Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics?

abstract：AIM:Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in ...

journal_title：Histopathology

authors： Lin CK,Tsai WC,Lin YC,Hueng DY

更新日期：2012-01-01 00:00:00

abstract：AIMS:Neoadjuvant chemotherapy followed by surgery is the standard of care for patients with gastro-oesophageal adenocarcinoma. The aims were to validate the utility of the tumour regression grade (TRG) in patients who have received chemotherapy and to investigate if (i) TRG correlates with tumour downstaging and (ii) T...

journal_title：Histopathology

authors： Fareed KR,Ilyas M,Kaye PV,Soomro IN,Lobo DN,Parsons SL,Madhusudan S

更新日期：2009-10-01 00:00:00

abstract：:The treatment of cancer has changed dramatically over the last decade, driven by increased understanding of the cancer genome, immune landscape, molecular alterations and aberrant pathways that drive cancer progression. Advances in molecular biology have led to the development of targeted agents, including monoclonal ...

journal_title：Histopathology

authors： Crusz SM,Miller RE

更新日期：2020-01-01 00:00:00

abstract：AIMS:Pathological staging in penectomies may be difficult due to the anatomical complexity of penile anatomy, and may be additionally challenging due to the low volume at most institutions. Our study aimed to assess the feasibility of whole-mount processing for penectomy specimens. METHODS AND RESULTS:A 7-year retrosp...

journal_title：Histopathology

authors： Ebel JJ,Shabsigh A,Sharp DS,Zynger DL

更新日期：2013-07-01 00:00:00

abstract：AIMS:To evaluate whether there is a correlation between the subcellular localization of maspin and the histological, molecular and biological features of pulmonary adenocarcinoma, particularly addressing the hypothesis that the tumour inhibitor properties of maspin may be linked to a nuclear, compared with a combined n...

journal_title：Histopathology

authors： Frey A,Soubani AO,Adam AK,Sheng S,Pass HI,Lonardo F

更新日期：2009-04-01 00:00:00

abstract：AIM:To evaluate the intraobserver and interobserver reproducibility of the HER2 in-situ hybridization (ISH) test in breast cancer by measuring the impact of counting different numbers of invasive cancer cells. METHODS AND RESULTS:A cohort of 101 primary invasive breast cancer cases were evaluated for HER2 gene amplifi...

journal_title：Histopathology

authors： Polónia A,Eloy C,Pinto J,Braga AC,Oliveira G,Schmitt F

更新日期：2017-08-01 00:00:00

abstract：AIMS:Chondrosarcoma is primarily a tumour of adulthood and old age. Some studies indicate that survival is worse in paediatric than in adult chondrosarcomas. In view of the rarity of paediatric chondrosarcoma, few large studies are currently available. METHODS AND RESULTS:We evaluated the clinical, radiological and pa...

journal_title：Histopathology

authors： Gambarotti M,Righi A,Picci P,Bertoni F,Manfrini M,Donati DM,Dei Tos AP,Vanel D

更新日期：2016-06-01 00:00:00

abstract：AIMS:To investigate the prognostic significance of chromosomal alterations in colorectal cancer patients. Histopathological tumour classification is still considered to be the gold standard for the characterization of solid tumours. However, it is well known that such established parameters do not satisfactorily predic...

journal_title：Histopathology

authors： Knösel T,Schlüns K,Stein U,Schwabe H,Schlag PM,Dietel M,Petersen I

更新日期：2003-10-01 00:00:00

abstract：AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common intra-oral salivary gland malignancy. The vast majority of PLGAs harbour a PRKD1 E710D hot-spot somatic mutation or somatic rearrangements of PRKD1, PRKD2 or PRKD3. Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to def...

journal_title：Histopathology

authors： Piscuoglio S,Fusco N,Ng CK,Martelotto LG,da Cruz Paula A,Katabi N,Rubin BP,Skálová A,Weinreb I,Weigelt B,Reis-Filho JS

更新日期：2016-06-01 00:00:00

abstract：AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...

journal_title：Histopathology

authors： Stanoszek LM,Chan MP,Palanisamy N,Carskadon S,Siddiqui J,Patel RM,Harms KL,Lowe L,Fullen DR,Harms PW

