Abstract:
:The numbers of IgA, IgM and IgG-containing cells were studied by means of an indirect immunoperoxidase technique and morphometry in liver biopsies of patients with primary biliary cirrhosis and chronic hepatitis, in whom serum immunoglobulin concentrations were also determined. In patients with primary biliary cirrhosis the absolute and relative number of IgM-containing cells in the liver was significantly higher, whereas the absolute and relative number of IgG-containing cells in the liver was significantly lower compared to patients with chronic hepatitis. IgM-containing cells in liver biopsies of patients with primary biliary cirrhosis correlated strongly with their serum IgM levels. It is concluded that determination of the pattern of immunoglobulin containing cells in liver biopsies may help in the differentiation of primary biliary cirrhosis from chronic hepatitis and that local production of IgM in the liver may contribute significantly to the high serum IgM levels in patients with primary biliary cirrhosis.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Van Spreeuwel JP,Van Gorp LH,Nadorp JH,Janssens AR,Lindeman J,Meijer CJdoi
10.1111/j.1365-2559.1984.tb02368.xsubject
Has Abstractpub_date
1984-07-01 00:00:00pages
559-66issue
4eissn
0309-0167issn
1365-2559journal_volume
8pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract:AIMS:To determine the frequency of point mutation in c-kit in CD117+ small cell lung cancer (SCLC). A significant proportion of SCLCs have been documented to be CD117+, thereby signifying they express the c-kit gene product. This finding suggests this tumour may be a potential target for tyrosine kinase inhibitor (TKI)...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02259.x
更新日期:2005-11-01 00:00:00
abstract::We have investigated the immunohistochemical expression of p53 protein in 96 cases of non-Hodgkin's lymphoma using a panel of five antibodies. Positive neoplastic cells were found in 30 (31.2%) cases, which could be divided into two groups according to their patterns of reactivity with the different antibodies; i.e. t...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00067.x
更新日期:1993-01-01 00:00:00
abstract:AIMS:The clinical outcome of patients with locally advanced rectal cancer who undergo neoadjuvant chemoradiotherapy (CRT) is influenced by the tumour response to treatment, which is reflected by tumour regression grade and post-treatment (y) TNM stage. Little is known about the prognostic value of pretreatment histopat...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13242
更新日期:2017-09-01 00:00:00
abstract:AIMS:More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and the receptor VEGFR-3. METHODS AND RESULTS:...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04307.x
更新日期:2012-12-01 00:00:00
abstract:AIMS:Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non-tumour tissue. METHODS AND RESULTS:I...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2007.02738.x
更新日期:2007-08-01 00:00:00
abstract:AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00376.x
更新日期:1998-04-01 00:00:00
abstract:AIMS:Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immun...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04210.x
更新日期:2012-07-01 00:00:00
abstract:AIMS:Neoadjuvant chemotherapy followed by surgery is the standard of care for patients with gastro-oesophageal adenocarcinoma. The aims were to validate the utility of the tumour regression grade (TRG) in patients who have received chemotherapy and to investigate if (i) TRG correlates with tumour downstaging and (ii) T...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03404.x
更新日期:2009-10-01 00:00:00
abstract:AIMS:We compared the immunohistochemical profiles of the rete ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. MATERIALS AND METHODS:Twenty-four women with no evide...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00938.x
更新日期:2000-07-01 00:00:00
abstract:AIMS:Hodgkin lymphoma treatments are largely based on the generation of reactive oxygen species, but increased expression of antioxidant enzymes may contribute to chemoresistance. The aims of this study were: to define the extent and prognostic value of oxidative stress marker and antioxidant enzyme expression in Hodgk...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12389
更新日期:2014-09-01 00:00:00
abstract::The AMeX method (cold Acetone fixation with subsequent Methyl benzoate and Xylene treatment and routine paraffin embedding) has been recently revived for simultaneous preservation of morphology of cells and their antigens. We propose a modification of this method (ModAMeX), with the use of proteolytic enzyme inhibitor...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb01606.x
更新日期:1989-11-01 00:00:00
abstract:AIMS:Biphenotypic sinonasal sarcoma (SNS) is a locally aggressive tumour that occurs in the sinonasal region. PAX3-MAML3 has recently been identified as a recurrent fusion gene event in this entity; however, a subset of tumours harbour alternative PAX3 rearrangement without the involvement of MAML3. In this study we so...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13045
更新日期:2016-12-01 00:00:00
abstract:AIMS: Follicular lymphoma (FL) is associated with bone marrow (BM) involvement in approximately 40-70% of cases. Previous studies have suggested that the immune-microenvironment of FL plays an important role in the clinical behaviour of the disease. To investigate the role of the microenvironment in BM involvement of ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04187.x
更新日期:2012-05-01 00:00:00
abstract:AIMS:To study three atypical glioneuronal tumours (GNTs), in order to shed light on the clinical and pathological features of this diverse tumour group. METHODS AND RESULTS:Clinical and neuropathological data for each case were retrospectively reviewed. Case 1 involved a 17-year-old boy with left leg movement difficul...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12750
