CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17.

abstract：:The CD30 antigen is a characteristic phenotypic feature of Sternberg-Reed and Hodgkin cells and is also found in a subset of large cell non-Hodgkin's lymphomas. The finding of CD30 positive cells in some centroblastic/centrocytic (cb/cc) follicular lymphomas prompted us to characterize the presence and distribution of...

journal_title：Histopathology

authors： Piris M,Gatter KC,Mason DY

更新日期：1991-01-01 00:00:00

abstract：AIMS:Breast cancer 1 (BRCA1) expression is down-regulated in a significant proportion of non-hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen (ER)-negative tumours. Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate ...

journal_title：Histopathology

authors： Thike AA,Tan PH,Ikeda M,Iqbal J

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to examine the immunohistochemical expression of p53 and bcl-2 in Kaposi's sarcoma and relate this with proliferation index (as measured by MIB-1 staining) and clinicopathological subtypes. Twenty formalin-fixed, paraffin-embedded cases of Kaposi's sarcoma were stained with commercially avail...

journal_title：Histopathology

authors： Dada MA,Chetty R,Biddolph SC,Schneider JW,Gatter KC

更新日期：1996-08-01 00:00:00

abstract：:Ten cases of malignant lymphoma of the colon and rectum complicating chronic inflammatory bowel disease are presented. Seven patients had chronic ulcerative colitis with a history varying from 6 to 20 years. There was extensive colitis in six of these patients and left-sided colitis in one. All seven lymphomas showed ...

journal_title：Histopathology

authors： Shepherd NA,Hall PA,Williams GT,Codling BW,Jones EL,Levison DA,Morson BC

更新日期：1989-10-01 00:00:00

abstract：:There are many significant differences, but also considerable overlap between the quantitative histopathological features of mild and marked atypical endometrial hyperplasias and well and moderately differentiated carcinomas, thus preventing its application to individual patient care. To try to overcome this problem, ...

journal_title：Histopathology

authors： Baak JP,Kurver PH,Overdiep SH,Delemarre JF,Boon ME,Lindeman J,Diegenbach PC

更新日期：1981-11-01 00:00:00

abstract：:A series of 10 sweat-gland carcinomas is reported. The ages of the patients at presentation ranged from 12 to 79 years. Three of the tumours had shown long latent periods with a mass present for up to 20 years. Prognosis proved to be related to the histological subtype. Thus, two papillary syringocystadeno-carcinomas,...

journal_title：Histopathology

authors： Dissanayake RV,Salm R

更新日期：1980-07-01 00:00:00

abstract：AIMS:Cyclin D1 overexpression was examined in early gastric carcinomas and precursor lesions with the following aims; (1) to assess the chronology of cyclin D1 overexpression in various stages of gastric carcinogenesis, (2) to correlate cyclin D1 overexpression with the Lauren type, the grade of differentiation and the...

journal_title：Histopathology

authors： Blok P,Craanen ME,van Diest PJ,Dekker W,Tytgat GN

更新日期：2000-02-01 00:00:00

abstract：AIMS:Using intraoperative frozen sections to diagnose pulmonary sclerosing pneumocytoma is always challenging. However, an accurate diagnosis is needed to guide surgical management and prevent unnecessary treatment. The aim of this study was to investigate the most frequently misdiagnosed histological patterns and eval...

journal_title：Histopathology

authors： Yang CH,Lee LY

更新日期：2018-02-01 00:00:00

abstract：AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...

journal_title：Histopathology

authors： Mao TL,Ayhan A,Kuo KT,Lin MC,Tseng LH,Ogawa H

更新日期：2015-10-01 00:00:00

abstract：AIMS:Conjunctival pigmented lesions have characteristic clinical and histopathological appearances. Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva. Our aim was to evaluate the possibility of...

journal_title：Histopathology

authors： Perra MT,Colombari R,Maxia C,Zucca I,Piras F,Corbu A,Bravo S,Scarpa A,Sirigu P

更新日期：2006-03-01 00:00:00

abstract：AIM:Dual-colour chromogenic in-situ hybridization (dc-CISH) is an emerging methodology for characterizing genomic alterations. This study was aimed at evaluating the performance of a dc-CISH kit (ZytoVision) in determining human epidermal growth factor receptor 2 (HER2) status in breast cancer. METHODS AND RESULTS:Two...

