Abstract:
:Anaplastic choroid plexus carcinoma is a tumour with a predilection for the posterior fossa of infants and can be difficult to distinguish histologically from medulloblastoma without the aid of immunocytochemistry using a panel of antibodies. Of a series of 17 choroid plexus carcinomas (five of which were classed as moderately differentiated and 12 as anaplastic) 17 expressed antigens to transthyretin, transferrin and cathepsin and 16 expressed carbonic anhydrase II. Eleven expressed at least one epithelial marker (cytokeratin or epithelial membrane antigen). In contrast, none of six medulloblastomas expressed epithelial markers, transrythetin, carbonic anhydrase II or transferrin, though three were positive with antibodies to cathepsin.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Newbould MJ,Kelsey AM,Arango JC,Ironside JW,Birch Jdoi
10.1111/j.1365-2559.1995.tb00643.xsubject
Has Abstractpub_date
1995-02-01 00:00:00pages
137-43issue
2eissn
0309-0167issn
1365-2559journal_volume
26pub_type
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