Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.

Abstract:

AIMS:To investigate the relation of fatty acid synthase (FAS) expression to the clinicopathological characteristics of gastric cancers and gastric tumorigenesis. METHODS AND RESULTS:FAS expression was examined immunohistochemically in 626 gastric cancers, 51 gastric adenomas, and non-neoplastic epithelium contiguous with cancer tissue including normal foveolae, intestinal metaplasia, regenerative epithelium, and gastric glands. FAS expression was found in more than 70% of gastric cancers. Interestingly, it occurred preferentially in differentiated carcinomas, male cases, and in patients over 51 years old. Although previous reports showed that FAS expression is closely related to cancer progression, in gastric cancers FAS expression had no relationship with prognosis, cancer progression as indicated by depth of invasion, venous and lymphatic permeation, and distant metastasis. Gastric tubular adenoma and intestinal metaplasia, which are thought to be associated with well-differentiated gastric carcinomas, showed a frequency of FAS expression similar to that of differentiated carcinomas; however, normal foveolae and gastric glands showed no or less FAS expression. CONCLUSIONS:FAS expression occurs at the early stage of tumorigenesis and plays important roles in the formation of precancerous foci rather than in the progression of carcinoma of the stomach.

journal_name

Histopathology

journal_title

Histopathology

authors

Kusakabe T,Nashimoto A,Honma K,Suzuki T

doi

10.1046/j.1365-2559.2002.01289.x

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

71-9

issue

1

eissn

0309-0167

issn

1365-2559

pii

1289

journal_volume

40

pub_type

杂志文章
  • What to do with high autofluorescence background in pancreatic tissues - an efficient Sudan black B quenching method for specific immunofluorescence labelling.

    abstract:AIMS:High levels of autofluorescence in tissue samples can entirely mask specific labellings with fluorophores and thus impair immunofluorescence histochemistry. In pancreatic tissue samples we observed autofluorescence as a common problem often mediated by the fixation and processing procedure. METHODS AND RESULTS:Us...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12935

    authors: Erben T,Ossig R,Naim HY,Schnekenburger J

    更新日期:2016-09-01 00:00:00

  • Identifying HIV infection in diagnostic histopathology tissue samples--the role of HIV-1 p24 immunohistochemistry in identifying clinically unsuspected HIV infection: a 3-year analysis.

    abstract:AIMS:Because of the clinical difficulty in identifying the early stages of human immunodeficiency virus (HIV) infection, the histopathologist often has to consider the diagnosis of HIV in tissue samples from patients with no previous suspicion of HIV infection. The aim was to investigate the practicality and utility of...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2010.03513.x

    authors: Moonim MT,Alarcon L,Freeman J,Mahadeva U,van der Walt JD,Lucas SB

    更新日期:2010-03-01 00:00:00

  • Biomarkers in bladder cancer.

    abstract::Cancer biomarkers provide an opportunity to diagnose tumours earlier and with greater accuracy. They can also identify those patients most at risk of disease recurrence and predict which tumours will respond to different therapeutic approaches. Such biomarkers will be especially useful in the diagnosis and management ...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2010.03592.x

    authors: Proctor I,Stoeber K,Williams GH

    更新日期:2010-07-01 00:00:00

  • Morphologically High-grade Trichoblastic Carcinoma: A Clinico-pathological Study with Long Term Clinical Follow-up.

    abstract:AIMS:Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterized by malignant transformation of a pre-existing benign trichoblastoma and subdivided histologically into low- and high-grade tumours. While morphologically low-grade trichoblastic carcinomas show an indolent b...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.14325

    authors: Mehta A,Davey J,Wiedemeyer K,Brenn T

    更新日期:2021-01-03 00:00:00

  • Staging of prostate cancer.

    abstract::Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging sy...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2011.04025.x

    authors: Cheng L,Montironi R,Bostwick DG,Lopez-Beltran A,Berney DM

    更新日期:2012-01-01 00:00:00

  • The molecular pathogenesis of Hodgkin lymphoma.