journal_title：Histopathology

authors： Hwang CC,Pintye M,Chang LC,Chen HY,Yeh KY,Chein HP,Lee N,Chen JR

更新日期：2011-11-01 00:00:00

abstract：:A recently described unifying proposal for mantle cell lymphoma has led to the formulation of strict diagnostic criteria based on morphology, immunology and molecular data to define this specific entity. Previous studies were often based on broader definitions such as centrocytic lymphoma, intermediately differentiate...

journal_title：Histopathology

authors： Pittaluga S,Wlodarska I,Stul MS,Thomas J,Verhoef G,Cassiman JJ,Van den Berghe H,de Wolf-Peeters C

更新日期：1995-01-01 00:00:00

abstract：:A series of 256 bone marrow biopsy specimens was obtained at different times from a group of patients with acute myeloid leukaemia, chronic granulocytic leukaemia and acute lymphoblastic leukaemia, and was analysed in parallel with peripheral blood smears and bone marrow aspirate samples. In five of these biopsy speci...

journal_title：Histopathology

authors： Islam A,Henderson ES

更新日期：1988-06-01 00:00:00

abstract：AIMS:Pulmonary artery (PA) dissection is a rare event which usually occurs in patients with underlying pulmonary hypertension. We describe two patients who developed PA dissection without pre-existing pulmonary hypertension and present an extensive review of the literature. METHODS AND RESULTS:In the first patient (a ...

journal_title：Histopathology

authors： Inayama Y,Nakatani Y,Kitamura H

更新日期：2001-05-01 00:00:00

abstract：:Analgesic nephropathy is known to have a high incidence in Australia where, following the experience in Scandinavia, reports have been published for some time recording the association between analgesic nephropathy and urothelial malignancies. The morbid anatomical features of analgesic nephropathy are now sufficientl...

journal_title：Histopathology

authors： Lomax-Smith J,Seymour AE

更新日期：1980-05-01 00:00:00

abstract：AIMS:We sought to delineate and describe three cases of a distinctive mesenchymal neoplasm of the vulva showing adipocytic differentiation and affecting young patients. METHODS AND RESULTS:In three patients between 13 and 38 years of age, the vulvar tumours had well-circumscribed borders and ranged in size from 35 to ...

journal_title：Histopathology

authors： Lae ME,Pereira PF,Keeney GL,Nascimento AG

更新日期：2002-06-01 00:00:00

abstract：AIMS:Prostate gland volume is generally assessed by transrectal ultrasound examination or magnetic resonance imaging at the time of prostatic biopsy or pre-brachytherapy planning. The volume is most commonly measured using the formula, prostate volume = height x width x length x pi/6, which is derived considering the g...

journal_title：Histopathology

authors： Varma M,Morgan JM

更新日期：2010-07-01 00:00:00

abstract：:Lobular carcinoma in situ and atypical lobular hyperplasia were first described over 50 years ago. Despite this long incubation period, the biological nature of the lesions remains controversial. They are generally regarded as 'risk indicators' of invasive cancer rather than true precursor lesions. When first describe...

journal_title：Histopathology

authors： Lishman SC,Lakhani SR

更新日期：1999-09-01 00:00:00

abstract：:We have studied the clinical, radiological and pathological features of three patients with recurrent massive lower gastrointestinal arterial haemorrhage. Case 1 was an example of Dieulafoy's vascular malformation within the proximal ascending colon in a 46-year-old woman. Cases 2 and 3 were men aged 81 and 83 years w...

journal_title：Histopathology

authors： Bateman AC,Beer TW,Bass PS,Odurny A,Gallagher PJ

更新日期：1996-09-01 00:00:00

abstract：:Five antibodies, MT1 (CD43), UCHL1 (CD45RO), OPD4, poly-CD3 and beta F1, were assessed for their reactivity with 50 archival cases of T-cell lymphoma in formalin-fixed paraffin-embedded tissue. All cases had been previously characterized as T-cell lymphomas, and the histological types included 14 cases of small cerebr...

journal_title：Histopathology

authors： Cabeçadas JM,Isaacson PG

更新日期：1991-11-01 00:00:00

abstract：AIMS:Rosai-Dorfman disease (RDD) commonly occurs in lymph nodes, but it can also affect the genitourinary (GU) system. In a search of GU RDD, we identified three cases involving the testis and three the kidney. METHODS AND RESULTS:The mean age was 52.4 (35-76) years. Tumour sizes were 3.6 cm on average (1.5-4.3) for t...