更新日期：2019-02-01 00:00:00

abstract：:We studied kidney sections from 15 cases of polyarteritis using an immunocytochemical technique to demonstrate cells containing immunoreactive renin. Ten cases of classical polyarteritis nodosa showed hyperplasia of renin-containing cells in areas of renal cortex with histological evidence of ischaemia--appearances in...

journal_title：Histopathology

authors： Graham PC,Lindop GB

更新日期：1990-04-01 00:00:00

abstract：AIMS:Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate efflux in glycolytic tumours. However, their role in solid tumours is still poorly understood. Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in...

journal_title：Histopathology

authors： Pinheiro C,Albergaria A,Paredes J,Sousa B,Dufloth R,Vieira D,Schmitt F,Baltazar F

更新日期：2010-06-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to det...

journal_title：Histopathology

authors： Yamauchi A,Ikeda J,Nakamichi I,Kohara M,Fukuhara S,Hino M,Kanakura Y,Ogawa H,Sugiyama H,Kanamaru A,Aozasa K,Osaka Lymphoma Study Group.

更新日期：2008-05-01 00:00:00

abstract：:Nineteen out of 121 consecutive cardiac biopsies from 107 patients were found to contain amyloid deposits on routine Congo red screening. Seventeen were left atrial appendages removed during mitral valvotomy for chronic rheumatic mitral valve disease while the remaining two were right atrial appendages excised during ...

journal_title：Histopathology

authors： Looi LM

更新日期：1981-11-01 00:00:00

abstract：AIMS:Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncer...

journal_title：Histopathology

authors： Miligy I,Mohan P,Gaber A,Aleskandarany MA,Nolan CC,Diez-Rodriguez M,Mukherjee A,Chapman C,Ellis IO,Green AR,Rakha EA

更新日期：2017-08-01 00:00:00

abstract：:During the last decade pathology has benefited from the rapid progress of image digitizing technology. The improvement in this technology had led to the creation of slide scanners which are able to produce whole slide images (WSI) which can be explored by image viewers in a way comparable to the conventional microscop...

journal_title：Histopathology

authors： Al-Janabi S,Huisman A,Van Diest PJ

更新日期：2012-07-01 00:00:00

abstract：:Wilms' tumour (nephroblastoma) has been associated with chromosomal abnormalities at the 11p13, 11p15 and 16q regions. A study into the possibility of mutations occurring within p53, the ubiquitous adult tumour suppressor gene, in Wilms' tumour was carried out. Thirty-eight cases were studied. Of these 36 were categor...

journal_title：Histopathology

authors： Cheah PL,Looi LM,Chan LL

更新日期：1996-01-01 00:00:00

abstract：AIMS:The presence of micrometastases in the sentinel lymph node (SLN) is an important prognostic parameter for melanoma patients. The aim was to determine the prognostic relevance of histopathological characteristics of micrometastases in the SLN, which has not been adequately addressed thus far. METHODS AND RESULTS:I...

journal_title：Histopathology

authors： Satzger I,Völker B,Al Ghazal M,Meier A,Kapp A,Gutzmer R

更新日期：2007-05-01 00:00:00

abstract：AIMS:Diversion colitis (DC) is a localized, relatively benign, iatrogenic condition which occurs in almost 100% of diverted colonic segments in patients who undergo ileostomy/colostomy for various reasons. The aim of this study was to establish histological features of DC in children. METHODS AND RESULTS:Twenty-three ...

journal_title：Histopathology

authors： Vujanić GM,Dojcinov SD

更新日期：2000-01-01 00:00:00

abstract：AIMS:To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' biopsy (MT), the accuracy of these diagnoses, and whether it is justified not to undertake surgical excision of non-malignant papillary lesions so diagnosed. METHODS AND RESULTS:...

journal_title：Histopathology

authors： Yamaguchi R,Tanaka M,Tse GM,Yamaguchi M,Terasaki H,Hirai Y,Nonaka Y,Morita M,Yokoyama T,Kanomata N,Naito Y,Akiba J,Yano H