    abstract::Hodgkin lymphoma (HL) is an unusual malignancy in that the tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, are a minor component of the tumour mass, the bulk of which is a mixed cellular infiltrate. There is compelling evidence that HRS cells are clonal B cells that have lost their B cell phenotype. Mature B...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2010.03705.x

    authors: Farrell K,Jarrett RF

    更新日期:2011-01-01 00:00:00

  • Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?

    abstract::Five antibodies, MT1 (CD43), UCHL1 (CD45RO), OPD4, poly-CD3 and beta F1, were assessed for their reactivity with 50 archival cases of T-cell lymphoma in formalin-fixed paraffin-embedded tissue. All cases had been previously characterized as T-cell lymphomas, and the histological types included 14 cases of small cerebr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1991.tb00231.x

    authors: Cabeçadas JM,Isaacson PG

    更新日期:1991-11-01 00:00:00

  • The role of CD5 expression in thymic carcinoma: possible mechanism for interaction with CD5+ lymphoid stroma (microenvironment).

    abstract:AIMS:Most thymic carcinomas express the lymphocyte marker CD5 aberrantly. This study was performed to examine the role of the self-reactive CD5 antigen in thymic carcinoma. METHODS AND RESULTS:We examined CD5 expression in thymic carcinoma in relation to the lymphoid stroma. All cases of thymic carcinoma examined expr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12742

    authors: Hosaka N,Ohe C,Miyasaka C,Nakano Y,Sakaida N,Uemura Y,Saito Y,Ikehara S,Tsubura A,Takahashi H

    更新日期:2016-02-01 00:00:00

  • Napsin A is a useful marker for metastatic adenocarcinomas of pulmonary origin.

    abstract:AIMS:To address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin. METHODS AND RESULTS:Fifty-four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF-1, CK7, CK20 and CDX2 ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12383

    authors: Kim MY,Go H,Koh J,Lee K,Min HS,Kim MA,Jeon YK,Lee HS,Moon KC,Park SY,Kim WH,Chung DH

    更新日期:2014-08-01 00:00:00

  • Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection.

    abstract:AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12499

    authors: Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

    更新日期:2015-01-01 00:00:00

  • A clinicopathological study of malignant odontogenic tumours.

    abstract:AIMS:Malignant odontogenic tumours (MOTs) are rare neoplasms occurring primarily within the jaw. The objective of this study was to determine the incidence, demographics and clinicopathological features of the MOTs from two institutions. METHODS AND RESULTS:The records of the Department of Oral Pathology, Faculty of D...

    journal_title:Histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2559.2012.04200.x

    authors: Chaisuparat R,Sawangarun W,Scheper MA

    更新日期:2012-07-01 00:00:00

  • Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma.

    abstract:AIMS:Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NP...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02920.x

    authors: Segawa Y,Oda Y,Yamamoto H,Uryu H,Shiratsuchi H,Hirakawa N,Tomita K,Yamamoto T,Oda S,Yamada T,Komune S,Tsuneyoshi M

    更新日期:2008-01-01 00:00:00

  • The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma.

    abstract:AIMS:Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biolo...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01587.x

    authors: Rajpert-De Meyts E,Jacobsen GK,Bartkova J,Aubry F,Samson M,Bartek J,Skakkebaek NE

    更新日期:2003-03-01 00:00:00

  • Choriocarcinoma in situ: a case at an early gestational stage.

    abstract::A case of choriocarcinoma in situ arising in an 11 week gestational placenta is reported. Histologically, a localized nodule, measuring 5 mm, of neoplastic trophoblastic proliferation appeared to arise directly from normal stem villi and projected into the intervillous space. The tumour was composed of biphasic cytotr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1995.tb00313.x

    authors: Fukunaga M,Ushigome S,Ishikawa E

    更新日期:1995-11-01 00:00:00

  • Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis.

    abstract:AIMS:To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge-shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. METHODS AND RESULTS:The hi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02822.x

    authors: Araya J,Kawabata Y,Tomichi N,Kaneko K,Hayashi K,Iwabuchi K,Terasaki Y,Kawashima T,Watanabe M

    更新日期:2007-10-01 00:00:00

  • HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category.

