当前位置： SCI文献检索 > HISTOPATHOLOGY期刊下所有文献 > Antibodies to cytokeratins bind to epitopes in human uterine smooth muscle cells in normal and pathological pregnancies.

Antibodies to cytokeratins bind to epitopes in human uterine smooth muscle cells in normal and pathological pregnancies.

Abstract：

:Cytokeratin antibodies have been widely used for the identification of trophoblast cells in the placental bed, following their invasion from the developing conceptus. Their identification centres upon the expression of cytokeratin in epithelial cells, from which trophoblast cells are derived. Our recent observations indicate that this strict relationship may be more complex than was thought. Cryostat and paraffin sections of human decidua and myometrium, taken from the placental bed and the uterotomy cut, were examined immunocytochemically for cytokeratins using ten antibody clones selected to identify different cytokeratin proteins and antigenic epitopes. Biopsy specimens were obtained from normal and pathological pregnancies (pre-eclampsia, fetal retardation, amnioninfection, hysterorrhexis, placenta praevia) at the time of caesarean section (26-41 weeks of pregnancy). Antibodies against nine clones, CAM 5.2, MNF 116, AE1/AE3, CK5, KS-B17.2, CY-90, M20, E3, and 34 beta E12 identified, as expected, syncytial giant cells and mononuclear trophoblasts within the placental bed and glandular epithelial cells throughout the uterus. In addition, they stained numerous fusiform cells that were classified by established criteria to represent smooth muscle cells, both within blood vessels and myometrium. No staining differences were observed between normal and pathological disorders. These results indicate that cytokeratin antibodies CAM 5.2, MNF 116 and AE1/AE3, and other antibodies targeting proteins 8 and 18, cross-react with epitopes expressed in cells other than giant trophoblastic cells and mononuclear trophoblasts in the uterus and, thus, caution has to be used when such antibodies are used for the diagnostic characterization of tissues related to the placental bed.

journal_name

Histopathology

journal_title

Histopathology

authors

Stiemer B,Graf R,Neudeck H,Hildebrandt R,Hopp H,Weitzel HK

doi

10.1111/j.1365-2559.1995.tb00303.x

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

407-14

issue

5

eissn

0309-0167

issn

1365-2559

journal_volume

27

pub_type

杂志文章

相关文献

HISTOPATHOLOGY文献大全
  • Overexpression of RAD51 occurs in aggressive prostatic cancer.

    abstract：AIMS:To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes. METHODS AND RESULTS:RAD51 expression identified immunohistochemically was compared between prostatic cancers occ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2009.03448.x

    authors： Mitra A,Jameson C,Barbachano Y,Sanchez L,Kote-Jarai Z,Peock S,Sodha N,Bancroft E,Fletcher A,Cooper C,Easton D,IMPACT Steering Committee and IMPACT and EMBRACE Collaborators.,Eeles R,Foster CS

    更新日期：2009-12-01 00:00:00

  • Neuropilin-2 expression in cancer.

    abstract：AIMS:Neuropilin-2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin-2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study was to validate a protocol for the evaluation of neuropilin-2 protein expression in situ, by comparison with in-situ ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2012.04224.x

    authors： Jubb AM,Sa SM,Ratti N,Strickland LA,Schmidt M,Callahan CA,Koeppen H

    更新日期：2012-09-01 00:00:00

  • Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBC

    abstract：AIMS:We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B cell lymphoma (DLBCLsn ) in a series of 240 cases of DLBCL not otherwise specified [DLBCLall (NOS) ], including DLBCLsn training set (n = 11) and validation set (n = 18), and DLBCLnon-sn (n = 211). METHODS AND RESUL...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/his.13106

    authors： Carreras J,Kikuti YY,Beà S,Miyaoka M,Hiraiwa S,Ikoma H,Nagao R,Tomita S,Martin-Garcia D,Salaverria I,Sato A,Ichiki A,Roncador G,Garcia JF,Ando K,Campo E,Nakamura N

    更新日期：2017-03-01 00:00:00

  • Tenascin-C in primary malignant melanoma of the skin.

