00:00

abstract：AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...

journal_title：Histopathology

authors： Jerome Marson V,Mazieres J,Groussard O,Garcia O,Berjaud J,Dahan M,Carles P,Daste G

更新日期：2004-08-01 00:00:00

abstract：:This histogenesis of cystic mucinous ovarian tumours is still controversial. It has been proposed that these neoplasms may arise from metaplastic ovarian surface epithelium. Others have suggested that these tumours represent monophyletic (intestinal) types of teratoma. Against this background we have studied the prese...

journal_title：Histopathology

authors： Louwerens JK,Schaberg A,Bosman FT

更新日期：1983-05-01 00:00:00

abstract：AIMS:Y-box binding protein-1 (YB-1) is known to modulate gene transcription and protein translation, as well as cellular response to drug treatment. The aim of this study is to correlate YB-1 protein expression levels with clinicopathological parameters in intestinal-type gastric cancer tissue samples (as categorized b...

journal_title：Histopathology

authors： Guo T,Yu Y,Yip GW,Baeg GH,Thike AA,Lim TK,Tan PH,Matsumoto K,Bay BH

更新日期：2015-03-01 00:00:00

abstract：AIMS:To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs). METHODS AND RESULTS:Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7,...

journal_title：Histopathology

authors： Handra-Luca A,Fléjou JF,Rufat P,Corcos O,Belghiti J,Ruszniewski P,Degott C,Bedossa P,Couvelard A

更新日期：2006-06-01 00:00:00

abstract：AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...

journal_title：Histopathology

authors： Mao TL,Ayhan A,Kuo KT,Lin MC,Tseng LH,Ogawa H

更新日期：2015-10-01 00:00:00

abstract：AIM:To train and individually validate a group of breast pathologists in specialty-specific digital primary diagnosis by using a novel protocol endorsed by the Royal College of Pathologists' new guideline for digital pathology. The protocol allows early exposure to live digital reporting, in a risk-mitigated environmen...

journal_title：Histopathology

authors： Williams BJ,Hanby A,Millican-Slater R,Nijhawan A,Verghese E,Treanor D

更新日期：2018-03-01 00:00:00

abstract：AIMS:Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates in a subset of patients suggest that a sensitive companion diagnostic test is required. The predictive value of programmed death ligand 1 (PD-L1) staining in melanoma has been questioned due to inconsist...

journal_title：Histopathology

authors： Koelzer VH,Gisler A,Hanhart JC,Griss J,Wagner SN,Willi N,Cathomas G,Sachs M,Kempf W,Thommen DS,Mertz KD

更新日期：2018-09-01 00:00:00

abstract：AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...

journal_title：Histopathology

authors： Ramani P,Nash R,Radevsky L,Patel A,Luckett M,Rogers C

更新日期：2012-12-01 00:00:00

abstract：AIMS:Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, are morphologically similar to pulmonary hamartomas, which are much more common. There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB imm...

journal_title：Histopathology

authors： Chatzopoulos K,Fritchie KJ,Aubry MC,Carney JA,Folpe AL,Boland JM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue and is often considered useful as a phenotypic marker in breast cancer diagnosis, with absence of its expression frequently observed in tumours of lobular subtype. However, the clinicopathological and prognostic value of E-cadhe...

journal_title：Histopathology

authors： Rakha EA,Abd El Rehim D,Pinder SE,Lewis SA,Ellis IO

更新日期：2005-06-01 00:00:00

abstract：AIMS:Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is caused by germline mutations in the Fumarate hydratase (FH) gene. In young women, the syndrome often presents with symptomatic uterine leiomyomas, leading to myomectomy or hysterectomy. In this study, we aimed to investigate the incidence and muta...

journal_title：Histopathology

authors： Liu C,Dillon J,Beavis AL,Liu Y,Lombardo K,Fader AN,Hung CF,Wu TC,Vang R,Garcia JE,Xing D

更新日期：2020-02-01 00:00:00

abstract：AIMS:BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR-associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR-associated non-uterine sarcomas in adult patients. METHODS AND RESULTS:The patients were four men an...

journal_title：Histopathology

authors： Yoshida A,Arai Y,Hama N,Chikuta H,Bando Y,Nakano S,Kobayashi E,Shibahara J,Fukuhara H,Komiyama M,Watanabe SI,Tamura K,Kawai A,Shibata T

更新日期：2020-03-01 00:00:00

abstract：AIMS:Secretory carcinoma (SC) is a rare histological type of breast cancer, and ETV6-NTRK3 gene fusion is highly specific to it. The differential diagnoses of SC include acinic cell carcinoma (ACCA) and cystic hypersecretory carcinoma (CHC), as well as invasive ductal carcinoma (IDC). For patients with these rare but d...

journal_title：Histopathology

authors： Osako T,Takeuchi K,Horii R,Iwase T,Akiyama F

更新日期：2013-10-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a d...

journal_title：Histopathology

authors： Johnson A,Akerman M,Cavallin-Ståhl E

更新日期：1987-06-01 00:00:00