Abstract:
:Lobular carcinoma in situ and atypical lobular hyperplasia were first described over 50 years ago. Despite this long incubation period, the biological nature of the lesions remains controversial. They are generally regarded as 'risk indicators' of invasive cancer rather than true precursor lesions. When first described, the 'carcinoma in situ' designation implied radical treatment in the form of a mastectomy. Subsequent observation has shown that the lesions are often multifocal and bilateral. The risk to the woman of developing invasive cancer after a diagnosis of lobular carcinoma in situ is small. Hence, the lesion has increasingly been regarded as a 'hyperplastic' proliferation, which although predicting for subsequent risk of invasive cancer, does not in itself need treatment. In this review, we challenge this view and explore the developments in the understanding of this controversial entity.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Lishman SC,Lakhani SRdoi
10.1046/j.1365-2559.1999.00815.xkeywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
195-200issue
3eissn
0309-0167issn
1365-2559pii
his815journal_volume
35pub_type
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