    abstract:AIMS:HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13253

    authors: Holzschuh MA,Czyz Z,Hauke S,Inwald EC,Polzer B,Brockhoff G

    更新日期:2017-10-01 00:00:00

  • Acquired aganglionosis following surgery for Hirschsprung's disease: a report of five cases during a 33-year experience with pull-through procedures.

    abstract::Acquired Hirschsprung's disease is a rare and controversial form of colonic aganglionosis. Little is known about its aetiology and pathogenesis. We report five cases encountered amongst 173 long-term follow-up patients treated for classical Hirschsprung's disease between 1957 and 1990 at the Red Cross Children's Hospi...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.1993.tb00096.x

    authors: Cohen MC,Moore SW,Neveling U,Kaschula RO

    更新日期:1993-02-01 00:00:00

  • Evolving techniques for gene fusion detection in soft tissue tumours.

    abstract::Chromosomal rearrangements resulting in the fusion of coding parts from two genes or in the exchange of regulatory sequences are present in approximately 20% of all human neoplasms. More than 1000 such gene fusions have now been described, with close to 100 of them in soft tissue tumours. Although little is still know...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/his.12272

    authors: Mertens F,Tayebwa J

    更新日期:2014-01-01 00:00:00

  • Immunoglobulin-containing cells in liver biopsies of patients with chronic hepatitis and primary biliary cirrhosis.

    abstract::The numbers of IgA, IgM and IgG-containing cells were studied by means of an indirect immunoperoxidase technique and morphometry in liver biopsies of patients with primary biliary cirrhosis and chronic hepatitis, in whom serum immunoglobulin concentrations were also determined. In patients with primary biliary cirrhos...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1984.tb02368.x

    authors: Van Spreeuwel JP,Van Gorp LH,Nadorp JH,Janssens AR,Lindeman J,Meijer CJ

    更新日期:1984-07-01 00:00:00

  • Inflammatory disease of the bile ducts-cholangiopathies: liver biopsy challenge and clinicopathological correlation.

    abstract::Liver biopsy challenge and clinicopathological correlation Liver biopsy interpretation in inflammatory diseases of the bile ducts or chronic cholangiopathies may be challenging, especially for pathologists working outside referral centres, where there is a limited exposure to relatively uncommon conditions. In view of...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2011.03853.x

    authors: Portmann B,Zen Y

    更新日期:2012-01-01 00:00:00

  • Staging of bladder cancer.

    abstract::Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/his.13734

    authors: Magers MJ,Lopez-Beltran A,Montironi R,Williamson SR,Kaimakliotis HZ,Cheng L

    更新日期:2019-01-01 00:00:00

  • Global Gleason grade groups in prostate cancer: concordance of biopsy and radical prostatectomy grades and predictors of upgrade and downgrade.

    abstract:AIMS:To evaluate concordance, upgrades and downgrades from biopsy to prostatectomy, and associated clincopathological parameters, using the recently proposed Gleason grade groups/International Society of Urologic Pathology (ISUP) grades. METHODS AND RESULTS:We evaluated 2529 patients who underwent biopsy and prostatec...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13179

    authors: Athanazio D,Gotto G,Shea-Budgell M,Yilmaz A,Trpkov K

    更新日期:2017-06-01 00:00:00

  • Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer.

    abstract:AIMS:Programmed death ligand 1 (PD-L1) immunohistochemistry has become a mandatory diagnostic test in the treatment of lung cancer. Several research initiatives have started to harmonise the five PD-L1 immunohistochemistry assays that have been used in clinical trials. Here, we report data on interlaboratory and intera...

    journal_title:Histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/his.13375

    authors: Scheel AH,Baenfer G,Baretton G,Dietel M,Diezko R,Henkel T,Heukamp LC,Jasani B,Jöhrens K,Kirchner T,Lasitschka F,Petersen I,Reu S,Schildhaus HU,Schirmacher P,Schwamborn K,Sommer U,Stoss O,Tiemann M,Warth A,Weichert

