Abstract:
AIMS:To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confused with primary or metastatic carcinoma. METHODS AND RESULTS:Molecular analysis demonstrated for the first time the presence of FUS-CHOP transcript in this liposarcoma variant. Microarray analysis revealed a gene expression profile related to a more aggressive tumour type when compared with other myxoid/round cell liposarcomas. CONCLUSIONS:The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.
journal_name
Histopathologyjournal_title
Histopathologyauthors
De Cecco L,Gariboldi M,Reid JF,Lagonigro MS,Tamborini E,Albertini V,Staurengo S,Pilotti S,Pierotti MAdoi
10.1111/j.1365-2559.2005.02064.xkeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
334-41issue
3eissn
0309-0167issn
1365-2559pii
HIS2064journal_volume
46pub_type
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