    abstract：AIMS:To investigate the expression and the prognostic role of glycoprotein Tenascin-C (Tn-C) in primary melanoma of the skin. METHODS AND RESULTS:The immunohistochemical expression of Tn-C was studied in 98 primary melanomas and related to inflammation, invasion, and patient outcome. Patients were followed up for dise...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2004.01976.x

    authors： Ilmonen S,Jahkola T,Turunen JP,Muhonen T,Asko-Seljavaara S

    更新日期：2004-10-01 00:00:00

  • Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.

    abstract：AIMS:Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosar...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2559.2001.01277.x

    authors： Goh YW,Spagnolo DV,Platten M,Caterina P,Fisher C,Oliveira AM,Nascimento AG

    更新日期：2001-11-01 00:00:00

  • Immunocytochemical study of 12E7 in small round-cell tumours of childhood: an assessment of its sensitivity and specificity.

    abstract：:12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue. The diagnostic utility of 12E7 as a marker of Ewing's sarcoma and peripheral neuroectodermal tumour was assessed. Immunocytochemical studies were performed on 120 small round-cell tumours from childre...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1993.tb01243.x

    authors： Ramani P,Rampling D,Link M

    更新日期：1993-12-01 00:00:00

  • Expression of apoptosis-regulatory proteins in lesions of pulmonary Langerhans cell histiocytosis.

    abstract：AIMS:Pulmonary Langerhans cell histiocytosis (PLCH) is characterized by the presence of lesions containing numerous activated Langerhans cells (LCs). An uncontrolled immune response sustained by activated LCs seems to be involved in the pathogenesis of the disease. The aim of this study was to establish whether disrupt...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2004.01875.x

    authors： Marchal J,Kambouchner M,Tazi A,Valeyre D,Soler P

    更新日期：2004-07-01 00:00:00

  • Immunohistochemical study of endometrial high-grade endometrioid carcinoma with or without a concurrent low-grade component: implications for pathogenetic and survival differences.

    abstract：AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/his.12664

    authors： Mao TL,Ayhan A,Kuo KT,Lin MC,Tseng LH,Ogawa H

    更新日期：2015-10-01 00:00:00

  • Hyaline globules in ovarian tumours.

    abstract：:Hyaline eosinophilic globules have so far been described in a restricted variety of tumour types. We have noted their presence in a variety of gynaecological malignancies, in particular mixed Müllerian tumours and other epithelial ovarian tumours. We therefore studied their incidence and distribution in a series of ma...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1993.tb01244.x

    authors： al-Nafussi AI,Hughes DE,Williams AR

    更新日期：1993-12-01 00:00:00

  • Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease.

    abstract：AIMS:Pathological or neuroprotective mechanisms in the brain in severe malaria may arise from microvascular obstruction with malaria-parasitized erythrocytes. This study aimed to investigate the role of hypoxia and induction of the vascular endothelial growth factor (VEGF) pathway in the neuropathophysiology of severe ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2010.03619.x

    authors： Medana IM,Day NP,Roberts R,Sachanonta N,Turley H,Pongponratn E,Hien TT,White NJ,Turner GD

    更新日期：2010-08-01 00:00:00

  • Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection.

    abstract：AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/his.12499

    authors： Munari E,Chaux A,Maldonado L,Compérat E,Varinot J,Bivalacqua TJ,Hoque MO,Netto GJ

    更新日期：2015-01-01 00:00:00

  • Nephroblastoma with fibroadenomatous-like structures.

    abstract：:Review of the histological sections of the tumours of 889 patients from the files of the SIOP Nephroblastoma trials and studies has revealed 23 cases with a distinctive growth pattern. Due to the similarity of the histological structures with the architecture of adenofibroma (fibroadenoma) of the ovary we have called ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1984.tb02321.x

    authors： Delemarre JF,Sandstedt B,Tournade MF

    更新日期：1984-01-01 00:00:00

  • Large cell lymphoma of bone. A report of three cases of B-cell origin.