    更新日期:2018-02-01 00:00:00

  • A UK NEQAS ICC and ISH multicentre study using the Kreatech Poseidon HER2 FISH probe: intersite variation can be rigorously controlled using FISH.

    abstract:AIM:To assess a new HER2 fluorescence in situ hybridization (FISH) test and report on multicentre intrasite and intersite variation. METHODS AND RESULTS:HER2 results were scored from 45 breast cancers in eight laboratories using the Kreatech Poseidon HER2 FISH probe (Kreatech Diagnostics, Amsterdam, the Netherlands). ...

    journal_title:Histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2559.2010.03493.x

    authors: Bartlett JM,Campbell FM,Ibrahim M,Thomas J,Wencyk P,Ellis I,Kay E,Connolly Y,O'Grady A,Barnett S,Starczynski J,Cunningham P,Miller K

    更新日期:2010-02-01 00:00:00

  • Leiomyoblastoma of the uterus: an immunohistochemical and electron microscopic study of distinctive tumours with immature smooth muscle cell differentiation mimicking fetal uterine myocytes.

    abstract:AIMS:We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus. METHODS AND RESULTS:The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies. Grossly, all tumours were present in the uterine body, an...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01602.x

    authors: Watanabe K,Ogura G,Suzuki T

    更新日期:2003-04-01 00:00:00

  • The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma.

    abstract:AIMS:Macrophage colony-stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and stimulates proliferation and differentiation of monocytes, macrophages and their bone marrow progenitors. M-CSF, CSF-1R, the macrophage marker CD68, and the pan T-lymphocyte marker CD3 are increased in many huma...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2008.03058.x

    authors: Richardsen E,Uglehus RD,Due J,Busch C,Busund LT

    更新日期:2008-07-01 00:00:00

  • Differentiation of ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma by immunostaining with beta-catenin.

    abstract:AIMS:To investigate whether localization of beta-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. Extra-ovarian cancers which metastasize to the ovaries, especially from colorectal adenocarcinoma, frequently mimic primary ovarian carcinomas,...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01687.x

    authors: Chou YY,Jeng YM,Kao HL,Chen T,Mao TL,Lin MC

    更新日期:2003-08-01 00:00:00

  • Monoclonal antibody HML-1 reactivity with adult T-cell leukaemia/lymphoma and other lymphomas.

    abstract::Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1), a causative virus of adult T-cell leukaemia/lymphoma (ATLL), is known to be transmitted by breast-feeding. Using a monoclonal antibody HML-1 which labels human intestinal intra-epithelial T lymphocytes, we have immunohistochemically examined ATLL tissues in order ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1994.tb01322.x

    authors: Kitajima S,Tokunaga M,Goto M,Sato E,Utsunomiya A,Ohtsuka M,Hanada S,Arima T

    更新日期:1994-09-01 00:00:00

  • Histological grading of invasive breast carcinoma--a simplification of existing methods in a large conservation series with long-term follow-up.

    abstract:AIMS:To assess the validity of grading in the Edinburgh Breast Conservation Series; a consecutive cohort of 1812 early breast cancer patients treated by breast conservation and radiotherapy between 1981 and 1998 in a single specialist centre with > or =9 years' follow-up and full staging data. METHODS AND RESULTS:A si...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2009.03429.x

    authors: Thomas JS,Kerr GR,Jack WJ,Campbell F,McKay L,Pedersen HC,Kunkler IH,Cameron DA,Chetty U,Bartlett JM

    更新日期:2009-12-01 00:00:00

  • Intestinal metaplasia subtyping: evaluation of Gomori's aldehyde fuchsin for routine diagnostic use.

    abstract:AIMS:Intestinal metaplasia (IM) has been implicated in the pathogenesis of gastro-oesophageal carcinoma, but because of its common occurrence, its specificity for use in cancer surveillance is low. IM subtypes characterized by mucin phenotype have been studied to try and improve specificity. METHODS AND RESULTS:On bal...

    journal_title:Histopathology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2559.1997.2110847.x

    authors: Shah KA,Deacon AJ,Dunscombe P,Price AB

    更新日期:1997-09-01 00:00:00