更新日期：2015-03-01 00:00:00

abstract：:A case of visceral botryomycosis of the liver in a 50-year-old man is reported. The clinical diagnosis was hepatocellular carcinoma. Pathological examination of the surgically resected specimen demonstrated microabscesses containing gram- positive microorganisms with surrounding fibrosis replacing liver parenchyma. An...

journal_title：Histopathology

authors： Omar T,Cooper K

更新日期：1995-07-01 00:00:00

abstract：:Two cases of papillary and cystic neoplasm of the pancreas (PCN) occurring in 17 and 21 year old women are reported with ultrastructural and immunohistochemical findings. A review of the English literature shows that although potentially malignant, PCN, which occurs mainly in young women, is amenable to surgical cure....

journal_title：Histopathology

authors： Learmonth GM,Price SK,Visser AE,Emms M

更新日期：1985-01-01 00:00:00

abstract：:Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...

journal_title：Histopathology

authors： Olenick SJ,Fan CC,Ryoo JW

更新日期：1994-08-01 00:00:00

abstract：AIMS:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily. Although its overexpression in various cancers has been reported, little is known about its expression and clinical significance in oral squamous cell carcinoma (OSCC). This study aimed to elucidate the clinical significanc...

journal_title：Histopathology

authors： Shinriki S,Jono H,Ueda M,Obayashi K,Nakamura T,Ota K,Ota T,Sueyoshi T,Guo J,Hayashi M,Hiraki A,Nakayama H,Yamashita S,Shinohara M,Ando Y

更新日期：2014-02-01 00:00:00

abstract：:A case is reported of nodular lymphocyte predominant Hodgkin's disease arising 13 years after the removal of a lymph node from the same site which showed marked progressive transformation of germinal centres. The morphological evidence for a histogenetic relationship between the two conditions is presented and discuss...

journal_title：Histopathology

authors： Crossley B,Heryet A,Gatter KC

更新日期：1987-06-01 00:00:00

abstract：:Aneuploidy is an important prognostic factor in many cancers. Chromosome 1 abnormalities are present in most breast carcinomas. These may be part of a non-specific increase in DNA (aneuploid status) or represent a restricted chromosomal abnormality. In 16 breast carcinomas we compared chromosome 1 aneusomy with ploidy...

journal_title：Histopathology

authors： Harrison MM,Magee HM,O'Loughlin JF,Gorey TF,Coyne JD,Dervan PA

更新日期：1997-03-01 00:00:00

abstract：AIMS:To evaluate primary and recurrent embryonal sarcoma of the liver and to improve recognition of its morphological variants and immunohistochemical features. METHODS AND RESULTS:Fourteen primary and two recurrent cases of hepatic embryonal sarcoma were evaluated histologically and investigated immunohistochemically...

journal_title：Histopathology

authors： Zheng JM,Tao X,Xu AM,Chen XF,Wu MC,Zhang SH

更新日期：2007-08-01 00:00:00

abstract：:Immunohistochemical studies on renal biopsies from eight patients with various types of glomerulonephritis showed that the interstitial foam cells belonged to the monocyte-macrophage lineage. There was a strong association between hypercholesterolaemia and the presence of renal interstitial foam cells. ...

journal_title：Histopathology

authors： Franco M,Schmitt F,Rejaili WA,Viero RM,Bacchi CE

更新日期：1992-02-01 00:00:00

abstract：:In a prospective autopsy study of male subjects with solic malignant neoplasms, six were shown to have metastatic deposits within the testis (2.5%). These were metastases from carcinoma of the prostate (two cases), melanoma (two cases), bronchial carcinoma (one case) and pleural mesothelioma (one case). In addition, f...

journal_title：Histopathology

authors： Tiltman AJ

更新日期：1979-01-01 00:00:00

abstract：AIMS:Glypican 3 (GPC3) has been reported to be overexpressed in yolk sac tumour (YST), but the sensitivity has not been compared with alpha-fetoprotein (AFP). YST can form numerous growth patterns and the expression of GPC3 in these patterns has not been studied. The aim was to address these aspects. METHODS AND RESUL...

journal_title：Histopathology

authors： Zynger DL,McCallum JC,Luan C,Chou PM,Yang XJ

更新日期：2010-05-01 00:00:00