    abstract：:Clinicopathological and immunohistological features of three cases of large cell lymphoma of bone are reported. On histological grounds, all the cases were diagnosed as histiocytic lymphomas (Rappaport) or primary centroblastic lymphomas, polymorphic subtype (Kiel). On immunophenotyping, malignant cells strongly react...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1988.tb01928.x

    authors： Falini B,Binazzi R,Pileri S,Mori A,Bertoni F,Canino S,Fagioli M,Minelli O,Ciani C,Pellicioli P

    更新日期：1988-02-01 00:00:00

  • Hamartomas of the breast: six novel diagnostic features in three-dimensional thick sections.

    abstract：:Fifteen hamartomas of the breast have been studied by dissecting microscopy of thick sections at a depth of 1.0 to 2.5 mm, and by conventional 5 microns deep sections. This combined approach has revealed six distinctive features, three in the parenchymal structure and three in the connective tissue components. Ducts (...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1994.tb01296.x

    authors： Davies JD,Kulka J,Mumford AD,Armstrong JS,Wells CA

    更新日期：1994-02-01 00:00:00

  • Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett's oesophagus.

    abstract：AIMS:To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett's oesophagus patients. METHODS AND RESULTS:Immunostaining was analysed on a total of 192 biopsy samples of 22 Barrett's patients with no dysplasia...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2011.03743.x

    authors： van de Winkel A,van Zoest KP,van Dekken H,Moons LM,Kuipers EJ,van der Laan LJ

    更新日期：2011-01-01 00:00:00

  • Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients.

    abstract：AIMS:To study whether coexpression of the two hypoxia-related proteins hypoxia-inducible factor (HIF)-1α and glucose transporter (GLUT)-1 has prognostic relevance in oral squamous cell carcinomas (OSCCs). METHODS AND RESULTS:Eighty-two OSCC samples were analysed for expression levels of HIF-1α and GLUT-1 by immunohist...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2011.03806.x

    authors： Eckert AW,Lautner MH,Schütze A,Taubert H,Schubert J,Bilkenroth U

    更新日期：2011-06-01 00:00:00

  • A systematic analysis of commonly used antibodies in cancer diagnostics.

    abstract：AIMS:Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/his.12255

    authors： Gremel G,Bergman J,Djureinovic D,Edqvist PH,Maindad V,Bharambe BM,Khan WA,Navani S,Elebro J,Jirström K,Hellberg D,Uhlén M,Micke P,Pontén F

    更新日期：2014-01-01 00:00:00

  • Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia.

    abstract：AIMS:Glutamate receptor antagonists have failed clinical stroke trials and it has been proposed that the action of N-methyl D-aspartate receptors is necessary for neuronal survival. Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial e...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2007.02703.x

    authors： Beschorner R,Simon P,Schauer N,Mittelbronn M,Schluesener HJ,Trautmann K,Dietz K,Meyermann R

    更新日期：2007-06-01 00:00:00

  • Monoclonal antibody HML-1 reactivity with adult T-cell leukaemia/lymphoma and other lymphomas.

    abstract：:Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1), a causative virus of adult T-cell leukaemia/lymphoma (ATLL), is known to be transmitted by breast-feeding. Using a monoclonal antibody HML-1 which labels human intestinal intra-epithelial T lymphocytes, we have immunohistochemically examined ATLL tissues in order ...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1994.tb01322.x

    authors： Kitajima S,Tokunaga M,Goto M,Sato E,Utsunomiya A,Ohtsuka M,Hanada S,Arima T

    更新日期：1994-09-01 00:00:00

  • High expression of MDR-1 gene and P-glycoprotein in initial and re-biopsy specimens of relapsed B-cell lymphoma.

    abstract：AIMS:Multidrug resistance (MDR) is a major obstacle in the treatment of lymphoma. The expression of MDR-1 mRNA and P-glycoprotein (MDR-1/P-gp) has been linked to MDR. We aimed to investigate the expression of MDR-1/P-gp in B-cell lymphoma. METHODS AND RESULTS:Samples at diagnosis and relapse from 10 patients with B-ce...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2559.2001.01076.x

    authors： Liu Q,Ohshima K,Kikuchi M

    更新日期：2001-03-01 00:00:00

  • Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis.