更新日期:2016-02-01 00:00:00
abstract::We have studied 74 benign intramuscular angiomas in order to try and correlate clinical behaviour with histological appearances. The purpose was to find means of predicting those which would recur. Mean age at presentation was 17.6 years and 85% of the cases presented before age 30. The male: female ratio was 1.4:1. A...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00814.x
更新日期:1991-01-01 00:00:00
abstract::Cytokeratin antibodies have been widely used for the identification of trophoblast cells in the placental bed, following their invasion from the developing conceptus. Their identification centres upon the expression of cytokeratin in epithelial cells, from which trophoblast cells are derived. Our recent observations i...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00303.x
更新日期:1995-11-01 00:00:00
abstract:AIMS:We report a case study to elucidate the pathogenesis of polyarteritis nodosa (PAN) type vasculitis, a rare complication of familial mediterranean fever (FMF). METHODS AND RESULTS:A woman with amyloidosis complicating FMF underwent a cadaveric renal transplantation and 5 years later suffered an acute myocardial in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00462.x
更新日期:1998-08-01 00:00:00
abstract:AIMS:Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci. METHODS AND RESULTS:Seventy-three CRCs with high-grade budding (> 10 budding foci in a x 20 objective field) were cl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02162.x
更新日期:2005-07-01 00:00:00
abstract::In recent years, there have been several important refinements in the classification of cutaneous mesenchymal neoplasms, including the description of new tumour types, along with the identification of novel and recurrent molecular genetic findings. In addition to providing new insights into tumour biology, many of the...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12930
更新日期:2016-05-01 00:00:00
abstract:AIMS:The differential diagnosis of benign hepatic lesions and well-differentiated hepatocellular carcinomas can be a challenge, especially in small biopsy specimens. Recently, novel proteins expressed by the neovasculature in hepatocellular carcinoma (HCC) have been identified. The aim of this study was to compare the ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02489.x
更新日期:2006-09-01 00:00:00
abstract:AIMS:Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14254
更新日期:2020-09-16 00:00:00
abstract::A case of visceral botryomycosis of the liver in a 50-year-old man is reported. The clinical diagnosis was hepatocellular carcinoma. Pathological examination of the surgically resected specimen demonstrated microabscesses containing gram- positive microorganisms with surrounding fibrosis replacing liver parenchyma. An...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1995.tb00294.x
更新日期:1995-07-01 00:00:00
abstract:AIMS:To investigate whether an antibody against an intracellular epitope can detect CD19 in routine biopsy specimens and thus to document in detail its expression in human lymphomas. METHOD AND RESULTS:A polyclonal antibody to the C terminus of CD19 was used to immunostain paraffin-embedded samples of normal and neopl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.02317.x
更新日期:2006-02-01 00:00:00
abstract:AIMS:There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to g...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13816
更新日期:2019-05-01 00:00:00
abstract:AIM:To assess the potential prognostic significance of a range of molecular and morphological parameters in glioblastomas that can be applied in the setting of a routine diagnostic neuropathology laboratory. METHODS AND RESULTS:A consecutive series of 107 adult glioblastomas were studied. Retinoblastoma and deleted-in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2004.01887.x
更新日期:2004-06-01 00:00:00
abstract:AIMS:Rheumatoid arthritis (RA) and pigmented villonodular synovitis (PVNS) are aggressive diseases with progressive joint destruction. The present study aims to define cell cycle phases, polyploidy and the immunophenotype of proliferating synovial cells in both diseases. METHODS AND RESULTS:Synovial tissues from patie...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2005.01959.x
更新日期:2005-05-01 00:00:00
abstract::Histological features were semi-quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile-duct lesions were prominent and a particular pattern was found in which segm...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1978.tb01716.x
更新日期:1978-07-01 00:00:00
abstract:AIMS:Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates in a subset of patients suggest that a sensitive companion diagnostic test is required. The predictive value of programmed death ligand 1 (PD-L1) staining in melanoma has been questioned due to inconsist...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13528
更新日期:2018-09-01 00:00:00
abstract::The reactivity of a monoclonal anti-neutrophil elastase antibody (NP57) with routinely processed biopsy samples from various acute leukaemias has been examined and compared with that of chloroacetate esterase and CD15 (hapten X), two other myeloid cell-associated markers detectable in paraffin sections. No staining wa...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1989.tb02205.x
更新日期:1989-06-01 00:00:00
abstract::Elastosis, a previously unreported feature, was found to be common in granular cell tumours. Twenty-four of 28 consecutive granular cell tumours were shown to display elastosis. The elastosis was found in three main sites: adventitial, interstitial and septal. Elastosis is statistically associated with the fibrosis pr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1990.tb01057.x
更新日期:1990-01-01 00:00:00