Abstract:
:Expression of the epidermal growth factor receptor (EGFR) was studied in cryosections from human thyroid tissues. Normal tissue (4 cases), nodular goitre (12), toxic goitre (9), adenoma (9), follicular carcinoma (1), papillary carcinoma (7) and poorly differentiated carcinoma (1) were used for immunohistochemistry. Northern blot analysis was performed in two nodular goitres, three adenomas, two papillary carcinomas, one follicular carcinoma and the adjacent normal tissue in five cases as well as in two cell lines from anaplastic carcinomas. Epidermal growth factor receptor immunoreactivity was detected in all tissues examined. The amount of EGFR mRNA did not differ between normal and abnormal tissues. However, the EGFR staining was weaker in normal thyroid tissue compared to the adjacent neoplastic areas suggesting an upregulation at the posttranslational level in the latter. A strong staining was also seen in hyperfunctioning thyroid glands. The EGFR location was mainly basal or basolateral in all thyroid tissues with normal histology and in toxic diffuse goitre. Pericellular and sometimes cytoplasmatic staining was seen in neoplastic tissues. In nodular goitre the staining was both basal, lateral and apical and varied in intensity. Our data suggest that a non-polarized location of EGFR probably indicates a loss of the normal epithelial cell polarity and could be interpreted as an early sign of dedifferentiation. Furthermore, a role for the EGFR is proposed, not only in the development of thyroid neoplasias but also in goitre formation.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Westermark K,Lundqvist M,Wallin G,Dahlman T,Hacker GW,Heldin NE,Grimelius Ldoi
10.1046/j.1365-2559.1996.d01-427.xsubject
Has Abstractpub_date
1996-03-01 00:00:00pages
221-7issue
3eissn
0309-0167issn
1365-2559journal_volume
28pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:Malignant odontogenic tumours (MOTs) are rare neoplasms occurring primarily within the jaw. The objective of this study was to determine the incidence, demographics and clinicopathological features of the MOTs from two institutions. METHODS AND RESULTS:The records of the Department of Oral Pathology, Faculty of D...
journal_title:Histopathology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2559.2012.04200.x
更新日期:2012-07-01 00:00:00
abstract:AIMS:Adenoviral inclusions are commonly seen in appendices from infants with intussusception. They are associated with focal epithelial budding and less frequently with epithelial shedding. These morphological changes could depend on the opposing effects of adenoviral gene products on CD95-mediated apoptosis. METHODS ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2840875.x
更新日期:1997-10-01 00:00:00
abstract:AIMS:Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland carcinomas. Epidermal growth factor receptor (EGFR) signalling pathway gene mutations are important in predicting a patient's prognosis, selecting molecularly targeted drugs and estimating the efficacy of a molecular therapy. However, their si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14100
更新日期:2020-06-01 00:00:00
abstract::Two cases of tubulovillous adenoma and adjacent colonic mucosa were studied in which intestinal spirochaetosis had heavily colonized the non-neoplastic but not the neoplastic epithelium. Ultrastructural and histochemical studies were performed and we postulate that the reason for this disparity is the normal microvill...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb01530.x
更新日期:1995-10-01 00:00:00
abstract::The morphology, phenotype, genotype and clinical behaviour of four cases of mantle cell lymphoma (centrocytic lymphoma) presenting primarily in mucosa (two gastric, one in large bowel and one tonsillar) are reviewed. Their relationship with the broader group of mantle cell and mucosa-associated lymphoid tissue (MALT) ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00248.x
更新日期:1995-05-01 00:00:00
abstract::The recognition of recurrent genetic alterations in specific tumour types has provided the basis for the reclassification of certain soft tissue neoplasms, and molecular analysis of patient material has the potential to provide both diagnostic and prognostic information. In this review, we evaluate the role of molecul...
journal_title:Histopathology
pub_type: 历史文章,杂志文章,评审
doi:10.1046/j.1365-2559.2000.01107.x
更新日期:2000-12-01 00:00:00
abstract::This review intends to update current knowledge regarding molecular cytogenetics in melanocytic tumours with a focus on cutaneous melanocytic lesions. Advantages and limitations of diverse, already established methods, such as (fluorescence) in situ hybridization and mutation analysis, to detect these cytogenetic alte...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.2009.03452.x
更新日期:2010-01-01 00:00:00
abstract:AIMS:Several studies have demonstrated that Na(+) /H(+) exchanger regulatory factor 1 (NHERF1) protein, which is overexpressed and heterogeneously distributed in different stages of breast cancer, could be used as a tumour marker for prognosis in molecular detection strategies. We observed that tumour-infiltrated lymph...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.03844.x
更新日期:2011-06-01 00:00:00
abstract:AIMS:To identify clinicopathological characteristics of cholangiocarcinoma and premalignant lesions arising in patients with primary sclerosing cholangitis (PSC). METHODS AND RESULTS:This study consisted of 25 patients with PSC and bile duct neoplasia [16 with cholangiocarcinoma and nine with biliary intra-epithelial ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.04048.x
更新日期:2011-12-01 00:00:00
abstract::Two patients are described in each of whom metastatic prostatic carcinoma presented as a tumour of the parotid gland. In one, primary prostate cancer had been diagnosed three years prior to the appearance of what was believed clinically to be an unrelated salivary lesion. In the other a neck swelling was the first ind...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.1997.d01-563.x
更新日期:1997-01-01 00:00:00
abstract:AIMS:To determine the expression of matrix metalloproteinases (MMPs)-2, -7 and -9 and beta-catenin in uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) and to investigate any difference in expression between EEC and USC which might explain the mechanism of invasion and aggressive behaviour of ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02612.x
更新日期:2007-02-01 00:00:00