    abstract：AIMS:To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge-shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. METHODS AND RESULTS:The hi...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2007.02822.x

    authors： Araya J,Kawabata Y,Tomichi N,Kaneko K,Hayashi K,Iwabuchi K,Terasaki Y,Kawashima T,Watanabe M

    更新日期：2007-10-01 00:00:00

  • Pigmented spindle cell carcinoid tumour of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms.

    abstract：AIMS:A variety of histological variants of thymic carcinoid tumour have been described. A rare case of pigmented spindle cell carcinoid tumour of the thymus is documented and compared with the reported cases of thymic pigmented carcinoid tumour in the literature, with a discussion of the differential diagnosis of spind...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2559.2002.01339.x

    authors： Kuo TT

    更新日期：2002-02-01 00:00:00

  • Microvessel density compared with the Chalkley count in a prognostic study of angiogenesis in breast cancer patients.

    abstract：AIMS:Evaluation of angiogenesis by intratumoral vessel profiles can be performed by different methods. The aim of this study was to investigate the prognostic value of estimates obtained by the intratumoral microvessel density (MVD) method and then to compare with corresponding estimates obtained by the Chalkley method...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2004.01848.x

    authors： Hansen S,Sørensen FB,Vach W,Grabau DA,Bak M,Rose C

    更新日期：2004-05-01 00:00:00

  • Dirofilariasis due to Dirofilaria repens in Italy, an emergent zoonosis: report of 60 new cases.

    abstract：AIMS:Sixty new cases of human dirofilariasis due to Dirofilaria repens, occurring in Italy between 1990 and 1999, are presented. This is the most extensive case study of this zoonosis reported worldwide by a single study group. The aim is to utilize this large experience to characterize the different histopathological ...

    journal_title：Histopathology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2559.2001.01099.x

    authors： Pampiglione S,Rivasi F,Angeli G,Boldorini R,Incensati RM,Pastormerlo M,Pavesi M,Ramponi A

    更新日期：2001-04-01 00:00:00

  • The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study.

    abstract：AIMS:Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immun...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2012.04210.x

    authors： Lee DY,Park JH,Shin HT,Yang JM,Jang KT,Kwon GY,Lee KH,Shim JS

    更新日期：2012-07-01 00:00:00

  • No evidence for c-erbB-2 overexpression in gastric carcinogenesis.

    abstract：AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2559.1998.00376.x

    authors： Blok P,Craanen ME,Dekker W,Offerhaus GJ,Tytgat GN

    更新日期：1998-04-01 00:00:00

  • Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue.

    abstract：AIMS:Tyrosine kinase receptors Her2/neu and c-Met play an important role in breast cancer development and progression. Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by two diffe...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2007.02732.x

    authors： Lindemann K,Resau J,Nährig J,Kort E,Leeser B,Annecke K,Welk A,Schäfer J,Vande Woude GF,Lengyel E,Harbeck N

    更新日期：2007-07-01 00:00:00

  • Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast.

    abstract：AIMS:Comedo carcinoma is generally regarded as the subtype of ductal carcinoma in situ (DCIS) most likely to progress to invasive carcinoma. Increased angiogenesis could be associated with an enhanced risk of progression and might therefore be a marker of poor prognosis, as can be demonstrated for invasive breast tumou...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.2005.02299.x

    authors： Vogl G,Dietze O,Hauser-Kronberger C

    更新日期：2005-12-01 00:00:00

  • Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in intrahepatic cholangiocarcinoma.

    abstract：:Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2559.1994.tb01570.x

    authors： Terada T,Nakanuma Y

    更新日期：1994-08-01 00:00:00

  • Structural and cell surface antigen expression in the rete ovarii and epoophoron differs from that in the Fallopian tube and in endometriosis.

    abstract：AIMS:We compared the immunohistochemical profiles of the rete ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. MATERIALS AND METHODS:Twenty-four women with no evide...

    journal_title：Histopathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2559.2000.00938.x

    authors： Russo L,Woolmough E,Heatley MK

    更新日期：2000-07-01 00:00:00