Morphological patterns of the liver in South American blastomycosis.

Abstract:

:Histological features were semi-quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile-duct lesions were prominent and a particular pattern was found in which segments of bile ducts were "disrupted" and replaced by inflammatory reaction. A classification of the lesions is proposed: Class o--near normal livers; Class I--predominance of necrosis and suppuration; Class II--predominance of tuberculoid granulomas; Class III--portal fibrosis and non-specific infiltrate. There has been no evidence that treatment could induce bile-duct proliferation, fatty change of liver cells, or cholestasis. On the other hand, less fibrosis was found in treated patients. Pathogenesis of the bile-duct lesions is discussed.

journal_name

Histopathology

journal_title

Histopathology

authors

Teixeira F,Gayotto LC,De Brito T

doi

10.1111/j.1365-2559.1978.tb01716.x

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

231-7

issue

4

eissn

0309-0167

issn

1365-2559

journal_volume

2

pub_type

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