journal_title：Histopathology

authors： Wang CC,Al-Hussain TO,Serrano-Olmo J,Epstein JI

更新日期：2014-12-01 00:00:00

abstract：AIMS:To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas. METHODS AND RESULTS:A total of 57 carcinomas and respective gastric tissues were inc...

journal_title：Histopathology

authors： Lacueva J,Perez-Ramos M,Soto JL,Oliver I,Andrada E,Medrano J,Perez-Vazquez T,Arroyo A,Carrato A,Ferragut JA,Calpena R

更新日期：2005-04-01 00:00:00

abstract：AIMS:SMAD4 acts as a tumour suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC) patients. Although next-generation sequencing (NGS) enabled us to detect numerous genetic alterations in a single assay, the clinical significance of SMAD4 alteration detected with NGS has not been...

journal_title：Histopathology

authors： Oyanagi H,Shimada Y,Nagahashi M,Ichikawa H,Tajima Y,Abe K,Nakano M,Kameyama H,Takii Y,Kawasaki T,Homma KI,Ling Y,Okuda S,Takabe K,Wakai T

更新日期：2019-05-01 00:00:00

abstract：AIMS:To test the effectiveness of a teaching resource (a decision tree with diagnostic criteria based on published literature) in improving the proficiency of Gleason grading of prostatic cancer by general pathologists. METHODS:A decision tree with diagnostic criteria was developed by a panel of urological pathologist...

journal_title：Histopathology

authors： Griffiths DF,Melia J,McWilliam LJ,Ball RY,Grigor K,Harnden P,Jarmulowicz M,Montironi R,Moseley R,Waller M,Moss S,Parkinson MC

更新日期：2006-05-01 00:00:00

abstract：AIMS:  Follicular lymphoma (FL) is associated with bone marrow (BM) involvement in approximately 40-70% of cases. Previous studies have suggested that the immune-microenvironment of FL plays an important role in the clinical behaviour of the disease. To investigate the role of the microenvironment in BM involvement of ...

journal_title：Histopathology

authors： Rajnai H,Bödör C,Balogh Z,Gagyi E,Csomor J,Krenács T,Tóth E,Matolcsy A

更新日期：2012-05-01 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1 (HIF-1) activity is regulated by prolyl hydroxylase (PHD1, PHD2, PHD3) and factor inhibiting HIF-1 (FIH) that target the α subunit of HIF-1 (HIF-1α) for proteosomal degradation. We hypothesised that the elevated HIF-1α level is due in some tumours to epigenetic silencing by DNA hypermeth...

journal_title：Histopathology

authors： Huang KT,Mikeska T,Dobrovic A,Fox SB

更新日期：2010-09-01 00:00:00

abstract：AIMS:The available evidence indicates that most non-uterine high-grade serous carcinomas (HGSCs) arise from the fallopian tube (FT), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment. METHODS...

journal_title：Histopathology

authors： Singh N,Gilks CB,Wilkinson N,McCluggage WG

更新日期：2015-09-01 00:00:00

abstract：AIMS:Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. RESULTS:The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immuno...

journal_title：Histopathology

authors： Montes-Moreno S,Climent F,González de Villambrosía S,González Barca EM,Batlle A,Insunza A,Pané-Foix M,Colorado M,Martin-Sánchez G,Espiga CR,Conde E,Piris MA

更新日期：2015-12-01 00:00:00

abstract：AIMS:Matrix metalloproteases (MMPs) and their inhibitors (TIMPs) play an essential role in the degradation of stromal connective tissue and basement membrane components. The aim of this study was to determine whether the dynamic analysis of these components can help to predict tumour aggressiveness. METHODS AND RESULT...

journal_title：Histopathology

authors： González LO,González-Reyes S,Marín L,González L,González JM,Lamelas ML,Merino AM,Rodríguez E,Pidal I,del Casar JM,Andicoechea A,Vizoso F

更新日期：2010-12-01 00:00:00

abstract：AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved...

journal_title：Histopathology

authors： Yang QQ,Deng YF

更新日期：2015-06-01 00:00:00