Abstract:
:Histological features were semi-quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile-duct lesions were prominent and a particular pattern was found in which segments of bile ducts were "disrupted" and replaced by inflammatory reaction. A classification of the lesions is proposed: Class o--near normal livers; Class I--predominance of necrosis and suppuration; Class II--predominance of tuberculoid granulomas; Class III--portal fibrosis and non-specific infiltrate. There has been no evidence that treatment could induce bile-duct proliferation, fatty change of liver cells, or cholestasis. On the other hand, less fibrosis was found in treated patients. Pathogenesis of the bile-duct lesions is discussed.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Teixeira F,Gayotto LC,De Brito Tdoi
10.1111/j.1365-2559.1978.tb01716.xsubject
Has Abstractpub_date
1978-07-01 00:00:00pages
231-7issue
4eissn
0309-0167issn
1365-2559journal_volume
2pub_type
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