abstract::A recently developed and validated histochemical method--immunogold-streptavidin enhancement--was used to determine oestrogen receptor content in paraffin sections of breast cancers. The selection of the best cut-off point to define oestrogen receptor status as rich or poor was made on the basis of survival data, usin...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb00735.x
更新日期:1990-10-01 00:00:00
abstract::Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01574.x
更新日期:1994-08-01 00:00:00
abstract::Intra-abdominal panniculitis is a tumour-like inflammatory condition of adipose tissue. The aetiology and pathogenesis of the disease is unknown, but a number of associated diseases have been recorded. It has been customary to deal with only primary cases in the literature. This study was undertaken in order to descri...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-486.x
更新日期:1996-07-01 00:00:00
abstract::High levels of bcl-2 protein have been found in a wide variety of human cancers. Since p53 gene inactivation occurs in over half of human cancers, it is possible that loss of p53-mediated repression of bcl-2 gene expression accounts, at least in part, for the frequent abnormalities in bcl-2 protein production seen in ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-431.x
更新日期:1996-04-01 00:00:00
abstract::The expression of cytokeratin intermediate filaments by a tumour has been accepted as evidence of an epithelial origin. Although there have been anecdotal reports of cytokeratin expression within tissues and neoplasms of non-epithelial origin, particularly muscle, there have been no comprehensive studies of its freque...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1987.tb02656.x
更新日期:1987-05-01 00:00:00
abstract::Formalin-fixed, paraffin-embedded material from 15 haemangioendotheliosarcomas and eight malignant haemangiopericytomas was stained with an immunohistochemical technique for the presence of factor VIII-related antigen (F VIII-RAg), actin, laminin and for reactivity with the lectin Ulex europaeus I (UEA-I). Haemangioen...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1988.tb01955.x
更新日期:1988-04-01 00:00:00
abstract:AIMS:To study the pathogenesis of tumoral calcinosis (TC), we investigated 111 cases registered in Zaire over 30 years. METHODS AND RESULTS:The patients were 108 black Africans and three Caucasians between 3 and 74 years of age (mean, 37.7; median, 39). The gender was known in 33 males and 46 females; in 79 the gender...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.6050831.x
更新日期:1997-07-01 00:00:00
abstract:AIMS:Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, are morphologically similar to pulmonary hamartomas, which are much more common. There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB imm...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13945
更新日期:2019-12-01 00:00:00
abstract:AIMS:The purpose of this study was to examine the occurrence of CD44 isoforms in breast carcinomas and their role in predicting clinical outcome. METHODS AND RESULTS:Shock-frozen tumour tissues from 110 patients with breast carcinoma were examined by immunohistochemistry using antibodies directed against CD44s, v5, v6...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2003.01622.x
更新日期:2003-06-01 00:00:00
abstract::Advances in modern chemotherapy and targeted treatments have resulted in lengthened survival in a variety of tumour types in the last decade. Increasingly in the 21st century, postchemotherapy resections are considered as a possible mode of treatment. Due to their exquisite chemosensitivity, resection of postchemother...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13078
更新日期:2017-01-01 00:00:00
abstract::Forty cases of the distinctive but poorly recognized aneurysmal variant of cutaneous fibrous histiocytoma are described. These tumours presented most commonly in middle-age adults, with a slight predilection for females. Anatomical distribution was wide with most cases occurring in the lower limb/limb girdle (50%), up...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00193.x
更新日期:1995-04-01 00:00:00
abstract::The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb01606.x
更新日期:1989-11-01 00:00:00
abstract:AIMS:There have been several cell kinetic studies of thymoma, but the effectiveness of using Ki67 antibody as a tool to measure proliferative activity in this tumour was rarely evaluated. We carried out an immuno-histochemical study using this antibody to assess the clinicopathological correlation and the prognostic si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00504.x
更新日期:1998-11-01 00:00:00
abstract:AIMS:To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge-shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. METHODS AND RESULTS:The hi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02822.x
更新日期:2007-10-01 00:00:00
abstract:AIMS:MUC4 is a transmembrane glycoprotein that plays a role in cell growth signalling and is expressed in various epithelial tissues. Gene expression profiling and immunohistochemical analyses revealed that MUC4 is also constantly and specifically expressed in low-grade fibromyxoid sarcomas and sclerosing epithelioid f...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13730
更新日期:2019-01-01 00:00:00
abstract:AIMS:Recent analyses have suggested that Hodgkin's or Reed-Sternberg (HRS) cells in most cases of classic Hodgkin's disease are derived from germinal centre B-cells. However, there is controversy over which B-cell antigens are expressed in HRS cells. METHODS AND RESULTS:We studied 51 cases of classic Hodgkin's disease...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00830.x
更新日期:2000-04-01 00:00:00
abstract::The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2002.01420.x
更新日期:2002-10-01 00:00:00
abstract:AIMS:The presence of micrometastases in the sentinel lymph node (SLN) is an important prognostic parameter for melanoma patients. The aim was to determine the prognostic relevance of histopathological characteristics of micrometastases in the SLN, which has not been adequately addressed thus far. METHODS AND RESULTS:I...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02681.x
更新日期:2007-05-01 00:00:00
abstract:AIMS:To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS:We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our instituti...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12147
更新日期:2013-08-01 00:00:00